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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sureshvarma D , MPharma

About VAPTAN 15MG TABLET 7'S

VAPTAN 15MG TABLET 7'S belongs to a group of medicines called vasopressin V2 receptor antagonist used to treat hyponatremia (low levels of sodium) in patients with heart failure, liver disease and hormonal imbalances such as Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Additionally, VAPTAN 15MG TABLET 7'S is also used to treat autosomal dominant polycystic kidney disease (ADPKD).
 
VAPTAN 15MG TABLET 7'S contains ‘tolvaptan’ that works by blocking the effect of vasopressin, resulting in decreased water reabsorption, a net increase in free water excretion (aquaresis) and an increase in serum sodium concentrations. This decrease in free water is not associated with an increased excretion of sodium or potassium ions, the increase in serum sodium concentration is solely a result of  increased urine production
 
You are advised to take VAPTAN 15MG TABLET 7'S for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as dizziness, headache, dry mouth, fatigue, diarrhoea, thirst and increased urge to urinate. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
 
Do not take VAPTAN 15MG TABLET 7'S if you are pregnant as it may cause foetal harm. Consult your doctor before taking VAPTAN 15MG TABLET 7'S if you are breastfeeding. VAPTAN 15MG TABLET 7'S is not recommended for children below 18 years as the efficacy and safety have not been established. VAPTAN 15MG TABLET 7'S may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Inform your doctor about all the medicines you are taking and about your health condition to rule out any unpleasant side-effects.

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Whats That

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Non returnable*
COD available

Online payment accepted

Composition

TOLVAPTAN

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

Uses of VAPTAN 15MG TABLET 7'S

Hyponatremia (low sodium levels) and autosomal dominant polycystic kidney disease (ADPKD).

Medicinal Benefits

VAPTAN 15MG TABLET 7'S belongs to a group of medicines called vasopressin V2 receptor antagonist. VAPTAN 15MG TABLET 7'S is used to treat hyponatremia (low levels of sodium) in patients with heart failure, liver disease and hormonal imbalances such as Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Besides this, VAPTAN 15MG TABLET 7'S is also used to treat autosomal dominant polycystic kidney disease (ADPKD). VAPTAN 15MG TABLET 7'S works by blocking the effect of vasopressin, a hormone which is involved in the formation of cysts in ADPKD patients. By blocking the effect of vasopressin, VAPTAN 15MG TABLET 7'S slows down the development of cysts in kidneys and reduces the symptoms of the disease. VAPTAN 15MG TABLET 7'S antagonises the effect of vasopressin, this results in an increase in free water clearance and decreases urine osmolality due to increased urinary excretion, thereby increases serum sodium concentrations.

Side Effects of VAPTAN 15MG TABLET 7'S

  • Dizziness
  • Headache
  • Dry mouth
  • Fatigue
  • Weakness
  • Diarrhoea
  • Thirst
  • Increased urge to urinate

Directions for Use

Swallow VAPTAN 15MG TABLET 7'S as a whole with a glass of water, do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take VAPTAN 15MG TABLET 7'S if you are allergic to any of its contents, if you have raised liver enzymes in the blood, very low blood volume, if there is no urine production, if you cannot tell that you are thirsty. Inform your doctor if you have liver disease, difficulty in urination, diabetes, high levels of uric acid, advanced kidney disease or if you have to restrict fluid intake due to certain medical conditions. Do not take VAPTAN 15MG TABLET 7'S if you are pregnant as it may cause foetal harm. Consult your doctor before taking VAPTAN 15MG TABLET 7'S if you are breastfeeding. VAPTAN 15MG TABLET 7'S is not recommended for children below 18 years as efficacy and safety have not been established. VAPTAN 15MG TABLET 7'S may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. 

Therapeutic Class

CARDIOVASCULAR AGENTS

Drug-Drug Interactions

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TolvaptanMifepristone
Critical
TolvaptanAtazanavir
Critical

Drug-Drug Interactions

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TolvaptanMifepristone
Critical
How does the drug interact with VAPTAN 15MG TABLET 7'S:
When VAPTAN 15MG TABLET 7'S is taken with Mifepristone, it may increase the levels of VAPTAN 15MG TABLET 7'S, which may increase the risk of side effects.

How to manage the interaction:
Taking VAPTAN 15MG TABLET 7'S and Mifepristone together is not recommended, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanAtazanavir
Critical
How does the drug interact with VAPTAN 15MG TABLET 7'S:
When VAPTAN 15MG TABLET 7'S and Atazanavir are taken together, may significantly increase the blood levels and effects of VAPTAN 15MG TABLET 7'S.

How to manage the interaction:
There may be a possibility of interaction between VAPTAN 15MG TABLET 7'S and Atazanavir, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanVoriconazole
Critical
How does the drug interact with VAPTAN 15MG TABLET 7'S:
Co-administration of VAPTAN 15MG TABLET 7'S together with Voriconazole may significantly increase the blood levels and effects of VAPTAN 15MG TABLET 7'S.

How to manage the interaction:
There may be a possibility of interaction between VAPTAN 15MG TABLET 7'S and Voriconazole, but it can be taken if prescribed by a doctor. If you experience difficulty swallowing, trouble speaking, muscle weakness call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanTelaprevir
Critical
How does the drug interact with VAPTAN 15MG TABLET 7'S:
When VAPTAN 15MG TABLET 7'S and Telaprevir are taken together, may significantly increase the blood levels and effects of VAPTAN 15MG TABLET 7'S.

How to manage the interaction:
There may be a possibility of interaction between VAPTAN 15MG TABLET 7'S and Telaprevir, but it can be taken if prescribed by a doctor. If you notice any of these signs - like difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanRitonavir
Critical
How does the drug interact with VAPTAN 15MG TABLET 7'S:
Taking Ritonavir and VAPTAN 15MG TABLET 7'S may significantly increase the blood levels of VAPTAN 15MG TABLET 7'S.

How to manage the interaction:
Taking VAPTAN 15MG TABLET 7'S with Ritonavir is not recommended as it can possibly result in an interaction, it can be taken if a doctor has advised it. If you notice any of these symptoms like difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, fits, contact a doctor. Do not discontinue any medications without consulting a doctor.
TolvaptanFosamprenavir
Critical
How does the drug interact with VAPTAN 15MG TABLET 7'S:
When VAPTAN 15MG TABLET 7'S is taken with Fosamprenavir, may significantly increase the blood levels and effects of VAPTAN 15MG TABLET 7'S.

How to manage the interaction:
There may be a possibility of interaction between VAPTAN 15MG TABLET 7'S and Fosamprenavir, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanKetoconazole
Critical
How does the drug interact with VAPTAN 15MG TABLET 7'S:
When VAPTAN 15MG TABLET 7'S is taken with Ketoconazole, may increase the risk of side effects.

How to manage the interaction:
Taking VAPTAN 15MG TABLET 7'S with Ketoconazole is not recommended as it can lead to an interaction, it can be taken if prescribed by a doctor. However, if you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanNefazodone
Critical
How does the drug interact with VAPTAN 15MG TABLET 7'S:
When VAPTAN 15MG TABLET 7'S and Nefazodone are taken together, may significantly increase the blood levels and effects of VAPTAN 15MG TABLET 7'S.

How to manage the interaction:
There may be a possibility of interaction between VAPTAN 15MG TABLET 7'S and Nefazodone, but it can be taken if prescribed by a doctor. If you notice any of these signs - like difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanItraconazole
Critical
How does the drug interact with VAPTAN 15MG TABLET 7'S:
Co-administration of VAPTAN 15MG TABLET 7'S and Itraconazole may significantly raise VAPTAN 15MG TABLET 7'S blood levels and effects.

How to manage the interaction:
There may be a possibility of interaction between VAPTAN 15MG TABLET 7'S and Itraconazole, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanBoceprevir
Critical
How does the drug interact with VAPTAN 15MG TABLET 7'S:
Co-administration of Boceprevir and VAPTAN 15MG TABLET 7'S may significantly increase the blood levels and effects of VAPTAN 15MG TABLET 7'S.

How to manage the interaction:
There may be a possibility of interaction between VAPTAN 15MG TABLET 7'S and Boceprevir, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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TOLVAPTANGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TOLVAPTANGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit

How to manage the interaction:
Consuming grapefruit juice while taking VAPTAN 15MG TABLET 7'S can increase the effects of VAPTAN 15MG TABLET 7'S. Avoid taking VAPTAN 15MG TABLET 7'S with grapefruit juice.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • TELITHROMYCIN
  • SULPHAMETHOXAZOLE+TRIMETHOPRIM
  • KETOCONAZOLE
  • ITRACONAZOLE
  • RITONAVIR
  • INDINAVIR
  • SAQUINAVIR
  • NELFINAVIR
  • NEFAZODONE
  • SPIRONOLACTONE
  • VALSARTAN
  • SACUBITRIL
  • HEPARIN

Diet & Lifestyle Advise

  • Eat a diet rich in whole grains, vegetables, and fruits.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight with proper diet and exercise.
  • Manage stress with meditation, yoga, and massage.
  • Drink plenty of fluids.
  • Rehydration beverages that contain electrolytes are also helpful.

Habit Forming

No

Special Advise

  • Regular monitoring of liver functioning and electrolyte levels while taking VAPTAN 15MG TABLET 7'S is advised.
  • Treatment with VAPTAN 15MG TABLET 7'S should be started and re-started in a hospital or in the presence of a healthcare professional to monitor the sodium levels in your blood closely.

Author Details

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Disease/Condition Glossary

Hyponatremia: Sodium is an important electrolyte that helps in maintaining water balance in and around the cells. It helps in proper nerve, muscle functioning and maintains stable blood pressure levels. Low levels of sodium in the blood are referred to as hyponatremia. Normal levels of sodium are 135-145 milliequivalance per litre. Hyponatremia occurs when the level is below 135mEq/L. Symptoms include weakness, tiredness, nausea, vomiting, headache, irritability, confusion and muscle spasms.

Autosomal Dominant Polycystic Kidney Disease (ADPKD): It is an inherited disorder in which cysts are developed in the kidney. These cysts are non-cancerous sacs that contain a water-like fluid which puts pressure on the surrounding tissues, leading to reduced kidney function. Symptoms include high blood pressure, swollen abdomen, and back or side pain.

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