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Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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Composition :

DIVALPROEX-500MG

Manufacturer/Marketer :

Earthmed Pharmaceutical Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Vtrey-500 Tablet

Vtrey-500 Tablet belongs to a group of medicines called anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. Additionally, Vtrey-500 Tablet is also used to treat manic episodes associated with bipolar disorder and prevent migraines. Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures.

Vtrey-500 Tablet contains 'Divalproex', which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. Vtrey-500 Tablet increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helping treat bipolar disorder. 

Take Vtrey-500 Tablet with or without food. Depending on your medical condition, you are advised to take Vtrey-500 Tablet for as long as your doctor has prescribed it for you. In some cases, you may experience certain common side-effects such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Vtrey-500 Tablet without consulting your doctor to avoid worsening seizures. Do not take Vtrey-500 Tablet if you are pregnant, as it could cause serious birth defects. If you are of childbearing age, use effective contraception while taking Vtrey-500 Tablet . Consult your doctor before taking Vtrey-500 Tablet if you are breastfeeding. Avoid driving or operating machinery as Vtrey-500 Tablet causes dizziness and may affect thinking and motor skills. Avoid consuming alcohol along with Vtrey-500 Tablet as it could lead to increased dizziness. Care should be taken while giving Vtrey-500 Tablet to children below two years as there is a higher risk of liver intoxication during the first 6months of treatment. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Vtrey-500 Tablet

Epilepsy, bipolar disorder, migraine

Directions for Use

Tablet/Capsule: Swallow it as a whole with a glass of water; do not chew or crush it.Syrup/Suspension/Drops: Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack; shake the pack well before each use.Sprinkle capsule: Swallow it as a whole with water or sprinkle the capsule contents on food and consume.

Medicinal Benefits

Vtrey-500 Tablet belongs to a group of medicines called anticonvulsants or anti-epileptics. Vtrey-500 Tablet is used to treat epilepsy/seizures/fits. Also, Vtrey-500 Tablet is used to treat mood disorders and prevent migraine headaches. Vtrey-500 Tablet decreases the excessive and abnormal nerve activity in the brain. Thereby helping in controlling seizures. Vtrey-500 Tablet treats mood disorders by increasing the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Vtrey-500 Tablet prevents migraine headaches by limiting the transmission of nerve pain. Vtrey-500 Tablet is used alone or in combination to treat simple, complex partial, and complex absence seizures. Vtrey-500 Tablet is used in combination to treat multiple seizures, such as absence seizures.

Storage

Store in a cool and dry place away from sunlight
Side effects of Vtrey-500 Tablet
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Eat eggs for zinc and other nutrients that support healthy vision.
  • Consume blueberries as antioxidants to combat eye strain.
  • Include broccoli in your diet for diverse eye-boosting nutrients.
  • Eat sweet potatoes as a natural source of vitamin A.
  • Snack on almonds for vitamin E and eye protection.
  • Add tomatoes to your diet for lycopene and vision protection.
  • Perform exercises that improve binocular vision, such as dot-to-dot cards, coloring within lines, and Brock string tests.
  • Wear an eye patch and perform tasks like playing games and solving puzzles.
  • Patching and eye exercises can improve symptoms.
  • Get plenty of rest and sleep.
  • Keep your body warm.
  • Drink plenty of fluids to stay hydrated.
  • Avoid strenuous activities.
  • Maintain good hygiene to prevent flu from spreading.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Drug Warnings

Do not take Vtrey-500 Tablet if you are allergic to any of its contents, have/ had liver problems or urea cycle disorders. Inform your doctor before taking Vtrey-500 Tablet if you have pancreatitis, blood problems or multi-organ hypersensitivity. Consult your doctor immediately if you experience suicidal tendencies while taking Vtrey-500 Tablet . Vtrey-500 Tablet may cause thrombocytopenia (low blood platelets), hyperammonemia (high levels of ammonia in the blood), hypothermia (low body temperature) and liver problems. Please do not stop taking Vtrey-500 Tablet without consulting your doctor to avoid worsening of seizures. Do not take Vtrey-500 Tablet if you are pregnant, as it could cause serious birth defects. If you are of childbearing age, use effective contraception while taking Vtrey-500 Tablet . Consult your doctor before taking Vtrey-500 Tablet if you are breastfeeding. Avoid driving or operating machinery as Vtrey-500 Tablet causes dizziness and may affect thinking and motor skills. Avoid consuming alcohol along with Vtrey-500 Tablet as it could lead to increased dizziness. Care should be taken while giving Vtrey-500 Tablet to children below 2 years as there is a higher risk of liver intoxication during the first six months of treatment.

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Vtrey-500 Tablet:
Coadministration of Glycerol phenylbutyrate and Vtrey-500 Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Vtrey-500 Tablet together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Vtrey-500 Tablet:
Coadministration of Ertapenem with Vtrey-500 Tablet may reduce the blood levels of Vtrey-500 Tablet and increase the risk of developing seizures.

How to manage the interaction:
Although there is a possible interaction, ertapenem can be taken with Vtrey-500 Tablet if prescribed by the doctor. Consult the doctor if you experience loss of seizure control or changes in behaviour. Do not stop using any medications without talking to your doctor.
DivalproexEsketamine
Severe
How does the drug interact with Vtrey-500 Tablet:
Coadministration of Esketamine and Vtrey-500 Tablet can increase the side effects of esketamine.

How to manage the interaction:
Although taking Vtrey-500 Tablet and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any symptoms like drowsiness and impaired motor coordination, consult the doctor immediately. Do not stop using any medications without talking to your doctor.
DivalproexBexarotene
Severe
How does the drug interact with Vtrey-500 Tablet:
Co-administration of Vtrey-500 Tablet and Bexarotene can increase the risk of pancreatitis (inflammation of the pancreas).

How to manage the interaction:
Co-administration of Vtrey-500 Tablet and Bexarotene can lead to an interaction, but it can be taken when advised by your doctor. However, if you experience any symptoms like nausea, vomiting, or stomach cramps, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexMipomersen
Severe
How does the drug interact with Vtrey-500 Tablet:
Co-administration of Vtrey-500 Tablet and mipomersen can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Vtrey-500 Tablet and mipomersen can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult the doctor immediately. Avoid alcohol consumption, and Do not stop using any medications without a doctor's advice.
DivalproexLomitapide
Severe
How does the drug interact with Vtrey-500 Tablet:
Co-administration of Vtrey-500 Tablet and Lomitapide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Vtrey-500 Tablet and lomitapide can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like fever, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, or yellowing of the skin or eyes, consult the doctor immediately. Do not stop using any medications without the doctor's advice.
How does the drug interact with Vtrey-500 Tablet:
Co-administration of Vtrey-500 Tablet and Meropenem can reduce the blood levels of Vtrey-500 Tablet sodium.

How to manage the interaction:
Co-administration of Vtrey-500 Tablet with Meropenem can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Vtrey-500 Tablet:
Co-administration of buprenorphine with Vtrey-500 Tablet may increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Buprenorphine with Vtrey-500 Tablet can result in an interaction, it can be taken when a doctor has advised it. However, if you experience shortness of breath, irregular heart rhythms, nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexSodium oxybate
Severe
How does the drug interact with Vtrey-500 Tablet:
Co-administration of Sodium oxybate and Vtrey-500 Tablet can increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Sodium oxybate and Vtrey-500 Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like dizziness, sweating, palpitations, and shortness of breath, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Vtrey-500 Tablet:
Coadministration of Ketoconazole and Vtrey-500 Tablet may increase the risk of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Vtrey-500 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain, fatigue, nausea, vomiting, stomach pain, dark urine, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilising fat instead of glucose for the generation of energy.
  • Atkins diet (high fay and controlled carbohydrates) is recommended for adolescents and adults.
  • Exercising regularly helps in maintaining weight and improving overall health. 
  • Rest well, get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower the stress, decrease pain sensitivity and improves coping skills.
  • Have a seizure response plan, help those around you know what to do.
  • Prepare your living area, small changes may reduce the risk of physical injury during a seizure.
  • Understand what triggers seizures and try reducing or avoiding them.
  • Please pay attention to overall health as it can help in reducing seizure activity.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Vtrey-500 Tablet decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures.

Vtrey-500 Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, this helps in blocking the nerve transmission across the brain and provides a calming effect.

Vtrey-500 Tablet limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition which is characterized by intense headaches.

Vtrey-500 Tablet may interact with aspirin and cause abnormal side-effects. So, it is recommended to take any medication along with Vtrey-500 Tablet only after consulting a doctor.

Vtrey-500 Tablet may improve the symptoms of depression. However, do not use it without consulting a doctor as it may also cause mood disturbances and suicidal thoughts in some patients.

Do not discontinue Vtrey-500 Tablet without consulting your doctor. To treat your condition effectually, continue taking Vtrey-500 Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Vtrey-500 Tablet ; your doctor will gradually reduce the dose to avoid worsening seizures.

Vtrey-500 Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.

Vtrey-500 Tablet may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising. Regular monitoring of blood count is advised while taking Vtrey-500 Tablet .

Topiramate (anticonvulsant) should not be taken along with Vtrey-500 Tablet as it may cause hyperammonemia (excess ammonia in the blood), hypothermia (low body temperature) and liver problems.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • PREGABALIN
  • TOPIRAMATE
  • PHENOBARBITAL
  • PRIMIDONE
  • PHENYTOIN
  • CARBAMAZEPINE
  • LAMOTRIGINE
  • FELBAMATE
  • ETHOSUXIMIDE
  • ZIDOVUDINE
  • DULOXETINE
  • ESCITALOPRAM
  • AMITRIPTYLINE
  • NORTRIPTYLINE
  • ARIPIPRAZOLE
  • LURASIDONE
  • QUETIAPINE
  • ALPRAZOLAM
  • RIFAMPICIN
  • WARFARIN
  • IMIPENEM
  • MEROPENEM
  • DIAZEPAM

Special Advise

  • Regular monitoring of blood count and coagulation tests are advised while taking Vtrey-500 Tablet as it may cause thrombocytopenia (low platelet levels).
  • Vtrey-500 Tablet may cause liver toxicity, usually during the first 6months of treatment. Children below two years are at a higher risk. Regular monitoring of liver function tests before treatment and at frequent intervals is advised.
  • Vtrey-500 Tablet might alter thyroid function tests and urine ketone tests. Inform the person doing the tests that you are taking Vtrey-500 Tablet .

Disease/Condition Glossary

Epilepsy: Epilepsy is a sudden rush of electricity in the brain. It is a disorder of the nervous system which occurs due to disturbed nerve cell activity in the brain. In epilepsy the brain's electrical rhythms become imbalanced, resulting in recurrent seizures. In patients with seizures, the typical brain electrical pattern is disrupted by sudden bursts of electrical impulse that affect an individual's consciousness, movements or sensations. Seizures are of two types: generalised and partial seizures. Generalised seizures affect the entire brain, whereas partial seizures affect only a part of the brain. Seizures can cause uncontrollable muscle twitches and spasms. Stronger seizures may cause people to become confused or unconscious. Possible causes include high fever, trauma, genetic disorder, brain injury or stroke.

Mood disorder: It is a mental health disorder which mainly affects a person's emotional state. A mood disorder is associated with episodes of mood swings ranging from manic highs to depressive lows.

Migraine: Migraine is a neurological condition which is characterized by intense headaches. Symptoms include nausea, vomiting, and sensitivity to light and sound.

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