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Reviewed By Sureshvarma D , MPharma
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Composition

SAFINAMIDE-50MG

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Xafinact 50 Tablet 10's

Xafinact 50 Tablet 10's belongs to a class of drugs called antiparkinson agents, which are used in combination with other drugs for the treatment of the signs and symptoms of Parkinson's disease. Parkinson’s disease is a disorder of the central nervous system that affects movement and locomotion. It causes stiffness, shaking, and difficulty in walking, coordination and balance. 

Xafinact 50 Tablet 10's contains 'safinamide', belonging to the group of medications called monoamine oxidase type B (MAO-B) inhibitors. It works by increasing the amount of dopamine (a natural substance that is needed to control movement) in the brain.

Xafinact 50 Tablet 10's may cause common side effects like cough, depression, indigestion, flu-like symptoms, insomnia (difficulty sleeping), joint pain, and peripheral oedema. Most of these side effects of  Xafinact 50 Tablet 10's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Xafinact 50 Tablet 10's or any other medicines, please tell your doctor. Please inform your doctor if you are using any medications other than Xafinact 50 Tablet 10's. If you are pregnant or breastfeeding, it is advised to inform your doctor. Xafinact 50 Tablet 10's is not recommended in albinism, retinal degeneration, uveitis, inherited retinopathy or severe progressive diabetic retinopathy. Xafinact 50 Tablet 10's should be used with caution in patients like schizophrenia (a mental illness that causes disturbed thinking, loss of interest in life, and strong or unusual emotions), bipolar disorder (mood that changes from depressed to abnormally excited), or psychosis; or if you have high or low blood pressure; dyskinesia (abnormal movements); or sleep problems. Xafinact 50 Tablet 10's may cause serotonin syndrome when used with MAO inhibitors, antidepressants, or opioid drugs.

Uses of Xafinact 50 Tablet 10's

Parkinson's disease

Directions for Use

Swallow Xafinact 50 Tablet 10's as a whole with water. Do not chew, crush or break it.

Medicinal Benefits

Xafinact 50 Tablet 10's belongs to a class of drugs called antiparkinson agents, which are used in combination with other drugs for the treatment of the signs and symptoms of Parkinson's disease. It works by increasing the amount of dopamine (a natural substance needed to control movement) in the brain. Thereby improving the symptoms of Parkinson’s disease.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Xafinact 50 Tablet 10's

  • Cough
  • Depression
  • Indigestion
  • Flu-like symptoms
  • Insomnia (difficulty in sleeping)
  • Joint pain
  • Peripheral oedema

Drug Warnings

If you are known to be allergic to Xafinact 50 Tablet 10's or any other medicines, please tell your doctor. Please inform your doctor if you are using any medications other than Xafinact 50 Tablet 10's. If you are pregnant or breastfeeding, it is advised to inform your doctor. Xafinact 50 Tablet 10's is not recommended in albinism, retinal degeneration, uveitis, inherited retinopathy or severe progressive diabetic retinopathy. Xafinact 50 Tablet 10's should be used with caution in patients like schizophrenia (a mental illness that causes disturbed thinking, loss of interest in life, and strong or unusual emotions), bipolar disorder (mood that changes from depressed to abnormally excited), or psychosis; or if you have high or low blood pressure; dyskinesia (abnormal movements); or sleep problems. Xafinact 50 Tablet 10's should be used caution with liver diseases. Xafinact 50 Tablet 10's may cause serotonin syndrome when used with MAO inhibitors, antidepressants or opioid drugs. A combination of MAOIs and dextromethorphan has been reported to cause episodes of psychosis or abnormal behaviour.

Drug-Drug Interactions

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SafinamideAmitriptyline
Critical
SafinamideBuspirone
Critical

Drug-Drug Interactions

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SafinamideAmitriptyline
Critical
How does the drug interact with Xafinact 50 Tablet:
Using Amitriptyline together with Xafinact 50 Tablet can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Xafinact 50 Tablet and Amitriptyline together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.
SafinamideBuspirone
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with Buspirone can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Buspirone is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideMethyldopa
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet and Methyldopa together can increase the risk of high blood pressure or brain related problems.

How to manage the interaction:
Taking Xafinact 50 Tablet with Methyldopa is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately If you experience symptoms such as severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting. Do not discontinue any medications without first consulting your doctor.
SafinamideImipramine
Critical
How does the drug interact with Xafinact 50 Tablet:
Coadministration of Xafinact 50 Tablet with Imipramine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet and imipramine together is not recommended as it can result in an interaction, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideLinezolid
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with Linezolid can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Linezolid is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. If you notice any of these symptoms like confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, shaking, incoordination, stomach cramps, nausea, vomiting, and loose stools, consult a doctor. Do not discontinue any medications without consulting a doctor.
SafinamideDuloxetine
Critical
How does the drug interact with Xafinact 50 Tablet:
Coadministration of Xafinact 50 Tablet with duloxetine can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Duloxetine is not recommended as it can result in an interaction, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
SafinamideLisdexamfetamine
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with Lisdexamfetamine may raise blood pressure and increased heart rate.

How to manage the interaction:
Taking Xafinact 50 Tablet with Lisdexamfetamine is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms like headache, sleep disturbances, tremor(shaking of hands & legs), restlessness, nervousness, anxiety, palpitation, and rapid heartbeat, consult a doctor. Do not stop using any medications without first talking to your doctor.
SafinamideLevomilnacipran
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with levomilnacipran can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with levomilnacipran is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideClomipramine
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with Clomipramine can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Clomipramine with Xafinact 50 Tablet can possibly result in an interaction but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination (seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
SafinamideFentanyl
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with Fentanyl can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Fentanyl is not recommended as it can result in an interaction, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, muscle pain, stomach cramps, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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SAFINAMIDE-50MGTyramine-containing food
Severe

Drug-Food Interactions

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SAFINAMIDE-50MGTyramine-containing food
Severe
Common Foods to Avoid:
Pepperoni, Miso Soup, Natto, Ricotta, Salami, Shoyu, Shrimp, Stilton Cheese, Swiss Cheese, Tamari, Tempeh, Fish, Farm Cheese, Fava Beans, Fermented Seafood, Fermented Tofu, Gorgonzola Cheese, Chicken Liver, Chocolates, Cottage Cheese, Cream Cheese, Dried Sausage, Dry-Type Summer Sausages, Cheddar Cheese, Cashews, Camembert, Beef Liver, American Cheese, Almonds, Avocado

How to manage the interaction:
Eating tyramine containing foods while you are taking Xafinact 50 Tablet can raise your blood pressure levels. Avoid Tyramine containing food while on the treatment with Xafinact 50 Tablet. Consult your doctor immediately If you experience symptoms such as headache, sleep disturbances, tremor(shaking of hands & legs), restlessness, nervousness, anxiety, palpitation, and rapid heartbeat. Do not stop taking the medication without consulting a doctor.

Diet & Lifestyle Advise

  • A balanced diet is essential to show improvement in Parkinson's disease, including grains and leafy foods, as this food is rich in vitamins, fibres, and minerals. With this food, one should also include dairy items, protein-rich nourishments, for example, meat and beans, and solid fats found in nuts, olive oil, fish, and eggs in their diet. However, limit the consumption of sugar.
  • Avoid intake of high-protein foods like soy protein, fish, eggs, chicken, beef, and pork. Eat more whole-grain foods such as whole wheat bread, oatmeal, brown rice or pasta.
  • Eat more fibre-rich foods to ease constipation.
  • Drink plenty of water to avoid headaches due to dehydration.
  • Avoid the consumption of alcohol as it may increase drowsiness.

Habit Forming

No

Therapeutic Class

ANTIPARKINSON AGENTS

Xafinact 50 Tablet 10's Substitute

Substitutes safety advice
  • Safion 50 Tablet 10's

    by Others

    14.04per tablet
  • Zafimove 50 Tablet 10's

    by Others

    12.47per tablet

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • DICLOFENAC
  • TRAMADOL
  • FLUOXETINE
  • BUPROPION
  • AMITRIPTYLINE
  • BALOFLOXACIN
  • CIPROFLOXACIN
  • CARBAMAZEPINE
  • ROSUVASTATIN
  • PITAVASTATIN
  • PRAVASTATIN
  • METHOTREXATE
  • GLYBURIDE
  • MEPERIDINE
  • METHADONE
  • PROPOXYPHENE
  • ISOCARBOXAZID
  • LINEZOLID
  • METHYLENE BLUE
  • MOCLOBEMIDE
  • PHENELZINE
  • PROCARBAZINE
  • RASAGILINE
  • SELEGILINE
  • TRANYLCYPROMINE
  • DEXTROMETHORPHAN
  • TOPOTECAN

Special Advise

  • Talk to your doctor if you develop hallucinations or other changes in your behaviour.

Disease/Condition Glossary

Parkinson’s disease: It is a disorder of the central nervous system that affects movement due to damage of nerve cells in the brain which reduces the levels of dopamine and leads to symptoms such as stiffness, tremor in one hand, shaking, difficulty in walking, coordination and balance. This condition can last for many years or life-long. Treatment with medicines and physiotherapy may help control the symptoms and provide a quality life for as long as possible.

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