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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Hari Kumar , MBBS
Non returnable*
COD available

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Consume Type :

ORAL

Return Policy :

Not Returnable

About Yorirab L 25mg/20mg Tablet

Yorirab L 25mg/20mg Tablet belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD), acidity, heartburn, Zollinger-Ellison syndrome, Helicobacter pylori infection, irritable bowel syndrome, indigestion, duodenal and gastric ulcers. The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to acidity. 
 
Yorirab L 25mg/20mg Tablet is a combination of two drugs, namely: Rabeprazole (proton pump inhibitor) and Levosulpiride (prokinetic agent). Rabeprazole works by blocking an enzyme called the gastric proton pump, which is responsible for acid production. Levosulpiride works by increasing the pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, Yorirab L 25mg/20mg Tablet helps in preventing acid reflux, thereby providing relief from acidity and heartburn.
 
You are advised to take Yorirab L 25mg/20mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as headache, nausea, vomiting, gas, abdominal pain, dizziness, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Inform your doctor if you have a history of gastrointestinal bleeding or intestinal obstruction. On long-term treatment, Yorirab L 25mg/20mg Tablet may cause osteoporosis and hypomagnesemia. Consult a doctor if you are pregnant or breastfeeding. Yorirab L 25mg/20mg Tablet may cause drowsiness and dizziness, so drive only if you are alert. Yorirab L 25mg/20mg Tablet is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol along with Yorirab L 25mg/20mg Tablet as it could lead to increased drowsiness and elevate stomach acid production. 

Uses of Yorirab L 25mg/20mg Tablet

Gastro-oesophageal reflux disease, acidity, indigestion heartburn, and peptic ulcers.

Directions for Use

Take Yorirab L 25mg/20mg Tablet 1hour prior to food. Swallow Yorirab L 25mg/20mg Tablet as a whole with a glass of water; do not chew or crush it.

Medicinal Benefits

Yorirab L 25mg/20mg Tablet is a combination of two drugs, namely: Rabeprazole and Levosulpiride. Yorirab L 25mg/20mg Tablet belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD), acidity, heartburn, Zollinger-Ellison syndrome, Helicobacter pylori infection, irritable bowel syndrome, indigestion, duodenal and gastric ulcers. Rabeprazole is a proton pump inhibitor that works by blocking an enzyme called gastric proton pump, which is responsible for the production of acid. Levosulpiride is a prokinetic agent that increases the pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, Yorirab L 25mg/20mg Tablet helps in preventing acid reflux, thereby providing relief from acidity and heartburn. 

Storage

Store in a cool and dry place away from sunlight

Side Effects of Yorirab L 25mg/20mg Tablet

  • Headache
  • Nausea
  • Vomiting
  • Flatulence
  • Abdominal pain
  • Dizziness
  • Diarrhoea 

Drug Warnings

Do not take Yorirab L 25mg/20mg Tablet if you are allergic to any of its components. Inform your doctor if you have a history of pheochromocytoma (tumour of the adrenal gland), epilepsy, mania, gastrointestinal bleeding, intestinal obstruction, or severe kidney or liver impairment. Yorirab L 25mg/20mg Tablet may cause osteoporosis (weak and brittle bones) and hypomagnesemia (low magnesium levels) on long-term treatment. Consult a doctor if you are pregnant or breastfeeding. Yorirab L 25mg/20mg Tablet may cause dizziness and drowsiness, so drive only if you are alert. Yorirab L 25mg/20mg Tablet is not recommended for children as safety and effectiveness have not been established.

Drug-Drug Interactions

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RabeprazoleErlotinib
Critical
RabeprazoleRilpivirine
Critical

Drug-Drug Interactions

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RabeprazoleErlotinib
Critical
How does the drug interact with Yorirab L 25mg/20mg Tablet:
When used in combination with erlotinib, Yorirab L 25mg/20mg Tablet may prevent the absorption of erlotinib into the circulation, which might make erlotinib less effective in treating cancer.

How to manage the interaction:
Taking Yorirab L 25mg/20mg Tablet with Erlotinib is not recommended as it can result in an interaction, it should be taken only if a doctor has advised it. Do not stop using any medications without consulting a doctor.
RabeprazoleRilpivirine
Critical
How does the drug interact with Yorirab L 25mg/20mg Tablet:
Co-administration of Yorirab L 25mg/20mg Tablet can make Rilpivirine less effective by reducing its absorption in the body.

How to manage the interaction:
Taking Yorirab L 25mg/20mg Tablet with Rilpivirine is not recommended, but can be taken if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.
RabeprazolePhenytoin
Severe
How does the drug interact with Yorirab L 25mg/20mg Tablet:
When Phenytoin and Yorirab L 25mg/20mg Tablet are taken in combination, Phenytoin will reduce the concentration or impact of Yorirab L 25mg/20mg Tablet.

How to manage the interaction:
Although taking Phenytoin and Yorirab L 25mg/20mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
RabeprazoleAcalabrutinib
Severe
How does the drug interact with Yorirab L 25mg/20mg Tablet:
Taking Yorirab L 25mg/20mg Tablet together with Acalabrutinib results in a decreased effectiveness of Acalabrutinib.

How to manage the interaction:
Although taking Yorirab L 25mg/20mg Tablet and Acalabrutinib together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
RabeprazoleDasatinib
Severe
How does the drug interact with Yorirab L 25mg/20mg Tablet:
Taking Dasatinib with Yorirab L 25mg/20mg Tablet may decrease the blood levels of Dasatinib and reduce its effectiveness.

How to manage the interaction:
Taking Yorirab L 25mg/20mg Tablet with Dasatinib together can result in an interaction, but it can be taken if a doctor has advised it. In case of any unusual side effects, contact a doctor. Do not stop using any medications without a doctor's advice.
RabeprazoleMethotrexate
Severe
How does the drug interact with Yorirab L 25mg/20mg Tablet:
Co-administration of Methotrexate with Yorirab L 25mg/20mg Tablet can increase the blood levels and side effects of Methotrexate.

How to manage the interaction:
Although there is a possible interaction between Yorirab L 25mg/20mg Tablet and Methotrexate, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
RabeprazoleAtazanavir
Severe
How does the drug interact with Yorirab L 25mg/20mg Tablet:
Co-administration of Atazanavir's blood levels and absorption can both be affected by Yorirab L 25mg/20mg Tablet, which decreases the atazanavir's ability to treat HIV.

How to manage the interaction:
Although taking Yorirab L 25mg/20mg Tablet and atazanavir together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
RabeprazoleGefitinib
Severe
How does the drug interact with Yorirab L 25mg/20mg Tablet:
Taking Yorirab L 25mg/20mg Tablet together with Gefitinib results in decreased levels of gefitinib in your blood. This can result in a decreased effectiveness of gefitinib in treating the disease.

How to manage the interaction:
Although taking Yorirab L 25mg/20mg Tablet and Gefitinib together can possibly result in an interaction, it can be taken if your doctor has prescribed it. To lessen the effects of the interaction, it is advised that you take gefitinib 12 hours before or 12 hours after Yorirab L 25mg/20mg Tablet. Do not discontinue any medications without a doctor's advice.
RabeprazoleClopidogrel
Severe
How does the drug interact with Yorirab L 25mg/20mg Tablet:
Taking Clopidogrel with Yorirab L 25mg/20mg Tablet can reduce the effectiveness of Clopidogrel.

How to manage the interaction:
Taking Clopidogrel and Yorirab L 25mg/20mg Tablet together possibly has an interaction, but you can take these medications together if a doctor has advised it. Do not stop using any medications without talking to a doctor.
RabeprazolePazopanib
Severe
How does the drug interact with Yorirab L 25mg/20mg Tablet:
Taking Yorirab L 25mg/20mg Tablet together with Pazopanib can result in a decreased effectiveness of Pazopanib in treating the disease.

How to manage the interaction:
Although taking Yorirab L 25mg/20mg Tablet and Pazopanib together can result in an interaction, but can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat smaller meals more often.
  • Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
  • Maintain a healthy weight by regular exercising.
  • Avoid lying down after eating to prevent acid reflux.
  • Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
  • Practice relaxation techniques and avoid stress by doing yoga or meditation.
  • Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea, and soda. 
  • Avoid sitting continuously as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.

Habit Forming

No

Therapeutic Class

ANTACIDS, ANTIULCERANTS

Yorirab L 25mg/20mg Tablet Substitute

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Yorirab L 25mg/20mg Tablet contains Rabeprazole and Levosulpiride. Rabeprazole works by blocking an enzyme called gastric proton pump, which is responsible for the production of acid. Levosulpiride works by increasing the pressure of the inferior oesophageal (food pipe) sphincter, thereby prevents the backflow of food and acid into the mouth. Together, Yorirab L 25mg/20mg Tablet helps in providing relief from acidity.

Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting on a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.

Yorirab L 25mg/20mg Tablet contains rabeprazole which might increase the risk of osteoporosis (weak and brittle bones). This mainly occurs in people taking higher doses of Yorirab L 25mg/20mg Tablet for longer durations. Inform your doctor if you are at risk of osteoporosis. Your doctor may prescribe calcium and vitamin D supplements.

Dry mouth could be a side-effect of Yorirab L 25mg/20mg Tablet. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help stimulate saliva and thereby prevent drying of the mouth.

Do not take Yorirab L 25mg/20mg Tablet for longer durations unless prescribed by the doctor. Yorirab L 25mg/20mg Tablet might cause bone problems and hypomagnesemia on long-term treatment. Talk to your doctor if you do not find symptomatic relief despite taking Yorirab L 25mg/20mg Tablet for 2 weeks.

Yorirab L 25mg/20mg Tablet might cause irregular periods/abnormal menstruation. Consult your doctor if you notice abnormal bleeding patterns.

Drug-Drug Interactions Checker List

  • WARFARIN
  • METHOTREXATE
  • DIGOXIN
  • MYCOPHENOLATE MOFETIL
  • TACROLIMUS
  • AMOXICILLIN
  • CLARITHROMYCIN

Special Advise

  • Yorirab L 25mg/20mg Tablet might cause false-positive results for secretin stimulation test, prolactin test, and tests for tetrahydrocannabinol (THC). Inform the person doing the tests that you are taking Yorirab L 25mg/20mg Tablet.
  • Regular blood tests for monitoring magnesium levels and bone density tests are advised if you are on long-term treatment with Yorirab L 25mg/20mg Tablet.
  • Inform your doctor if you are due to have Chromogranin A test.

Disease/Condition Glossary

Acidity: The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like GERD, acidity, heartburn, and peptic ulcers.

Gastroesophageal reflux disease (GERD): It occurs when stomach acid frequently flows into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn and acidity. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing. 

Stomach ulcers: Stomach ulcers are sores that develop on the stomach and intestine lining due to erosion of the protective stomach lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion. 

Indigestion: Indigestion is the feeling of fullness. It occurs due to slow gastric emptying. Symptoms include stomach pain, bloating, heartburn, nausea, and vomiting.

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