Zaporil 50 mg Tablet 10's

Written By Santoshini Reddy G , M Pharmacy

Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

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MRP ₹58

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₹8.7 Cashback (15%)

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Whats That

About Zaporil 50 mg Tablet

Zaporil 50 mg Tablet belongs to a group of medicines called antipsychotics used to treat schizophrenia. Additionally, Zaporil 50 mg Tablet is also used to reduce the risk of suicidal behaviour in patients with schizophrenia or other similar disorders. Schizophrenia is a medical condition in which the person may feel, hear or see things that are not there, believe things that are not true, or feel unusually suspicious or confused.

Zaporil 50 mg Tablet contains ‘Clozapine’, which works by blocking the effects of chemical receptors in the brain, such as dopamine and serotonin. Thus, it helps in improving mood, behaviour and thoughts.

You are advised to take Zaporil 50 mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, Zaporil 50 mg Tablet may cause side effects such as tachycardia (fast heartbeat), dizziness, headache, tremor, sweating, dry mouth, nausea, constipation and visual disturbances. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Zaporil 50 mg Tablet suddenly, as it might cause withdrawal symptoms. Consult your doctor if you are pregnant. Do not take Zaporil 50 mg Tablet if you are breastfeeding, as it may pass into breastmilk. Avoid driving as Zaporil 50 mg Tablet may cause drowsiness and dizziness. Zaporil 50 mg Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol with Zaporil 50 mg Tablet as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Zaporil 50 mg Tablet

Schizophrenia

Directions for Use

Tablet/Capsule: Swallow it as a whole with a glass of water, do not chew or crush it.Orodispersible/Mouth dissolving tablet: Check the label for directions before use. Place the tablet in the mouth and allow it to dissolve.

Medicinal Benefits

Zaporil 50 mg Tablet belongs to a group of medicines called antipsychotics. Zaporil 50 mg Tablet is used to treat schizophrenia and to reduce the risk of suicidal behaviour in patients with schizophrenia or other similar disorders. Zaporil 50 mg Tablet works by blocking the effects of chemical receptors in the brain, such as dopamine and serotonin, thereby helping in improving mood, behaviour and thoughts. Zaporil 50 mg Tablet is used to treat schizophrenia when other antipsychotic drugs are ineffective or have caused severe adverse effects. Zaporil 50 mg Tablet is also used to treat psychotic disorders in patients with Parkinson’s disease when standard treatments have failed.

Storage

Keep Zaporil 50 mg Tablet out of reach and sight of children.

Side effects of Zaporil 50 mg Tablet

Headache

Dealing with Medication-Induced Headache:

Hydrate your body: Drink enough water to prevent dehydration and headaches.
Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
Take rest: lie down in a quiet, dark environment.
Cold or warm compresses can help reduce tension.
Stay Upright: Maintain good posture to keep symptoms from getting worse.
To treat headaches naturally, try acupuncture or massage therapy.
Over-the-counter pain relievers include acetaminophen and ibuprofen.
Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
Frequent Headaches: If you get reoccurring headaches, consult your doctor.
Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Sedation

Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.

Dizziness

Here are the 7 steps to manage Dizziness caused by medication:

Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
When standing up, do so slowly and carefully to avoid sudden dizziness.
Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Fast Heart Rate

Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):

Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.

Low Blood Pressure

Managing Low Blood Pressure Triggered by Medication: Expert Advice:

If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
Take regular breaks to sit or lie down if you need to stand for long periods.
When lying down, elevate your head with extra pillows to help improve blood flow.
Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.

Excessive Saliva Production

Regularly brush your tongue and teeth to prevent Excessive Saliva Production.
Avoid eating foods high in sugar or acid since these foods might increase saliva production, which increases the Excessive Saliva Production.
Keep your head up straight and maintain proper posture to prevent saliva from collecting in your mouth.

Constipation

Here are the steps to cope with constipation as a side effect of medication:

Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Drug Warnings

Do not take Zaporil 50 mg Tablet if you are allergic to any of its contents if you have galactose intolerance, total lactase deficiency, glucose-galactose malabsorption, low number of white blood cells or if you are taking medicines that can cause low levels of white blood cells, bone marrow disorder, epilepsy, circulatory collapse (pronounced fall in blood pressure that can lead to unconsciousness), brain disorders, severe kidney disease, heart disease, liver disease with jaundice, liver failure or paralytic ileus (small intestine disorder). Inform your doctor if you have a low number of white blood cells or platelet count, orthostatic hypotension, epilepsy, enlarged prostate or difficulty urinating, glaucoma, severe constipation, diabetes, heart, liver or kidney problems. Consult your doctor if you are pregnant. Do not take Zaporil 50 mg Tablet if you are breastfeeding, as it may pass into breastmilk.

Drug-Drug Interactions

ClozapineMetoclopramide

Critical

ClozapineRopinirole

Critical

Drug-Drug Interactions

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ClozapineMetoclopramide

Critical

How does the drug interact with Zaporil 50 mg Tablet:
Co-administration of Metoclopramide with Zaporil 50 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Metoclopramide with Zaporil 50 mg Tablet is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.

ClozapineRopinirole

Critical

How does the drug interact with Zaporil 50 mg Tablet:
When Ropinirole is taken with Zaporil 50 mg Tablet, it may not work as well.

How to manage the interaction:
Taking Ropinirole with Zaporil 50 mg Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as drowsiness, low blood pressure, dizziness, and lightheadedness. Do not stop using any medications without consulting doctor.

ClozapinePotassium citrate

Critical

How does the drug interact with Zaporil 50 mg Tablet:
Taking Zaporil 50 mg Tablet and Potassium citrate (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and other gastrointestinal injury.

How to manage the interaction:
Co-administration of Potassium citrate with Zaporil 50 mg Tablet is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.

ClozapineCisapride

Critical

How does the drug interact with Zaporil 50 mg Tablet:
When Zaporil 50 mg Tablet is taken with Cisapride, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Zaporil 50 mg Tablet with Cisapride there may be a possibility of interaction, but it can be taken if prescribed by a doctor. Call a doctor immediately if you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.

ClozapinePimozide

Critical

How does the drug interact with Zaporil 50 mg Tablet:
When Zaporil 50 mg Tablet is taken with Pimozide, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Zaporil 50 mg Tablet with Pimozide there may be a possibility of interaction, but it can be taken if prescribed by a doctor. Call a doctor immediately if you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.

ClozapineSparfloxacin

Critical

How does the drug interact with Zaporil 50 mg Tablet:
When Zaporil 50 mg Tablet is taken with Sparfloxacin, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Zaporil 50 mg Tablet with Sparfloxacin there may be a possibility of interaction, but it can be taken if prescribed by a doctor. Call a doctor immediately if you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.

ClozapineFlibanserin

Critical

How does the drug interact with Zaporil 50 mg Tablet:
When Flibanserin and Zaporil 50 mg Tablet are taken together, may increase side effects.

How to manage the interaction:
There may be a possibility of interaction between Zaporil 50 mg Tablet and Flibanserin, but it can be taken if prescribed by a doctor. If you notice any of these signs - like dizziness, drowsiness, fatigue, and difficulty concentrating, call a doctor right away. Do not stop using any medications without a doctor's advice.

ClozapineIsoprenaline

Severe

How does the drug interact with Zaporil 50 mg Tablet:
Taking Isoprenaline and Zaporil 50 mg Tablet may increase the effect of irregular heart rhythm that can be serious.

How to manage the interaction:
Taking Isoprenaline with Zaporil 50 mg Tablet together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you experience any of the following symptoms, please call a doctor right away: sudden dizziness, feeling lightheaded, fainting, difficulty breathing, or heart palpitations. Do not stop using any medications without talking to a doctor.

ClozapineDapsone

Severe

How does the drug interact with Zaporil 50 mg Tablet:
Taking Dapsone with Zaporil 50 mg Tablet may increase the risk of infections.

How to manage the interaction:
Although there is a possible interaction between Dapsone and Zaporil 50 mg Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience fever, muscle aches, shortness of breath, and pain or burning during urination, contact a doctor immediately. Do not stop using any medications without consulting a doctor.

ClozapineGanciclovir

Severe

How does the drug interact with Zaporil 50 mg Tablet:
Zaporil 50 mg Tablet can cause higher levels of Ganciclovir in the blood by reducing its excretion rate. This can increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Ganciclovir and Zaporil 50 mg Tablet, you can take these medicines together if prescribed by a doctor. If you're having any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, weight loss, or pain, it's important to contact a doctor right away. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Maintain a healthy diet and exercise regularly.
Include fruits, vegetables, and fibre-rich food in your diet.
Cut down on sugars, salts and saturated fats.
Drink enough fluids to stay hydrated.
Regularly attend therapy sessions.
Perform meditation and yoga.
Follow a regular sleep pattern.
Avoid smoking and alcohol consumption.
Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Side Effects of Zaporil 50 mg Tablet

Tachycardia (fast heartbeat)
Dizziness
Headache
Tremor
Sweating
Low blood pressure
Dry mouth
Nausea
Constipation
Visual disturbances

Habit Forming

No

Therapeutic Class

PSYCHOTHERAPEUTICS

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Author Details

Written By

Santoshini Reddy G

M Pharmacy

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 8, 2025 | 9:33 AM IST

We provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does Zaporil 50 mg Tablet work?

Zaporil 50 mg Tablet works by blocking the effects of chemical receptors in the brain, such as dopamine and serotonin, thereby improving mood, behaviour and thoughts.

Can I stop taking Zaporil 50 mg Tablet if I feel well?

Do not discontinue Zaporil 50 mg Tablet without consulting your doctor, as it could cause withdrawal symptoms. To treat your condition effectually, continue taking Zaporil 50 mg Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Zaporil 50 mg Tablet .

Does Zaporil 50 mg Tablet increase the risk of infections?

Zaporil 50 mg Tablet may cause agranulocytosis (low levels of white blood cells), making you more prone to infections. Consult your doctor immediately if you experience flu-like symptoms, sore throat or fever.

How to cope with dry mouth?

Dry mouth could be a side-effect of Zaporil 50 mg Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

Does Zaporil 50 mg Tablet cause orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing)?

Orthostatic hypotension could be a side-effect of Zaporil 50 mg Tablet . Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking; instead, lie down and get up slowly only when you feel better.

Does Zaporil 50 mg Tablet cause irregular heartbeat?

Zaporil 50 mg Tablet may cause tachycardia (fast heartbeat). Talk to your doctor if you experience irregular or fast heartbeat even at rest, chest pain, unexplained tiredness or breathing problems.

What if I forget a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take your regular dose. Please don't take a double dose to make up for a missed one.

Drug-Drug Interactions Checker List

ARIPIPRAZOLE
OLANZAPINE
RISPERIDONE
QUETIAPINE
HALOPERIDOL
LURASIDONE
LITHIUM
LORAZEPAM
ALPRAZOLAM
BENZTROPINE MESYLATE
DULOXETINE
ESCITALOPRAM
SERTRALINE
DIVALPROEX SODIUM
CLONAZEPAM
LAMOTRIGINE

Special Advise

Regular monitoring of blood count is advised as Zaporil 50 mg Tablet may cause agranulocytosis (low white blood cells).
Zaporil 50 mg Tablet may cause blood lipids (fats) alteration, which could lead to weight gain. Your doctor might monitor your weight and blood lipid levels regularly.
If you have a liver disorder, regular liver function tests are recommended for as long as Zaporil 50 mg Tablet has been prescribed.
Zaporil 50 mg Tablet might cause thrombosis (blood clotting in the vein). If you are due to have any surgery, inform your doctor that you are taking Zaporil 50 mg Tablet .
Zaporil 50 mg Tablet might affect how your body controls temperature; therefore, be cautious while exercising, taking hot baths or sauna.

Disease/Condition Glossary

Schizophrenia: It is a severe mental illness in which the person may see, hear or feel things that are not there, believe things that are not true, or feel unusually suspicious or confused. Schizophrenia is a long-term disease that affects brain functioning. People with schizophrenia may seem like they have lost touch with reality, which might cause significant distress for the individual, their friends and family. The exact cause is unknown; however, conditions like genetics, environment, brain structure and function could be the risk factors. Symptoms include hallucinations, delusions, thought disorders, movement disorders, disorganised thinking, loss of interest, lack of emotions, etc.