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Written By Sureshvarma D , MPharma
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Manufacturer/Marketer :

Eris Life Sciences Ltd

Consume Type :

ORAL

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Not Returnable

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About Zayo 50 Tablet

Zayo 50 Tablet belongs to a class of cardiovascular agents that is used in the treatment of heart failure. It helps to reduce the risk of death and hospitalization in adults with chronic heart failure. Also, it can be used in children 1 to less than 18 years old to treat heart failure. Heart failure is a chronic condition in which the heart cannot pump blood as effectively as it should.

Zayo 50 Tablet is a combination of two medicines: Valsartan and sacubitril. Valsartan belongs to the class of drugs called angiotensin receptor blockers (ARBs) that block the effect of angiotensin II receptors that tighten the blood vessels. By blocking the effect of angiotensin II receptors, Valsartan makes it easier for the heart to pump blood to all body parts by relaxing and widening the blood vessels. Sacubitril belongs to the class of drugs known as neprilysin inhibitors which work by relaxing and widening the blood vessels and makes it easier for the heart to pump blood to all body parts. Together, Zayo 50 Tablet helps in the treatment of heart failure.

Take Zayo 50 Tablet with or without food or as directed by your doctor. Do not crush, chew or break the tablet, swallow it as a whole with a glass of water. You are advised to take Zayo 50 Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as cough, dizziness, nausea, diarrhea, weakness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Zayo 50 Tablet for as long as your doctor has prescribed it. Try not to stop taking it on your own as it may cause a sudden increase the blood pressure, chest pain, or heart attack.  Do not be reluctant to speak with your doctor if you experience any difficulty while taking Zayo 50 Tablet . Do not take Zayo 50 Tablet with ACE inhibitors (such as captopril, enalapril) since the risk of side effects may increase. Do not take Zayo 50 Tablet for at least 36 hours before or after taking an ACE inhibitor drug. Inform your doctor before taking Zayo 50 Tablet if you have kidney or liver problems, if you are pregnant or breastfeeding, or if you have a history of hereditary angioedema (rapid oedema or swelling beneath the area of skin).

Uses of Zayo 50 Tablet

Heart failure.

Directions for Use

Tablet: Swallow it as a whole with water; do not crush, break or chew it.Suspension: Shake the suspension bottle well before use. Check the label for directions and take it with or without food with a measuring cup in the dose and duration prescribed by the doctor.

Medicinal Benefits

Zayo 50 Tablet is a combination of two medicines Valsartan and sacubitril. Valsartan belongs to the class of drugs called angiotensin receptor blockers (ARBs) that block the effect of angiotensin II receptors that tighten the blood vessels. By blocking the effect of angiotensin II receptors, Valsartan makes it easier for the heart to pump blood to all body parts by relaxing and widening the blood vessels. Sacubitril belongs to the class of drugs known as neprilysin inhibitors which work by relaxing and widening the blood vessels and makes it easier for the heart to pump blood to all body parts. Zayo 50 Tablet helps in the treatment of certain types of heart failure. It may also help you to live longer and lowers the frequency of hospitalizations for heart failure.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Zayo 50 Tablet

  • Cough
  • Dizziness
  • Diarrhea
  • Fainting
  • Headache
  • Nausea
  • Stomach pain
  • Vertigo (sensation of feeling off-balance)
  • Weakness

Drug Warnings

Keep your doctor informed if you have kidney or liver diseases. Discuss with your doctor if you are taking any other medicines along with Zayo 50 Tablet . Avoid smoking and alcohol consumption. Pregnant women and breastfeeding women should consult their doctor before taking Zayo 50 Tablet . A prolonged intake of Zayo 50 Tablet can cause an altered potassium level so, regular monitoring of potassium is required. Driving and operating heavy machinery should not be done as it may cause dizziness and drowsiness. Orthostatic hypotension (sudden lowering of blood pressure n standing) might occur, so patients using Zayo 50 Tablet should get up with caution. Speak to your doctor if you have diabetes before taking Zayo 50 Tablet . Inform your doctor about your current medicines such as aliskiren (medication to treat high blood pressure), any other heart or blood pressure medicines, lithium, mineral supplements that contain potassium. Inform your doctor if you feel light-headed or have little or no urination, rapid weight gain, swelling in your hands, feet, or ankles after taking Zayo 50 Tablet .

Drug-Drug Interactions

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ValsartanAliskiren
Critical
ValsartanTriamterene
Severe

Drug-Drug Interactions

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ValsartanAliskiren
Critical
How does the drug interact with Zayo 50 Tablet:
Using Aliskiren together with Zayo 50 Tablet may increase the risk of serious side effects (kidney problems, low blood pressure, or high potassium levels).

How to manage the interaction:
Taking Zayo 50 Tablet with Aliskiren is not advised as it can result in an interaction, it can be taken if a doctor has advised it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
ValsartanTriamterene
Severe
How does the drug interact with Zayo 50 Tablet:
The use of Triamterene and Zayo 50 Tablet may increase the risk of side effects (low blood pressure, kidney function impairment, and hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Triamterene together with Zayo 50 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue any medication without consulting a doctor.
ValsartanRamipril
Severe
How does the drug interact with Zayo 50 Tablet:
Taking Ramipril with Zayo 50 Tablet may increase the risk of side effects (low blood pressure, kidney function impairment, and hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Ramipril together with Zayo 50 Tablet can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you feel nausea, vomiting, weakness, confusion, tingling in the hands and feet, a sensation of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. You must drink enough fluids while taking these medications. Do not stop taking any medication without consulting a doctor.
ValsartanPotassium citrate
Severe
How does the drug interact with Zayo 50 Tablet:
Co-administration of Potassium citrate with Zayo 50 Tablet may increase the risk of side effects such as low blood pressure, kidney function impairment, and hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Potassium citrate together with Zayo 50 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. Maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
ValsartanPerindopril
Severe
How does the drug interact with Zayo 50 Tablet:
Coadministration of Perindopril with Zayo 50 Tablet may increase the risk of side effects (low blood pressure, kidney function impairment, and hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Perindopril together with Zayo 50 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience symptoms such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat, contact a doctor. Do not discontinue any medication without consulting a doctor.
ValsartanTizanidine
Severe
How does the drug interact with Zayo 50 Tablet:
Coadministration of Tizanidine and Zayo 50 Tablet may increase the risk of low blood pressure.

How to manage the interaction:
Although taking Tizanidine together with Zayo 50 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate, contact a doctor. Do not discontinue any medication without consulting a doctor.
ValsartanCaptopril
Severe
How does the drug interact with Zayo 50 Tablet:
The use of Captopril and Zayo 50 Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Zayo 50 Tablet and Captopril, you can take these medicines together if prescribed by a doctor. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, contact a doctor. Do not discontinue any medications without a doctor's advice.
ValsartanMoexipril
Severe
How does the drug interact with Zayo 50 Tablet:
Coadministration of Moexipril together with Zayo 50 Tablet may increase the risk of side effects (blood pressure, kidney function impairment, and hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Moexipril together with Zayo 50 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience symptoms such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat, contact a doctor. Do not discontinue any medication without consulting a doctor.
ValsartanLisinopril
Severe
How does the drug interact with Zayo 50 Tablet:
Coadministration of Lisinopril and Zayo 50 Tablet may increase the risk of side effects (low blood pressure, kidney function impairment, hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Lisinopril together with Zayo 50 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience symptoms, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat, contact a doctor. Do not discontinue any medication without consulting a doctor.
ValsartanTrimethoprim
Severe
How does the drug interact with Zayo 50 Tablet:
Using trimethoprim together with Zayo 50 Tablet may increase potassium levels in the blood.

How to manage the interaction:
Although taking Trimethoprim together with Zayo 50 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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SACUBITRIL-24MG+VALSARTAN-26MGPotassium rich foods
Moderate

Drug-Food Interactions

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SACUBITRIL-24MG+VALSARTAN-26MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Co-administration of Zayo 50 Tablet along with moderate-to-high dietary potassium intake, especially salt substitutes may lead to high potassium levels in the blood. Avoid taking potassium-containing salt substitutes or over-the-counter potassium supplements along with Zayo 50 Tablet as this can lead to high potassium levels in blood. However, if you experience weakness, irregular heartbeat, confusion, tingling of the extremities, or feelings of heaviness in the legs, consult a doctor.

Diet & Lifestyle Advise

  • You are advised to consume low salt and low-fat diet while taking Zayo 50 Tablet .
  • Regular exercise is also recommended to complement treatment with Zayo 50 Tablet .
  • Eat a diet rich in whole grains, vegetables, fruits.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight with proper diet and exercise.
  • Managing stress with meditation, yoga, massage would also help in treating high blood pressure.

Habit Forming

No

Therapeutic Class

CARDIOVASCULAR AGENTS

Zayo 50 Tablet Substitute

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Zayo 50 Tablet is a combination of Valsartan and sacubitril. Valsartan belongs to the class of drugs called angiotensin receptor blockers (ARBs) that block the effect of angiotensin II receptors that tighten the blood vessels. By blocking the effect of angiotensin II receptors, Valsartan makes it easier for the heart to pump blood to all body parts by relaxing and widening the blood vessels. Sacubitril belongs to the class of drugs known as neprilysin inhibitors which work by relaxing and widening the blood vessels and makes it easier for the heart to pump blood to all body parts. Zayo 50 Tablet helps in the treatment of certain types of heart failure. It may also help you to live longer and lowers the frequency of hospitalizations for heart failure.

Please do not stop taking Zayo 50 Tablet without consulting your doctor on your own as it may lead to rising in blood pressure. Continue taking Zayo 50 Tablet for as long as your doctor has prescribed it to you. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Zayo 50 Tablet .

Orthostatic hypotension could be a side-effect of Zayo 50 Tablet . Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead lie down and get up slowly only when you feel better. People taking Zayo 50 Tablet are advised to monitor their blood pressure levels to avoid unpleasant events regularly.

High blood pressure increases the workload on the arteries and heart. If untreated, it could damage the heart, brain, and kidney's blood vessels, resulting in a stroke, heart failure, or kidney failure. Hypertension increases the risk of heart attacks.

Talk to your doctor before taking potassium supplements, potassium-sparing diuretics, or salt substitutes along with Zayo 50 Tablet as it might cause an increase in serum potassium and serum creatinine levels.

Zayo 50 Tablet may cause a headache as a common side effect, especially in the first few days of treatment. However, if the condition persists or worsens, please consult a doctor to reduce the dose initially.

Zayo 50 Tablet is not recommended for patients with severe hypotension (low blood pressure) as it may increase the risk of worsening the condition. Therefore, inform your doctor if you have low blood pressure before taking Zayo 50 Tablet .

Drug-Drug Interactions Checker List

  • ASPIRIN
  • ROSUVASTATIN
  • ATORVASTATIN
  • INSULIN DETEMIR
  • METOPROLOL
  • BUDESONIDE
  • FORMOTEROL

Special Advise

  • Regularly monitor blood pressure levels to prevent hypotension (low blood pressure).
  • Get up slowly while rising from a lying or sitting position as Zayo 50 Tablet may cause dizziness.
  • Keep your doctor informed about your health/disease conditions and the medicines you are taking.

Disease/Condition Glossary

Heart failure is a chronic condition in which the heart cannot pump blood as effectively as it should. Heart failure may occur due to certain conditions like high blood pressure, swelling or damage of heart muscle, faulty heart valves, or narrow arteries in the heart. Symptoms of heart failure include shortness of breath, tiredness, fast heartbeat, and swollen legs. 

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