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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Hari Kumar , MBBS
Non returnable*
COD available

Online payment accepted

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Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Zerodol-MR Tablet

Zerodol-MR Tablet is a combination medicine used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle pain, tooth pain, bone and joint pain, and headache. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable.
 
Zerodol-MR Tablet contains Tizanidine (muscle relaxant) and Aceclofenac (NSAID). Tizanidine works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. Aceclofenac works by blocking the effect of prostaglandins which cause pain and inflammation. Thereby, reduces mild to moderate pain and inflammation. Together, Zerodol-MR Tablet helps in relieving pain due to muscle spasms.
 
You are advised to take Zerodol-MR Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience common side-effects such as nausea, vomiting, stomach pain, loss of appetite, heartburn, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. Zerodol-MR Tablet may cause drowsiness and dizziness, so drive with caution. Zerodol-MR Tablet is not recommended for children as safety and efficacy have not been established. Avoid consuming alcohol with Zerodol-MR Tablet as it could lead to increased drowsiness and dizziness; it might also increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any interactions.

Uses of Zerodol-MR Tablet

Pain and inflammation associated with musculoskeletal and joint disorders.

Directions for Use

Swallow Zerodol-MR Tablet as a whole with a glass of water; do not chew or break it.

Medicinal Benefits

Zerodol-MR Tablet is a combination of two drugs, namely: Tizanidine and Aceclofenac. Zerodol-MR Tablet is a combination medicine used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle pain, tooth pain, bone and joint pain, and headache. Tizanidine is a muscle relaxant that works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. Aceclofenac is an analgesic that works by blocking the effect of a chemical messenger known as cyclo-oxygenase (COX) enzymes that make another chemical prostaglandins which are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, lesser prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Together, Zerodol-MR Tablet helps in relieving pain due to muscle spasms.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Zerodol-MR Tablet

  • Nausea
  • Vomiting
  • Stomach pain
  • Diarrhoea
  • Loss of appetite
  • Heartburn

Drug Warnings

Do not take Zerodol-MR Tablet if you are allergic to any of its components. Inform your doctor if you have/ had high blood pressure, heart problems, stomach ulcer or perforation, bleeding problems such as bleeding from the stomach, intestine or brain, bypass surgery, heart attack, blood circulation problems, or inflammation of the intestine, high cholesterol, diabetes, asthma, inflammatory bowel disease, liver or kidney problems. Consult your doctor if you are pregnant or breastfeeding. Zerodol-MR Tablet may cause drowsiness and dizziness, so drive only if you are alert. Zerodol-MR Tablet is not recommended for children as safety and effectiveness have not been established. Stop taking Zerodol-MR Tablet and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools.

Drug-Drug Interactions

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TizanidineFluvoxamine
Critical
TizanidineDronedarone
Critical

Drug-Drug Interactions

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TizanidineFluvoxamine
Critical
How does the drug interact with Zerodol-MR Tablet:
Taking Fluvoxamine with Zerodol-MR Tablet it can increases the risk of side effects.

How to manage the interaction:
Although Fluvoxamine with Zerodol-MR Tablet is not recommended, but can be taken together if prescribed by a doctor. However, if you experience drowsiness, dizziness, low blood pressure, slurred speech, confusion, or severe weakness, contact your doctor immediately. Do not stop using any medications without consulting a doctor.
TizanidineDronedarone
Critical
How does the drug interact with Zerodol-MR Tablet:
Coadministration of Zerodol-MR Tablet with Dronedarone can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Zerodol-MR Tablet with Dronedarone is generally avoided as it can result in an interaction, it can be taken when prescribed by a doctor. If you experience sudden dizziness, shortness of breath, palpitations, or chest pain, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
TizanidineCiprofloxacin
Critical
How does the drug interact with Zerodol-MR Tablet:
Coadministration of Ciprofloxacin and Zerodol-MR Tablet together can increase the risk of side effects.

How to manage the interaction:
Using Ciprofloxacin and Zerodol-MR Tablet together is avoided, as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience drowsiness, weakness, sweating, or palpitations contact the doctor immediately. Do not discontinue any medications without consulting the doctor.
TizanidineSaquinavir
Critical
How does the drug interact with Zerodol-MR Tablet:
Combining Zerodol-MR Tablet with Saquinavir can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Zerodol-MR Tablet with Saquinavir is not recommended, as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhoea or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
TizanidineZiprasidone
Critical
How does the drug interact with Zerodol-MR Tablet:
Co-administration of Zerodol-MR Tablet with Ziprasidone can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Zerodol-MR Tablet with Ziprasidone is not recommended, as it can result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting. Do not discontinue any medications without consulting a doctor.
TizanidineCisapride
Critical
How does the drug interact with Zerodol-MR Tablet:
Coadministration of Zerodol-MR Tablet with Cisapride can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Zerodol-MR Tablet with Cisapride is avoided as it can result in an interaction, it can be taken if your doctor has advised it. Contact your doctor immediately if you experience sudden dizziness, shortness of breath, palpitations, or vomiting. Do not discontinue any medications without consulting your doctor.
AceclofenacAtenolol
Severe
How does the drug interact with Zerodol-MR Tablet:
Co-administration of Atenolol with Zerodol-MR Tablet could increase the risk of low blood pressure.

How to manage the interaction:
Although there is a possible interaction between Atenolol and Zerodol-MR Tablet, you can take these medicines together if prescribed by a doctor. Consult a doctor if you experience excessive sweating, shortness of breath, palpitations, or chest discomfort. Do not discontinue any medications without consulting a doctor.
TizanidineIndapamide
Severe
How does the drug interact with Zerodol-MR Tablet:
Co-administration of Zerodol-MR Tablet with Indapamide may reduce blood pressure greatly leading to side effects.

How to manage the interaction:
Although taking Indapamide and Zerodol-MR Tablet together can cause an interaction, it can be taken if a doctor has suggested it. However, if you notice any of these signs - feeling dizzy, having a headache, feeling lightheaded, or fainting, Consult a doctor. Do not discontinue any medications without a doctor's advice.
TizanidineClozapine
Severe
How does the drug interact with Zerodol-MR Tablet:
Coadministration of Zerodol-MR Tablet with Clozapine together can raise the risk of an abnormal heart rhythm. The risk is higher if you have any history of heart issues or electrolyte disturbances.

How to manage the interaction:
Taking Zerodol-MR Tablet with Clozapine together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
TizanidineQuinapril
Severe
How does the drug interact with Zerodol-MR Tablet:
Combining Zerodol-MR Tablet and Quinapril can lower your blood pressure.

How to manage the interaction:
Taking Zerodol-MR Tablet and Quinapril together can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like headache, dizziness, lightheadedness, fainting, and changes in pulse or heart rate, contact your doctor immediately. Avoid driving or operating hazardous machinery until you know how the medications affect you, use caution when getting up from a sitting or lying position, and do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercising regularly helps in muscle stretching so that they are less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
  • Massages can also be helpful.
  • Rest well, get plenty of sleep.
  • To avoid developing pressure sores, change your position at least every two hours.
  • Hot or cold therapy can help treat muscle spasms. Apply an ice-pack or hot-pack on the muscle for 15-20minutes.
  • Stay hydrated, drink plenty of water.

Habit Forming

No

Therapeutic Class

ANALGESICS

Zerodol-MR Tablet Substitute

Substitutes safety advice
  • Dolccure-MR Tablet 10's

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    6.20per tablet
  • Acon TZ 100mg/2mg Tablet

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  • Accetiz 100 mg/2 mg Tablet

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  • Acewok TZ 100mg/2mg Tablet

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  • Aceclofia MR 100mg/2mg Tablet

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Author Details

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Zerodol-MR Tablet contains Tizanidine and Aceclofenac. Tizanidine works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. Aceclofenac works by blocking the effect of prostaglandins, thereby reduces mild to moderate pain and inflammation.

Zerodol-MR Tablet is used to reduce and relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Arthritis is the tenderness and swelling in the joints.

Diarrhoea might be a side-effect of Zerodol-MR Tablet . Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Dry mouth could be a side-effect of Zerodol-MR Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevents drying of the mouth.

Taking Zerodol-MR Tablet can elevate symptoms of gastric ulcer and bleeding. So, talk to your doctor before taking Zerodol-MR Tablet if you have gastrointestinal bleeding or other bleeding problems like haemophilia before using Zerodol-MR Tablet .

Drug-Drug Interactions Checker List

  • HYDROCODONE
  • CITALOPRAM
  • ESCITALOPRAM
  • DULOXETINE
  • FLUOXETINE
  • FLUVOXAMINE
  • PAROXETINE
  • SERTRALINE
  • LITHIUM
  • ZOLPIDEM
  • PREGABALIN
  • DIPHENHYDRAMINE

Disease/Condition Glossary

Pain: Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Pain may be dull or sharp; it might be constant or may come and go. The tolerance level of pain might vary from person to person. Pain can be generalized (overall body aches) or localized (affecting a specific body area). The common causes of pain include headache, muscle strain, cramps, cuts, bone fractures, and arthritis.

Arthritis: It is a joint disease in which the two ends of the joints come together due to the breakdown of a protective covering called cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms include pain, stiffness, inflammation and tenderness.

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