Zienam 500 mg Injection 1's

Question 1

How does Zienam 500 mg Injection 1's work?

Accepted Answer

Zienam 500 mg Injection 1's is a combination of two drugs, namely: Cilastatin and Imipenem. Cilastatin inhibits the dehydropeptidase enzyme, which causes the breakdown of Imipenem, thereby helps imipenem to stay active for a longer duration. Imipenem prevents the formation of the bacterial protective covering, which is necessary for the survival of the bacteria. Together, Zienam 500 mg Injection 1's helps to treat bacterial infections.

Question 2

Does Zienam 500 mg Injection 1's cause diarrhoea?

Accepted Answer

Diarrhoea might be a side-effect of Zienam 500 mg Injection 1's. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience prolonged diarrhoea with abdominal pain, consult your doctor. Do not take anti-diarrheal medicine on your own.

Question 3

Can I take Probenecid with Zienam 500 mg Injection 1's?

Accepted Answer

Concomitant administration of Probenecid (used to treat gout and hyperuricemia) along with Zienam 500 mg Injection 1's is not recommended as it might result in an increase of plasma levels and half-life of Imipenem.

Question 4

Is it safe to take Ganciclovir along with Zienam 500 mg Injection 1's?

Accepted Answer

Ganciclovir (anti-viral) should not be co-administered along with Zienam 500 mg Injection 1's unless benefits outweigh the risks as generalised seizures have been reported when taken together.

Question 5

Does Zienam 500 mg Injection 1's cause discolouration of urine?

Accepted Answer

Zienam 500 mg Injection 1's may cause changes in urine colour and amount of urine. Do not worry and consult your doctor if you have any concerns regarding this.

Question 6

Does Zienam 500 mg Injection 1's cause thrush?

Accepted Answer

Zienam 500 mg Injection 1's may rarely cause thrush or candidiasis, which is a fungal infection occurring due to the overgrowth of yeast-like fungus in the mouth or throat. Regularly rinse your mouth with water to prevent the growth of fungus.

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