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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
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Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About ZIGMA CR 400MG TABLET

ZIGMA CR 400MG TABLET belongs to a group of medicines called anticonvulsants or anti-epileptics used to treat epilepsy (fits) and trigeminal neuralgia (pain in the face's nerves). Epilepsy is a neurological disorder in which there is a sudden rush of electric impulses (electric activity) in the brain. As a result, the brain's electrical rhythms become imbalanced, resulting in recurrent episodes of seizures or fits. Trigeminal neuralgia is a condition which affects the trigeminal nerve that carries sensations from the face to the brain. 

ZIGMA CR 400MG TABLET contains 'Carbamazepine' that reduces the electrical impulses and subsequent firing of the nerve impulses that cause fits. Thus, ZIGMA CR 400MG TABLET decreases the excessive and abnormal nerve activity in the brain, thereby controlling seizures. 

You are advised to take ZIGMA CR 400MG TABLET for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as dizziness, tiredness, uncontrolled movements, nausea, headache, changes in liver enzymes or low white blood cells count, and minor skin reactions. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

To treat your condition effectually, continue taking ZIGMA CR 400MG TABLET for as long as your doctor has prescribed. Please do not stop taking ZIGMA CR 400MG TABLET without consulting your doctor to avoid worsening of seizures. Do not take ZIGMA CR 400MG TABLET if you are pregnant or planning for pregnancy unless prescribed by the doctor as it could lead to serious congenital disabilities. It is safe to take ZIGMA CR 400MG TABLET while breastfeeding; however, consult your doctor immediately if you think that the baby is having side-effects like excessive sleepiness, skin reactions or yellowing of skin or eyes. ZIGMA CR 400MG TABLET causes drowsiness and dizziness, so drive only if you are alert. ZIGMA CR 400MG TABLET should not be given to children unless prescribed. Avoid consuming alcohol along with ZIGMA CR 400MG TABLET as it could lead to increased dizziness and sleepiness. Consult your doctor immediately if you experience suicidal tendencies. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Uses of ZIGMA CR 400MG TABLET

Epilepsy/seizures, Trigeminal neuralgia

Directions for Use

Tablet/Capsule: Swallow it as a whole with a glass of water; do not chew, or crush the tablet/capsule.Syrup/Suspension/Drops: Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack; shake the pack well before each use.

Medicinal Benefits

ZIGMA CR 400MG TABLET belongs to a group of medicines called anti-convulsants or anti-epileptics used to treat epilepsy and trigeminal neuralgia (face nerve pain). ZIGMA CR 400MG TABLET works by reducing the electrical impulses and subsequent firing of the nerve impulses that cause fits. ZIGMA CR 400MG TABLET decreases the excessive and abnormal nerve activity in the brain, thereby helping in controlling seizures. ZIGMA CR 400MG TABLET is also used to relieve nerve pain associated with trigeminal neuralgia. People with glossopharyngeal neuralgia may also experience benefit with ZIGMA CR 400MG TABLET. ZIGMA CR 400MG TABLET is not associated with any psychological or physical dependence, and there is no potential for abuse.

Storage

Store in a cool and dry place away from sunlight

Side Effects of ZIGMA CR 400MG TABLET

  • Dizziness
  • Tiredness
  • Uncontrolled movements
  • Nausea
  • Headache
  • Changes in liver enzymes
  • Low white blood cells count
  • Minor skin reactions

Drug Warnings

Do not take ZIGMA CR 400MG TABLET if you are allergic to 'Carbamezapine' or any of its contents, have serious heart problems, blood illnesses, bone marrow problems, hypothyroidism, glaucoma, urinary retention, osteoporosis or taking anti-depressants called monoamine oxidase inhibitors (MAO's) within the last 14 days or taking herbal preparations containing St. John's wort as an antidepressant. Inform the doctor if you have low sodium levels in the blood or take medicines that could lower the blood's sodium levels, or using hormonal contraceptives. Do not stop taking ZIGMA CR 400MG TABLET without consulting your doctor to avoid worsening of seizures episodes. Do not take ZIGMA CR 400MG TABLET if you are pregnant unless prescribed by the doctor as ZIGMA CR 400MG TABLET might cause serious congenital disabilities. It is safe to take ZIGMA CR 400MG TABLET while breastfeeding; however, consult your doctor immediately if you think that the baby is having side-effects like excessive sleepiness, skin reactions or yellowing of skin or eyes. ZIGMA CR 400MG TABLET causes drowsiness and dizziness, so drive only if you are alert. ZIGMA CR 400MG TABLET should not be given to people less than 18 years of age until and unless prescribed by the doctor. Avoid consuming alcohol along with ZIGMA CR 400MG TABLET as it could lead to increased dizziness and sleepiness. Consult your doctor immediately if you experience suicidal tendencies or mood swings. 

Drug-Drug Interactions

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CarbamazepineLinezolid
Critical
CarbamazepineTranylcypromine
Critical

Drug-Drug Interactions

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CarbamazepineLinezolid
Critical
How does the drug interact with Zigma CR 400 Tablet:
Using Zigma CR 400 Tablet with Linezolid can cause serotonin syndrome(a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Zigma CR 400 Tablet and Linezolid together is not recommended, but it can be taken if prescribed by a doctor. However, if you experience symptoms such as confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, stomach pain, nausea, vomiting, and diarrhea, consult the doctor. Do not discontinue any medications without consulting a doctor.
CarbamazepineTranylcypromine
Critical
How does the drug interact with Zigma CR 400 Tablet:
Using Zigma CR 400 Tablet with tranylcypromine can increase the risk of serotonin syndrome( a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Zigma CR 400 Tablet with Tranylcypromine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience hallucination(seeing and hearing things which do not exist), seizure(fits),increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
CarbamazepineBoceprevir
Critical
How does the drug interact with Zigma CR 400 Tablet:
Using Zigma CR 400 Tablet with Boceprevir may decrease the blood levels of Boceprevir, which may make Boceprevir less effective in treating the hepatitis C.

How to manage the interaction:
Taking Zigma CR 400 Tablet with Boceprevir is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without a doctor's advice.
CarbamazepineLurasidone
Critical
How does the drug interact with Zigma CR 400 Tablet:
Co-administration of lurasidone with Zigma CR 400 Tablet may result in significantly lower blood levels of lurasidone, making the medication less effective.

How to manage the interaction:
Although there is an interaction between lurasidone and Zigma CR 400 Tablet, it is not recommended that you take it unless your doctor has prescribed it. Consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
CarbamazepineRilpivirine
Critical
How does the drug interact with Zigma CR 400 Tablet:
When Rilpivirine is taken with Zigma CR 400 Tablet, it may decrease the blood levels of Rilpivirine, which may make Rilpivirine less effective in treating HIV infection.

How to manage the interaction:
Taking Rilpivirine with Zigma CR 400 Tablet is generally not advised, but it can be taken if prescribed by the doctor. Without consulting a doctor, never stop taking any drugs.
CarbamazepineNimodipine
Critical
How does the drug interact with Zigma CR 400 Tablet:
When Nimodipine is taken with Zigma CR 400 Tablet, it may decrease the blood levels of Nimodipine, which may make Nimodipine less effective in treating your condition.

How to manage the interaction:
Taking Nimodipine with Zigma CR 400 Tablet is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without a doctor's advice.
CarbamazepineNefazodone
Critical
How does the drug interact with Zigma CR 400 Tablet:
When Nefazodone is taken with Zigma CR 400 Tablet, it can effect both the medications. It increases the levels of Zigma CR 400 Tablet leading to side effects. At the same time, it may decrease the blood levels of Nefazodone, which may make Nefazodone less effective in treating your condition.

How to manage the interaction:
Taking Nefazodone with Zigma CR 400 Tablet is not recommended, but it can be taken if prescribed by the doctor. However, if you experience headache, nausea, vomiting, dizziness, confusion, slurred speech, visual disturbances, shaking, consult the doctor.
CarbamazepinePraziquantel
Critical
How does the drug interact with Zigma CR 400 Tablet:
When Praziquantel is taken with Zigma CR 400 Tablet, it may decrease the blood levels of Praziquantel, which may make Praziquantel less effective in treating your condition.

How to manage the interaction:
Taking Zigma CR 400 Tablet with Praziquantel is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without a doctor's advice.
CarbamazepineDaclatasvir
Critical
How does the drug interact with Zigma CR 400 Tablet:
When Daclatasvir is taken with Zigma CR 400 Tablet, it may decrease the blood levels of Daclatasvir, which may make Daclatasvir less effective in treating your Hepatitis C.

How to manage the interaction:
Taking Daclatasvir with Zigma CR 400 Tablet is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without a doctor's advice.
CarbamazepineArtemether
Critical
How does the drug interact with Zigma CR 400 Tablet:
Using Zigma CR 400 Tablet with Artemether may decrease the blood levels of Artemether, which may make Artemether less effective in treating your malaria.

How to manage the interaction:
Taking Zigma CR 400 Tablet with Artemether is not recommended, but can be taken if prescribed by the doctor. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilizing fat instead of glucose for the generation of energy.
  • Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
  • Rest well, get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Exercise, meditation and yoga can help lower the stress, decrease pain sensitivity and improves coping skills.
  • Prepare your living area; small changes may reduce the risk of physical injury during a seizure.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

ZIGMA CR 400MG TABLET Substitute

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

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Special Advise

  • Regular monitoring of sodium levels while taking ZIGMA CR 400MG TABLET is advised to prevent hyponatremia.
  • Prolonged intake of ZIGMA CR 400MG TABLET can cause severe skin reactions called Stevens Johnsons syndrome (SJS) and toxic epidermal necrolysis (TEN). So in case you have any skin blister or rash immediately contact a doctor. 
  • ZIGMA CR 400MG TABLET may cause low blood cell count, so if you have any red or purple spots on the body, let your doctor know about this. 

Disease/Condition Glossary

Epilepsy/Seizures: Seizures, also known as fits or convulsions, is a single occurrence of abnormal electrical activity in the brain, whereas epilepsy is a chronic neurological disorder characterised by recurrent seizures. The possible causes of epilepsy include traumatic brain injury, scarring on the brain after a brain injury, high fever, stroke, vascular diseases, lack of oxygen to the brain, brain tumours, and genetic disorders. Symptoms include mood changes, anxiousness, nausea, dizziness, weakness, headache, muscle jerking, spasms, loss of balance, teeth clenching, rapid blinking or eye movements, biting the tongue, confusion, and loss of consciousness.

Trigeminal neuralgia: It is a condition affecting the trigeminal nerve in the face that causes painful sensations similar to electric shock on one side of the face. Symptoms include mild to severe facial pain often triggered by speaking, chewing, or brushing the teeth.

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