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  3. Zonisep 50 Capsule 10's

Zonisep 50 Capsule 10's, Pack of 10 CAPSULES
Zonisep 50 Capsule 10's, Pack of 10 CAPSULES
Zonisep 50 Capsule 10's, Pack of 10 CAPSULES
Zonisep 50 Capsule 10's, Pack of 10 CAPSULES
Zonisep 50 Capsule 10's, Pack of 10 CAPSULES
Written By Urvashi Bharti , MBBS
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Non returnable*
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Composition :

ZONISAMIDE-50MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Return Policy :

Not Returnable

Expires on or after :

About Zonisep 50 Capsule

Zonisep 50 Capsule belongs to a group of medicines called anti-convulsants or anti-epileptics used to treat epilepsy (seizures/fits). Epilepsy is a sudden rush of electricity in the brain. In epilepsy the brain's electrical rhythms become imbalanced, resulting in recurrent seizures. In patients with seizures, the typical brain electrical pattern is disrupted by sudden bursts of electrical impulses that affect an individual’s consciousness, movements, or sensations.

Zonisep 50 Capsule contains 'Zonisamide’ that reduces the abnormal and excessive activity of nerve impulses in the brain that cause fits or seizures. Thereby helps in controlling seizures. In patients with seizures, the typical brain electrical pattern is disrupted by sudden bursts of electrical impulses that affect an individual’s consciousness, movements, or sensations. Zonisep 50 Capsule is used alone or in combination to treat and prevent partial seizures in adults and children above 6 years of age.

Take Zonisep 50 Capsule as prescribed by your doctor. You are advised to take Zonisep 50 Capsule for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as dizziness, irritability, loss of appetite, memory impairment, double vision, confusion, depression, constipation, nausea, headache, uncontrolled movements. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Zonisep 50 Capsule for as long as your doctor has prescribed. Please do not stop taking Zonisep 50 Capsule without consulting your doctor to avoid worsening of seizures. Do not take Zonisep 50 Capsule if you are pregnant or planning for pregnancy unless prescribed by the doctor. Avoid taking Zonisep 50 Capsule while breastfeeding as it may cause side-effects in the breastfed babies. Zonisep 50 Capsule should not be given to children unless prescribed. Zonisep 50 Capsule causes drowsiness and dizziness, so drive if you are alert. Zonisep 50 Capsule should not be given to children unless prescribed. Avoid consuming alcohol along with Zonisep 50 Capsule as it could lead to increased dizziness and sleepiness. Consult your doctor immediately if you experience mood swings or suicidal tendencies. Zonisep 50 Capsule can cause permanent vision loss, inform your doctor immediately if you have any eye pain, redness, or any changes in your vision. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Zonisep 50 Capsule

Epilepsy/Seizures

Directions for Use

Tablet/Capsule: Swallow it as a whole with a glass of water; do not chew, or crush the tablet/capsule.Syrup/Suspension/Drops: Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack; shake the pack well before each use.

Medicinal Benefits

Zonisep 50 Capsule belongs to a group of medicines called anti-convulsants or anti-epileptics. Zonisep 50 Capsule is used to treat epilepsy/seizures/fits. Epilepsy is a sudden rush of electricity in the brain. Zonisep 50 Capsule works by blocking the sodium and calcium current in the brain and suppress the abnormal and excessive activity of nerve impulses in the brain that cause fits and pain. Thereby help in controlling seizures. Zonisep 50 Capsule is used alone or in combination to treat and prevent partial seizures and generalized seizures in adults. Zonisep 50 Capsule may be used as solo therapy or in combination in treating and preventing seizures in children above 6 years of age. Zonisep 50 Capsule is not associated with any psychological or physical dependence, and there is no potential for abuse.

Storage

Store in a cool and dry place away from sunlight
Side effects of Zonisep 50 Capsule
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Manage stress by practising deep breathing, yoga or meditation.
  • Participating in activities you enjoy, or exercising may also help manage agitation.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Exercise regularly. Try physical activities like walking, running, or dancing.
  • Manage stress by practising deep breathing, yoga or meditation.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Exercise regularly. Try physical activities like walking, running, or dancing.
  • Limit stimulants like tea, coffee and alcohol.
  • Identify triggers and try managing them.
  • Take a break by scheduling time for yourself.
  • Try creative activities like writing, dancing or painting as it helps release tension.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Regular eye exams can detect conditions causing Involuntary Eye Movement.
  • Alcohol and drugs should be avoided as they can increase the symptoms of nystagmus.
  • Wearing corrective lenses for refractive errors can reduce eye strain and symptoms.
  • Stress management and getting proper sleep can help to reduce symptoms.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

Drug Warnings

Do not take Zonisep 50 Capsule if you are allergic to Zonisamide or any of its contents. Avoid intake of Zonisep 50 Capsule if you are pregnant or planning for pregnancy unless prescribed by the doctor. Breastfeeding mothers should consult the doctor before using Zonisep 50 Capsule to pass into the breast milk and affect the baby. Zonisep 50 Capsule should not be given to children unless prescribed. Inform your doctor before taking Zonisep 50 Capsule if you have or had kidney and liver problems, glaucoma, high levels of ammonia, osteoporosis, depression, heart problems if you have low levels of bicarbonate in blood you have previously suffered from kidney stones. Do not stop taking Zonisep 50 Capsule without consulting your doctor to avoid worsening of seizure episodes. Zonisep 50 Capsule causes drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with Zonisep 50 Capsule as it could lead to increased dizziness and sleepiness. Consult your doctor immediately if you experience mood swings or suicidal tendencies. Zonisep 50 Capsule can cause permanent vision loss, inform your doctor immediately if you have any eye pain, redness, or any changes in your vision.

Drug-Drug Interactions

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ZonisamideFlavoxate
Severe
ZonisamideQuetiapine
Severe

Drug-Drug Interactions

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ZonisamideFlavoxate
Severe
How does the drug interact with Zonisep 50 Capsule:
Co-administration of Flavoxate and Zonisep 50 Capsule may increase body temperature and decrease sweating.

How to manage the interaction:
If you are supposed to take Flavoxate and Zonisep 50 Capsule together, a doctor may adjust the dose or monitor you more frequently to safely use both medications. Drink plenty of fluids during warm weather and when exercising and contact a doctor if you have decreased sweating or a fever. Avoid activities requiring mental alertness such as driving or operating hazardous machinery, until you know how the medications affect you. Do not discontinue any medication without consulting a doctor.
ZonisamideQuetiapine
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Quetiapine with Zonisep 50 Capsule can increase the risk or severity of Zonisep 50 Capsule side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Quetiapine with Zonisep 50 Capsule together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
ZonisamideTrihexyphenidyl
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Trihexyphenidyl with Zonisep 50 Capsule can increase the risk or severity of Zonisep 50 Capsule side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Trihexyphenidyl with Zonisep 50 Capsule together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
ZonisamideAmitriptyline
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Amitriptyline and Zonisep 50 Capsule both increase body temperature while decreasing sweating.

How to manage the interaction:
Zonisep 50 Capsule and Amitriptyline interact, however, if prescribed by a doctor, they can both be used. Some people may experience heat stroke and need to be hospitalized, especially in warm weather and while engaging in intense exercise. Children are especially at risk. If you feel sleepy, uneasy, or lightheaded after taking these medications combined, consult a doctor. Without consulting a doctor, never stop taking medicines.
ZonisamideSolifenacin
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Solifenacin with Zonisep 50 Capsule can increase the risk or severity of Zonisep 50 Capsule side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Solifenacin with Zonisep 50 Capsule together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
ZonisamideAcetazolamide
Severe
How does the drug interact with Zonisep 50 Capsule:
Co-administration of Acetazolamide with Zonisep 50 Capsule may increase the risk or severity of metabolic acidosis (elevated levels of acid in the blood) and kidney stones.

How to manage the interaction:
Although there is a possible interaction between Acetazolamide and Zonisep 50 Capsule, you can take these medicines together if prescribed by your doctor. If you experience symptoms such as fever, sudden back pain, abdominal pain, blood in the urine, tiredness, loss of appetite, irregular heartbeat, decreased sweating, trouble thinking clearly, and rapid breathing, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ZonisamideClozapine
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Clozapine with Zonisep 50 Capsule can increase the risk or severity of Zonisep 50 Capsule side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Clozapine with Zonisep 50 Capsule together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
ZonisamideClomipramine
Severe
How does the drug interact with Zonisep 50 Capsule:
Co-administration of Clomipramine with Zonisep 50 Capsule can increase the risk or severity of Zonisep 50 Capsule

How to manage the interaction:
Taking Clomipramine with Zonisep 50 Capsule together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
ZonisamideCyclobenzaprine
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Zonisep 50 Capsule with Cyclobenzaprine can cause increased body temperature and decrease sweating.

How to manage the interaction:
Taking Cyclobenzaprine with Zonisep 50 Capsule together is generally avoided as it can result in an interaction, it can be taken only if your doctor has advised it. However, if you experience changes in fever, shortness of breath, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
ZonisamidePropantheline
Severe
How does the drug interact with Zonisep 50 Capsule:
Coadministration of Propantheline with Zonisep 50 Capsule can increase the risk or severity of Zonisep 50 Capsule side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Propantheline with Zonisep 50 Capsule together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilizing fat instead of glucose for the generation of energy.
  • Atkins diet (high fay and controlled carbohydrates) is recommended for adolescents and adults.
  • Rest well, get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Exercise, meditation, and yoga can help lower stress, decrease pain sensitivity, and improves coping skills.
  • Prepare your living area; small changes may reduce the risk of physical injury during a seizure.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

Zonisep 50 Capsule Substitute

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Author Details

Doctor image

Written By

Urvashi Bharti

MBBS

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 8, 2025 | 9:32 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Zonisep 50 Capsule consists of 'zonisamide' that decreases the brain's excessive and abnormal nerve activity by blocking sodium and calcium currents in your brain and body. This reduces abnormal electrical activity between your nerve cells.

Consult your doctor before taking Zonisep 50 Capsule if you are pregnant or planning for pregnancy. Your doctor will prescribe Zonisep 50 Capsule only if the benefits outweigh the risks. If you are planning for pregnancy, use contraception while taking Zonisep 50 Capsule .

Zonisep 50 Capsule should be used with caution during hot weather as it may increase the chance of having a heat stroke. Inform your doctor if you have heat intolerance or fever. To avoid this condition, it is advisable to drink a lot of cold fluid and water, move to a cooler place, especially in summer.

No, Zonisep 50 Capsule is not a habit-forming drug. However, it can cause side-effects, especially when you stop taking it suddenly.

Do not discontinue Zonisep 50 Capsule without consulting your doctor. To treat your condition effectually continue taking Zonisep 50 Capsule for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Zonisep 50 Capsule ; your doctor will gradually reduce the dose to avoid precipitating seizures.

Consult your doctor before taking Zonisep 50 Capsule if you have had kidney stones. Your doctor will prescribe Zonisep 50 Capsule only if the benefits outweigh the risks. Zonisep 50 Capsule should be taken with caution in patients with kidney stones. You may be at increased risk of developing more kidney stones. Reduce the risk of kidney stones, drink sufficient water.

Consult your doctor before taking Zonisep 50 Capsule if you have glaucoma. Zonisep 50 Capsule is contraindicated in patients with narrow-angle glaucoma. Zonisep 50 Capsule may cause blindness on long-term use in the case of patients with narrow-angle glaucoma.

Drug-Drug Interactions Checker List

  • AMITRIPTYLINE
  • DULOXETINE
  • SERTRALINE
  • FLUOXETINE
  • GABAPENTIN
  • LAMOTRIGINE
  • PREGABALIN
  • PHENYTOIN
  • TOPIRAMATE
  • ARIPIPRAZOLE
  • QUETIAPINE
  • LITHIUM
  • ALPRAZOLAM
  • ERYTHROMYCIN
  • CLARITHROMYCIN
  • TELITHROMYCIN
  • CHLORPHENIRAMINE
  • CODEINE
  • OXYCODONE
  • TRAMADOL
  • MORPHINE
  • DIPHENHYDRAMINE
  • KETOCONAZOLE
  • ITRACONAZOLE
  • FLUCONAZOLE
  • TRIAZOLAM
  • TROLEANDOMYCIN
  • BROMPHENIRAMINE

Special Advise

  • Regular monitoring of bicarbonate levels while taking Zonisep 50 Capsule is advised to prevent low blood bicarbonate levels.
  • Zonisep 50 Capsule may cause low blood cell count, so if you have any red or purple spots on the body, let your doctor know about this.

Disease/Condition Glossary

Epilepsy: Epilepsy is a sudden rush of electricity in the brain. It is a disorder of the nervous system which occurs due to disturbed nerve cell activity in the brain. In epilepsy the brain's electrical rhythms become imbalanced, resulting in recurrent seizures. In patients with seizures, the typical brain electrical pattern is disrupted by sudden bursts of electrical impulses that affect an individual's consciousness, movements, or sensations. Seizures are of two types: generalized and partial seizures. Generalized seizures affect the entire brain, whereas partial seizures affect only a part of the brain. Seizures can cause uncontrollable muscle twitches and spasms. Stronger seizures may cause people to become confused or unconscious. Possible causes include high fever, trauma, genetic disorder, brain injury, or stroke.

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