Zoryl-M 1 Tablet 20's belongs to a class of medicines called anti-diabetic drugs used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone. Type 2 diabetes is a chronic (long-lasting) condition that affects the way our body processes glucose. People with type 2 diabetes either do not produce enough insulin, or the insulin produced is unable to perform its function in the body (insulin resistance).

Zoryl-M 1 Tablet 20's is a combination of two antidiabetic drugs, namely: Glimepiride and Metformin. Glimepiride works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood. Metformin PR is a prolonged-release formulation that releases the drug in smaller portions over a longer duration of time. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin which enables these cells to remove sugar more effectively from the blood.

Take Zoryl-M 1 Tablet 20's as prescribed by your doctor. You are advised to take Zoryl-M 1 Tablet 20's for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience stomach pain, nausea, diarrhoea, vomiting, headache or metallic taste. Most of these side effects of Zoryl-M 1 Tablet 20's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Zoryl-M 1 Tablet 20's or any other medicines, please tell your doctor. Zoryl-M 1 Tablet 20's is not recommended for children. Avoid breastfeeding while taking Zoryl-M 1 Tablet 20's as it may be excreted in human milk. If you are pregnant or planning for pregnancy, please inform your doctor before taking Zoryl-M 1 Tablet 20's as it may harm the unborn baby. Avoid alcohol consumption with Zoryl-M 1 Tablet 20's as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body). Drive only if you are alert after taking Zoryl-M 1 Tablet 20's. Take short, frequent meals and avoid prolonged fasting while taking Zoryl-M 1 Tablet 20's.

Zoryl-M 1 Tablet 20's contains Glimepiride and Metformin used in the treatment of type 2 diabetes. Glimepiride stimulates cells in the pancreas that produce insulin which helps to remove sugar from the blood. Metformin PR is a prolonged-release formulation that releases the drug in smaller portions over a longer duration of time. Metformin reduces sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin which enables these cells to remove sugar more effectively from the blood.

• Stomach pain
• Nausea
• Diarrhoea
• Vomiting
• Headache
• Metallic taste

If you are allergic to Zoryl-M 1 Tablet 20's or any other medicines, please tell your doctor. Zoryl-M 1 Tablet 20's is not recommended for children. Avoid breastfeeding while taking Zoryl-M 1 Tablet 20's as it may be excreted in human milk. If you are pregnant or planning for pregnancy, please inform your doctor before taking Zoryl-M 1 Tablet 20's as it may harm the unborn baby. Avoid alcohol consumption with Zoryl-M 1 Tablet 20's as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body). Drive only if you are alert after taking Zoryl-M 1 Tablet 20's. Take short, frequent meals and avoid prolonged fasting while taking Zoryl-M 1 Tablet 20's. Beware of symptoms of hypoglycemia (low blood sugar) which include sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc. Whenever you experience any of these symptoms, immediately consume 5-6 candies or 3 glucose biscuits, or 3 teaspoons of honey/sugar, and also consult your doctor. Make sure to carry these with you at all times, especially during long travels.

Drug-Drug Interaction: Zoryl-M 1 Tablet 20's may have interaction with antibiotics (rifampicin, trimethoprim), calcium channel blockers (verapamil), antacids (cimetidine), HIV/AIDS drugs (dolutegravir), heart-related medicine (ranolazine), anticancer drugs (vandetanib, crizotinib, olaparib), antifungals (fluconazole, miconazole), water pill (acetazolamide), antidiabetic drug (insulin), anticonvulsants (phenytoin).

Drug-Food Interaction: Zoryl-M 1 Tablet 20's may interact with alcohol. Therefore, avoid the consumption of alcohol with Zoryl-M 1 Tablet 20's as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Drug-Disease Interaction: If you have severe infections, uncontrolled diabetes, lactic acidosis or ketoacidosis (accumulation of ketone bodies in the blood), dehydration, or liver or kidney problems, inform your doctor before taking Zoryl-M 1 Tablet 20's.

• RIFAMPICIN
• TRIMETHOPRIM
• VERAPAMIL
• CIMETIDINE
• DOLUTEGRAVIR
• RANOLAZINE
• VANDETANIB
• CRIZOTINIB
• OLAPARIB
• FLUCONAZOLE
• MICONAZOLE
• ACETAZOLAMIDE
• INSULIN
• PHENYTOIN

• Do regular exercise such as cycling, walking, jogging, dancing, or swimming for a minimum of 30 minutes per day. Invest at least 150 minutes of your week in exercise.
• Maintain healthy body weight as obesity is also related to the onset of diabetes.
• Maintain a low-fat and low-sugar diet. Replace carbohydrates-containing foods with whole grains, fruits, and vegetables as carbohydrates turn to sugars leading to high blood sugar.
• Avoid consumption of alcohol and quit smoking.

Regular blood tests are recommended while taking Zoryl-M 1 Tablet 20's to monitor blood sugar levels.

Type 2 diabetes: It is a chronic (long-lasting) condition that keeps the body away from properly utilizing insulin. Hence, people affected with type 2 diabetes either do not produce enough insulin, or there is resistance to the action of insulin. Middle-aged or older are most likely to suffer from type 2 diabetes, so it is also known as adult-onset diabetes. Symptoms of type 2 diabetes include frequent urination at night, increased thirst, slow wound healing, increased hunger, fatigue, and blurred vision. In some cases, there may be weight gain, while in rare cases, weight loss may be observed. The complication of type 2 diabetes also includes nerve problems, kidney problems, damaged retina of eyes or blindness, loss of limbs, sexual dysfunction, and increase chance of heart attack or stroke.