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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

About Zuvicin 10 Injection 1's

Zuvicin 10 Injection 1's is an anti-cancer medicine that is used in conjunction with other drugs to treat breast cancer in people who have had tumor removal surgery. Zuvicin 10 Injection 1's is used as adjuvant chemotherapy in women with axillary lymph nodes with involvement resection of breast cancer (abnormal growth in the cells of the breast).

Zuvicin 10 Injection 1's contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.

Zuvicin 10 Injection 1's may cause certain side effects such as nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, diarrhoea, and pain at the site of injection. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. A trained healthcare doctor will administer Zuvicin 10 Injection 1's. So, do not self-administer. Your doctor will decide the dose of the medicine based on your health condition.

Zuvicin 10 Injection 1's should be avoided if you are allergic to it. It is contraindicated in patients having a recent history of myocardial infarction (MI) or heart attack, patients with baseline neutrophil count < 1500 cells/mm3, severe arrhythmias, previous treatment with anthracyclines, and severe hepatic dysfunction. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any medicines such as cardiotoxic drugs (eg, Thalidomide, doxorubicin, Abiraterone, tamoxifen, letrozole), and cimetidine, as it can cause serious adverse effects. Zuvicin 10 Injection 1's is known to cause embryo-fetal toxicity. Hence it is contraindicated in pregnant or breastfeeding women. Zuvicin 10 Injection 1's is not recommended for children as it is known to cause anthracycline-induced acute manifestations of cardiotoxicity and chronic CHF.

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Whats That

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Non returnable*
COD available

Online payment accepted

Synonym

EPIRUBICIN HYDROCHLORIDE

Composition

EPIRUBICIN-10MG

Consume Type

PARENTERAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of Zuvicin 10 Injection 1's

Breast Cancer

Medicinal Benefits

Zuvicin 10 Injection 1's contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. It is used as adjuvant chemotherapy in women with axillary lymph nodes with involvement resection of breast cancer.

Side Effects of Zuvicin 10 Injection 1's

  • Nausea
  • Abdominal pain
  • Vomiting
  • Dizziness
  • Back pain
  • Pain at the site of injection
  • Red discoloration of urine
  • Loss of appetite
  • Mouth sores
  • Tiredness
  • Weight gain
  • Pale skin

Directions for Use

A trained healthcare professional will administer Zuvicin 10 Injection 1's. Hence, do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Zuvicin 10 Injection 1's should be avoided if you are allergic to it. It is contraindicated in patients having a recent history of myocardial infarction (MI) or heart attack, patients with baseline neutrophil count < 1500 cells/mm3, severe arrhythmias, previous treatment with anthracyclines and severe hepatic dysfunction. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any medicines such as cardiotoxic drugs (e.g., Thalidomide, doxorubicin, Abiraterone, tamoxifen, letrozole), and cimetidine, as it can cause serious adverse effects. Zuvicin 10 Injection 1's is known to cause embryo-fetal toxicity. Hence it is contraindicated in pregnant or breastfeeding women. Zuvicin 10 Injection 1's is not recommended for children as it is known to cause anthracycline-induced acute manifestations of cardiotoxicity and chronic CHF. Do not stop receiving Zuvicin 10 Injection 1's without a doctor’s advice, as it can cause serious health conditions. Zuvicin 10 Injection 1's is known to cause severe life-threatening haematological reactions, tissue necrosis, cardiomyopathy, secondary acute myelogenous leukaemia, and severe myelosuppression in some patients. Hence careful monitoring of the patient is needed while receiving the medicine.

Therapeutic Class

ANTINEOPLASTIC

Drug-Drug Interactions

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EpirubicinZiprasidone
Critical
EpirubicinMifepristone
Severe

Drug-Drug Interactions

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EpirubicinZiprasidone
Critical
How does the drug interact with Zuvicin 10 Injection 1's:
Using ziprasidone together with Zuvicin 10 Injection 1's can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Ziprasidone with Zuvicin 10 Injection 1's is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
EpirubicinMifepristone
Severe
How does the drug interact with Zuvicin 10 Injection 1's:
Co-administration of Zuvicin 10 Injection 1's with mifepristone can increase the risk of irregular heart rhythms. Prolonged treatment with Mifepristone may result in low potassium levels.

How to manage the interaction:
Taking Zuvicin 10 Injection 1's with mifepristone together is avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, rapid heartbeat, weakness, tiredness, drowsiness, confusion, painful muscle cramping, nausea, or vomiting, constipation, abdominal cramping, chest pain, and/or swelling in the legs or feet, get medical attention. Do not discontinue any medications without consulting a doctor.
EpirubicinEtanercept
Severe
How does the drug interact with Zuvicin 10 Injection 1's:
When Etanercept is used with Zuvicin 10 Injection 1's, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Etanercept with Zuvicin 10 Injection 1's can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EpirubicinCeritinib
Severe
How does the drug interact with Zuvicin 10 Injection 1's:
Taking Ceritinib with Zuvicin 10 Injection 1's can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Although taking Ceritinib and Zuvicin 10 Injection 1's together can evidently cause an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
EpirubicinMoxifloxacin
Severe
How does the drug interact with Zuvicin 10 Injection 1's:
Using Moxifloxacin together with Zuvicin 10 Injection 1's can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Moxifloxacin with Zuvicin 10 Injection 1's together can result in an interaction, but it can be taken if a doctor has advised it. If you experience irregular heart rhythm, vomiting, dizziness, difficulty breathing, or irregular heartbeat call a doctor right away. Do not discontinue any medications without consulting a doctor.
EpirubicinChloroquine
Severe
How does the drug interact with Zuvicin 10 Injection 1's:
Using chloroquine together with Zuvicin 10 Injection 1's can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a interaction between Chloroquine and Zuvicin 10 Injection 1's, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
EpirubicinGatifloxacin
Severe
How does the drug interact with Zuvicin 10 Injection 1's:
Taking Zuvicin 10 Injection 1's with Gatifloxacin can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Zuvicin 10 Injection 1's with Gatifloxacin together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EpirubicinInfliximab
Severe
How does the drug interact with Zuvicin 10 Injection 1's:
Combining Infliximab with Zuvicin 10 Injection 1's can increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Infliximab with Zuvicin 10 Injection 1's together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, contact a doctor right away. Do not stop using any medications without a doctor's advice.
EpirubicinNilotinib
Severe
How does the drug interact with Zuvicin 10 Injection 1's:
Coadministration of Zuvicin 10 Injection 1's and nilotinib can increase the risk of an irregular heart rhythm. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Zuvicin 10 Injection 1's and nilotinib together can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
EpirubicinTofacitinib
Severe
How does the drug interact with Zuvicin 10 Injection 1's:
Taking Tofacitinib with Zuvicin 10 Injection 1's may increase the risk of serious infection.

How to manage the interaction:
Co-administration of Zuvicin 10 Injection 1's with Tofacitinib can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - make sure to call your doctor right away. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • THALIDOMIDE
  • DOXORUBICIN
  • ABIRATERONE
  • TAMOXIFEN
  • LETROZOLE
  • PACLITAXEL
  • DOCETAXEL
  • CIMETIDINE
  • CILNIDIPINE
  • NIFEDIPINE

Diet & Lifestyle Advise

  • Try to eat more healthy fats, fruits, vegetables and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.
  • Doing meditation and yoga for some time is very effective in helping cancer patients maintain a healthy attitude and body.

Habit Forming

No

Special Advise

  • Avoid having intercourse while on treatment with Zuvicin 10 Injection 1's.
  • Regular monitoring of complete blood count  (CBC) and liver function (LFT) is important while receiving Zuvicin 10 Injection 1's.

Disease/Condition Glossary

Breast Cancer: Breast cancer is a type of cancer with abnormal growth in the cells of the breast. There are different kinds of breast cancer, such as cancer occurring in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), and in the fatty tissue or the fibrous connective tissue within the breast. Symptoms of breast cancer include a lump in the breast, breast pain, redness, swelling, nipple discharge other than breast milk, bloody discharge, a lump or swelling under the arm, unexplained change in shape, size or appearance of the breast, peeling, flaking or scaling of the skin. 

Zuvicin 10 Injection 1's Substitute

Substitutes safety advice
  • EPIRUBITEC 10MG INJECTION

    423.00per tablet
  • EPITHRA INJECTION 10MG

    225.90per tablet
  • Epineon-10 Injection 1's

    167.40per tablet
  • Adricin 10 Injection 1's

    369.00per tablet
  • Epitaz 10 mg Injection 1's

    542.70per tablet
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