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Reviewed By Sunny S , MBBS
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Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Zyrik 300mg Tablet 10's

Zyrik 300mg Tablet 10's belongs to a class of medication called 'enzyme inhibitor', primarily used to decrease blood uric acid levels in the body. It is used to treat Gout (increased uric acid leading to inflammation), kidney stones, bladder stones. Gout is a type of inflammatory reaction (allergic reaction) to uric acid crystals that form and accumulate inside joints, especially  big toe, due to high uric acid levels in the blood resulting in immense pain in joints. 

Zyrik 300mg Tablet 10's contains allopurinol, which works by inhibiting the enzyme xanthine oxidase, the enzyme responsible for the formation of uric acid. It stops uric acid formation inside the body without affecting the essential mechanism of cells and the body. 

Take Zyrik 300mg Tablet 10's as prescribed by your doctor. You are advised to take Zyrik 300mg Tablet 10's for as long as your doctor has prescribed it for you, depending upon your medical condition. The most common side effects of Zyrik 300mg Tablet 10's are upset stomach, diarrhoea, skin rash, drowsiness. Most of these side effects of Zyrik 300mg Tablet 10's are temporary, do not require medical attention, and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. 

Do not take Zyrik 300mg Tablet 10's if you are allergic to any of its ingredients. Zyrik 300mg Tablet 10's contains monohydrated lactose, if you are intolerant to some sugars, call your doctor before taking this drug. If you are pregnant or planning to get pregnant, are breast-feeding ask your doctor for advice before taking this medicine. Drink at least 2-3 litres of water so that you stay hydrated. For people who have kidney disease or renal dysfunction, dose adjustment is required. If you lose unexplained weight, please visit your doctor immediately.

Uses of Zyrik 300mg Tablet 10's

Gout (increased uric acid in joints), Kidney stones, Bladder stones

Directions for Use

Take Zyrik 300mg Tablet 10's with or without food as directed by your physician. Swallow it as a whole with a glass of water. Do not crush, chew, or break it.

Medicinal Benefits

Zyrik 300mg Tablet 10's contains an 'enzyme inhibitor', medication, primarily used to decrease blood uric acid levels in the body. In addition to this, it is sometimes also used to treat pain caused by pancreas disease, seizures, and improve survival after bypass surgery. It also prevents the rejection of a kidney transplant. Zyrik 300mg Tablet 10's contains allopurinol, an enzyme inhibitor primarily used to decrease blood uric acid levels in the body. It works by inhibiting the enzyme xanthine oxidase, the enzyme responsible for the formation of uric acid. It stops uric acid formation inside the body without affecting the essential mechanism of cells and the body.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Zyrik 300mg Tablet 10's

  • Upset stomach
  • Diarrhea
  • Nausea
  • Skin rash
  • Drowsiness
  • Feeling or being sick

Drug Warnings

Do not take Zyrik 300mg Tablet 10's if you are allergic to any of its ingredients. Zyrik 300mg Tablet 10's contains monohydrated lactose; if your doctor mentioned that you are intolerant to some sugars, call your doctor before taking this drug. If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine, you have heart problems or high blood pressure and you take diuretics and/or a medicine called ACE-inhibitors, you have thyroid problems. In rare cases, Zyrik 300mg Tablet 10's can cause bone marrow depression, especially in patients who are already taking that can cause bone marrow depression. For people who have kidney disease or renal dysfunction, dose adjustment is required. If you lose unexplained weight, please visit your doctor immediately. Zyrik 300mg Tablet 10's can cause drowsiness so do not operate machinery or car as it can impair judgment.

Drug-Drug Interactions

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AllopurinolDidanosine
Critical
AllopurinolCaptopril
Severe

Drug-Drug Interactions

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AllopurinolDidanosine
Critical
How does the drug interact with Zyrik 300 mg Tablet:
When Didanosine is taken with Zyrik 300 mg Tablet, can increase the blood levels of didanosine.

How to manage the interaction:
Taking Zyrik 300 mg Tablet with Didanosine lead to an interaction, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.
AllopurinolCaptopril
Severe
How does the drug interact with Zyrik 300 mg Tablet:
Co-administration of Zyrik 300 mg Tablet with Captopril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Zyrik 300 mg Tablet and Captopril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue the medication without consulting a doctor.
AllopurinolEnalapril
Severe
How does the drug interact with Zyrik 300 mg Tablet:
Co-administration of Zyrik 300 mg Tablet with Enalapril increase the risk of severe allergic reactions and infections.

How to manage the interaction:
There may be a possibility of interaction between Zyrik 300 mg Tablet and Enalapril, but it can be taken if prescribed by a doctor. If you experience swelling, itching, rashes, fever, muscle pain, weakness, chills, sore throat, or fatigue, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
AllopurinolDeferiprone
Severe
How does the drug interact with Zyrik 300 mg Tablet:
Co-administration of Zyrik 300 mg Tablet with Deferiprone may increase the risk of dangerous blood clots.

How to manage the interaction:
If you are supposed to take Zyrik 300 mg Tablet and Deferiprone together, your doctor may advise you to take blood thinner or monitor you more frequently to safely use both medications. However, if you experience shortness of breath, chest pain, coughing up blood, difficulty breathing, sudden loss of vision, and/or pain, redness or swelling in an arm or leg, contact your doctor immediately as these may be signs and symptoms of blood clots. Do not discontinue any medications without consulting a doctor.
AllopurinolAzathioprine
Severe
How does the drug interact with Zyrik 300 mg Tablet:
Co-administration of Zyrik 300 mg Tablet with Azathioprine may increase the effects of azathioprine.

How to manage the interaction:
There may be a possibility of interaction between Azathioprine and Zyrik 300 mg Tablet, but it can be taken if prescribed by a doctor. However, if you experience chills, fever, body pains, sore throat, weakness, muscle pain, mouth sores, easy bruising or bleeding, pale stools, darkened urine, or severe nausea, vomiting, and diarrhoea, consult a doctor. Do not stop using any medications without a doctor's advice.
AllopurinolQuinapril
Severe
How does the drug interact with Zyrik 300 mg Tablet:
Co-administration of Zyrik 300 mg Tablet with Quinapril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Zyrik 300 mg Tablet and Quinapril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also, let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue any medications without consulting a doctor.
AllopurinolMoexipril
Severe
How does the drug interact with Zyrik 300 mg Tablet:
Co-administration of Zyrik 300 mg Tablet with Moexipril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Zyrik 300 mg Tablet and Moexipril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also, let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue any medications without consulting a doctor.
AllopurinolPerindopril
Severe
How does the drug interact with Zyrik 300 mg Tablet:
Co-administration of Zyrik 300 mg Tablet with Perindopril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Zyrik 300 mg Tablet and Perindopril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms, contact your doctor immediately . Do not discontinue any medications without consulting a doctor.
AllopurinolRamipril
Severe
How does the drug interact with Zyrik 300 mg Tablet:
Co-administration of Zyrik 300 mg Tablet with Ramipril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Zyrik 300 mg Tablet and Ramipril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also, let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue the medication without consulting a doctor.
AllopurinolEntecavir
Severe
How does the drug interact with Zyrik 300 mg Tablet:
Coadministration of Zyrik 300 mg Tablet with Entecavir may increase the blood levels of one or both medicines and increase side effects.

How to manage the interaction:
If you are supposed to take Zyrik 300 mg Tablet and Entecavir together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience increased side effects, contact your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Purines are found in certain foods such as alcohol, fish, meat, bacon. People with gout should restrict or avoid them greatly.
  • Losing weight helps lower the levels of uric acid.
  • It is also beneficial to drink plenty of fluids. However, the restricted use of alcohol and tobacco is recommended, raising the levels of uric acid.
  • Maintain a diet that is rich in fruits, vegetables, whole grains, and low-fat dairy products.

Habit Forming

No

Therapeutic Class

GOUT THERAPY

Zyrik 300mg Tablet 10's Substitute

Substitutes safety advice
  • Zyloric 300 Tablet 10's

    by Others

    5.63per tablet
  • Axanthine 300mg Tablet 10's

    by Others

    8.82per tablet
  • CIPLORIC 300MG TABLET

    by Others

    6.30per tablet

Drug-Diseases Interactions

verifiedApollotooltip
ALLOPURINOL-300MGAbnormality of white blood cells, not elsewhere classified
Moderate
ALLOPURINOL-300MGVolume depletion
Moderate

Drug-Diseases Interactions

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ALLOPURINOL-300MGAbnormality of white blood cells, not elsewhere classified
Moderate
How does the disease interact with Zyrik 300 mg Tablet:
Zyrik 300 mg Tablet should be administered cautiously to patients with or predisposed to bone marrow suppression.

How to manage the interaction:
Zyrik 300 mg Tablet should be used with caution in patients with or who are at risk of developing bone marrow suppression.
ALLOPURINOL-300MGVolume depletion
Moderate
How does the disease interact with Zyrik 300 mg Tablet:
Zyrik 300 mg Tablet should be used with caution in patients with dehydration.

How to manage the interaction:
Zyrik 300 mg Tablet should be used with caution in patients with dehydration. Adequate hydration is necessary during treatment with Zyrik 300 mg Tablet.
ALLOPURINOL-300MGAlcoholic liver disease
Moderate
How does the disease interact with Zyrik 300 mg Tablet:
Zyrik 300 mg Tablet should be administered cautiously in patients with liver disease.

How to manage the interaction:
Zyrik 300 mg Tablet should be used with caution in patients with liver disease. Regular monitoring of liver function tests is recommended in these patients during the early stages of therapy.
ALLOPURINOL-300MGOther disorders of kidney and ureter, not elsewhere classified
Moderate
How does the disease interact with Zyrik 300 mg Tablet:
Zyrik 300 mg Tablet should be used with caution in patients with renal dysfunction.

How to manage the interaction:
Zyrik 300 mg Tablet should be used with caution in kidney failure patients. Kidney function should be monitored during the initial stages of therapy, and the dosage reduced or the drug withdrawn if necessary.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • CAPTOPRIL
  • AMPICILLIN
  • AMOXICILLIN
  • DICOUMAROL
  • PHENPROCOUMON
  • WARFARIN
  • CHLORPROPAMIDE
  • TOLBUTAMIDE
  • PHENYTOIN
  • CARBAMAZEPINE
  • AZATHIOPRINE
  • MERCAPTOPURINE
  • CYCLOPHOSPHAMIDE
  • CYCLOSPORINE
  • THEOPHYLLINE

Special Advise

  • Drink at least 8 glasses of water or other fluids each day while taking Zyrik 300mg Tablet 10's unless directed to do otherwise by your doctor. If you are a kidney patient consult a doctor before any fluid intake. 
  • If you are intolerant to sugars, please mention your doctor before starting Zyrik 300mg Tablet 10's.
  • The doctor will monitor your kidney function constantly before and during you take Zyrik 300mg Tablet 10's.
  • A liver function test should be done regularly to monitor liver enzymes as Zyrik 300mg Tablet 10's can cause liver enzyme fluctuations.

Disease/Condition Glossary

Gout: It is a type of inflammatory (allergic reaction) to uric acid crystals that form and accumulate inside feet, knuckles, and surrounding bone joints due to high uric acid levels in the blood, resulting in immense pain in joints. The pain may be severe, but the condition improves with medication. To avoid bone and cartilage damage and weakening of the kidneys, repeated gout attacks can require long-term medication. In areas such as the wrists, elbows, feet, or earlobes, chronic gout sufferers can feel small hard lumps forming over time in the soft flesh. These deposits are concentrations of uric acid crystals, called tophi, and over time can cause pain and stiffness. 

Kidney stones: It is a problem in which hard deposits occur in the kidney leading to stones. A kidney stone comprises mainly four types of calcium oxalate, uric acid, struvite and cystine. It is due to the increased level of uric acid in the body. As a result, uric acid crystals start depositing in the kidney, known as renal calculi/nephrolithiasis/urolithiasis.

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