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Composition :

ALLOPURINOL-300MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Zyrik 300 mg Tablet

Zyrik 300 mg Tablet belongs to a class of medication called 'enzyme inhibitor', primarily used to decrease blood uric acid levels in the body. It is used to treat Gout (increased uric acid leading to inflammation), kidney stones, bladder stones. Gout is a type of inflammatory reaction (allergic reaction) to uric acid crystals that form and accumulate inside joints, especially  big toe, due to high uric acid levels in the blood resulting in immense pain in joints. 

Zyrik 300 mg Tablet contains allopurinol, which works by inhibiting the enzyme xanthine oxidase, the enzyme responsible for the formation of uric acid. It stops uric acid formation inside the body without affecting the essential mechanism of cells and the body. 

Take Zyrik 300 mg Tablet as prescribed by your doctor. You are advised to take Zyrik 300 mg Tablet for as long as your doctor has prescribed it for you, depending upon your medical condition. The most common side effects of Zyrik 300 mg Tablet are upset stomach, diarrhoea, skin rash, drowsiness. Most of these side effects of Zyrik 300 mg Tablet are temporary, do not require medical attention, and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. 

Do not take Zyrik 300 mg Tablet if you are allergic to any of its ingredients. Zyrik 300 mg Tablet contains monohydrated lactose, if you are intolerant to some sugars, call your doctor before taking this drug. If you are pregnant or planning to get pregnant, are breast-feeding ask your doctor for advice before taking this medicine. Drink at least 2-3 litres of water so that you stay hydrated. For people who have kidney disease or renal dysfunction, dose adjustment is required. If you lose unexplained weight, please visit your doctor immediately.

Uses of Zyrik 300 mg Tablet

Gout (increased uric acid in joints), Kidney stones, Bladder stones

Directions for Use

Take Zyrik 300 mg Tablet with or without food as directed by your physician. Swallow it as a whole with a glass of water. Do not crush, chew, or break it.

Medicinal Benefits

Zyrik 300 mg Tablet contains an 'enzyme inhibitor', medication, primarily used to decrease blood uric acid levels in the body. In addition to this, it is sometimes also used to treat pain caused by pancreas disease, seizures, and improve survival after bypass surgery. It also prevents the rejection of a kidney transplant. Zyrik 300 mg Tablet contains allopurinol, an enzyme inhibitor primarily used to decrease blood uric acid levels in the body. It works by inhibiting the enzyme xanthine oxidase, the enzyme responsible for the formation of uric acid. It stops uric acid formation inside the body without affecting the essential mechanism of cells and the body.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Zyrik 300 mg Tablet

  • Upset stomach
  • Diarrhea
  • Nausea
  • Skin rash
  • Drowsiness
  • Feeling or being sick

Drug Warnings

Do not take Zyrik 300 mg Tablet if you are allergic to any of its ingredients. Zyrik 300 mg Tablet  contains monohydrated lactose; if your doctor mentioned that you are intolerant to some sugars, call your doctor before taking this drug. If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine, you have heart problems or high blood pressure and you take diuretics and/or a medicine called ACE-inhibitors, you have thyroid problems. In rare cases, Zyrik 300 mg Tablet can cause bone marrow depression, especially in patients who are already taking that can cause bone marrow depression. For people who have kidney disease or renal dysfunction, dose adjustment is required. If you lose unexplained weight, please visit your doctor immediately. Zyrik 300 mg Tablet can cause drowsiness so do not operate machinery or car as it can impair judgment.

Drug-Drug Interactions

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AllopurinolDidanosine
Critical
AllopurinolPegloticase
Severe

Drug-Drug Interactions

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AllopurinolDidanosine
Critical
How does the drug interact with Zyrik 300 mg Tablet:
When Didanosine is taken with Zyrik 300 mg Tablet, can increase the blood levels of didanosine.

How to manage the interaction:
Taking Zyrik 300 mg Tablet with Didanosine lead to an interaction, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.
AllopurinolPegloticase
Severe
How does the drug interact with Zyrik 300 mg Tablet:
Co-administration of Zyrik 300 mg Tablet with Pegloticase can increase the chances of side effects.

How to manage the interaction:
Co-administration of Zyrik 300 mg Tablet with Pegloticase can possibly result in an interaction, but it can be taken if your doctor has advised it. This is more common in people who already have high uric acid levels, which may not be obvious if they are taking other uric acid-lowering medications. Do not stop using any medications without first talking to your doctor.
AllopurinolRamipril
Severe
How does the drug interact with Zyrik 300 mg Tablet:
Co-administration of Zyrik 300 mg Tablet with Ramipril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Zyrik 300 mg Tablet and Ramipril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also, let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue the medication without consulting a doctor.
AllopurinolAzathioprine
Severe
How does the drug interact with Zyrik 300 mg Tablet:
Co-administration of Zyrik 300 mg Tablet with Azathioprine may increase the effects of azathioprine.

How to manage the interaction:
There may be a possibility of interaction between Azathioprine and Zyrik 300 mg Tablet, but it can be taken if prescribed by a doctor. However, if you experience chills, fever, body pains, sore throat, weakness, muscle pain, mouth sores, easy bruising or bleeding, pale stools, darkened urine, or severe nausea, vomiting, and diarrhoea, consult a doctor. Do not stop using any medications without a doctor's advice.
AllopurinolPerindopril
Severe
How does the drug interact with Zyrik 300 mg Tablet:
Co-administration of Zyrik 300 mg Tablet with Perindopril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Zyrik 300 mg Tablet and Perindopril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms, contact your doctor immediately . Do not discontinue any medications without consulting a doctor.
AllopurinolEntecavir
Severe
How does the drug interact with Zyrik 300 mg Tablet:
Coadministration of Zyrik 300 mg Tablet with Entecavir may increase the blood levels of one or both medicines and increase side effects.

How to manage the interaction:
If you are supposed to take Zyrik 300 mg Tablet and Entecavir together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience increased side effects, contact your doctor.
AllopurinolLisinopril
Severe
How does the drug interact with Zyrik 300 mg Tablet:
Co-administration of Zyrik 300 mg Tablet with Lisinopril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Zyrik 300 mg Tablet and Lisinopril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness chills, sore throat, extreme tiredness, body pains, consult a doctor. Do not discontinue any medications without consulting a doctor.
AllopurinolFosinopril
Severe
How does the drug interact with Zyrik 300 mg Tablet:
Co-administration of Zyrik 300 mg Tablet with Fosinopril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Zyrik 300 mg Tablet and Fosinopril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue any medications without consulting a doctor.
AllopurinolTrandolapril
Severe
How does the drug interact with Zyrik 300 mg Tablet:
Co-administration of Zyrik 300 mg Tablet with Trandolapril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Zyrik 300 mg Tablet and Trandolapril you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue the medication without consulting a doctor.
AllopurinolCaptopril
Severe
How does the drug interact with Zyrik 300 mg Tablet:
Co-administration of Zyrik 300 mg Tablet with Captopril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Zyrik 300 mg Tablet and Captopril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Purines are found in certain foods such as alcohol, fish, meat, bacon. People with gout should restrict or avoid them greatly.
  • Losing weight helps lower the levels of uric acid.
  • It is also beneficial to drink plenty of fluids. However, the restricted use of alcohol and tobacco is recommended, raising the levels of uric acid.
  • Maintain a diet that is rich in fruits, vegetables, whole grains, and low-fat dairy products.

Habit Forming

No

Therapeutic Class

GOUT THERAPY

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Drug-Diseases Interactions

verifiedApollotooltip
ALLOPURINOL-300MGAbnormality of white blood cells, not elsewhere classified
Moderate
ALLOPURINOL-300MGVolume depletion
Moderate

Drug-Diseases Interactions

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ALLOPURINOL-300MGAbnormality of white blood cells, not elsewhere classified
Moderate
How does the disease interact with Zyrik 300 mg Tablet:
Zyrik 300 mg Tablet should be administered cautiously to patients with or predisposed to bone marrow suppression.

How to manage the interaction:
Zyrik 300 mg Tablet should be used with caution in patients with or who are at risk of developing bone marrow suppression.
ALLOPURINOL-300MGVolume depletion
Moderate
How does the disease interact with Zyrik 300 mg Tablet:
Zyrik 300 mg Tablet should be used with caution in patients with dehydration.

How to manage the interaction:
Zyrik 300 mg Tablet should be used with caution in patients with dehydration. Adequate hydration is necessary during treatment with Zyrik 300 mg Tablet.
ALLOPURINOL-300MGAlcoholic liver disease
Moderate
How does the disease interact with Zyrik 300 mg Tablet:
Zyrik 300 mg Tablet should be administered cautiously in patients with liver disease.

How to manage the interaction:
Zyrik 300 mg Tablet should be used with caution in patients with liver disease. Regular monitoring of liver function tests is recommended in these patients during the early stages of therapy.
ALLOPURINOL-300MGOther disorders of kidney and ureter, not elsewhere classified
Moderate
How does the disease interact with Zyrik 300 mg Tablet:
Zyrik 300 mg Tablet should be used with caution in patients with renal dysfunction.

How to manage the interaction:
Zyrik 300 mg Tablet should be used with caution in kidney failure patients. Kidney function should be monitored during the initial stages of therapy, and the dosage reduced or the drug withdrawn if necessary.

FAQs

Zyrik 300 mg Tablet contains allopurinol, an enzyme inhibitor that works by inhibiting the enzyme xanthine oxidase, the enzyme responsible for uric acid formation. It stops uric acid formation inside the body without affecting the essential mechanism of cells and the body. 

If you are taking Zyrik 300 mg Tablet and it makes you vomit, then your contraceptive pill would not be effective, and it could lead to unwanted pregnancy. If you are of childbearing age, inform your doctor before starting Zyrik 300 mg Tablet and use another form of contraceptive like condoms.

Initially, when you start Zyrik 300 mg Tablet , it can increase the number of gout attacks. Please do not stop taking Zyrik 300 mg Tablet on having an acute attack (sudden attack) of gout as it can make the attack even worse. Co-administration with an anti-inflammatory agent (colchicine) is recommended and slowly increasing the dose of Zyrik 300 mg Tablet .

Generally, when Zyrik 300 mg Tablet is given to elderly patients (above 65 years), the dose is lowered depending upon the patient's condition. Also, if mention all underlining disease you suffer from which could affect Zyrik 300 mg Tablet , the dose will be adjusted accordingly by your doctor

Yes, Zyrik 300 mg Tablet can cause drowsiness in some people. It can even make you feel dizzy or have a problem with coordination. It is advisable to avoid driving or operate machinery to avoid any unpleasant side effects.

No, Zyrik 300 mg Tablet is not an anti-inflammatory medicine. It works by inhibiting the enzyme xanthine oxidase, the enzyme responsible for the formation of uric acid. It stops uric acid formation inside the body without affecting the essential mechanism of cells and the body. 

It may take several weeks to lower the uric acid levels, before you start feeling better or notice any significant reduction in attacks of gout.

Drug-Drug Interactions Checker List

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  • MERCAPTOPURINE
  • CYCLOPHOSPHAMIDE
  • CYCLOSPORINE
  • THEOPHYLLINE

Special Advise

  • Drink at least 8 glasses of water or other fluids each day while taking Zyrik 300 mg Tablet unless directed to do otherwise by your doctor. If you are a kidney patient consult a doctor before any fluid intake. 
  • If you are intolerant to sugars, please mention your doctor before starting Zyrik 300 mg Tablet .
  • The doctor will monitor your kidney function constantly before and during you take Zyrik 300 mg Tablet .
  • A liver function test should be done regularly to monitor liver enzymes as Zyrik 300 mg Tablet can cause liver enzyme fluctuations.

Disease/Condition Glossary

Gout: It is a type of inflammatory (allergic reaction) to uric acid crystals that form and accumulate inside feet, knuckles, and surrounding bone joints due to high uric acid levels in the blood, resulting in immense pain in joints. The pain may be severe, but the condition improves with medication. To avoid bone and cartilage damage and weakening of the kidneys, repeated gout attacks can require long-term medication. In areas such as the wrists, elbows, feet, or earlobes, chronic gout sufferers can feel small hard lumps forming over time in the soft flesh. These deposits are concentrations of uric acid crystals, called tophi, and over time can cause pain and stiffness. 

Kidney stones: It is a problem in which hard deposits occur in the kidney leading to stones. A kidney stone comprises mainly four types of calcium oxalate, uric acid, struvite and cystine. It is due to the increased level of uric acid in the body. As a result, uric acid crystals start depositing in the kidney, known as renal calculi/nephrolithiasis/urolithiasis.

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