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Written By ,
Reviewed By Sureshvarma D , MPharma
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Whats That

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Composition

EVEROLIMUS

Manufacturer/Marketer

Novartis India Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About AFINITOR 10 MG TABLET

AFINITOR 10 MG TABLET belongs to the group of medicine called ‘anti-cancer’. It is primarily used to treat breast cancer, pancreatic cancer, lung cancer and kidney cancer. Breast cancer is a type of cancer that develops in breast cells stimulated by the female sex hormone known as estrogen. Pancreatic cancer is described as a cancerous growth in the pancreas which normally begins in the cells that generate the juices that help break down food and the hormones which help in controlling blood sugar levels. Lung cancer is the uncontrolled growth of abnormal cells in one or both lungs. 

AFINITOR 10 MG TABLET contains 'Everolimus' which belongs to the group of medicines known as 'kinase inhibitors'. It works by decreases the activity of the immune system of the body and prevents rejection of the transplanted organ. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it stops the spread of cancerous cells.

Take AFINITOR 10 MG TABLET as prescribed by your doctor. You are advised to take AFINITOR 10 MG TABLET for as long as your doctor has prescribed it for you depending on your medical conditions. You may experience weakness, infection, sinus inflammation, cough, diarrhea, fever, fatigue, otitis media (infection of the ear), stomatitis (Inflammation of the mouth) and upper respiratory tract infection. Most of these side effects of AFINITOR 10 MG TABLET do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

To treat your condition effectually, continue taking AFINITOR 10 MG TABLET for as long as your doctor has prescribed. If you are known to be allergic to AFINITOR 10 MG TABLET or any other medicines, please tell your doctor. Do not take AFINITOR 10 MG TABLET if you are pregnant or planning for pregnancy as AFINITOR 10 MG TABLET may harm the unborn baby. AFINITOR 10 MG TABLET should not be taken by breastfeeding mothers as it may cause harm to the newborn baby. AFINITOR 10 MG TABLET causes tiredness, thus, it is advisable not to drive unless you are alert. Elderly people are more sensitive to medicine so they may adjust the dosage according to their condition.

Uses of AFINITOR 10 MG TABLET

Breast cancer, pancreatic cancer, lung cancer and kidney cancer.

Directions for Use

Take AFINITOR 10 MG TABLET with or without food as advised by the doctor. Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

AFINITOR 10 MG TABLET is indicated to the patients dealing with breast cancer, pancreatic cancer, lung cancer, kidney cancer and stomach/ intestinal cancer. Cancer of this type tends to spread quickly in other parts of the body. AFINITOR 10 MG TABLET travels through the bloodstream and effectively destroys cancerous cells and other parts of the body. It works by decreases the activity of the immune system of the body and prevents rejection of the transplanted organ. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it stops the spread of cancerous cells. Besides this, it is also effective in people with genetic disorders to treat some types of tumors in the brain or kidney.

Storage

Store in a cool and dry place away from sunlight

Side Effects of AFINITOR 10 MG TABLET

  • Tiredness
  • Breathlessness
  • Dizziness
  • Headache
  • Loss of appetite
  • Infection
  • Mouth ulcers 
  • Sinus inflammation
  • Cough
  • Diarrhea
  • Fever
  • High level of sugar in the blood (hyperglycemia)
  • Signs of low level of red blood cells (anemia) 
  • Otitis media (infection of the ear)
  • Stomatitis (Inflammation of the mouth)
  • Upper respiratory tract infection.
  • Swelling of arms, hands, feet, and ankles

Drug Warnings

If you are known to be allergic to AFINITOR 10 MG TABLET or any other medicines, please tell your doctor. AFINITOR 10 MG TABLET should not be taken in the conditions like liver disease, diabetes and high level of cholesterol. Do not take AFINITOR 10 MG TABLET if you have recent surgery, infection and hepatitis B. AFINITOR 10 MG TABLET may weaken your immune system, inform your doctor before taking AFINITOR 10 MG TABLET . AFINITOR 10 MG TABLET may also impair your kidney function. Therefore, monitor your kidney function regularly while taking AFINITOR 10 MG TABLET . AFINITOR 10 MG TABLET may cause cough, fever and shortness of breathing, thereby inform your doctor while taking your AFINITOR 10 MG TABLET . AFINITOR 10 MG TABLET may cause skin cancer, if you observe night sweating, weight loss, or change in color and size of the mole inform your doctor. Do not take AFINITOR 10 MG TABLET if you are pregnant or planning for pregnancy as AFINITOR 10 MG TABLET may harm the unborn baby. AFINITOR 10 MG TABLET should not be taken by breastfeeding mothers as it may cause harm to the newborn baby. AFINITOR 10 MG TABLET causes tiredness, thus, it is advisable not to drive unless you are alert. Elderly people are more sensitive to medicine so they may adjust the dosage according to their condition.

Drug-Drug Interactions

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EverolimusAmprenavir
Severe
EverolimusBacitracin
Severe

Drug-Drug Interactions

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EverolimusAmprenavir
Severe
How does the drug interact with Afinitor 10 Mg Tablet:
Taking Afinitor 10 Mg Tablet with Amprenavir can considerably raise blood levels of Afinitor 10 Mg Tablet, increasing the risk of serious side effects (pneumonitis - lung inflammation, infection, mouth ulcers, anemia, or bleeding).

How to manage the interaction:
Taking Afinitor 10 Mg Tablet with Amprenavir together can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
EverolimusBacitracin
Severe
How does the drug interact with Afinitor 10 Mg Tablet:
Afinitor 10 Mg Tablet can cause kidney issues, and taking it with bacitracin, can enhance the risk.

How to manage the interaction:
Although taking Bacitracin and Afinitor 10 Mg Tablet together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medication without consulting a doctor.
EverolimusIohexol
Severe
How does the drug interact with Afinitor 10 Mg Tablet:
Injections of iohexol and related contrast agents can occasionally cause kidney damage, and mixing them with other medication that might adversely harm the kidney, such as Afinitor 10 Mg Tablet, may enhance the risk.

How to manage the interaction:
Taking Afinitor 10 Mg Tablet with Iohexol together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult your doctor immediately. Drink lots of fluid after the procedure to stay hydrated and to flush the contrast agent out of your kidneys. Do not stop using any medications without first talking to your doctor.
EverolimusKetoprofen
Severe
How does the drug interact with Afinitor 10 Mg Tablet:
Afinitor 10 Mg Tablet can cause kidney issues, and taking it with ketoprofen, can enhance the risk.

How to manage the interaction:
There may be a possibility of interaction between Afinitor 10 Mg Tablet and Ketoprofen, but it can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not stop using any medications without talking to a doctor.
EverolimusLetermovir
Severe
How does the drug interact with Afinitor 10 Mg Tablet:
Taking Afinitor 10 Mg Tablet with letermovir can considerably raise blood levels of Afinitor 10 Mg Tablet, increasing the risk of serious side effects (pneumonitis - lung inflammation, infection, mouth ulcers, anemia, or bleeding).

How to manage the interaction:
Although taking Afinitor 10 Mg Tablet and Letermovir together can cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without a doctor's advice.
EverolimusPhenobarbital
Severe
How does the drug interact with Afinitor 10 Mg Tablet:
Phenobarbital can drastically lower Afinitor 10 Mg Tablet levels in the blood, making the medicine less effective in treating the illness.

How to manage the interaction:
Although taking phenobarbital with Afinitor 10 Mg Tablet can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without talking to a doctor.
EverolimusLeflunomide
Severe
How does the drug interact with Afinitor 10 Mg Tablet:
When Afinitor 10 Mg Tablet is used with leflunomide, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Leflunomide and Afinitor 10 Mg Tablet together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EverolimusMefenamic acid
Severe
How does the drug interact with Afinitor 10 Mg Tablet:
Coadministration of Mefenamic acid with Afinitor 10 Mg Tablet can increase the risk or severity of kidney disease.

How to manage the interaction:
Taking Mefenamic acid with Afinitor 10 Mg Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any symptoms of nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
EverolimusTobramycin
Severe
How does the drug interact with Afinitor 10 Mg Tablet:
Using tobramycin together with Afinitor 10 Mg Tablet can increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Afinitor 10 Mg Tablet and Tobramycin, you can take these medicines together if prescribed by a doctor. However, if you experience sudden weight gain, feeling out of breath, or having kidney problems. If you experience nausea, vomiting, loss of appetite, weight loss, swelling, muscle cramps, weakness, dizziness, confusion, or an irregular heartbeat contact a doctor immediately. Do not stop using any medications without a doctor's advice.
EverolimusErythromycin
Severe
How does the drug interact with Afinitor 10 Mg Tablet:
Erythromycin may considerably raise Afinitor 10 Mg Tablet levels in the blood. This can increase the risk or severity of side effects (pneumonitis - lung inflammation, infection, mouth ulcers, anemia, or bleeding).

How to manage the interaction:
Although taking erythromycin and Afinitor 10 Mg Tablet together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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EVEROLIMUSGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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EVEROLIMUSGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Taking Afinitor 10 Mg Tablet with grapefruit juice can raise blood levels and enhance the effects of Afinitor 10 Mg Tablet. Since the co-administration of Afinitor 10 Mg Tablet along with grapefruit juice can lead to an interaction, You should not consume grapefruit juice or eat grapefruits while taking Afinitor 10 Mg Tablet.

Diet & Lifestyle Advise

  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yogurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep, rest well.
  • Performing yoga and other relaxation techniques may also improve physical and mental health and may reduce your stress levels.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • KETOCONAZOLE
  • ITRACONAZOLE
  • VORICONAZOLE
  • CLARITHROMYCIN
  • TELITHROMYCIN
  • ERYTHROMYCIN
  • RITONAVIR
  • EFAVIRENZ
  • RAMIPRIL
  • VERAPAMIL
  • DILTIAZEM
  • DRONEDARONE
  • IMATINIB
  • PHENYTOIN
  • CARBAMAZEPINE
  • PHENOBARBITAL
  • FLUCONAZOLE

Special Advise

  • AFINITOR 10 MG TABLET should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking AFINITOR 10 MG TABLET .
  • Do not have immunizations/vaccinations without a doctor's advice.
  • Avoid contact with people who have recently received live vaccines.

Disease/Condition Glossary

Breast cancer: It is a type of cancer that develops in breast cells that are stimulated by a female sex hormone called estrogen. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), in the fatty tissue or the fibrous connective tissue within the breast. The tumor cells invade other healthy breast cells and can travel to lymph nodes which are a primary pathway for the cancer cells to move to other parts of the body. 

Lung cancer: It happens when cells in the lung begin to grow in an uncontrolled manner. The most common form of lung cancer is non-small cell lung cancer (NSCLC). It happens when cells that form the lining of the lung start growing uncontrollably. Persons who smoke are at high risk of lung cancer. A common symptom of lung cancer is a cough that does not go easily followed by shortness of breath. Cancerous cells of the lung spread off and travel through the bloodstream to distant regions of the body and grow.

Pancreatic cancer: It is described as a cancerous growth in the pancreas which normally begins in the cells that generate the juices. Juices are produced by the pancreas ( a gland present behind your stomach) help in the breakdown of food and hormones which help in controlling blood sugar levels.

Kidney cancer: Kidneys are the organs on either side of your backbone directly above your waist. The tubes present inside clean and filter your blood, taking out waste foods and making urine. Kidney cancer produces in the lining of tiny tubes inside your kidneys.

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