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Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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Composition :

ACITRETIN-25MG

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Aceret 25 Capsule

Aceret 25 Capsule belongs to a group of medications called ‘retinoids’ used to treat psoriasis. Psoriasis is an autoimmune (immune system attacks healthy cells) skin disorder in which the skin becomes scaly, swollen, and itchy. It mostly affects the knee, elbows, scalp, and trunk. It is a lifelong condition, and treatment is given to remove affected skin cells and avoid flare-ups of the disease.

The Aceret 25 Capsule contains ‘Acitretin’, which belongs to the class of retinoids derived from vitamin A. It has anti-inflammatory and antiproliferative (decreases skin cell multiplication) properties. It works by slowing down the progression of the disease. It reduces the speed of skin cell growth and gradually clears the affected skin. It helps reduce the redness, scaling, and thickness of psoriasis rashes.

Aceret 25 Capsule is available in the form of tablets/capsules. You should take this medicine exactly as prescribed by your doctor. Aceret 25 Capsule may cause side-effects such as dry lips, peeling of the skin, especially the palms of the hands and soles of the feet, nose bleed, scaling and thinning of healthy skin, reddening of the skin, itching, burning sensation on the skin, sticky skin, hair loss, swelling and pain in the area around your nails, fragile nails, inflammation of the eye (conjunctivitis), increased thirst, and feeling cold. These side effects usually go away after discontinuing the treatment. However, if any of these side effects persist or worsen, inform your doctor immediately.

Do not take Aceret 25 Capsule if you are allergic to Acitretin or any other ingredients present in it. Aceret 25 Capsule should not be used in patients with liver or kidney failure, high cholesterol, and taking other medicines containing retinoids or supplements containing vitamin A. Aceret 25 Capsule should not be used in pregnant and breastfeeding women. Aceret 25 Capsule should be used with caution in children as it may affect growth and bone development. Aceret 25 Capsule may require dose adjustments when used in older people. Do not take alcohol, as it may increase the risk of side effects. Aceret 25 Capsule may cause vision problems, especially in the dark, so do not drive or operate heavy machinery if you notice any vision problems.

Uses of Aceret 25 Capsule

Psoriasis

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Aceret 25 Capsule contains ‘Acitretin’ that belongs to the class of ‘retinoids’. Retinoids are derived from vitamin A (retinol) and have anti-inflammatory and antiproliferative (reduces rapid skin cell division) action. Aceret 25 Capsule works by slowing down the progression of the diseases. Aceret 25 Capsule is used when the skin condition doesn’t improve with other conventional therapies. It can treat severe or extensive skin problems where the skin has become thick and scaly such as psoriasis. It can be long-term maintenance therapy for psoriasis patients. It can also be used in the treatment of other skin conditions such as ichthyosis (genetic skin disorder), pityriasis (skin rashes that appear as large spots on the chest, abdomen, or back), and lichen planus (itchy, non-infectious rashes on arms and legs).

Storage

Store in a cool and dry place away from sunlight
Side effects of Aceret 25 Capsule
  • Moisturize your nails with oil or lotion.
  • Cover your nails with gloves while cleaning utensils or other objects.
  • Maintain short, clean nails with gentle care.
  • Avoid damaging your nails by picking or biting.
  • Limit using nail polish and choose a gentle remover.
  • Wash hands with mild cleaner and warm water.
  • Refrain from using strong chemicals that can dry out your nails.
  • Wear long sleeves and pants to protect your fragile skin, especially when doing things like gardening or working outside.
  • Limit exposure to the sun, and when going outdoors, use sunscreen to avoid damaging your skin.
  • Keep your skin hydrated and protected by using moisturizing creams.
  • Use soft padding to cover sharp edges on furniture to prevent injuries.
  • Stop taking any medication that causes skin thinning, and if frequent skin tears occur, consult a doctor or dermatologist for further advice.
  • Consider taking protein and collagen supplements with your doctor's approval to slow skin thinning.
  • You can also take vitamin supplements, like A, B complex, C, D, and E, along with minerals like iron, zinc, biotin, selenium, and chromium, to improve your skin health.
  • Your doctor may recommend regular liver function tests (LFT) to monitor liver enzyme levels.
  • To support your liver, eat a healthy diet with lots of fruits, vegetables, lean proteins, and healthy fats.
  • Avoid eating processed meats, sugary foods, and unhealthy fats.
  • Limit your alcohol consumption, since too much can worsen liver function and contribute to high levels of Alkaline Phosphatase (ALP).
  • Stay active with regular exercise, drink plenty of water, and try to avoid harmful chemicals that can damage your liver.
  • Quit smoking to lower the risk of elevated ALP levels.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
  • Apply moisturizer immediately after showering or bathing.
  • Use a moisturizer containing lanolin, petroleum jelly, glycerine, hyaluronic acid or jojoba oil.
  • Do not use hot water for bathing. Instead use warm water and limit showers and bath to 5 to 10 minutes.
  • Apply a sunscreen with SPF-30 or higher.
  • Avoid harsh soaps, detergents and perfumes.
  • Do not scratch or rub the skin.
  • Drink adequate water to prevent dehydration.
  • Wear pants, full sleeves and a wide-brimmed hat while going out in the sun.

Drug Warnings

Aceret 25 Capsule should not be used in pregnant and breastfeeding women. So, the doctor may advise you to take a pregnancy test before using Aceret 25 Capsule . You should also take effective and reliable contraception (such as an intrauterine device, contraceptive implant, or contraceptive pill and condom) during the treatment and after three years of discontinuing the treatment. You should take reliable contraception even if your periods are not regular or not sexually active unless your doctor decides that this is unnecessary. You should not donate blood during the treatment and after three years of discontinuing the treatment. Aceret 25 Capsule should be used in caution in patients with diabetes as it can alter blood glucose levels. Aceret 25 Capsule may cause vision problems, especially in the night-time. So, inform your doctor if you notice vision problems. Do not wear contact lenses during the treatment as the Aceret 25 Capsule may cause dry eyes. Aceret 25 Capsule may increase skin sensitivity, so avoid going in strong sunlight and using a sunbed. Aceret 25 Capsule may affect your mood, so inform your doctor if you have mental health problems like depression. Also, inform your doctor if you notice drastic mood changes while using Aceret 25 Capsule .

Drug-Drug Interactions

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AcitretinEthanol
Critical

Drug-Drug Interactions

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AcitretinEthanol
Critical
How does the drug interact with Aceret 25 Capsule:
Coadministration of Aceret 25 Capsule with Ethanol can increase the risk and severity of birth defects.

How to manage the interaction:
Taking Aceret 25 Capsule with Ethanol together is avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Aceret 25 Capsule:
Coadministration of Aceret 25 Capsule with Doxycycline can increase the risk and severity of vision problems.

How to manage the interaction:
Taking Aceret 25 Capsule with Doxycycline together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AcitretinEtonogestrel
Critical
How does the drug interact with Aceret 25 Capsule:
Coadministration of Aceret 25 Capsule with Etonogestrel can increase the risk and severity of birth defects when taken in pregnant women.

How to manage the interaction:
Taking Aceret 25 Capsule with Etonogestrel together is generally avoided as it can result in an interaction which can be serious, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Aceret 25 Capsule:
Coadministration of Aceret 25 Capsule with Levonorgestrel can increase the risk and severity of birth defects in unborn when taken by a pregnant woman.

How to manage the interaction:
Taking Aceret 25 Capsule with Levonorgestrel together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Consult a doctor if you get pregnant while taking these medications. Never use Aceret 25 Capsule if you are pregnant. Do not stop using any medications without talking to a doctor.
How does the drug interact with Aceret 25 Capsule:
Co-administration of Aceret 25 Capsule with Oxytetracycline can increase the risk of a rare and serious condition called pseudotumor cerebri (caused by increased pressure in the brain).

How to manage the interaction:
Taking Aceret 25 Capsule with Oxytetracycline together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Aceret 25 Capsule:
Coadministration of Aceret 25 Capsule with Medroxyprogesterone can increase the risk and severity of birth defects when taken by a pregnant woman.

How to manage the interaction:
Taking Aceret 25 Capsule with Medroxyprogesterone together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. Consult a doctor if you get pregnant while taking these medications. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Aceret 25 Capsule:
Coadministration of Aceret 25 Capsule with Tetracycline can increase the risk and severity of pseudotumor cerebri (caused by increased pressure in the brain).

How to manage the interaction:
Taking Aceret 25 Capsule with Tetracycline together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AcitretinDemeclocycline
Critical
How does the drug interact with Aceret 25 Capsule:
Coadministration of Aceret 25 Capsule with Demeclocycline can increase the risk and severity of pseudotumor cerebri (caused by increased pressure in the brain).

How to manage the interaction:
Taking Aceret 25 Capsule with Demeclocycline together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Aceret 25 Capsule:
Co-administration of Aceret 25 Capsule with Minocycline may increase the risk of a serious condition called pseudomotor cerebral (false brain tumour).

How to manage the interaction:
There's a possible interaction between Aceret 25 Capsule and Minocycline should be used together only if prescribed by a doctor. However, if you develop symptoms such as nausea, vomiting, headache, or visual disturbances during treatment with either medication, contact a doctor immediately. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Aceret 25 Capsule:
Coadministration of Aceret 25 Capsule with Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Aceret 25 Capsule and Leflunomide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Use mild soap while taking baths and prefer warm baths.
  • Do not scratch or pick your skin to avoid infecting the affected area.
  • Avoid harsh products on your skin.
  • Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
  • Limit intake of food that might trigger allergies such as dairy products, soy, eggs, and nuts.
  • Avoid consuming foods with excess sugar, as it may flare up inflammation.
  • Include fruits, vegetables, whole grains, healthy fats, and fish in your diet.
  • Avoid getting in contact with harsh soaps, detergents, and rough fabrics. 

Habit Forming

No

Therapeutic Class

RETINOIDS

Drug-Diseases Interactions

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ACITRETIN-25MGDisorders of lipoprotein metabolism and other lipidaemias
Severe
ACITRETIN-25MGOther disorders of kidney and ureter, not elsewhere classified
Severe

Drug-Diseases Interactions

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ACITRETIN-25MGDisorders of lipoprotein metabolism and other lipidaemias
Severe
How does the disease interact with Aceret 25 Capsule:
Aceret 25 Capsule is contraindicated in patients with chronic abnormally elevated blood lipid values.

How to manage the interaction:
Serum lipids must be more closely monitored in high-risk patients and during long-term treatment with Aceret 25 Capsule. Dietary modifications, reduction in dose of Aceret 25 Capsule, or drug therapy should be employed to control significant elevations of triglycerides, and if hypertriglyceridemia and low HDL levels persist, discontinuation of Aceret 25 Capsule should be considered.
ACITRETIN-25MGOther disorders of kidney and ureter, not elsewhere classified
Severe
How does the disease interact with Aceret 25 Capsule:
Aceret 25 Capsule is contraindicated in patients with severely impaired kidney function.

How to manage the interaction:
It is recommended to monitor kidney function as per clinical guidelines.
ACITRETIN-25MGOther disorders of brain
Severe
How does the disease interact with Aceret 25 Capsule:
The use of retinoids has been associated with causing of intracranial hypertension.

How to manage the interaction:
If you develop early signs and symptoms of pseudomotor cerbri (false brain tumor) such as nausea, vomiting, headache and visual disturbances, contact your doctor immediately.
ACITRETIN-25MGAlcoholic liver disease
Moderate
How does the disease interact with Aceret 25 Capsule:
The use of retinoids has been associated with elevations in liver enzymes and toxic hepatitis. Therapy with Aceret 25 Capsule is contraindicated in patients with severely impaired liver function.

How to manage the interaction:
This medicine should be used with caution in patients with liver disease. Monitoring liver enzymes is recommended in these patients.
ACITRETIN-25MGType 1 diabetes mellitus
Moderate
How does the disease interact with Aceret 25 Capsule:
The use of Aceret 25 Capsule its affect by the blood sugar levels and result in problems with blood sugar control.

How to manage the interaction:
It should be used with caution in diabetic patients, and regular monitoring of blood sugar levels is recommended during therapy.
ACITRETIN-25MGTopical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
Moderate
How does the disease interact with Aceret 25 Capsule:
Ophthalmologic manifestations have been reported with the use of Aceret 25 Capsule.

How to manage the interaction:
If you experience visual difficulties while taking Aceret 25 Capsule, contact your doctor.

FAQs

Aceret 25 Capsule contains 'Acitretin', which belongs to the class of 'retinoids' and is used to treat severe psoriasis. It has anti-inflammatory action and reduces the rashes' redness, scaling, and thickness. It also has antiproliferative properties and slows down the disease's progression by reducing the speed of skin cell growth.

Aceret 25 Capsule may cause vision problems suddenly, especially in the dark. So, inform your doctor immediately if you experience vision problems. Also, refrain from activities such as driving or operating heavy machinery if you have a problem with your vision.

You should not donate blood during the treatment with Aceret 25 Capsule and within three years of discontinuing the treatment. An unborn baby may get harmed if a pregnant woman receives your donated blood.

Aceret 25 Capsule may not affect your immune system. It is not an immunosuppressant. It controls psoriasis by slowing down the progression of the disease.

Aceret 25 Capsule may affect blood glucose levels and should be used with caution in patients with diabetes. You may have to regularly monitor blood glucose levels while using this medicine.

Drug-Drug Interactions Checker List

  • TETRACYCLINE
  • METHOTREXATE
  • PHENYTOIN

Special Advise

  • Growth and bone development should be regularly monitored if the Aceret 25 Capsule is given to children.
  • Patients with diabetes are advised to monitor blood glucose levels while using this medicine regularly.
  • Patients with high cholesterol should regularly monitor fat levels in the blood while using this medicine.
  • Your doctor may also check liver function before, during, and after three weeks of discontinuing Aceret 25 Capsule , as this medicine may affect liver function.
  • If Aceret 25 Capsule is prescribed for the long-term, your doctor may perform an x-ray of certain bones once a year, as this medicine may affect bone development.
  • Aceret 25 Capsule may cause birth defects, so women planning for pregnancy are advised to the regular pregnancy test and should not become pregnant for the next three years after using Aceret 25 Capsule .

Disease/Condition Glossary

Psoriasis: Psoriasis is an autoimmune skin disease characterized by red, itchy, and scaly rashes. It occurs when the immune system mistakenly attacks healthy skin cells. In this condition, skin cells grow and build up rapidly, resulting in scaly rashes, mostly on the knees, elbows, scalp, and trunk. Stress and cold can act as triggers for this disease. It is a chronic disease and doesn’t have a permanent cure. Treatment is given to control the disease and prevent flare-ups.

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