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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

About Advagraf 1mg Capsule 10's

Advagraf 1mg Capsule 10's belongs to a class of drugs called immunosuppressants used to prevent rejection of a transplanted organ such as a liver, kidney, or heart. Organ rejection occurs when a patient’s immune system recognizes the donor organ as foreign and tries to eliminate it.

Advagraf 1mg Capsule 10's contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that normally attacks foreign invaders and defend the body against foreign cells and infection. Thus, prevents organ rejection in transplanted patients and helps the body in accepting the new organ.

Take Advagraf 1mg Capsule 10's as prescribed. You are advised to use Advagraf 1mg Capsule 10's for as long as your doctor has recommended it for you based on your medical condition. Some people may experience nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. Most of these side effects of Advagraf 1mg Capsule 10's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Tacrolimus or any other medicines, please tell your doctor. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Advagraf 1mg Capsule 10's. Avoid alcohol consumption with Advagraf 1mg Capsule 10's. Drive only if you are alert, as Advagraf 1mg Capsule 10's may cause some people vision problems or nervous disturbances. If you are about to get vaccinated, inform your doctor before taking Advagraf 1mg Capsule 10's. Advagraf 1mg Capsule 10's may increase the risk of infections or skin cancer as it lowers the body’s immune defence system.

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Whats That

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Non returnable*
COD available

Online payment accepted

Composition

TACROLIMUS-1MG

Consume Type

ORAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of Advagraf 1mg Capsule 10's

Prevent transplanted organ rejection

Medicinal Benefits

Advagraf 1mg Capsule 10's contains Tacrolimus, an immunosuppressant used to prevent organ rejection after a transplant. Advagraf 1mg Capsule 10's suppresses the activity of T and B lymphocytes (cells in the immune system) that normally attacks foreign invaders and defend the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in patients who have had organ transplants.

Side Effects of Advagraf 1mg Capsule 10's

  • Nausea
  • Diarrhoea
  • Headache
  • Kidney problems
  • Infection
  • Constipation
  • Fever
  • High blood pressure

Directions for Use

Capsule: Take the capsule as advised by the doctor. Swallow it as a whole with water; do not crush, break or chew it.Granules: The granules should be mixed with water to make an oral suspension. Drink the prepared suspension immediately. Do not save the suspension for later use.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Please tell your doctor if you are allergic to Tacrolimus or other medicines. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Advagraf 1mg Capsule 10's. Avoid alcohol consumption with Advagraf 1mg Capsule 10's. Drive only if you are alert, as Advagraf 1mg Capsule 10's may cause vision problems or nervous disturbances in some people. If you are about to get vaccinated, inform your doctor before taking Advagraf 1mg Capsule 10's. Advagraf 1mg Capsule 10's may increase the risk of infections or skin cancer as it lowers the body’s immune defence system. While taking Advagraf 1mg Capsule 10's, you are advised to wear protective clothing and sunscreen while going out. You are recommended to use glass or metal materials to prepare the oral suspension. Avoid using plastic (PVC) materials to prepare the suspension as the granules will stick to a plastic container, and your child may not receive their full dose. Do not inhale or let the granules or prepared oral suspension come in contact with your skin or eyes. In case of accidental contact with skin, wash the area well with soap and water, and if it comes in contact with the eyes, rinse with plain water.

Therapeutic Class

IMMUNOSUPPRESSANTS

Drug-Drug Interactions

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TacrolimusDronedarone
Critical
TacrolimusZiprasidone
Critical

Drug-Drug Interactions

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TacrolimusDronedarone
Critical
How does the drug interact with Advagraf 1mg Capsule 10's:
Taking Advagraf 1mg Capsule 10's with dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Advagraf 1mg Capsule 10's with Dronedarone is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusZiprasidone
Critical
How does the drug interact with Advagraf 1mg Capsule 10's:
Taking Advagraf 1mg Capsule 10's with Ziprasidone can increase the risk of irregular heart rhythm

How to manage the interaction:
Taking Advagraf 1mg Capsule 10's with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusThioridazine
Critical
How does the drug interact with Advagraf 1mg Capsule 10's:
Combining Advagraf 1mg Capsule 10's with Thioridazine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Advagraf 1mg Capsule 10's with Thioridazine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusSaquinavir
Critical
How does the drug interact with Advagraf 1mg Capsule 10's:
Taking Advagraf 1mg Capsule 10's with saquinavir can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Advagraf 1mg Capsule 10's with Saquinavir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusCidofovir
Critical
How does the drug interact with Advagraf 1mg Capsule 10's:
Taking cidofovir with Advagraf 1mg Capsule 10's can increase the risk of kidney problems.

How to manage the interaction:
Taking Advagraf 1mg Capsule 10's with Cidofovir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without first talking to your doctor.
TacrolimusMifepristone
Critical
How does the drug interact with Advagraf 1mg Capsule 10's:
Taking Advagraf 1mg Capsule 10's with Mifepristone may significantly increase the blood levels of Advagraf 1mg Capsule 10's, which may increase the risk and/or severity of side effects.

How to manage the interaction:
Taking Advagraf 1mg Capsule 10's with Mifepristone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
TacrolimusZiprasidone
Critical
How does the drug interact with Advagraf 1mg Capsule 10's:
Taking Advagraf 1mg Capsule 10's with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Advagraf 1mg Capsule 10's with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
TacrolimusEtanercept
Severe
How does the drug interact with Advagraf 1mg Capsule 10's:
Taking etanercept together with Advagraf 1mg Capsule 10's may increase the risk of serious infections.

How to manage the interaction:
Although taking etanercept and Advagraf 1mg Capsule 10's together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
TacrolimusPiroxicam
Severe
How does the drug interact with Advagraf 1mg Capsule 10's:
Taking Advagraf 1mg Capsule 10's with piroxicam may increase risk of kidney problems.

How to manage the interaction:
Although taking Advagraf 1mg Capsule 10's and piroxicam together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
TacrolimusPosaconazole
Severe
How does the drug interact with Advagraf 1mg Capsule 10's:
Taking Advagraf 1mg Capsule 10's with posaconazole may significantly increase the blood levels of Advagraf 1mg Capsule 10's, which may increase the risk of kidney problems, diabetes, hyperkalemia (high potassium levels in the blood), high blood pressure, irregular heart rhythm and infections.

How to manage the interaction:
Although using Posaconazole and Advagraf 1mg Capsule 10's together can result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, red or irritated skin, body sores, discomfort or burning during urination, numbness or tingling, fits, dizziness, lightheadedness, fainting, and chest pain. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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TACROLIMUS-1MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TACROLIMUS-1MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking of grapefruit or grapefruit juice while on Advagraf 1mg Capsule 10's treatment may lead to increased Advagraf 1mg Capsule 10's levels in blood. Avoid or limit grapefruit or grapefruit juice intake during treatment with Advagraf 1mg Capsule 10's.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CYCLOSPORINE
  • SIROLIMUS
  • NELFINAVIR
  • PHENYTOIN
  • ITRACONAZOLE
  • KETOCONAZOLE
  • VORICONAZOLE
  • ERYTHROMYCIN
  • CLARITHROMYCIN
  • TRIAMTERENE
  • AMILORIDE

Diet & Lifestyle Advise

Kidney transplant:

  • Include fruits and vegetables in your daily routine.
  • Follow a vitamin-C-rich diet.
  • Reduce salt intake.
  • Eat a handful of walnuts and almonds every day.
  • Reduce intake of unhealthy cholesterol and fats.
  • Consume dark chocolate with at least 70% cocoa.

Liver and Heart transplant:

  • Eat whole-grain bread, cereals and other grains, fruits and vegetables, lean meats, fish and poultry.
  • Maintain a low-fat and low-salt diet.
  • Drink low-fat milk or eat other low-fat dairy products to maintain adequate calcium.
  • Stay hydrated by drinking sufficient water and other fluids.
  • Avoid alcohol consumption.
  • Avoid grapefruit and grapefruit juice. 

Habit Forming

No

Special Advise

Regular blood tests and certain other tests are recommended while taking Advagraf 1mg Capsule 10's to check blood sugar levels, kidney functioning and potassium levels in the blood.

Author Details

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Disease/Condition Glossary

Organ rejection: It occurs when a patient’s immune system recognizes the donor organ as foreign and tries to eliminate it. Organ rejection may be hyperacute (occurs in minutes to hours), acute (occurs within the first few months), or chronic (occurs after a year or anytime beyond). The symptoms of organ rejection may vary based on the type of organ transplant you have had. However, if you experience pain, fever, or other signs of illness, contact your doctor immediately.

Advagraf 1mg Capsule 10's Substitute

Substitutes safety advice
  • Tacsant 1 mg Capsule 10's

    38.75per tablet
  • Prograf 1 mg Capsule 10's

    40.28per tablet
  • Pangraf 1 Capsule 10's

    40.91per tablet
  • Tacrograf 1 Capsule 10's

    40.86per tablet
  • Tacroren 1 Capsule 10's

    40.86per tablet
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