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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

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Composition

TACROLIMUS-1MG

Manufacturer/Marketer

Intas Pharmaceuticals Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Takfa 1 Capsule 10's

Takfa 1 Capsule 10's belongs to a class of drugs called immunosuppressants used to prevent rejection of a transplanted organ such as a liver, kidney, or heart. Organ rejection occurs when a patient’s immune system recognizes the donor organ as foreign and tries to eliminate it.

Takfa 1 Capsule 10's contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that normally attacks foreign invaders and defend the body against foreign cells and infection. Thus, prevents organ rejection in transplanted patients and helps the body in accepting the new organ.

Take Takfa 1 Capsule 10's as prescribed. You are advised to use Takfa 1 Capsule 10's for as long as your doctor has recommended it for you based on your medical condition. Some people may experience nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. Most of these side effects of Takfa 1 Capsule 10's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Tacrolimus or any other medicines, please tell your doctor. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Takfa 1 Capsule 10's. Avoid alcohol consumption with Takfa 1 Capsule 10's. Drive only if you are alert, as Takfa 1 Capsule 10's may cause some people vision problems or nervous disturbances. If you are about to get vaccinated, inform your doctor before taking Takfa 1 Capsule 10's. Takfa 1 Capsule 10's may increase the risk of infections or skin cancer as it lowers the body’s immune defence system.

Uses of Takfa 1 Capsule 10's

Prevent transplanted organ rejection

Directions for Use

Capsule: Take the capsule as advised by the doctor. Swallow it as a whole with water; do not crush, break or chew it.Granules: The granules should be mixed with water to make an oral suspension. Drink the prepared suspension immediately. Do not save the suspension for later use.

Medicinal Benefits

Takfa 1 Capsule 10's contains Tacrolimus, an immunosuppressant used to prevent organ rejection after a transplant. Takfa 1 Capsule 10's suppresses the activity of T and B lymphocytes (cells in the immune system) that normally attacks foreign invaders and defend the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in patients who have had organ transplants.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Takfa 1 Capsule 10's

  • Nausea
  • Diarrhoea
  • Headache
  • Kidney problems
  • Infection
  • Constipation
  • Fever
  • High blood pressure

Drug Warnings

Please tell your doctor if you are allergic to Tacrolimus or other medicines. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Takfa 1 Capsule 10's. Avoid alcohol consumption with Takfa 1 Capsule 10's. Drive only if you are alert, as Takfa 1 Capsule 10's may cause vision problems or nervous disturbances in some people. If you are about to get vaccinated, inform your doctor before taking Takfa 1 Capsule 10's. Takfa 1 Capsule 10's may increase the risk of infections or skin cancer as it lowers the body’s immune defence system. While taking Takfa 1 Capsule 10's, you are advised to wear protective clothing and sunscreen while going out. You are recommended to use glass or metal materials to prepare the oral suspension. Avoid using plastic (PVC) materials to prepare the suspension as the granules will stick to a plastic container, and your child may not receive their full dose. Do not inhale or let the granules or prepared oral suspension come in contact with your skin or eyes. In case of accidental contact with skin, wash the area well with soap and water, and if it comes in contact with the eyes, rinse with plain water.

Drug-Drug Interactions

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TacrolimusThioridazine
Critical
TacrolimusDronedarone
Critical

Drug-Drug Interactions

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TacrolimusThioridazine
Critical
How does the drug interact with Takfa 1 Capsule:
Combining Takfa 1 Capsule with Thioridazine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Takfa 1 Capsule with Thioridazine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusDronedarone
Critical
How does the drug interact with Takfa 1 Capsule:
Taking Takfa 1 Capsule with dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Takfa 1 Capsule with Dronedarone is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusSaquinavir
Critical
How does the drug interact with Takfa 1 Capsule:
Taking Takfa 1 Capsule with saquinavir can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Takfa 1 Capsule with Saquinavir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusMifepristone
Critical
How does the drug interact with Takfa 1 Capsule:
Taking Takfa 1 Capsule with Mifepristone may significantly increase the blood levels of Takfa 1 Capsule, which may increase the risk and/or severity of side effects.

How to manage the interaction:
Taking Takfa 1 Capsule with Mifepristone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
TacrolimusZiprasidone
Critical
How does the drug interact with Takfa 1 Capsule:
Taking Takfa 1 Capsule with Ziprasidone can increase the risk of irregular heart rhythm

How to manage the interaction:
Taking Takfa 1 Capsule with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusCidofovir
Critical
How does the drug interact with Takfa 1 Capsule:
Taking cidofovir with Takfa 1 Capsule can increase the risk of kidney problems.

How to manage the interaction:
Taking Takfa 1 Capsule with Cidofovir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without first talking to your doctor.
TacrolimusZiprasidone
Critical
How does the drug interact with Takfa 1 Capsule:
Taking Takfa 1 Capsule with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Takfa 1 Capsule with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
TacrolimusKetorolac
Severe
How does the drug interact with Takfa 1 Capsule:
Taking Takfa 1 Capsule with ketorolac may cause kidney problems.

How to manage the interaction:
Although taking Ketorolac and Takfa 1 Capsule together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, breathlessness, cramps, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without consulting a doctor.
TacrolimusEdoxaban
Severe
How does the drug interact with Takfa 1 Capsule:
Taking Takfa 1 Capsule and Edoxaban may increase the blood levels of edoxaban and may increase the risk of bleeding complications.

How to manage the interaction:
Although taking deferasirox and theophylline together can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop using any medications without consulting doctor.
TacrolimusPapaverine
Severe
How does the drug interact with Takfa 1 Capsule:
Taking Takfa 1 Capsule together with papaverine can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Although taking Takfa 1 Capsule and papaverine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without consulting doctor.

Drug-Food Interactions

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TACROLIMUS-1MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TACROLIMUS-1MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking of grapefruit or grapefruit juice while on Takfa 1 Capsule treatment may lead to increased Takfa 1 Capsule levels in blood. Avoid or limit grapefruit or grapefruit juice intake during treatment with Takfa 1 Capsule.

Diet & Lifestyle Advise

Kidney transplant:

  • Include fruits and vegetables in your daily routine.
  • Follow a vitamin-C-rich diet.
  • Reduce salt intake.
  • Eat a handful of walnuts and almonds every day.
  • Reduce intake of unhealthy cholesterol and fats.
  • Consume dark chocolate with at least 70% cocoa.

Liver and Heart transplant:

  • Eat whole-grain bread, cereals and other grains, fruits and vegetables, lean meats, fish and poultry.
  • Maintain a low-fat and low-salt diet.
  • Drink low-fat milk or eat other low-fat dairy products to maintain adequate calcium.
  • Stay hydrated by drinking sufficient water and other fluids.
  • Avoid alcohol consumption.
  • Avoid grapefruit and grapefruit juice. 

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

Takfa 1 Capsule 10's Substitute

Substitutes safety advice
  • Tacsant 1 mg Capsule 10's

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  • Prograf 1 mg Capsule 10's

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    40.28per tablet
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  • Tacrograf 1 Capsule 10's

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  • Tacroren 1 Capsule 10's

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    40.86per tablet

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CYCLOSPORINE
  • SIROLIMUS
  • NELFINAVIR
  • PHENYTOIN
  • ITRACONAZOLE
  • KETOCONAZOLE
  • VORICONAZOLE
  • ERYTHROMYCIN
  • CLARITHROMYCIN
  • TRIAMTERENE
  • AMILORIDE

Special Advise

Regular blood tests and certain other tests are recommended while taking Takfa 1 Capsule 10's to check blood sugar levels, kidney functioning and potassium levels in the blood.

Disease/Condition Glossary

Organ rejection: It occurs when a patient’s immune system recognizes the donor organ as foreign and tries to eliminate it. Organ rejection may be hyperacute (occurs in minutes to hours), acute (occurs within the first few months), or chronic (occurs after a year or anytime beyond). The symptoms of organ rejection may vary based on the type of organ transplant you have had. However, if you experience pain, fever, or other signs of illness, contact your doctor immediately.

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