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About Ames L 75mg/40mg Capsule SR

Ames L 75mg/40mg Capsule SR belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD). Gastroesophageal reflux disease occurs when stomach acid frequently flows back into the food pipe (oesophagus); this causes acidity, pain and heartburn. Symptoms include heartburn, sour or bitter taste in the mouth and difficulty swallowing.

Ames L 75mg/40mg Capsule SR contains Esomeprazole and Levosulpiride. Esomeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Levosulpiride works by increasing the stomach and intestinal movement and pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, Ames L 75mg/40mg Capsule SR helps in preventing acid reflux, thereby providing relief from acidity and heartburn.

You are advised to take Ames L 75mg/40mg Capsule SR for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as headache, abdominal pain, constipation, diarrhoea, flatulence, nausea and vomiting. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Inform your doctor before taking Ames L 75mg/40mg Capsule SR if you have a history of gastrointestinal bleeding or intestinal obstruction. On long-term treatment, Ames L 75mg/40mg Capsule SR may increase the risk of bone fractures. Consult your doctor if you are pregnant or breastfeeding. Ames L 75mg/40mg Capsule SR may cause drowsiness and dizziness, so drive only if you are alert. Ames L 75mg/40mg Capsule SR should not be given to children as safety has not been established. Avoid consuming alcohol along with Ames L 75mg/40mg Capsule SR as it could lead to increased drowsiness and can elevate the production of stomach acid.

Uses of Ames L 75mg/40mg Capsule SR

Gastro-oesophageal reflux disease.

Directions for Use

Take Ames L 75mg/40mg Capsule SR 1hour prior food. Swallow Ames L 75mg/40mg Capsule SR as a whole with a glass of water, do not chew, or crush it.

Medicinal Benefits

Ames L 75mg/40mg Capsule SR belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD). Ames L 75mg/40mg Capsule SR is a combination of two drugs, namely: Esomeprazole (proton pump inhibitor) and Levosulpiride (prokinetic agent). Esomeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Levosulpiride works by increasing the stomach and intestinal movement and pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, Ames L 75mg/40mg Capsule SR helps in preventing acid reflux, thereby providing relief from acidity and heartburn.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Ames L 75mg/40mg Capsule SR if you are allergic to any of its contents, if you are taking nelfinavir (anti-HIV), if you have a gastrointestinal haemorrhage, mechanical obstruction or perforation, epilepsy, mania, porphyria, or cardiac impairment. Inform your doctor before taking Ames L 75mg/40mg Capsule SR if you have severe liver or kidney problems; if you are due to have Chromogranin A test; if you experience unexplained weight loss, stomach pain, indigestion, vomit food or blood, or if you pass black stools. On long-term treatment, Ames L 75mg/40mg Capsule SR may increase the risk of bone fractures. Do not take Ames L 75mg/40mg Capsule SR if you are pregnant or breastfeeding. Ames L 75mg/40mg Capsule SR may cause dizziness and drowsiness, so drive only if you are alert. Ames L 75mg/40mg Capsule SR should not be given to children as safety has not been established. Avoid consuming alcohol along with Ames L 75mg/40mg Capsule SR as it could lead to increased drowsiness and can elevate the production of stomach acid. 

Drug-Drug Interactions

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EsomeprazoleRilpivirine
Critical

Drug-Drug Interactions

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EsomeprazoleRilpivirine
Critical
How does the drug interact with Ames L 75mg/40mg Capsule SR:
Ames L 75mg/40mg Capsule SR may reduce rilpivirine absorption and blood levels, making the medicine less effective against HIV.

How to manage the interaction:
Although taking Ames L 75mg/40mg Capsule SR with Rilpivirine can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if your symptoms do not improve. Do not discontinue using any medications without consulting a doctor.
How does the drug interact with Ames L 75mg/40mg Capsule SR:
Ames L 75mg/40mg Capsule SR decreases the absorption of Pazopanib. This results in reduced efficacy of Pazopanib.

How to manage the interaction:
Although taking Ames L 75mg/40mg Capsule SR and Pazopanib can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not stop taking any medications without consulting your doctor.
How does the drug interact with Ames L 75mg/40mg Capsule SR:
Combining Ames L 75mg/40mg Capsule SR with Citalopram can increase the risk of irregular heart rhythm. .

How to manage the interaction:
Co-administration of Ames L 75mg/40mg Capsule SR with Citalopram can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any symptoms like irregular heart rhythm, dizziness, fainting, or shortness of breath, it's important to contact your doctor immediately. Do not stop using any medications without a doctor's advice.
EsomeprazoleNelfinavir
Severe
How does the drug interact with Ames L 75mg/40mg Capsule SR:
Taking nelfinavir with Ames L 75mg/40mg Capsule SR may decrease the effects of nelfinavir.

How to manage the interaction:
Although taking Ames L 75mg/40mg Capsule SR and Nelfinavir can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not stop taking any medications without consulting your doctor.
How does the drug interact with Ames L 75mg/40mg Capsule SR:
Using Dasatinib together with Ames L 75mg/40mg Capsule SR may decrease the levels of Dasatinib.

How to manage the interaction:
Although taking Ames L 75mg/40mg Capsule SR together with Dasatinib can result in an interaction, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ames L 75mg/40mg Capsule SR:
Ames L 75mg/40mg Capsule SR may interfere with the absorption of Acalabrutinib and reduce their efficacy.

How to manage the interaction:
Taking Ames L 75mg/40mg Capsule SR with Acalabrutinib together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.
How does the drug interact with Ames L 75mg/40mg Capsule SR:
Ames L 75mg/40mg Capsule SR can make Dacomitinib less effective by reducing its absorption and lowering its concentration in the blood.

How to manage the interaction:
Co-administration of Ames L 75mg/40mg Capsule SR with Dacomitinib can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.
How does the drug interact with Ames L 75mg/40mg Capsule SR:
Ames L 75mg/40mg Capsule SR reduces the absorption of atazanavir, resulting in reduced efficacy of atazanavir.

How to manage the interaction:
Although there is a possible interaction between Ames L 75mg/40mg Capsule SR and atazanavir, they can be taken together if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Ames L 75mg/40mg Capsule SR:
Taking tacrolimus with Ames L 75mg/40mg Capsule SR may significantly increase the blood levels of tacrolimus, which can lead to an increased risk of side effects.

How to manage the interaction:
Although taking Ames L 75mg/40mg Capsule SR with Tacrolimus can result in an interaction, they can be taken together if prescribed by your doctor. However, contact a doctor immediately if you experience irregular heartbeat, blurring of vision, fever, chills, or muscle spasms. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ames L 75mg/40mg Capsule SR:
Coadministration of erlotinib and Ames L 75mg/40mg Capsule SR can reduce effects of erlotinib.

How to manage the interaction:
Taking Erlotinib and Ames L 75mg/40mg Capsule SR together is generally avoided as it can possibly result in an interaction. It can be taken if your doctor has advised it. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat smaller meals more often.
  • Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
  • Maintain a healthy weight by regular exercising.
  • Avoid lying down after eating as it causes acid reflux.
  • Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
  • Practise relaxation techniques and avoid stress by doing yoga or meditation.
  • Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda. 
  • Avoid sitting continuously as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.

Habit Forming

No

Therapeutic Class

GASTROINTESTINAL AGENTS

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Ames L 75mg/40mg Capsule SR is a combination of two drugs, namely: Esomeprazole and Levosulpiride. Esomeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Levosulpiride works by increasing the stomach and intestinal movement and pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, Ames L 75mg/40mg Capsule SR helps in preventing acid reflux, thereby providing relief from acidity.

Diarrhoea might be a side-effect of Ames L 75mg/40mg Capsule SR. Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Do not take Ames L 75mg/40mg Capsule SR with nelfinavir (a drug used to treat HIV infections). Consult your doctor before taking Ames L 75mg/40mg Capsule SR with other medicines to rule out unpleasant side-effects.

Ames L 75mg/40mg Capsule SR contains esomeprazole which might increase the risk of fracture in the wrist, hip or spine. This mainly occurs in people taking Ames L 75mg/40mg Capsule SR for longer durations. Inform your doctor if you have osteoporosis or if you are taking corticosteroids, your doctor may prescribe calcium and vitamin D supplements.

Ames L 75mg/40mg Capsule SR may cause changes in blood tests for checking liver functioning. Inform the person doing the tests that you are taking Ames L 75mg/40mg Capsule SR.

Dry mouth could be a side-effect of Ames L 75mg/40mg Capsule SR. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • NAPROXEN
  • ATAZANAVIR
  • CLOPIDOGREL
  • WARFARIN
  • CILOSTAZOL
  • KETOCONAZOLE
  • ITRACONAZOLE
  • VORICONAZOLE
  • ERLOTINIB
  • METHOTREXATE
  • CITALOPRAM
  • IMIPRAMINE
  • CLOMIPRAMINE
  • DULOXETINE
  • DIAZEPAM
  • PHENYTOIN
  • CISAPRIDE
  • DIGOXIN
  • TACROLIMUS
  • RIFAMPICIN

Special Advise

  • Ames L 75mg/40mg Capsule SR may cause changes in blood tests for checking liver functioning. Inform the person doing the tests that you are taking Ames L 75mg/40mg Capsule SR.
  • Inform your doctor before taking Ames L 75mg/40mg Capsule SR if you are due to have Chromogranin A test.

Disease/Condition Glossary

Gastroesophageal reflux disease (GERD): The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like GERD, acidity, heartburn and peptic ulcers. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn and acidity. Symptoms include heartburn, sour or bitter taste in the mouth and difficulty swallowing.

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