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Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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Manufacturer/Marketer :

Aristo Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

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About Amlosafe LS 2.5 mg/2.5 mg Tablet

Amlosafe LS 2.5 mg/2.5 mg Tablet belongs to the class of 'anti-hypertensive drugs', primarily used to treat hypertension (high blood pressure). Hypertension is a medical condition in which the blood exerts high pressure (force exerted by circulating blood) against blood vessels' walls. This condition makes the heart work harder in pumping blood to the whole body. Hypertension can cause severe health complications, including stroke, heart failure, heart attack, and kidney failure.

Amlosafe LS 2.5 mg/2.5 mg Tablet is a combination of medicine that consists of Amlodipine (calcium channel blocker) and Lisinopril (angiotensin-converting enzyme inhibitor). Amlodipine belongs to the class of 'calcium channel blockers and is used to treat high blood pressure, Prinzmetal's or variant angina (chest pain), and other conditions caused by coronary artery disease. It relaxes blood vessels so that blood passes through them easily, lowering blood pressure. Amlodipine also improves blood supply to the heart muscle to receive more oxygen and thus preventing chest pain. Lisinopril belongs to the class of 'Angiotensin-Converting Enzyme (ACE) Inhibitors.' It relaxes and widens the blood vessels making it easier for the heart to pump blood throughout the body, lowering blood pressure. Lisinopril also decreases the body’s production of certain substances that raise blood pressure.

Amlosafe LS 2.5 mg/2.5 mg Tablet is an orally administered drug in the form of a tablet and capsule. You can take Amlosafe LS 2.5 mg/2.5 mg Tablet with food or without food. Swallow it as a whole with a glass of water. Do not chew, bite, or break it. Your doctor will advise you how often you take Amlosafe LS 2.5 mg/2.5 mg Tablet based on your medical condition. In some cases, you may experience blurred vision, sweating, confusion, tiredness, stomach upset, flushing (sense of warmth in the face, ears, neck and trunk), dizziness, headache, and swelling of the ankles or feet. Most of these side effects of Amlosafe LS 2.5 mg/2.5 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, please contact your doctor.

Do not stop taking Amlosafe LS 2.5 mg/2.5 mg Tablet without consulting your doctor since it may worsen your condition and increase the risk of future heart problems. Regular monitoring of blood pressure, electrolyte levels and kidney functioning is advised while taking Amlosafe LS 2.5 mg/2.5 mg Tablet . Inform your doctor if you are suffering from kidney, liver or heart diseases. Please tell your doctor if you are taking other medicines or allergic to Amlosafe LS 2.5 mg/2.5 mg Tablet . Reducing the amount of table salt (sodium chloride) in your food often relieves the body's swelling. Let your doctor know if you use any prescription and non-prescription medications you are taking, including vitamins, before starting Amlosafe LS 2.5 mg/2.5 mg Tablet . If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Amlosafe LS 2.5 mg/2.5 mg Tablet can be prescribed accordingly.

Uses of Amlosafe LS 2.5 mg/2.5 mg Tablet

Hypertension (high blood pressure)

Directions for Use

Take the tablet with or without food or as directed by your physician. Swallow it with a glass of water. Do not crush, chew, or break it. Try to take it at a fixed time every day. Do not double the dose if missed.

Medicinal Benefits

Amlosafe LS 2.5 mg/2.5 mg Tablet treats hypertension (high blood pressure) and consists of Amlodipine (calcium channel blocker) and Lisinopril (angiotensin-converting enzyme inhibitor). Amlodipine is a 'calcium channel blocker' and treats high blood pressure, Prinzmetal's or variant angina (chest pain), and other conditions caused by coronary artery disease. It relaxes blood vessels so that blood passes through them easily, lowering blood pressure. It also treats chest pain by improving the blood supply to the heart muscle to receive more oxygen. Amlodipine also improves a person's tolerance to exercise and keeps the blood pressure at acceptable levels. Lisinopril is an 'Angiotensin-Converting Enzyme (ACE) Inhibitor.' It relaxes and widens the blood vessels making it easier for the heart to pump blood throughout the body, lowering blood pressure.

Storage

Keep Amlosafe LS 2.5 mg/2.5 mg Tablet out of sight and reach of children.

Drug Warnings

  • Do not use Amlosafe LS 2.5 mg/2.5 mg Tablet if you are allergic to Amlosafe LS 2.5 mg/2.5 mg Tablet or its components.
  • Please inform your doctor if you are using any prescription and non-prescription medications, including vitamins, before starting Amlosafe LS 2.5 mg/2.5 mg Tablet .
  • Let your doctor know if you have any history of severe heart, kidney or liver diseases, high potassium levels (hyperkalaemia), bone marrow suppression, and aortic stenosis (heart valve problem). 
  • It is essential to inform your doctor if you are a breastfeeding mother before using Amlosafe LS 2.5 mg/2.5 mg Tablet since Amlodipine may pass into the breast milk.
  • Lisinopril is not recommended during pregnancy since it harms the unborn baby. Please ask your doctor if you plan to conceive or are pregnant before using Amlosafe LS 2.5 mg/2.5 mg Tablet .
  • Amlosafe LS 2.5 mg/2.5 mg Tablet can increase the chances of light-headedness so rise slowly if you are sitting/lying and avoid operating any machine or doing any work that needs mental alertness.

Drug-Drug Interactions

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AmlodipineDantrolene
Critical

Drug-Drug Interactions

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How does the drug interact with Amlosafe LS 2.5/2.5 Tablet:
Combining Aliskiren with Amlosafe LS 2.5/2.5 Tablet can increase the potassium levels in the blood.

How to manage the interaction:
Although taking Aliskiren and Amlosafe LS 2.5/2.5 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience symptoms including weakness, tiredness, confusion, numbness or tingling, and irregular heartbeats. Do not discontinue any medications without a doctor's advice.
AmlodipineDantrolene
Critical
How does the drug interact with Amlosafe LS 2.5/2.5 Tablet:
Using Amlosafe LS 2.5/2.5 Tablet together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Amlosafe LS 2.5/2.5 Tablet with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
How does the drug interact with Amlosafe LS 2.5/2.5 Tablet:
Taking Teriflunomide with Amlosafe LS 2.5/2.5 Tablet affects the liver and may increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Amlosafe LS 2.5/2.5 Tablet and Teriflunomide, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor: liver problems, fever, feeling cold, joint discomfort, swelling, bruising, skin irritation, itching, not feeling hungry, tiredness, feeling sick, throwing up, stomach ache, dark urine, liver harm, or bleeding. Do not stop using any medications without a doctor's advice.
How does the drug interact with Amlosafe LS 2.5/2.5 Tablet:
Co-administration of Azilsartan medoxomil with Amlosafe LS 2.5/2.5 Tablet can increase potassium levels in the blood.

How to manage the interaction:
Although taking Azilsartan medoxomil with Amlosafe LS 2.5/2.5 Tablet can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience vomiting, weakness, confusion, tingling in your hands and feet, or palpitations. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Amlosafe LS 2.5/2.5 Tablet:
Coadministration of Amlosafe LS 2.5/2.5 Tablet and Valsartan may increase the risk of side effects (low blood pressure, kidney function impairment, hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Amlosafe LS 2.5/2.5 Tablet together with Valsartan may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience symptoms, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat, contact a doctor. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Amlosafe LS 2.5/2.5 Tablet:
Taking Tizanidine and Amlosafe LS 2.5/2.5 Tablet may have additive effects in lowering the blood pressure.

How to manage the interaction:
Taking Tizanidine with Amlosafe LS 2.5/2.5 Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult our doctor immediately if you experience symptoms such as headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. Do not discontinue any medications without consulting a doctor.
LisinoprilPotassium citrate
Severe
How does the drug interact with Amlosafe LS 2.5/2.5 Tablet:
Taking Potassium citrate with Amlosafe LS 2.5/2.5 Tablet may increase potassium levels in the blood, which can lead to kidney failure, muscular paralysis, and abnormal heart rhythm.

How to manage the interaction:
Although taking Potassium citrate and Amlosafe LS 2.5/2.5 Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. It is advised to reduce the intake of potassium-rich foods. Do not discontinue any medications without a doctor's advice.
LisinoprilEprosartan
Severe
How does the drug interact with Amlosafe LS 2.5/2.5 Tablet:
Taking Amlosafe LS 2.5/2.5 Tablet with Eprosartan can increase the risk of high potassium levels.

How to manage the interaction:
Taking Amlosafe LS 2.5/2.5 Tablet with Eprosartan together can possibly result in an interaction, but it can be taken if your doctor has advised it. it can be taken if your doctor has prescribed it. However, consult your doctor if you experience nausea, vomiting, weakness, confusion, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue any medications without consulting a doctor.
LisinoprilMipomersen
Severe
How does the drug interact with Amlosafe LS 2.5/2.5 Tablet:
Taking Amlosafe LS 2.5/2.5 Tablet with Mipomersen affects the liver and may increase the risk of liver problems.

How to manage the interaction:
Co-administration of Amlosafe LS 2.5/2.5 Tablet with Mipomersen can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, tiredness, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Amlosafe LS 2.5/2.5 Tablet:
Co-administration of Allopurinol with Amlosafe LS 2.5/2.5 Tablet may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Allopurinol and Amlosafe LS 2.5/2.5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness chills, sore throat, extreme tiredness, body pains, consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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AMLODIPINE-2.5MG+LISINOPRIL-2.5MGPotassium rich foods
Moderate

Drug-Food Interactions

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AMLODIPINE-2.5MG+LISINOPRIL-2.5MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Taking Amlosafe LS 2.5/2.5 Tablet with potassium-containing salt substitutes or potassium supplements can cause high levels of potassium in the blood. Avoid taking potassium-containing salt substitutes or potassium supplements while being treated with Amlosafe LS 2.5/2.5 Tablet.

Diet & Lifestyle Advise

  • Keep your weight under control with body mass index (BMI) between 19.5 and 24.9.
  • Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help lower your raised blood pressure by about 5 mm of Hg.
  • Limit sodium chloride intake (table salt) in your daily diet to 2300 mg daily or less than 1500 mg is ideal for most adults.
  • If you are taking alcohol, use only one serving for women and two servings for men.
  • Quit smoking to lower the risk of heart disease.
  • Avoid chronic stress, as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress.
  • Monitor your blood pressure daily, and if you notice any fluctuations frequently, please contact your doctor immediately.
  • Try including heart-healthy omega-3 fatty acid-containing foods in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

Side Effects of Amlosafe LS 2.5 mg/2.5 mg Tablet

  • Confusion
  • Sweating
  • Tiredness
  • Dizziness
  • Headache
  • Blurred vision
  • Stomach upset
  • Swelling of the ankles or feet
  • Flushing (sense of warmth in the face, ears, neck and trunk)

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Amlosafe LS 2.5 mg/2.5 mg Tablet Substitute

Substitutes safety advice

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Amlosafe LS 2.5 mg/2.5 mg Tablet treats hypertension (high blood pressure) and consists of Amlodipine (calcium channel blocker) and Lisinopril (angiotensin-converting enzyme inhibitor). Amlodipine is a 'calcium channel blocker' and treats high blood pressure, Prinzmetal's or variant angina (chest pain), and other conditions caused by coronary artery disease. It relaxes blood vessels so that blood passes through them easily, lowering blood pressure.

Amlosafe LS 2.5 mg/2.5 mg Tablet is recommended to use in dose and duration as advised by the doctor. Do not stop taking Amlosafe LS 2.5 mg/2.5 mg Tablet on your own, as it may lead to a sudden rise in blood pressure and increases the risk of heart attack and stroke.

Amlosafe LS 2.5 mg/2.5 mg Tablet may increase blood potassium levels in people with diabetes, poor kidney function, and patients using potassium-sparing diuretics or taking potassium supplements. Please consult your doctor before taking Amlosafe LS 2.5 mg/2.5 mg Tablet if you have diabetes.

Amlodipine in Amlosafe LS 2.5 mg/2.5 mg Tablet can cause ankle swelling upon long-term use. Please try to keep your feet in an elevated position when sitting for long hours. If the problem persists, please consult your doctor and do as advised.

Even though your blood pressure becomes normal after using Amlosafe LS 2.5 mg/2.5 mg Tablet , it may switch back to high ranges if you stop using it. Your doctor may change the dosing schedule based on your blood pressure range.

Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and return to your regular dosing schedule.

Drug-Drug Interactions Checker List

  • SIMVASTATIN
  • PREDNISOLONE
  • BENDROFLUMETHIAZIDE
  • NAPROXEN
  • INSULIN GLARGINE
  • PREGABALIN
  • SITAGLIPTIN
  • ALLOPURINOL
  • SILDENAFIL
  • METOPROLOL
  • RAMIPRIL
  • FUROSEMIDE
  • IBUPROFEN
  • METFORMIN

Special Advise

  • Monitor your blood pressure regularly and seek medical advice if you notice any drastic fluctuations.
  • Amlosafe LS 2.5 mg/2.5 mg Tablet may affect patients with hepatic impairment, and hence it is used cautiously, and Liver function monitoring and Liver Function Tests are advised to monitor the liver enzyme changes.
  • Your doctor may advise you to get a regular kidney function test and blood examinations for potassium levels and other electrolytes while using Amlosafe LS 2.5 mg/2.5 mg Tablet to rule out any renal impairment.

Disease/Condition Glossary

Hypertension: When your blood pressure is too high, you have a chronic condition. The amount of blood pumped by the heart and the amount of resistance exerted by the arteries against the blood flow is called blood pressure. When the heart pumps more blood, the arteries narrow, and the blood pressure rises. Uncontrolled blood pressure can lead to serious heart problems such as stroke and heart attack. High blood pressure can also damage the brain (stroke) and lead to kidney failure. The systolic and diastolic pressures of blood are measured. The contraction and relaxation of the heart are represented by systolic blood pressure. Diastolic pressure is exerted in the blood vessels when the heart is at rest and not beating. The ideal blood pressure range is 90/60 mmHg to 120/80 mmHg. When systolic blood pressure exceeds 140mmHg, and diastolic pressure exceeds 90mmHg, hypertension is diagnosed. Hypertension symptoms include headaches, nosebleeds, vomiting, and chest pain.

Have a query?

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Alcohol

Caution

Alcohol may lower your blood pressure. Limit or avoid consuming alcohol while on treatment with Amlosafe LS 2.5 mg/2.5 mg Tablet is advisable.

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Pregnancy

Unsafe

Lisinopril in Amlosafe LS 2.5 mg/2.5 mg Tablet is a pregnancy D category drug and is not recommended during pregnancy since it causes harmful effects on the developing foetus. However, it is advised to seek medical advice before using Amlosafe LS 2.5 mg/2.5 mg Tablet if you plan to conceive or pregnant.

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Breast Feeding

Caution

There are limited studies on how Amlosafe LS 2.5 mg/2.5 mg Tablet affects breastfed infants. However, Amlodipine in Amlosafe LS 2.5 mg/2.5 mg Tablet passes into the breast milk during breastfeeding. Please consult your doctor before using Amlosafe LS 2.5 mg/2.5 mg Tablet if you are a lactating mother.

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Driving

Caution

Amlosafe LS 2.5 mg/2.5 mg Tablet may cause side effects from lowering blood pressure, such as dizziness or tiredness. If you feel dizzy or tired when taking this medicine, do not drive or use any tools or machines.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before using Amlosafe LS 2.5 mg/2.5 mg Tablet . Your doctor may adjust the dose based on your condition.

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases before using Amlosafe LS 2.5 mg/2.5 mg Tablet . Amlosafe LS 2.5 mg/2.5 mg Tablet is primarily eliminated by the kidney and can be accumulated in patients with renal impairment. Your doctor may adjust the dose based on your condition.

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Children

Unsafe

Amlosafe LS 2.5 mg/2.5 mg Tablet is not recommended for children as efficacy and safety have not been established.

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