Amlodipine+lisinopril
About
Amlodipine+lisinopril belongs to the class of 'anti-hypertensive drugs', primarily used to treat hypertension (high blood pressure). Hypertension is a medical condition in which the blood exerts high pressure (force exerted by circulating blood) against blood vessels' walls. This condition makes the heart work harder in pumping blood to the whole body. Hypertension can cause severe health complications, including stroke, heart failure, heart attack, and kidney failure.
Amlodipine+lisinopril is a combination of medicine that consists of Amlodipine (calcium channel blocker) and Lisinopril (angiotensin-converting enzyme inhibitor). Amlodipine belongs to the class of 'calcium channel blockers and is used to treat high blood pressure, Prinzmetal's or variant angina (chest pain), and other conditions caused by coronary artery disease. It relaxes blood vessels so that blood passes through them easily, lowering blood pressure. Amlodipine also improves blood supply to the heart muscle to receive more oxygen and thus preventing chest pain. Lisinopril belongs to the class of 'Angiotensin-Converting Enzyme (ACE) Inhibitors.' It relaxes and widens the blood vessels making it easier for the heart to pump blood throughout the body, lowering blood pressure. Lisinopril also decreases the body’s production of certain substances that raise blood pressure.
Amlodipine+lisinopril is an orally administered drug in the form of a tablet and capsule. You can take Amlodipine+lisinopril with food or without food. Swallow it as a whole with a glass of water. Do not chew, bite, or break it. Your doctor will advise you how often you take Amlodipine+lisinopril based on your medical condition. In some cases, you may experience blurred vision, sweating, confusion, tiredness, stomach upset, flushing (sense of warmth in the face, ears, neck and trunk), dizziness, headache, and swelling of the ankles or feet. Most of these side effects of Amlodipine+lisinopril do not require medical attention and gradually resolve over time. However, if the side effects are persistent, please contact your doctor.
Do not stop taking Amlodipine+lisinopril without consulting your doctor since it may worsen your condition and increase the risk of future heart problems. Regular monitoring of blood pressure, electrolyte levels and kidney functioning is advised while taking Amlodipine+lisinopril. Inform your doctor if you are suffering from kidney, liver or heart diseases. Please tell your doctor if you are taking other medicines or allergic to Amlodipine+lisinopril. Reducing the amount of table salt (sodium chloride) in your food often relieves the body's swelling. Let your doctor know if you use any prescription and non-prescription medications you are taking, including vitamins, before starting Amlodipine+lisinopril. If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Amlodipine+lisinopril can be prescribed accordingly.
Uses of Amlodipine+lisinopril
Medicinal Benefits
Amlodipine+lisinopril treats hypertension (high blood pressure) and consists of Amlodipine (calcium channel blocker) and Lisinopril (angiotensin-converting enzyme inhibitor). Amlodipine is a 'calcium channel blocker' and treats high blood pressure, Prinzmetal's or variant angina (chest pain), and other conditions caused by coronary artery disease. It relaxes blood vessels so that blood passes through them easily, lowering blood pressure. It also treats chest pain by improving the blood supply to the heart muscle to receive more oxygen. Amlodipine also improves a person's tolerance to exercise and keeps the blood pressure at acceptable levels. Lisinopril is an 'Angiotensin-Converting Enzyme (ACE) Inhibitor.' It relaxes and widens the blood vessels making it easier for the heart to pump blood throughout the body, lowering blood pressure.
Directions for Use
Storage
Side Effects of Amlodipine+lisinopril
- Confusion
- Sweating
- Tiredness
- Dizziness
- Headache
- Blurred vision
- Stomach upset
- Swelling of the ankles or feet
- Flushing (sense of warmth in the face, ears, neck and trunk)
In-Depth Precautions and Warning
Drug Warnings
- Do not use Amlodipine+lisinopril if you are allergic to Amlodipine+lisinopril or its components.
- Please inform your doctor if you are using any prescription and non-prescription medications, including vitamins, before starting Amlodipine+lisinopril.
- Let your doctor know if you have any history of severe heart, kidney or liver diseases, high potassium levels (hyperkalaemia), bone marrow suppression, and aortic stenosis (heart valve problem).
- It is essential to inform your doctor if you are a breastfeeding mother before using Amlodipine+lisinopril since Amlodipine may pass into the breast milk.
- Lisinopril is not recommended during pregnancy since it harms the unborn baby. Please ask your doctor if you plan to conceive or are pregnant before using Amlodipine+lisinopril.
- Amlodipine+lisinopril can increase the chances of light-headedness so rise slowly if you are sitting/lying and avoid operating any machine or doing any work that needs mental alertness.
Drug Interactions
Drug-Drug Interactions: Amlodipine+lisinopril may interact with drugs reducing cholesterol (simvastatin), corticosteroids (prednisolone), painkillers (ibuprofen, naproxen), anti-hypertensive drugs (ramipril, metoprolol, bendroflumethiazide), drugs treating impotence (sildenafil), gout medicine (allopurinol), diabetic drugs (Insulin glargine, metformin, sitagliptin), water pills (furosemide), and fits medicine (pregabalin).
Drug-Food Interactions: Amlodipine+lisinopril may interact or have decreased effect when used with alcohol and high potassium foods.
Drug-Disease Interactions: Before using Amlodipine+lisinopril, let your doctor know if have heart, kidney or liver diseases, high potassium levels (hyperkalaemia), bone marrow suppression, and aortic stenosis (heart valve problem).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionAlcohol may lower your blood pressure. Limit or avoid consuming alcohol while on treatment with Amlodipine+lisinopril is advisable.
Pregnancy
unsafeLisinopril in Amlodipine+lisinopril is a pregnancy D category drug and is not recommended during pregnancy since it causes harmful effects on the developing foetus. However, it is advised to seek medical advice before using Amlodipine+lisinopril if you plan to conceive or pregnant.
Breast Feeding
cautionThere are limited studies on how Amlodipine+lisinopril affects breastfed infants. However, Amlodipine in Amlodipine+lisinopril passes into the breast milk during breastfeeding. Please consult your doctor before using Amlodipine+lisinopril if you are a lactating mother.
Driving
cautionAmlodipine+lisinopril may cause side effects from lowering blood pressure, such as dizziness or tiredness. If you feel dizzy or tired when taking this medicine, do not drive or use any tools or machines.
Liver
cautionLet your doctor know if you have any history of liver diseases before using Amlodipine+lisinopril. Your doctor may adjust the dose based on your condition.
Kidney
cautionLet your doctor know if you have any history of kidney diseases before using Amlodipine+lisinopril. Amlodipine+lisinopril is primarily eliminated by the kidney and can be accumulated in patients with renal impairment. Your doctor may adjust the dose based on your condition.
Children
unsafeAmlodipine+lisinopril is not recommended for children as efficacy and safety have not been established.
Habit Forming
Diet & Lifestyle Advise
- Keep your weight under control with body mass index (BMI) between 19.5 and 24.9.
- Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help lower your raised blood pressure by about 5 mm of Hg.
- Limit sodium chloride intake (table salt) in your daily diet to 2300 mg daily or less than 1500 mg is ideal for most adults.
- If you are taking alcohol, use only one serving for women and two servings for men.
- Quit smoking to lower the risk of heart disease.
- Avoid chronic stress, as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress.
- Monitor your blood pressure daily, and if you notice any fluctuations frequently, please contact your doctor immediately.
- Try including heart-healthy omega-3 fatty acid-containing foods in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.
Special Advise
- Monitor your blood pressure regularly and seek medical advice if you notice any drastic fluctuations.
- Amlodipine+lisinopril may affect patients with hepatic impairment, and hence it is used cautiously, and Liver function monitoring and Liver Function Tests are advised to monitor the liver enzyme changes.
- Your doctor may advise you to get a regular kidney function test and blood examinations for potassium levels and other electrolytes while using Amlodipine+lisinopril to rule out any renal impairment.
Patients Concern
Disease/Condition Glossary
Hypertension: When your blood pressure is too high, you have a chronic condition. The amount of blood pumped by the heart and the amount of resistance exerted by the arteries against the blood flow is called blood pressure. When the heart pumps more blood, the arteries narrow, and the blood pressure rises. Uncontrolled blood pressure can lead to serious heart problems such as stroke and heart attack. High blood pressure can also damage the brain (stroke) and lead to kidney failure. The systolic and diastolic pressures of blood are measured. The contraction and relaxation of the heart are represented by systolic blood pressure. Diastolic pressure is exerted in the blood vessels when the heart is at rest and not beating. The ideal blood pressure range is 90/60 mmHg to 120/80 mmHg. When systolic blood pressure exceeds 140mmHg, and diastolic pressure exceeds 90mmHg, hypertension is diagnosed. Hypertension symptoms include headaches, nosebleeds, vomiting, and chest pain.
FAQs
Amlodipine+lisinopril treats hypertension (high blood pressure) and consists of Amlodipine (calcium channel blocker) and Lisinopril (angiotensin-converting enzyme inhibitor). Amlodipine is a 'calcium channel blocker' and treats high blood pressure, Prinzmetal's or variant angina (chest pain), and other conditions caused by coronary artery disease. It relaxes blood vessels so that blood passes through them easily, lowering blood pressure.
Amlodipine+lisinopril is recommended to use in dose and duration as advised by the doctor. Do not stop taking Amlodipine+lisinopril on your own, as it may lead to a sudden rise in blood pressure and increases the risk of heart attack and stroke.
Amlodipine+lisinopril may increase blood potassium levels in people with diabetes, poor kidney function, and patients using potassium-sparing diuretics or taking potassium supplements. Please consult your doctor before taking Amlodipine+lisinopril if you have diabetes.
Amlodipine in Amlodipine+lisinopril can cause ankle swelling upon long-term use. Please try to keep your feet in an elevated position when sitting for long hours. If the problem persists, please consult your doctor and do as advised.
Even though your blood pressure becomes normal after using Amlodipine+lisinopril, it may switch back to high ranges if you stop using it. Your doctor may change the dosing schedule based on your blood pressure range.
Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and return to your regular dosing schedule.
