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Written By Veda Maddala , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
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Composition :

AMPHOTERICIN B-50MG

Manufacturer/Marketer :

Bharat Serums and Vaccines Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Amphomul 50 Injection

Amphomul 50 Injection belongs to a class of medication called 'antifungal' used to treat severe fungal infections like leishmaniasis. A fungal infection is a disease in which fungi attack the tissue and cause infection. Fungi are commonly present in nature but do not cause infections normally. However, if the person has a weak immune system, certain types of fungi may infect them. 

Amphomul 50 Injection contains Amphotericin B, which kills fungi by destroying the fungal outer cell membrane. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents.

Amphomul 50 Injection is given by a doctor or nurse. In some cases, you may experience fever, chills, irregular heartbeat, high or low blood pressure, breathing problems, nausea, vomiting, headache, shaking, muscle cramps or pain. Most of these side effects of Amphomul 50 Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Amphomul 50 Injection or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Amphomul 50 Injection. Amphomul 50 Injection is not recommended for children below one month as the safety and effectiveness were not established. Avoid driving after taking Amphomul 50 Injection as it may affect your ability to drive. If you experience severe adverse effects such as chest pain or difficulty in breathing, or encephalopathy (a brain disease which may cause you to behave strangely, be confused or feel drowsy), seek immediate medical help.

Uses of Amphomul 50 Injection

Severe fungal infections

Directions for Use

Amphomul 50 Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Amphomul 50 Injection contains Amphotericin B, an antifungal used to treat severe fungal infections. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Amphomul 50 Injection damages fungal cell membranes and kills fungi. Amphomul 50 Injection is used to treat infections such as blood infection with candida, cryptococcus, fusarium, zygomycetes, aspergillus, coccidiodes or blastomycetes, or cryptococcal meningitis (inflammation of the brain).

Storage

Store in a cool and dry place away from sunlight

Side Effects of Amphomul 50 Injection

  • Fever
  • Chills
  • Irregular heartbeat
  • High or low blood pressure
  • Breathing problems
  • Nausea
  • Vomiting
  • Headache
  • Shaking
  • Muscle cramps or pain

Drug Warnings

If you are allergic to Amphotericin B or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Amphomul 50 Injection. Amphomul 50 Injection is not recommended for children below one month as the safety and effectiveness were not established. Avoid driving after taking Amphomul 50 Injection as it may affect your ability to drive. If you experience severe adverse effects such as chest pain, difficulty breathing, or encephalopathy (a brain disease that may cause you to behave strangely, be confused or feel drowsy), seek immediate medical help. If you have diabetes, electrolyte imbalance (low magnesium or potassium levels in the blood), kidney, liver or heart problems, inform your doctor before taking Amphomul 50 Injection.

Drug-Drug Interactions

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Amphotericin bStreptozocin
Critical
Amphotericin bAmiodarone
Severe

Drug-Drug Interactions

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Amphotericin bStreptozocin
Critical
How does the drug interact with Amphomul 50 Injection:
Taking Amphomul 50 Injection and streptozocin together can enhance kidney injury and can cause damage to the ear.

How to manage the interaction:
Taking Streptozocin with Amphomul 50 Injection is not recommended as it can result in an interaction, it can be taken if a doctor has advised it.
Amphotericin bAmiodarone
Severe
How does the drug interact with Amphomul 50 Injection:
Coadministration of amiodarone together with Amphomul 50 Injection may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Even though Amiodarone and Amphomul 50 Injection interact, they can be used if prescribed by a doctor. If you have heart issues or electrolyte imbalances, you may be at greater risk. If you experience unexpected dizziness, lightheadedness, fainting, shortness of breath, weakness, tiredness, drowsiness, confusion, muscle pain, dizziness, nausea, or vomiting, or heart palpitations, get medical attention. Do not discontinue any medications without consulting a doctor.
Amphotericin bDronedarone
Severe
How does the drug interact with Amphomul 50 Injection:
Dronedarone used with Amphomul 50 Injection may raise the chance of a significantly abnormal heart rhythm, although it is a rare side effect.

How to manage the interaction:
Although there is a possible interaction between Amphomul 50 Injection and Dronedarone, you can take these medicines together if prescribed by a doctor. You should also notify a doctor if you suffer any of the following symptoms: weakness, weariness, sleepiness, disorientation, muscular pain, cramps, dizziness, nausea, or vomiting. Do not stop using any medications without talking to a doctor.
Amphotericin bHuman immunoglobulin
Severe
How does the drug interact with Amphomul 50 Injection:
Taking Human immunoglobulin with Amphomul 50 Injection, may raise the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Human immunoglobulin and Amphomul 50 Injection, you can take these medicines together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Amphotericin bIopamidol
Severe
How does the drug interact with Amphomul 50 Injection:
Coadministration of Amphomul 50 Injection and Iopamidol may increase the risk of kidney problem.

How to manage the interaction:
Taking Amphomul 50 Injection with Iopamidol together can result in an interaction, but it can be taken if a doctor has advised it. It's important to keep an eye on how much you pee. If you notice any changes like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm let the doctor know right away. Do not discontinue any medications without consulting a doctor.
Amphotericin bArsenic trioxide
Severe
How does the drug interact with Amphomul 50 Injection:
Using arsenic trioxide together with Amphomul 50 Injection cholesteryl sulfate can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Co-administration of Amphomul 50 Injection with Arsenic trioxide can result in an interaction, but it can be taken if a doctor has advised it. If you experience irregular heartbeat, feeling suddenly dizzy or lightheaded, fainting, a fast or strong heartbeat, feeling weak or tired, feeling sleepy or confused, muscle pain, or feeling sick to your stomach. Do not stop using any medications without talking to a doctor.
Amphotericin bIodixanol
Severe
How does the drug interact with Amphomul 50 Injection:
Coadministration of Amphomul 50 Injection and Iodixanol can cause higher levels of Iodixanol in the blood by reducing its excretion rate.

How to manage the interaction:
There may be a possibility of interaction between Amphomul 50 Injection and Iodixanol, but it can be taken if prescribed by a doctor. It's important to keep an eye on how much you pee. If you notice any changes, like peeing more or less than usual, it's a good idea to let the doctor know right away. These changes could be a sign of different health issues, like problems with your kidneys, diabetes, or dehydration. Other symptoms to watch out for include feeling sick, throwing up, not wanting to eat, gaining or losing weight suddenly, or having trouble breathing. Do not stop using any medications without talking to a doctor.
Amphotericin bMetrizamide
Severe
How does the drug interact with Amphomul 50 Injection:
Coadministration of Amphomul 50 Injection and Metrizamide may increase the risk of kidney damage.

How to manage the interaction:
Co-administration of Amphomul 50 Injection with Metrizamide can result in an interaction, but it can be taken if a doctor has advised it. If you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, let the doctor know. Do not stop using any medications without talking to a doctor.
Amphotericin bIotalamic acid
Severe
How does the drug interact with Amphomul 50 Injection:
Coadministration of Amphomul 50 Injection and Iotalamic acid may decrease the excretion rate of Iothalamic acid which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Amphomul 50 Injection and Iotalamic acid, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
Amphotericin bZiprasidone
Severe
How does the drug interact with Amphomul 50 Injection:
Co-administration of Ziprasidone with Amphomul 50 Injection may raise the chance of a significantly abnormal heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Amphomul 50 Injection and Ziprasidone, but it can be taken if prescribed by a doctor. However, if you experience abrupt dizziness, lightheadedness, fainting, or rapid or pounding heartbeats, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, nausea, or vomiting, contact a doctor immediately. You may need regular monitoring of your electrolyte (magnesium, potassium) levels. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Wash your hands regularly and keep your hands clean to prevent the spread of germs.
  • Avoid dusty activities and digging in the soil.
  • Wear shoes, a long-sleeved t-shirt and long pants while doing outdoor activities such as yard work, gardening or visiting wooded areas to protect from fungus commonly present in the environment.
  • Maintain a diet that is low in sugar, refined carbohydrates, mould-containing foods and yeast.

Habit Forming

No

Therapeutic Class

ANTIFUNGALS

Amphomul 50 Injection Substitute

Substitutes safety advice
  • AMPHOTIN 50MG INJECTION

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    214.20per tablet
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  • Ampholip 50 Injection 10 ml

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Amphomul 50 Injection contains Amphotericin B, an antifungal that works by damaging fungal cell membranes, thereby killing fungi.

You are not recommended to take Amphomul 50 Injection with furosemide as co-administration of these medicines may increase the risk of hypokalaemia (low potassium levels in the blood), and in severe cases, it may lead to paralysis, muscle weakness, irregular heart rhythm, difficulty in breathing or swallowing. However, please consult your doctor before taking Amphomul 50 Injection with other medicines.

Amphomul 50 Injection may cause blue lips and skin, probably during infusion or in the initial 2 days of treatment. However, your doctor or nurse may arrange certain simple treatments to control such adverse effects.

Yes, a test dose of Amphomul 50 Injection may be given in smaller amounts before starting the treatment to check if you are sensitive to any of the ingredients.

You are recommended to use Amphomul 50 Injection for as long as your doctor has prescribed it. However, the usual treatment is for a minimum of 14 days. Please consult a doctor if you experience any difficulty while taking Amphomul 50 Injection.

Amphomul 50 Injection is not used to treat viral infections. Amphomul 50 Injection is an antifungal that kills fungi and is used to treat severe fungal infections.

Drug-Drug Interactions Checker List

  • ZIDOVUDINE
  • CICLOSPORIN
  • FLUCYTOSINE
  • FUROSEMIDE
  • METHOTREXATE

Special Advise

  • Regular blood tests are recommended while taking Amphomul 50 Injection to monitor blood, liver or kidney functioning and potassium levels.

Disease/Condition Glossary

Fungal infection is a disease in which fungi attack the tissue and cause infection. Fungi are commonly present in nature but do not cause infections normally. However, if the person has a weak immune system, certain types of fungi may infect them. Cryptococcal meningitis is a fungal infection of tissues covering the spinal cord (meninges) and brain. The symptoms include headache, hallucinations, fever, stiff neck, sensitivity to light, nausea and vomiting. Fungal infections in the lungs may be more serious and life-threatening and often cause symptoms similar to tuberculosis or bacterial pneumonia.

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