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  3. Aplevant 0.75 mg Injection 1's

Aplevant 0.75 mg Injection 1's, Pack of 1 Injection
Aplevant 0.75 mg Injection 1's, Pack of 1 Injection
Aplevant 0.75 mg Injection 1's, Pack of 1 Injection
Aplevant 0.75 mg Injection 1's, Pack of 1 Injection
Written By Divya L , PharmaD
Reviewed By Santoshini Reddy G , M Pharmacy
Non returnable*
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Whats That

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Composition :

DULAGLUTIDE-0.75MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Aplevant 0.75 mg Injection

Aplevant 0.75 mg Injection belongs to the class of anti-diabetic drugs primarily used to treat type 2 diabetes mellitus. Diabetes mellitus is a metabolic disease that causes high blood sugar levels. It occurs when the insulin (a hormone produced by the beta cells of the pancreas) is resistant in breaking the glucose to produce energy (insulin resistance) or the pancreas produces little or no insulin at all.

Aplevant 0.75 mg Injection contains Dulaglutide that belongs to the class of ‘incretin mimetics’. Dulaglutide works by increasing insulin release from the pancreas during high blood sugar levels (after meals) and decreasing the amount of sugar the liver makes. Aplevant 0.75 mg Injection also prevents the risk of heart diseases in type 2 diabetes patients.

Your doctor will decide the dose and duration of Aplevant 0.75 mg Injection based on your medical condition. Some common side effects of Aplevant 0.75 mg Injection include nausea, vomiting, diarrhoea, decreased appetite, stomach pain, constipation, and feeling tired. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Before starting Aplevant 0.75 mg Injection, let your doctor know if you have any medical history of heart, kidney or liver diseases. It is advised to limit your alcohol intake while using Aplevant 0.75 mg Injection to avoid low blood sugar levels. Pregnant and breastfeeding women should consult their doctor before starting Aplevant 0.75 mg Injection. Aplevant 0.75 mg Injection may make you feel tired, hence drive and operate machinery only when you are feeling better. Aplevant 0.75 mg Injection is not recommended for children and adolescents under 18 years of age.

Uses of Aplevant 0.75 mg Injection

Type 2 Diabetes mellitus.

Directions for Use

Aplevant 0.75 mg Injection should be administered subcutaneously (under the skin) in the abdomen, thigh or upper arm. Your doctor or nurse will guide you on how to use the injection. Your doctor will prescribe the dosage based on your disease condition and tolerance. Your doctor may start the course with a low dose and gradually maintain an effective dose to achieve the required blood glucose control.

Medicinal Benefits

Aplevant 0.75 mg Injection is used to treat type 2 diabetes mellitus. It is an incretin mimetic that mimics the action of a natural hormone called Incretin (a metabolic hormone that stimulates a decrease in blood glucose levels). It works by increasing insulin release from the pancreas during high blood sugar levels (after meals) and decreases the amount of sugar the liver makes. Aplevant 0.75 mg Injection also reduces the risk of serious heart diseases, such as heart attack or stroke in patients with type 2 diabetes and heart disease. Aplevant 0.75 mg Injection may be advised with or without other medications along with diet and exercise to control blood sugar levels. 

Storage

Store in a cool and dry place away from sunlight
Side effects of Aplevant 0.75 mg Injection
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • To manage high lipase levels, take the prescribed medication as directed by your doctor.
  • Avoid alcohol to prevent irritation of the pancreas and liver and to prevent interactions with your medications.
  • Follow a low-fat, high-fibre, and low-red meat diet.
  • Stay well-hydrated by drinking 8-12 cups of fluids daily.
  • If you are diagnosed with pancreatitis, you may need to stay in the hospital for fluids, pain relief, and to manage nausea, with a gradual transition to an easy-to-digest diet.
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

Drug Warnings

Brief your medical history to the doctor if you have heart, kidney or liver diseases, pancreatitis (inflammation of the pancreas), stomach disorders like acid reflux, gastroparesis (delayed gastric emptying), hypoglycaemia (low blood sugar levels), diabetic retinopathy, and type 1 diabetes before starting Aplevant 0.75 mg Injection. Aplevant 0.75 mg Injection is contraindicated in patients with multiple endocrine neoplasia type 2, diabetic ketoacidosis (diabetes complication where the body produces excess blood acids (ketones)), and personal or family history of thyroid cancer. Do not share an injection pen, cartridge, or syringe with another person, even if the needle is changed. It is advised to limit your alcohol intake while using Aplevant 0.75 mg Injection to avoid low blood sugar levels. Pregnant and breastfeeding women should consult their doctor before starting this medication. Aplevant 0.75 mg Injection may make you feel tired; hence drive and operate machinery only when you are feeling better. Aplevant 0.75 mg Injection is not recommended for children and adolescents under 18 years of age.

Drug-Drug Interactions

verifiedApollotooltip
DulaglutideBexarotene
Severe
DulaglutideGatifloxacin
Severe

Drug-Drug Interactions

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DulaglutideBexarotene
Severe
How does the drug interact with Aplevant 0.75 mg Injection:
Co-administration of Aplevant 0.75 mg Injection with Bexarotene may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Aplevant 0.75 mg Injection and Bexarotene, you can take these medicines together if prescribed by a doctor. If you're having symptoms like vomiting, stomach pain, or vomiting, contact a doctor right away. Do not stop using any medications without talking to a doctor.
DulaglutideGatifloxacin
Severe
How does the drug interact with Aplevant 0.75 mg Injection:
Co-administration of Aplevant 0.75 mg Injection with Gatifloxacin may increase the risk or severity of low blood sugar.

How to manage the interaction:
Although there is a possible interaction between Aplevant 0.75 mg Injection and Gatifloxacin, you can take these medicines together if prescribed by a doctor. However, if you experience sweating, headache, shortness of breath, or palpitations, contact a doctor immediately. Do not discontinue any medication without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a fibre-rich diet and include healthy carbohydrates from fruits, vegetables and whole grains to maintain your blood glucose levels.
  • Eat at regular intervals.
  • Keep a check on your weight and exercise regularly to keep your heart healthy.
  • Follow your doctor's guide on noticing and managing the early symptoms of high/low blood sugar levels.
  • Gastrointestinal side effects can be managed with simple modifications in your lifestyle. These include cutting down on sugars and fatty foods, avoiding carbonated drinks and foods that cause gas. 

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

Aplevant 0.75 mg Injection Substitute

Substitutes safety advice

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Author Details

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Written By

Divya L

PharmaD

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 8, 2025 | 9:42 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
DULAGLUTIDE-0.75MGOther diseases of stomach and duodenum
Severe
DULAGLUTIDE-0.75MGAcute pancreatitis
Severe

Drug-Diseases Interactions

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DULAGLUTIDE-0.75MGOther diseases of stomach and duodenum
Severe
How does the disease interact with Aplevant 0.75 mg Injection:
Aplevant 0.75 mg Injection delays stomach emptying and has not been investigated in individuals with gastroparesis, therefore it is not indicated in these patients.

How to manage the interaction:
Aplevant 0.75 mg Injection is not recommended in patients with gastroparesis (delayed stomach emptying).
DULAGLUTIDE-0.75MGAcute pancreatitis
Severe
How does the disease interact with Aplevant 0.75 mg Injection:
The usage of GLP-1 receptor agonists has been associated with a small number of cases of acute pancreatitis. Other diabetes treatments should be examined in individuals with a history of pancreatitis, while it is unclear if they are at higher risk. Patients using GLP-1 receptor agonists should be closely monitored for signs and symptoms of pancreatitis. If this diagnosis is suspected, the therapy should be stopped promptly and appropriate care instituted. If pancreatitis is diagnosed, GLP-1 receptor agonist treatment should be terminated completely.

How to manage the interaction:
Patients receiving treatment with Aplevant 0.75 mg Injection should be carefully observed for signs and symptoms of pancreatitis such as pain in the stomach or back, bloating (belly feels full and tight), nausea, vomiting, indigestion, sweating, fast heart rate, or weight loss. If you notice any of these symptoms, contact your doctor immediately.
DULAGLUTIDE-0.75MGMalignant neoplasm of thyroid gland
Severe
How does the disease interact with Aplevant 0.75 mg Injection:
GLP-1 receptor agonist diabetes medications are not recommended for people who have a personal or family history of medullary thyroid cancer or who have Multiple Endocrine Neoplasia syndrome type 2 (MEN2).

How to manage the interaction:
Aplevant 0.75 mg Injection is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (cancer inside thyroid gland) and in patients with Multiple Endocrine Neoplasia syndrome type 2 (tumors in the thyroid, parathyroid glands, and adrenal glands).

FAQs

Aplevant 0.75 mg Injection contains Dulaglutide that increases the insulin release from the pancreas after meals when your body has high blood glucose levels. Thus, Aplevant 0.75 mg Injection helps lower the blood sugar levels in type 2 diabetes mellitus.

Aplevant 0.75 mg Injection may cause low blood sugar levels (hypoglycaemia) and can make you hungry, dizzy, irritable, confused, anxious, or shaky. Hence, it is advised to take Aplevant 0.75 mg Injection with a meal. To immediately treat hypoglycaemia, it is advised to eat or drink fast-acting sugar sources like fruit juices, hard candy, raisins, or non-diet soda.

Use injection solution only if it is clear, colourless, and contains no particles. Administer the injection subcutaneously (under the skin) in the abdomen, thigh or upper arm. Your doctor or nurse will guide you on how to use the injection. You can take Aplevant 0.75 mg Injection with or without a meal. However, it is advised to take the injection preferably with a meal since it lowers the blood sugar levels and may cause gastrointestinal side effects. Do not share an injection pen, cartridge, or syringe with another person, even if the needle is changed.

Your doctor may advise Aplevant 0.75 mg Injection with or without other medications to control your blood sugar levels. Take Aplevant 0.75 mg Injection with other anti-diabetic medicines only if prescribed by the doctor. If you are also prescribed insulin, take Aplevant 0.75 mg Injection and insulin injections separately. Please do not mix them. You can inject both injections in the same body region, but the injection sites should not be next to each other.

Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose.

Store the unused Aplevant 0.75 mg Injection in a refrigerator at 2°C to 8°C protected from the light. You may also store Aplevant 0.75 mg Injection at room temperature of 15°C to 30°C for up to 14 days before use. Do not freeze Aplevant 0.75 mg Injection. Do not use Aplevant 0.75 mg Injection if it is frozen.

Drug-Drug Interactions Checker List

  • INSULIN GLARGINE
  • LEVOTHYROXINE
  • PROPRANOLOL
  • METOPROLOL
  • TIMOLOL

Special Advise

It is advised to monitor your blood sugar levels regularly.

Disease/Condition Glossary

Diabetes mellitus: It is a metabolic disease that causes high blood sugar levels. Diabetes mellitus is also known as adult-onset diabetes. It occurs when the insulin (a hormone produced by the beta cells of the pancreas) is resistant in breaking the glucose to produce energy (insulin resistance) or the pancreas (an organ behind the stomach) produce little or no insulin at all. This disease mostly occurs in people above 40 years but can also occur in childhood based on the risk factors. The treatment includes oral glucose-lowering medicines and insulin shots. 

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