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  3. Apregen 125 mg/80 mg Kit 1's

Apregen 125 mg/80 mg Kit 1's, Pack of 1 CAPSULE
Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Whats That

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Composition :

APREPITANT-205MG

Manufacturer/Marketer :

Cellgen Biopharma

Consume Type :

ORAL

Return Policy :

Not Returnable

About Apregen 125 mg/80 mg Kit 1's

Apregen 125 mg/80 mg Kit 1's belongs to a class of drugs called anti-emetics. It is used in combination with other medicines to prevent nausea and vomiting caused by chemotherapy (anti-cancer medicines) in adults and adolescents aged 12 years and above. Nausea is a feeling of uneasiness in the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.

Apregen 125 mg/80 mg Kit 1's contains Aprepitant, a neurokinin 1 (NK1) receptor antagonist which works by blocking the neurokinin-1 receptor (causes the feeling of sickness) present in the vomiting centre in the brain. Thus, it helps prevent nausea and vomiting. 

Take Apregen 125 mg/80 mg Kit 1's as prescribed. You are recommended to take Apregen 125 mg/80 mg Kit 1's for as long as your doctor has advised it. In some cases, Apregen 125 mg/80 mg Kit 1's may cause common side effects such as headache, constipation, loss of appetite, tiredness, indigestion, and hiccups. Most of these side effects do not require medical attention and gradually resolve over time. However, consult your doctor immediately if the side effects persist or worsen. 

Please tell your doctor if you are allergic to Apregen 125 mg/80 mg Kit 1's or any other medicines. Apregen 125 mg/80 mg Kit 1's is not recommended for children below 12 years of age. If you are pregnant or breastfeeding, please inform your doctor before taking Apregen 125 mg/80 mg Kit 1's. Avoid driving or operating machinery if you feel dizzy or sleepy after taking Apregen 125 mg/80 mg Kit 1's. If you are taking other prescription or non-prescription medicines, inform your doctor before taking Apregen 125 mg/80 mg Kit 1's.

Uses of Apregen 125 mg/80 mg Kit 1's

Chemotherapy-induced nausea and vomiting

Directions for Use

Take Apregen 125 mg/80 mg Kit 1's with or without food as advised by your doctor. Always take Apregen 125 mg/80 mg Kit 1's together with other medicines. Swallow it as a whole with some liquid; do not crush, break or chew it.

Medicinal Benefits

Apregen 125 mg/80 mg Kit 1's contains Aprepitant, an anti-emetic (a drug used to treat nausea and vomiting) that works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it is used in combination with other medicines to prevent nausea and vomiting caused by anti-cancer medicines in adults and adolescents from the age of 12 years. 

Storage

Store in a cool and dry place away from sunlight
Side effects of Apregen 125 mg/80 mg Kit
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If you have excess nerve pain and numbness, soak in Epsom salt and warm water. This can help ease the pain and associated discomfort.
  • Use compression socks and make sure to rest for a while to get relief from pain.
  • Avoid smoking and intake of alcohol or fluids that aggravate the pain.
  • Massage your feet or affected area often to get relief from pain. Take the medication prescribed by your doctor without fail.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Drug Warnings

Please tell your doctor if you are allergic to Apregen 125 mg/80 mg Kit 1's or any other medicines. Apregen 125 mg/80 mg Kit 1's is not recommended for children below 12 years of age. If you are pregnant or breastfeeding, please inform your doctor before taking Apregen 125 mg/80 mg Kit 1's. Avoid driving or operating machinery if you feel dizzy or sleepy after taking Apregen 125 mg/80 mg Kit 1's. If you are taking any other prescription or non-prescription medicines, inform your doctor before taking Apregen 125 mg/80 mg Kit 1's.

Drug-Drug Interactions

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AprepitantTerfenadine
Critical
AprepitantCisapride
Critical

Drug-Drug Interactions

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AprepitantTerfenadine
Critical
How does the drug interact with Apregen 125 mg/80 mg Kit:
Co-administration with Apregen 125 mg/80 mg Kit and Terfenadine may increase the blood levels of Terfenadine and leads to irregular heartbeat.

How to manage the interaction:
Taking Apregen 125 mg/80 mg Kit and Terfenadine together is not recommended as it can lead to an interaction. It is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantCisapride
Critical
How does the drug interact with Apregen 125 mg/80 mg Kit:
Co-administration with Apregen 125 mg/80 mg Kit and Cisapride may cause irregular heart rhythm.

How to manage the interaction:
Although taking Apregen 125 mg/80 mg Kit and Cisapride together is not recommended as it can lead to an interaction, it is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantPimozide
Critical
How does the drug interact with Apregen 125 mg/80 mg Kit:
Using pimozide together with Apregen 125 mg/80 mg Kit may significantly increase the blood levels of pimozide. High blood levels of pimozide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Apregen 125 mg/80 mg Kit and Pimozide together is not recommended; as it can lead to an interaction, you can take them if your doctor advises you to. If you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, get immediate medical help. Do not discontinue any medications without consulting a doctor.
AprepitantFlibanserin
Critical
How does the drug interact with Apregen 125 mg/80 mg Kit:
Using flibanserin together with Apregen 125 mg/80 mg Kit can significantly increase the blood levels of flibanserin.

How to manage the interaction:
Taking Flibanserin and Apregen 125 mg/80 mg Kit together is not recommended as it can lead to an interaction; they can be taken if prescribed by a doctor. Consult a doctor if you develop any symptoms, such as extreme sleepiness or low blood pressure, that cause dizziness, lightheadedness, or fainting. To reduce the chance of these side effects, use Flibanserin at bedtime. Do not discontinue any medications without consulting a doctor.
AprepitantAstemizole
Critical
How does the drug interact with Apregen 125 mg/80 mg Kit:
Co-administration with Apregen 125 mg/80 mg Kit and Astemizole may increase the blood levels of Astemizole.

How to manage the interaction:
Although taking Apregen 125 mg/80 mg Kit and Astemizole together is not recommended as it can lead to an interaction, it is safe if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor. Astemizole should not be combined with any other medications without a doctor's advice.
AprepitantEliglustat
Critical
How does the drug interact with Apregen 125 mg/80 mg Kit:
Apregen 125 mg/80 mg Kit combined with Eliglustat can considerably raise blood levels of Eliglustat. This raises the possibility of cardiac adverse effects such as abnormal heart rhythm, heart block, and cardiac arrest.

How to manage the interaction:
Taking Apregen 125 mg/80 mg Kit and Eliglustat together is not recommended as it can lead to an interaction; they can be consumed if prescribed by a doctor. Consult a doctor if you have symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, weak heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without consulting a doctor.
AprepitantLomitapide
Critical
How does the drug interact with Apregen 125 mg/80 mg Kit:
Lomitapide blood levels can be significantly increased by combining it with Apregen 125 mg/80 mg Kit.

How to manage the interaction:
Although using Lomitapide and Apregen 125 mg/80 mg Kit together may cause an interaction, they can be taken if advised by a doctor. Consult a doctor if you have any of the following symptoms: diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, gas, constipation, liver problems causing fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, dark colored urine, light-colored stools, and yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AprepitantAvanafil
Severe
How does the drug interact with Apregen 125 mg/80 mg Kit:
Apregen 125 mg/80 mg Kit may considerably raise Avanafil levels in the blood. This increases the severity of side effects.

How to manage the interaction:
Although the co-administration of Apregen 125 mg/80 mg Kit and Avanafil may result in an interaction, they can be taken if prescribed by a doctor. Contact a doctor if you have any of the following symptoms: low blood pressure, dizziness, lightheadedness, fainting, visual problems, ringing sound in the ears, vision or hearing loss, chest pain or tightness, irregular heartbeat, or priapism (prolonged and painful erection unrelated to sexual activity). Do not discontinue any medications without doctor's consultation.
AprepitantBrigatinib
Severe
How does the drug interact with Apregen 125 mg/80 mg Kit:
Coadministration of Brigatinib with Apregen 125 mg/80 mg Kit may raise blood levels of Brigtinib.

How to manage the interaction:
Although co-administration of Apregen 125 mg/80 mg Kit and Brigatinib may result in an interaction, it can be used if prescribed by a doctor. Consult a doctor if you have any of the following symptoms: nausea, vomiting, diarrhea, high blood pressure, high blood sugar, slow heart rate, visual disturbances, paleness, fatigue, dizziness, fainting, fever, chills, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, or pain during urination. Do not discontinue any medications without consulting a doctor.
AprepitantCobimetinib
Severe
How does the drug interact with Apregen 125 mg/80 mg Kit:
Co-administration of Apregen 125 mg/80 mg Kit with Cobimetinib may result in a rise in Cobimetinib blood levels.

How to manage the interaction:
Although taking Apregen 125 mg/80 mg Kit with cobimetinib may cause an interaction, it is safe to do so if advised by your doctor. Consult a doctor if you have nausea, vomiting, diarrhea, mouth sores, bleeding, heart issues, rash, sensitivity to light, eye difficulties, or muscle damage. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy and low-fat diet that includes lots of fruits and vegetables, lean meats, skinless poultry, nuts, fish, whole grains, and plant-based oils, especially in small portions, as it will be easy for digestion.
  • Avoid eating over-sweet food and include more salty food, especially if you have been vomiting. 
  • Increase the intake of fluids. Drink a small amount of water after small intervals to stay hydrated. 
  • Avoid taking greasy or oily foods, as these foods trigger nausea and vomiting. 
  • If the smell of food makes you feel sick (vomit), do not cook food, as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.

Habit Forming

No

Therapeutic Class

ANTIEMETICS

Apregen 125 mg/80 mg Kit 1's Substitute

Substitutes safety advice

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 20, 2024 | 1:17 PM IST

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Drug-Diseases Interactions

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APREPITANT-205MGAlcoholic liver disease
Moderate

Drug-Diseases Interactions

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APREPITANT-205MGAlcoholic liver disease
Moderate
How does the disease interact with Apregen 125 mg/80 mg Kit:
The liver is primarily responsible for Apregen 125 mg/80 mg Kit metabolism. Apregen 125 mg/80 mg Kit was well tolerated in investigations of patients with mild to moderate hepatic impairment (Child-Pugh score 5 to 9), and no clinically significant changes in its pharmacokinetics were seen. As a result, there is no need to change the dosage of Apregen 125 mg/80 mg Kit in this patient population. Apregen 125 mg/80 mg Kit should be used with caution in patients with severe hepatic impairment (Child-Pugh score > 9), as there is no clinical or pharmacokinetic data in this population.

How to manage the interaction:
Apregen 125 mg/80 mg Kit is metabolized by the liver, hence it is usually not recommended in patients with mild to moderate liver disease as it can increase the Apregen 125 mg/80 mg Kit level in the body. Increased levels can increase the risk and severity of Apregen 125 mg/80 mg Kit side effects. However, you can take it when advised by your doctor. If you experience headache, fatigue, low appetite, constipation, diarrhea, nausea, and hiccups contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

FAQs

Apregen 125 mg/80 mg Kit 1's works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it is used in combination with other medicines to prevent nausea and vomiting caused by anti-cancer medicines in adults and adolescents from the age of 12 years.

You are not recommended to take erythromycin with Apregen 125 mg/80 mg Kit 1's as it may increase the blood levels and effects of Apregen 125 mg/80 mg Kit 1's. Contact your doctor if your condition changes or experience side effects such as diarrhoea, constipation, nausea, or loss of appetite. However, please consult your doctor before taking other medicines with Apregen 125 mg/80 mg Kit 1's.

You are advised not to take hormonal birth control medicines such as birth control pills, implants, skin patches, and certain Intrauterine devices (IUDs) as they may not work properly when taken together with Apregen 125 mg/80 mg Kit 1's. Therefore, you are recommended to use another or additional non-hormonal form of birth control method during treatment with Apregen 125 mg/80 mg Kit 1's and for up to 2 months after using Apregen 125 mg/80 mg Kit 1's.

Drug-Drug Interactions Checker List

  • PIMOZIDE
  • TERFENADINE
  • ASTEMIZOLE
  • CISAPRIDE
  • TACROLIMUS
  • EVEROLIMUS
  • CYCLOSPORINE
  • SIROLIMUS
  • FENTANYL
  • ALFENTANIL
  • QUINIDINE
  • ETOPOSIDE
  • IRINOTECAN
  • ifosfamide
  • ACENOCOUMAROL
  • WARFARIN
  • CLARITHROMYCIN
  • TELITHROMYCIN
  • RIFAMPICIN
  • PHENYTOIN
  • CARBAMAZEPINE
  • TRIAZOLAM
  • PHENOBARBITAL
  • MIDAZOLAM
  • KETOCONAZOLE
  • VORICONAZOLE
  • POSACONAZOLE
  • ITRACONAZOLE
  • NEFAZODONE
  • DEXAMETHASONE
  • METHYLPREDNISOLONE
  • ALPRAZOLAM
  • TOLBUTAMIDE

Disease/Condition Glossary

Nausea and vomiting: Nausea is an uneasiness in the stomach that usually precedes vomiting. Vomiting, on the other hand, is a normal bodily response in which a person desires to evacuate stomach contents from the mouth aggressively. In brief, nausea and vomiting are symptoms of a variety of disorders, including infections, motion sickness, an early stage of pregnancy, and gastroparesis (slow stomach emptying). Vomiting is controlled by a receptor in the brain known as the chemoreceptor trigger zone (CTZ). After chemotherapy and radiation therapy, nausea and vomiting are common side effects. It can also arise as a side effect of an operation or surgery. Controlling vomiting and nausea in cancer patients is critical for conducting daily tasks. It can cause mental abnormalities, lack of appetite, malnutrition, and dehydration if not managed.

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