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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
Non returnable*
COD available

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Composition :

FOSAPREPITANT-150MG

Manufacturer/Marketer :

Axiommax Oncology Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Aprifast 150 mg Injection

Aprifast 150 mg Injection belongs to a class of drugs called anti-emetics. It is used in combination with other medicines to prevent nausea and vomiting caused by chemotherapy (anti-cancer medicines). Nausea is a feeling of uneasiness in the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.

Aprifast 150 mg Injection contains Fosaprepitant, a neurokinin 1 (NK1) receptor antagonist which is converted to aprepitant in the body. It works by blocking neurokinin 1 receptors (causes a feeling of sickness) present in the vomiting centre in the brain. Thus, it helps prevent nausea and vomiting. 

Aprifast 150 mg Injection will be administered by a healthcare professional; do not self-administer. In some cases, Aprifast 150 mg Injection may cause common side effects such as headache, hiccups, tiredness, loss of appetite, indigestion, and constipation. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, consult your doctor immediately. 

If you are allergic to Fosaprepitant or other medicines, please tell your doctor. If you are pregnant or breastfeeding, please inform your doctor before receiving Aprifast 150 mg Injection. Drive only if you are alert after receiving Aprifast 150 mg Injection. If you are taking other prescription or non-prescription medicines, inform your doctor before receiving Aprifast 150 mg Injection.

Uses of Aprifast 150 mg Injection

Chemotherapy-induced nausea and vomiting

Directions for Use

Aprifast 150 mg Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Aprifast 150 mg Injection contains Fosaprepitant, an anti-emetic (a drug used to treat nausea and vomiting) which is converted to aprepitant in the body. It works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps prevent nausea and vomiting caused by anti-cancer medicines.

Storage

Store in a cool and dry place away from sunlight
Side effects of Aprifast 150 mg Injection
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Stay hydrated by taking fluids like water, juices and soups etc.
  • Eat fruits and vegetables which contain vitamins.
  • Take iron rich food like dry fruits, green leafy vegetables and sea food etc.
  • Reduce intake of milk, cheese, yogurt, soy, chocolate, ice cream, Grapes, Popcorn, canned salmon, pomegranate.
  • Regular exercise like walking, jogging is helpful.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Tell your doctor about any pain or discomfort at the infusion site.
  • Apply a warm compress to reduce swelling and ease pain.
  • Switch infusion sites to avoid irritating the same spot.
  • Practice calming techniques like deep breathing, meditation, or yoga to manage pain and anxiety.

Drug Warnings

If you are allergic to Fosaprepitant or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, please inform your doctor before receiving Aprifast 150 mg Injection. Drive only if you are alert after receiving Aprifast 150 mg Injection. If you are taking any other prescription or non-prescription medicines, inform your doctor before receiving Aprifast 150 mg Injection. If you are using warfarin (blood thinner), your doctor may recommend blood tests after you receive Aprifast 150 mg Injection to check your blood clotting.

Drug-Drug Interactions

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AprepitantTerfenadine
Critical

Drug-Drug Interactions

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AprepitantTerfenadine
Critical
How does the drug interact with Aprifast 150 mg Injection:
Co-administration with Aprifast 150 mg Injection and Terfenadine may increase the blood levels of Terfenadine and leads to irregular heartbeat.

How to manage the interaction:
Taking Aprifast 150 mg Injection and Terfenadine together is not recommended as it can lead to an interaction. It is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
How does the drug interact with Aprifast 150 mg Injection:
Using pimozide together with Aprifast 150 mg Injection may significantly increase the blood levels of pimozide. High blood levels of pimozide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Aprifast 150 mg Injection and Pimozide together is not recommended; as it can lead to an interaction, you can take them if your doctor advises you to. If you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, get immediate medical help. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Aprifast 150 mg Injection:
Co-administration with Aprifast 150 mg Injection and Cisapride may cause irregular heart rhythm.

How to manage the interaction:
Although taking Aprifast 150 mg Injection and Cisapride together is not recommended as it can lead to an interaction, it is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantEliglustat
Critical
How does the drug interact with Aprifast 150 mg Injection:
Aprifast 150 mg Injection combined with Eliglustat can considerably raise blood levels of Eliglustat. This raises the possibility of cardiac adverse effects such as abnormal heart rhythm, heart block, and cardiac arrest.

How to manage the interaction:
Taking Aprifast 150 mg Injection and Eliglustat together is not recommended as it can lead to an interaction; they can be consumed if prescribed by a doctor. Consult a doctor if you have symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, weak heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without consulting a doctor.
AprepitantAstemizole
Critical
How does the drug interact with Aprifast 150 mg Injection:
Co-administration with Aprifast 150 mg Injection and Astemizole may increase the blood levels of Astemizole.

How to manage the interaction:
Although taking Aprifast 150 mg Injection and Astemizole together is not recommended as it can lead to an interaction, it is safe if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor. Astemizole should not be combined with any other medications without a doctor's advice.
AprepitantLomitapide
Critical
How does the drug interact with Aprifast 150 mg Injection:
Lomitapide blood levels can be significantly increased by combining it with Aprifast 150 mg Injection.

How to manage the interaction:
Although using Lomitapide and Aprifast 150 mg Injection together may cause an interaction, they can be taken if advised by a doctor. Consult a doctor if you have any of the following symptoms: diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, gas, constipation, liver problems causing fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, dark colored urine, light-colored stools, and yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AprepitantFlibanserin
Critical
How does the drug interact with Aprifast 150 mg Injection:
Using flibanserin together with Aprifast 150 mg Injection can significantly increase the blood levels of flibanserin.

How to manage the interaction:
Taking Flibanserin and Aprifast 150 mg Injection together is not recommended as it can lead to an interaction; they can be taken if prescribed by a doctor. Consult a doctor if you develop any symptoms, such as extreme sleepiness or low blood pressure, that cause dizziness, lightheadedness, or fainting. To reduce the chance of these side effects, use Flibanserin at bedtime. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Aprifast 150 mg Injection:
Co-administration of Ibrutinib together with Aprifast 150 mg Injection may significantly increase the blood levels of Ibrutinib.

How to manage the interaction:
Even though there is an interaction between Aprifast 150 mg Injection and Ibrutinib, it can be taken if a doctor prescribes it. However, doctor if you experience any of the following symptoms: paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in the phlegm, red or inflamed skin, body sores, increased or decreased urination, pain while urinating, nausea, vomiting or loss of hunger, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without a doctor's advice.
AprepitantVenetoclax
Severe
How does the drug interact with Aprifast 150 mg Injection:
Using venetoclax in conjunction with Aprifast 150 mg Injection may drastically increase venetoclax blood levels and effects.

How to manage the interaction:
Although using Venetoclax and Aprifast 150 mg Injection together may cause an interaction, it can be used if advised by a doctor. Consult a doctor if you have any of the following symptoms: nausea, vomiting, diarrhea, weakness, paleness, or unusual bleeding. Do not discontinue any medications without consulting a doctor.
AprepitantHydrocodone
Severe
How does the drug interact with Aprifast 150 mg Injection:
The levels of Hydrocodone in the blood may be significantly raised by Aprifast 150 mg Injection.

How to manage the interaction:
Although co-administration of Aprifast 150 mg Injection and Hydrocodone can lead to an interaction, it can be taken if prescribed by a doctor. Consult a doctor if you have any symptoms like difficulty in breathing, dizziness, fainting, confusion, excessive sleepiness, or a slow heartbeat. Without consulting a doctor, never stop taking medicines.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy and low-fat diet that includes lots of fruits and vegetables, skinless poultry, lean meats, nuts, fish, whole grains, and plant-based oils, especially in small portions, as it will be easy for digestion.
  • Avoid eating over-sweet food and include more salty food, especially if you have been vomiting. 
  • Increase the intake of fluids. Drink a small amount of water after small intervals to stay hydrated. 
  • Avoid taking greasy or oily foods, as these foods trigger nausea and vomiting. 
  • If the smell of food makes you feel sick (vomit), do not cook food, as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.

Habit Forming

No

Therapeutic Class

ANTIEMETICS

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Author Details

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Drug-Diseases Interactions

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FOSAPREPITANT-150MGAlcoholic liver disease
Moderate

Drug-Diseases Interactions

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FOSAPREPITANT-150MGAlcoholic liver disease
Moderate
How does the disease interact with Aprifast 150 mg Injection:
The liver is primarily responsible for Aprifast 150 mg Injection metabolism. Aprifast 150 mg Injection was well tolerated in investigations of patients with mild to moderate hepatic impairment (Child-Pugh score 5 to 9), and no clinically significant changes in its pharmacokinetics were seen. As a result, there is no need to change the dosage of Aprifast 150 mg Injection in this patient population. Aprifast 150 mg Injection should be used with caution in patients with severe hepatic impairment (Child-Pugh score > 9), as there is no clinical or pharmacokinetic data in this population.

How to manage the interaction:
Aprifast 150 mg Injection is metabolized by the liver, hence it is usually not recommended in patients with mild to moderate liver disease as it can increase the Aprifast 150 mg Injection level in the body. Increased levels can increase the risk and severity of Aprifast 150 mg Injection side effects. However, you can take it when advised by your doctor. If you experience headache, fatigue, low appetite, constipation, diarrhea, nausea, and hiccups contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

FAQs

Aprifast 150 mg Injection works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps prevent nausea and vomiting caused by anti-cancer medicines.

Aprifast 150 mg Injection may cause constipation as a common side effect. However, if the condition persists or worsens, please consult your doctor.

You are advised not to take hormonal birth control medicines such as birth control pills, implants, skin patches, and certain intrauterine devices (IUDs) as they may not work properly when taken together with Aprifast 150 mg Injection. Therefore, you are recommended to use another or additional non-hormonal form of birth control method during treatment with Aprifast 150 mg Injection and for up to 1 month after using Aprifast 150 mg Injection.

Drug-Drug Interactions Checker List

  • PIMOZIDE
  • ASTEMIZOLE
  • TERFENADINE
  • CISAPRIDE
  • TACROLIMUS
  • EVEROLIMUS
  • CYCLOSPORINE
  • SIROLIMUS
  • FENTANYL
  • ALFENTANIL
  • QUINIDINE
  • ETOPOSIDE
  • IRINOTECAN
  • IFOSFAMIDE
  • ACENOCOUMAROL
  • WARFARIN
  • CLARITHROMYCIN
  • TELITHROMYCIN
  • RIFAMPICIN
  • PHENYTOIN
  • CARBAMAZEPINE
  • TRIAZOLAM
  • PHENOBARBITAL
  • MIDAZOLAM
  • KETOCONAZOLE
  • VORICONAZOLE
  • POSACONAZOLE
  • ITRACONAZOLE
  • NEFAZODONE
  • DILTIAZEM
  • DEXAMETHASONE
  • ALPRAZOLAM
  • TOLBUTAMIDE

Disease/Condition Glossary

Nausea and vomiting: Nausea is an uneasiness in the stomach that usually precedes vomiting. Vomiting, on the other hand, is a normal bodily response in which a person desires to evacuate stomach contents from the mouth aggressively. In brief, nausea and vomiting are symptoms of a variety of disorders, including infections, motion sickness, an early stage of pregnancy, and gastroparesis (slow stomach emptying). Vomiting is controlled by a receptor in the brain known as the chemoreceptor trigger zone (CTZ). After chemotherapy and radiation therapy, nausea and vomiting are common side effects. It can also arise as a side effect of an operation or surgery. Controlling vomiting and nausea in cancer patients is critical for conducting daily tasks. It can cause mental abnormalities, lack of appetite, malnutrition, and dehydration if not managed.

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