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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Hari Kumar , MBBS
Non returnable*
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Composition :

DEFERASIROX-400MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Asunra 400 mg Tablet

Asunra 400 mg Tablet belongs to the group of medicines called iron chelators. Asunra 400 mg Tablet is indicated for treating chronic iron overload due to blood transfusions (transfusional hemosiderosis) in patients two years older. It can also be indicated for treating chronic iron overload in patients ten years of age and older with non-transfusion-dependent thalassemia (NTDT).

The active ingredient in Asunra 400 mg Tablet is deferasirox. It is a trivalent iron selective chelating agent. It binds the excess iron and eliminates it through faeces. The danger of organ damage is reduced as a result.

Asunra 400 mg Tablet is available in the form of oral formulations. Please take Asunra 400 mg Tablet in the dose and duration prescribed by your doctor based on specific medical conditions. In some cases, you may experience common side effects such as diarrhoea, vomiting, nausea, abdominal pain, skin rashes, and increased serum creatinine. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue using Asunra 400 mg Tablet for as long as your doctor has prescribed it. Do not use Asunra 400 mg Tablet without a doctor's advice if you have a skin reaction or irritation to any medicine. Consult your doctor before using the Asunra 400 mg Tablet if you are pregnant or breastfeeding. Do not use Asunra 400 mg Tablet in more than prescribed doses or longer duration as it may cause adverse effects. Keep your doctor informed about your health condition and all the medicines you take before taking Asunra 400 mg Tablet to rule out any side effects.

Uses of Asunra 400 mg Tablet

Asunra 400 mg Tablet is indicated for treating chronic iron overload that occurs due to blood transfusions (transfusional hemosiderosis) in patients two years of age and older. It can also be indicated for treating chronic iron overload in patients ten years of age and older with non-transfusion-dependent thalassemia (NTDT).

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Deferasirox is the active component in Asunra 400 mg Tablet. It's a chelating agent that selectively binds to trivalent iron. It binds extra iron and excretes it in the faeces. As a result, the risk of organ damage is lowered.

Storage

Store in a cool and dry place away from sunlight
Side effects of Asunra 400 mg Tablet
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Increased creatinine levels must be corrected immediately with the help of a doctor.
  • Reduce strenuous activities that can lead to muscle breakdown and production of creatinine.
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding tissue.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Avoid smoking and drinking alcohol.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Drug Warnings

Do not take Asunra 400 mg Tablet if you are allergic to Asunra 400 mg Tablet or its ingredients. Asunra 400 mg Tablet is not usually recommended if you are a pregnant or lactating woman; there is not enough information to say whether it's safe. However, your doctor may prescribe it if they think the medicine's benefits outweigh the risks. It is unknown whether Asunra 400 mg Tablet alters the ability to drive, so do not drive or operate machinery if you experience any symptoms affecting your ability to concentrate and react. Seek medical attention if the symptoms persist longer. Avoid consuming alcohol along with Asunra 400 mg Tablet as it could lead to unpleasant side effects. Should monitor elderly and paediatric patients closely for toxicity.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Asunra 400 mg Tablet:
Using Asunra 400 mg Tablet together with Aspirin may increase your risk of developing gastrointestinal ulcers and bleeding.

How to manage the interaction:
Taking Aspirin with Asunra 400 mg Tablet together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of hunger, and/or black, tarry stools, increased or decreased urination, fluid retention, swelling, breathing difficulty, muscle pains, tiredness, weakness, confusion, and abnormal heart rhythm, consult the doctor. If you experience diarrhea or vomiting while taking these medications, stay hydrated. Do not stop taking any medications without talking to a doctor.
How does the drug interact with Asunra 400 mg Tablet:
Taking Asunra 400 mg Tablet with methotrexate may increase the risk of kidney damage.

How to manage the interaction:
Although there is a possible interaction between Asunra 400 mg Tablet and methotrexate, you can take these medicines together if prescribed by a doctor. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Asunra 400 mg Tablet:
Asunra 400 mg Tablet may cause kidney problems and combining it with capreomycin may increase that risk.

How to manage the interaction:
Although taking Capreomycin and Asunra 400 mg Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhoea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Asunra 400 mg Tablet:
Combining Asunra 400 mg Tablet and apixaban may raise the risk of stomach bleeding and ulcers.

How to manage the interaction:
Even though there is an interaction between Apixaban and Asunra 400 mg Tablet, they can be taken if a doctor prescribes it. If you experience potential gastrointestinal injury symptoms like abdominal pain, bloating, dizziness, lightheadedness, loss of hunger, nausea, vomiting (especially with either dry or fresh blood that looks like coffee grounds), and red or black stool, consult a doctor. Without consulting a doctor, never stop taking any medication.
DeferasiroxBacitracin
Severe
How does the drug interact with Asunra 400 mg Tablet:
Asunra 400 mg Tablet may cause kidney problems and combining it with bacitracin may increase that risk.

How to manage the interaction:
Although taking Bacitracin and Asunra 400 mg Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhoea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Asunra 400 mg Tablet:
Using Asunra 400 mg Tablet together with abciximab may increase the risk of gastrointestinal ulcers.

How to manage the interaction:
Co-administration of Abciximab with Asunra 400 mg Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
DeferasiroxCortisone
Severe
How does the drug interact with Asunra 400 mg Tablet:
Using Asunra 400 mg Tablet together with cortisone may increase the risk of gastrointestinal ulcers and bleeding.

How to manage the interaction:
Co-administration of Cortisone with Asunra 400 mg Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts. If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Asunra 400 mg Tablet:
Using Asunra 400 mg Tablet together with Prasugrel may increase the risk of gastrointestinal ulcers.

How to manage the interaction:
Co-administration of Prasugrel with Asunra 400 mg Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Asunra 400 mg Tablet:
Using Asunra 400 mg Tablet together with Piroxicam may increase the risk of ulcers.

How to manage the interaction:
Co-administration of Piroxicam with Asunra 400 mg Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
DeferasiroxVoclosporin
Severe
How does the drug interact with Asunra 400 mg Tablet:
Asunra 400 mg Tablet may cause kidney problems and combining it with voclosporin may increase that risk.

How to manage the interaction:
Although taking voclosporin and Asunra 400 mg Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhoea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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DEFERASIROX-400MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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DEFERASIROX-400MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
The blood levels and effects of caffeine may be enhanced by Asunra 400 mg Tablet. Avoid consumption of caffeinated drinks during the treatment with Asunra 400 mg Tablet. If you experience any unusual symptoms call a doctor.

Diet & Lifestyle Advise

  • Choose foods high in nutrients, such as fruits, vegetables, and whole grains.
  • Replace fatty protein sources with lean alternatives and consume modest quantities of healthy fat sources for improved well-being.
  • Create a diet that includes vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources.
  • Instead of saturated and trans fats, choose monounsaturated and polyunsaturated fats (fish, nuts, and vegetable oils).
  • Select/prepare foods and beverages with fewer added sugars/caloric sweeteners.
  • Be mindful of salt; consume no more than 2,300 mg each day.
  • Limit or avoid alcohol and caffeine consumption.

Habit Forming

No

Therapeutic Class

CHELATING AGENTS

Asunra 400 mg Tablet Substitute

Substitutes safety advice

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Deferasirox is the active component in Asunra 400 mg Tablet. It's a chelating agent that selectively binds to trivalent iron. It binds extra iron and excretes it in the faeces. As a result, the risk of organ damage is lowered.

No, it is a prescribed drug given by a physician for preventing specific medical conditions. Taking it on your own can cause unwanted side effects.

Take the missed dose as soon as possible. However, skip the missed dose and return to your regular dosing schedule if it is time for the next dose. Do not take a double dose to make up for the dose that you missed.

Asunra 400 mg Tablet is safe if used in the dose and duration recommended by your doctor. Take it precisely as directed, and do not skip any dose. Follow your doctor's guidelines carefully and inform your doctor if any of the side effects disturb you.

Hemochromatosis, or iron overload, is a condition in which your body stores too much iron. It can cause severe damage to your body, including to your heart, liver and pancreas.

Drug-Drug Interactions Checker List

  • ALUMINIUM HYDROXIDE
  • REPAGLINIDE
  • THEOPHYLLINE
  • BUSULFAN
  • ASPIRIN
  • CELECOXIB
  • DILTIAZEM
  • PARACETAMOL

Special Advise

  • Monitor blood counts, liver function, and renal function monthly.
  • Monitor serum ferritin monthly to assess the patient’s response to therapy and minimize the risk of over-chelation.

Disease/Condition Glossary

Hemochromatosis, or iron overload, is a condition in which your body stores too much iron. It can cause severe damage to your body, including to your heart, liver and pancreas.

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