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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

About Atazor 300 mg Capsule

Atazor 300 mg Capsule is an antiretroviral medicine used in the treatment of HIV infection. HIV is a retroviral infection that attacks and destroys immune cells. This reduces the body's ability to fight infections and illnesses. If this condition is left untreated, it can lead to Acquired Immuno Deficiency Syndrome (AIDS). Symptoms of HIV include fever, chills, night sweats, muscle aches, etc.

Atazor 300 mg Capsule contains Atazanavir, which belongs to the class of protease inhibitors. It works by inhibiting the protease enzyme production, which is required for the HIV-infected cells to make new viruses. This causes inhibition of viral replication.

Atazor 300 mg Capsule may cause certain side effects such as nausea, headache, stomach pain, loss of appetite, vomiting, depression, fever, tiredness, back pain, blood in urine, diarrhea, muscle pain, dizziness, and allergic reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. Atazor 300 mg Capsule should be taken as advised by your doctor. Your doctor will decide the dose of the medicine based on your health condition. Do not take more than the recommended dose.

Atazor 300 mg Capsule should be avoided if you are allergic to it. It is contraindicated in patients with Stevens-Johnson syndrome, erythema multiforme or patients taking alfuzosin, triazolam, orally administered midazolam, ergot derivatives, rifampin, irinotecan, lovastatin, simvastatin, indinavir, cisapride, pimozide, as it can cause serious side effects. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, diabetes, or immune reconstitution syndrome on priority. Atazor 300 mg Capsule should be given to pregnant and breastfeeding women only if recommended by the doctor. Atazor 300 mg Capsule is not recommended for children below six years of age as safety and efficacy are not established.

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Whats That

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Non returnable*
COD available

Online payment accepted

Synonym

ATAZANAVIR SULPHATE

Composition

ATAZANAVIR-300MG

Manufacturer/Marketer

Emcure Pharma Ltd (Renal Care)

Consume Type

ORAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of Atazor 300 mg Capsule

HIV Infection

Medicinal Benefits

Atazor 300 mg Capsule contains Atazanavir, which belongs to the class of protease inhibitors. It works by inhibiting the protease enzyme production, which is required for the HIV-infected cells to make new viruses. This causes inhibition of viral replication. Atazor 300 mg Capsule is used alone or in combination with other antiretroviral medicines to help reduce the symptoms, control the infection, and prevent opportunistic infections effectively. It also helps in improving the quality of life of a patient with HIV. 

Side Effects of Atazor 300 mg Capsule

  • Nausea
  • Abdominal pain
  • Vomiting
  • Dizziness
  • Back pain
  • Blood in urine
  • Loss of appetite
  • Mouth sores
  • Tiredness
  • Depression

Directions for Use

Take Atazor 300 mg Capsule as advised by your doctor. It can be taken with or without food. Swallow as a whole with a glass of water. Do not chew or crush or break the medicine.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Atazor 300 mg Capsule should be avoided if you are allergic to it. It is contraindicated in patients with Stevens-Johnson syndrome, erythema multiforme or patients taking alfuzosin, triazolam, orally administered midazolam, ergot derivatives, rifampin, irinotecan, lovastatin, simvastatin, indinavir, cisapride, pimozide, as it can cause serious side effects. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, diabetes, or immune reconstitution syndrome on priority. Atazor 300 mg Capsule should be given to pregnant and breastfeeding women only if recommended by the doctor. Atazor 300 mg Capsule is not recommended for children below six years of age as safety and efficacy are not established. This medicine may cause dizziness; hence avoid driving or operating machines while taking Atazor 300 mg Capsule.

Therapeutic Class

ANTIVIRALS

Drug-Drug Interactions

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AtazanavirNimodipine
Critical
AtazanavirAlfuzosin
Critical

Drug-Drug Interactions

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AtazanavirNimodipine
Critical
How does the drug interact with Atazor 300 mg Capsule:
When Atazor 300 mg Capsule is taken with Nimodipine, it can increase the risk of side effects.

How to manage the interaction:
Taking Nimodipine with Atazor 300 mg Capsule is not recommended, as it can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience irregular heart rhythm, swelling, and low blood pressure, consult the doctor. Do not discontinue any medications without a doctor's advice.
AtazanavirAlfuzosin
Critical
How does the drug interact with Atazor 300 mg Capsule:
Concomitant use of Alfuzosin with Atazor 300 mg Capsule can increase the risk of low blood pressure.

How to manage the interaction:
Coadministration of Alfuzosin with Atazor 300 mg Capsule is not recommended, however, it can be taken if your doctor has advised it. Contact your doctor immediately if you experience dizziness, palpitations, difficulty swallowing, or sweating. It is recommended to monitor your blood pressure regularly. Do not discontinue any medications without first consulting your doctor.
AtazanavirMidazolam
Critical
How does the drug interact with Atazor 300 mg Capsule:
Atazor 300 mg Capsule and Midazolam co-administration may considerably enhance Midazolam blood levels and effects.

How to manage the interaction:
Although taking Atazor 300 mg Capsule and Midazolam together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
AtazanavirNevirapine
Critical
How does the drug interact with Atazor 300 mg Capsule:
When Atazor 300 mg Capsule is taken with Nevirapine, it can reduce the levels and side effects of Atazor 300 mg Capsule & increase the blood levels and effects of nevirapine.

How to manage the interaction:
Taking Nevirapine with Atazor 300 mg Capsule is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience a rash on any parts of your body, loss of appetite, nausea, vomiting, jaundice (yellowing of the skin and/or eyes), dark-coloured urine, pale-coloured stools, or pain or ache in the right abdominal area below your ribs, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AtazanavirSildenafil
Critical
How does the drug interact with Atazor 300 mg Capsule:
Combining Atazor 300 mg Capsule and Sildenafil can increase the blood levels and side effects of sildenafil.

How to manage the interaction:
Taking Atazor 300 mg Capsule and Sildenafil together is avoided as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, shortness of breath, dizziness, lightheadedness, fainting, visual disturbances, ringing in the ears, vision or hearing loss, chest pain or tightness, irregular heartbeat, and/or priapism (prolonged and painful erection unrelated to sexual activity), contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
AtazanavirTolvaptan
Critical
How does the drug interact with Atazor 300 mg Capsule:
When Tolvaptan and Atazor 300 mg Capsule are taken together, may significantly increase the blood levels and effects of Tolvaptan.

How to manage the interaction:
There may be a possibility of interaction between Tolvaptan and Atazor 300 mg Capsule, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
AtazanavirSimvastatin
Critical
How does the drug interact with Atazor 300 mg Capsule:
Combining Atazor 300 mg Capsule and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Atazor 300 mg Capsule and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-coloured urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
AtazanavirSilodosin
Critical
How does the drug interact with Atazor 300 mg Capsule:
Co-administration of Atazor 300 mg Capsule and Silodosin together can increase the effectiveness of Silodosin which may lead to side effects including extremely low blood pressure, increased heart rate.

How to manage the interaction:
Taking Atazor 300 mg Capsule and Silodosin together is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, or heart palpitation, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
AtazanavirClindamycin
Severe
How does the drug interact with Atazor 300 mg Capsule:
Co-administration of Clindamycin with Atazor 300 mg Capsule may increase the effects of Clindamycin.

How to manage the interaction:
Although there is a possible interaction, clindamycin can be taken with Atazor 300 mg Capsule if prescribed by the doctor. Consult the prescriber if you experience persistent nausea, vomiting, diarrhea, or abdominal pain. Do not discontinue the medication without consulting a doctor.
AtazanavirOmeprazole
Severe
How does the drug interact with Atazor 300 mg Capsule:
When taken together, omeprazole, through decreasing stomach acid, can reduce Atazor 300 mg Capsule absorption and blood levels, making the medication less effective.

How to manage the interaction:
Although taking omeprazole with Atazor 300 mg Capsule can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • PRAZOSIN
  • ALFUZOSIN
  • CISAPRIDE
  • ESTRADIOL
  • CYCLOSPORIN
  • TACROLIMUS
  • CLARITHROMYCIN

Diet & Lifestyle Advise

  • Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food such as vegetables and fruit as it helps to boost your immune system. Try to take lean protein and whole grains.
  • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry or seafood.
  • Eat bland and low-fat foods, and avoid spicy or oily foods if you experience nausea or vomiting.
  • Practise safe sex by using condoms; it helps in reducing contact with semen and vaginal fluids.
  • Never share personal items with body fluids or blood on them, such as razor blades or toothbrushes.
  • Avoid sharing used needles, other injection or drug equipment.
  • Get tested for other sexually transmitted infections, such as gonorrhoea or syphilis.
  • Try to reduce emotional and physical stress by spending time with your family or doing whatever makes you happy.
  • Drink more fluids and avoid alcoholic beverages to prevent dehydration. 

Habit Forming

No

Special Advise

  • Get an HIV test done at least every three months.
  • Regular kidney and liver function and bone mineral density tests while taking Atazor 300 mg Capsule are advised. 
  • Regularly get blood and urine tests done while taking Atazor 300 mg Capsule.
  • Atazor 300 mg Capsule may still develop infections or other illnesses associated with HIV infection or AIDS. So, people taking Atazor 300 mg Capsule should be carefully monitored throughout the treatment.

Disease/Condition Glossary

HIV Infection: Human Immunodeficiency Virus (HIV) is a retroviral infection that attacks and damages the cells of the immune system. This weakens the ability to fight against infections and diseases. If this condition is left untreated, it can lead to Acquired Immuno Deficiency Virus (AIDS). Symptoms of HIV include headache, fever, chills, joint pain, fatigue, swollen lymph nodes, sore throat, mouth nodes, muscle aches, etc. Atazor 300 mg Capsule helps reduce the symptoms, control the infection, and also helps improve the HIV patient’s quality of life.

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