Aztolet 40 Tablet 10's

Written By Bayyarapu Mahesh Kumar , M Pharmacy

Reviewed By Sunny S , MBBS

MRP ₹339

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₹50.9 Cashback (15%)

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Whats That

About Aztolet 40 Tablet

Aztolet 40 Tablet is a combination drug composed of a blood-thinning agent and cholesterol-lowering agent primarily used to prevent heart attack and stroke in the future. It lowers the raised level of cholesterol and fats (triglycerides) in our bodies. A heart attack occurs when your coronary arteries (blood vessels supplying blood and oxygen to the heart) becomes blocked due to the build-up of fats (plaque), including cholesterol. These plaques narrow the arteries, leading to atherosclerosis and coronary artery disease, mainly for most heart attacks.

Aztolet 40 Tablet is composed of two medicines, namely: Atorvastatin and Clopidogrel. Atorvastatin is a lipid-lowering medication which blocks the enzyme required to make cholesterol in the body. As a result, it lowers the bad cholesterol (low-density lipoproteins or LDL) and triglycerides (TG) and increases the levels of good cholesterol (high-density lipoproteins or HDL). Clopidogrel is a blood thinner (anticoagulant) that collectively prevents a clot in the blood vessels. Together Aztolet 40 Tablet reduces the increased levels of bad cholesterol (low-density lipoprotein and triglycerides) and prevents blood clots, thereby reducing the risk of heart attack, stroke and heart-related chest pain (angina).

You can take Aztolet 40 Tablet with food or without food. It should be swallowed whole with a glass of water. Do not chew, bite, or break it. Your doctor will advise you on how often you take this medicine based on your medical condition. You may sometimes experience headaches, ankle swelling (oedema), slow heart rate, and nausea. Aztolet 40 Tablet is known to cause dizziness, so driving should be avoided. Most of these side effects of Aztolet 40 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking a Aztolet 40 Tablet of your own. Suddenly stopping using Aztolet 40 Tablet may worsen your condition and increase your risk of a future heart attack. Let your doctor know if you are sensitive to atorvastatin or clopidogrel or have any active liver disease (liver enzyme abnormalities), active bleeding issues (like peptic ulcer, brain haemorrhage), or muscle problem (myopathy, rhabdomyolysis). The patient should inform the doctor they are taking Aztolet 40 Tablet before any surgery or any new medicine is taken. Atorvastatin, present in Aztolet 40 Tablet is a pregnancy category X drug, so it should not be given to pregnant women. It may cause harm to the foetus if administered to pregnant or breastfeeding women.

Uses of Aztolet 40 Tablet

Hyperlipidemia (Increased cholesterol), Prevention of heart attack, Prevention of stroke.

Directions for Use

Swallow the tablet as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Atorvastatin is a lipid-lowering medication that blocks the enzyme required to make cholesterol in the body. As a result, it lowers the bad cholesterol (low-density lipoproteins or LDL) and triglycerides (TG) and increases the levels of good cholesterol (high-density lipoproteins or HDL). Clopidogrel is a blood thinner (anticoagulant) that collectively prevents clot formation in the blood vessels. Together Aztolet 40 Tablet reduces the increased levels of bad cholesterol (low-density lipoprotein and triglycerides) and prevents blood clots, thereby reducing the risk of heart attack, stroke and heart-related chest pain (angina).

Storage

Keep Aztolet 40 Tablet out of the sight and reach of children.

Side effects of Aztolet 40 Tablet

Common Cold

Here are the steps to manage the medication-triggered Common Cold:

Inform your doctor about the common cold symptoms you're experiencing due to medication.
Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.

Stomach Pain

Drink water or other clear fluids.
To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
Include bland foods like rice, toast, crackers, and rice in your diet.
Avoid lying down immediately after eating as it may cause indigestion or heartburn.
Avoid acidic and spicy food as it may cause indigestion.

Bleeding Stomach

Indigestion

Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:

Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Inflammation Of Stomach Lining

Drug Warnings

Tell your doctor if you are sensitive to Atorvastatin or clopidogrel, have any active liver disease, active bleeding issues (like peptic ulcer, brain haemorrhage), are pregnant or planning to become pregnant or breastfeeding. The patient should inform the doctor that they are taking Aztolet 40 Tablet before any surgery is scheduled or any new medicine is taken. Atorvastatin present in Aztolet 40 Tablet is a pregnancy category X drug, so it is contraindicated in pregnant women. As it may cause harm to the foetus if administered to pregnant women. The risk of muscle disease might increase if Aztolet 40 Tablet is taken with an antibiotic (clarithromycin), anti-HIV drugs (ritonavir, lopinavir, darunavir, atazanavir, indinavir) and antifungal (itraconazole). Coadministration with anticoagulants like warfarin may cause gastric bleeding and other bleeding problems. So, if you are using any blood-thinning agents, let your doctor know about this. Aztolet 40 Tablet contains Atorvastatin which can cause muscle problems like myopathy and rhabdomyolysis. Patients with active liver disease should use the Aztolet 40 Tablet with caution. The safety and effectiveness of Aztolet 40 Tablet have not been established, so its use should be avoided in paediatric patients or children younger than ten years of age. Discontinuation of Aztolet 40 Tablet may lead to cardiovascular events like heart attack, stroke and angina (heart-related chest pain). Hence, you should consult a doctor before stopping the dose of Aztolet 40 Tablet .

Drug-Drug Interactions

ClopidogrelSelexipag

Critical

ClopidogrelMifepristone

Critical

Drug-Drug Interactions

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ClopidogrelSelexipag

Critical

How does the drug interact with Aztolet 40 Tablet:
When Selexipag and Aztolet 40 Tablet are taken together, the body's ability to break down Selexipag may be reduced.

How to manage the interaction:
Taking Aztolet 40 Tablet with Selexipag is not recommended, please consult your doctor before taking it. They can be taken if prescribed by your doctor.

ClopidogrelMifepristone

Critical

How does the drug interact with Aztolet 40 Tablet:
Taking Aztolet 40 Tablet together with mifepristone increases the risk of vaginal bleeding in women.

How to manage the interaction:
Although taking Aztolet 40 Tablet with mifepristone is not recommended, that would certainly result in interaction, it can be taken if a doctor prescribes it. If you experience prolonged and heavy bleeding, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.

AtorvastatinPosaconazole

Critical

How does the drug interact with Aztolet 40 Tablet:
Taking Aztolet 40 Tablet with Posaconazole can increase the blood levels of Aztolet 40 Tablet. This can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between posaconazole with Aztolet 40 Tablet, they can be taken together if advised by your doctor. However, contact the doctor if you experience unexplained muscle pain, weakness, fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.

ClopidogrelTiclopidine

Severe

How does the drug interact with Aztolet 40 Tablet:
Taking Aztolet 40 Tablet with ticlopidine can reduced effectiveness of Aztolet 40 Tablet.

How to manage the interaction:
Taking Aztolet 40 Tablet and Ticlopidine together possibly has an interaction, but you can take these medications together if your doctor has advised it. Do not stop using any medications without talking to your doctor.

ClopidogrelPonatinib

Severe

How does the drug interact with Aztolet 40 Tablet:
Using ponatinib together with Aztolet 40 Tablet may increase the risk of bleeding

How to manage the interaction:
Although taking Aztolet 40 Tablet and Ponatinib together can cause an interaction, they can be taken together if prescribed by a doctor. However, contact your doctor immediately if you experience bleeding, dizziness, or black stools. Do not discontinue any medications without consulting your doctor.

ClopidogrelPanobinostat

Severe

How does the drug interact with Aztolet 40 Tablet:
Taking Aztolet 40 Tablet together with Panobinostat can increases the risk of bleeding.

How to manage the interaction:
Although taking Aztolet 40 Tablet together with panobinostat can result in interaction, it can be taken if prescribed by a doctor. However, consult your doctor immediately if you experience dizziness, lightheadedness, redness or blackness, sticky stools, or severe headache. Do not discontinue any medication without consulting your doctor.

ClopidogrelRepaglinide

Severe

How does the drug interact with Aztolet 40 Tablet:
Aztolet 40 Tablet increases the blood levels of Repaglinide, which results in increased effectiveness of Repaglinide. When these medicines are taken together, you may experience low blood sugar (hypoglycemia).

How to manage the interaction:
Although taking Aztolet 40 Tablet with Repaglinide may result in interaction, it can be taken if prescribed by a doctor. However, if you experience any signs of hypoglycemia (low blood sugar), consult your doctor immediately. Common symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, weakness, tremor, nausea, hunger, sweating, and palpitation. It is advised to monitor your blood sugar levels if you experience the above symptoms. Do not discontinue any medication without consulting a doctor.

ClopidogrelDefibrotide

Severe

How does the drug interact with Aztolet 40 Tablet:
Taking Aztolet 40 Tablet with Defibrotide can increase the risk of bleeding.

How to manage the interaction:
Although taking Aztolet 40 Tablet and Defibrotide together can cause an interaction, it can be taken if your doctor has suggested it. However, consult a doctor if you experience bleeding, bruising, feeling dizzy or lightheaded, having black or tarry stools, experiencing a severe headache, feeling weak, or having bleeding or vomiting. Do not discontinue any medications without first consulting your doctor.

ClopidogrelPrasugrel

Severe

How does the drug interact with Aztolet 40 Tablet:
Taking Aztolet 40 Tablet together with Prasugrel will have an additive effect and increase the risk of bleeding.

How to manage the interaction:
Although taking Aztolet 40 Tablet together with Prasugrel may result in interaction, it can be taken if prescribed by a doctor. However, If you experience any unusual bleeding or have other signs of bleeding like feeling dizzy or lightheaded, red or black, sticky stools, or having a severe headache, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.

ClopidogrelProtamine

Severe

How does the drug interact with Aztolet 40 Tablet:
Taking Protamine with Aztolet 40 Tablet can increase the risk of bleeding.

How to manage the interaction:
Taking Protamine with Aztolet 40 Tablet together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Low cholesterol diet along with a regular exercise regime is found to complement treatment with Aztolet 40 Tablet effectively.
Stick to a freshly prepared home-cooked meal and avoid processed, packed foods that contain hidden sugar and extra calories.
Try to replace most of your saturated fats with unsaturated fats to reduce total cholesterol and LDL cholesterol (bad cholesterol) quickly.
Foods like avocados, olive oil, fatty fish and nuts contain many heart-healthy unsaturated fats, so eating them regularly is beneficial.
Include a diet enriched in fats like fish oils, polyunsaturated oils, and omega-3 fatty acids, which are good for heart health.
Quit smoking and avoid excessive intake of alcohol.

Side Effects of Aztolet 40 Tablet

Bleeding (stomach, gastrointestinal, nose bleeding)
Rash
Diarrhoea
Stomach ulcer
Muscle disease (like myopathy, rhabdomyolysis)
Abdominal pain

Habit Forming

No

Therapeutic Class

CARDIOVASCULAR AGENTS

Aztolet 40 Tablet Substitute

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Atoclop 40 Tablet

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Author Details

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Reviewed By

Sunny S

MBBS

Last Updated

Jul 8, 2025 | 9:29 AM IST

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Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Can Aztolet 40 Tablet cause blood thinning?

Yes, Aztolet 40 Tablet contains clopidogrel which prevents blood clotting. It works by preventing platelets (a type of blood cell) from sticking together and forming clots which in turn prevents the risk of heart attack and stroke.

Can taking Aztolet 40 Tablet increase the risk of bleeding?

Yes, taking Aztolet 40 Tablet can increase the risk of bleeding as it contains aspirin and clopidogrel which belongs to a class of blood-thinning agents. So, please be very cautious while shaving, cutting fingernails or toenails, or using sharp objects to avoid any bleeding. Let your doctor know before going any surgical procedure, that you are taking Aztolet 40 Tablet .

Is Aztolet 40 Tablet safe for pregnant mother and fetus?

No. Aztolet 40 Tablet contains Atorvastatin which is pregnancy category X medicine and can cause harm to both pregnant mother and unborn baby. Even if you are planning for pregnancy tell your doctor that you are using Aztolet 40 Tablet .

Does intake of Aztolet 40 Tablet affects muscle?

Yes, prolonged use of Aztolet 40 Tablet may cause muscle diseases like myopathy and rhabdomyolysis. So if you feel any musculoskeletal pain after taking Aztolet 40 Tablet consult your doctor about this issue.

What foods should I avoid when taking Aztolet 40 Tablet ?

Do not drink grapefruit juice while taking Aztolet 40 Tablet . Grapefruit juice may increase the blood-thinning effect of your medicine.

Can I drink alcohol with Aztolet 40 Tablet ?

Drinking alcohol with Aztolet 40 Tablet may damage your liver and increase liver enzymes like transaminase. So, Aztolet 40 Tablet should be used with caution who consume alcohol and/or have past history of liver disease.

What will happen if I accidentally take overdosage of Aztolet 40 Tablet ?

If you accidentally take an overdose of Aztolet 40 Tablet you may have liver problems (increased secretion of liver enzymes) and bleeding complications. If problems persist you should immediately go to the nearby clinic or hospital.

Which are the tests required after using Aztolet 40 Tablet ?

You should have a total lipid profile (TG, HDL, LDL, VLDL, TC) and Blood coagulation tests like Complete blood count (CBC), Factor V assay, Fibrinogen Test, Prothrombin time (PT or PT-INR), Platelet count, Thrombin time and Bleeding time to analyze your blood clot timing and cholesterol level.

Drug-Drug Interactions Checker List

CLARITHROMYCIN
RITONAVIR
LOPINAVIR
DARUNAVIR
ATAZANAVIR
INDINAVIR
ITRACONAZOLE
WARFARIN
COUMADIN
HEPARIN
COLCHICINE
DIGOXIN
CYCLOSPORINE

Special Advise

If you have a high cholesterol level, try to have a lipid profile test (LFT) every 6 months.

Disease/Condition Glossary

Atherosclerosis: Atherosclerosis occurs when fats, cholesterol, and other substances known as plaque deposit on your artery walls that restrict blood flow. This plaque formation triggers blood clots, narrows the arteries' size, and hardens them. This, in turn, can lead to various heart complications like atherosclerosis, heart attack, heart-related chest pain (angina), and stroke. However, it can also affect the body's arteries apart from the heart.