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Reviewed By Hari Kumar , MBBS
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Composition :

BARICITINIB-4MG

Manufacturer/Marketer :

Mankind Pharma Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Barikind 4 Tablet

Barikind 4 Tablet belongs to the group of immunomodulators. Barikind 4 Tablet is used in the treatment of hospitalised cases of coronavirus disease, an infection caused by COVID-19 and is also used to treat Rheumatoid Arthritis. Rheumatoid arthritis is a chronic inflammatory and autoimmune disorder of the joints. Atopic dermatitis is a skin disease in which the skin becomes red, inflamed and itchy.  Coronavirus disease is an infectious disease caused by SARS-CoV-2. It can range from a mild cold to a serious form of pneumonia

Barikind 4 Tablet contains ‘’Baricitinib.’’ Barikind 4 Tablet works by inhibiting viral entry into body cells, limits viral replication and also controls the release of inflammatory mediators called cytokines.

Take Barikind 4 Tablet as prescribed by the doctor. Barikind 4 Tablet may cause certain common side effects such as throat infection, fatigue and high blood cholesterol. Most of these adverse effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist. 

It is advisable to inform the doctor if you are allergic to Barikind 4 Tablet or any of its components. Keep your doctor informed if you suffer from any medical disorders. Avoid Barikind 4 Tablet in case of a history of thromboembolism, abdominal disorders such as diverticulitis, cancer, liver disease, chronic infections such as tuberculosis, hepatitis B and C and shingles, and any anaemias. Keep your doctor informed if you have recently had any surgery or are scheduled for surgery in the near future. Offer a detailed medical and vaccination history. Discuss any recent vaccinations with the doctor. Inform the doctor if you are on any other JAK-2 inhibitor medicines, painkillers, steroids and/or drugs that affect the immunity and immune system of the body. Consult your doctor if you are planning to get pregnant or are breastfeeding. Avoid Barikind 4 Tablet use with alcohol.

Uses of Barikind 4 Tablet

Rheumatoid Arthritis, Atopic Dermatitis, COVID-19

Directions for Use

Take Barikind 4 Tablet with or without food as advised by the doctor. Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Barikind 4 Tablet is an immunomodulator used in the treatment of various types of cancers and infections such as Covid-19. Barikind 4 Tablet contains Baricitinib. Baricitinib works by inhibiting the entry of the virus into the body cells. Barikind 4 Tablet targets an enzyme called Janus kinase (JAK-2), which is responsible for the formation of cytokines. Cytokines are inflammatory mediators. Hence, by inhibiting a cytokine-forming enzyme, Baricitinib reduces the level of cytokines in the body, thus relieving signs of inflammation.  In addition, Baricitinib works by reducing viral replication, thus arresting the progress of the disease.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Barikind 4 Tablet

  • Throat infections
  • High blood cholesterol
  • Cold sores
  • Rash
  • Acne

Drug Warnings

It is advisable to inform the doctor if you are allergic to Barikind 4 Tablet or any of its components. Keep your doctor informed if you suffer from any medical disorders. Avoid Barikind 4 Tablet in case of a history of thromboembolism, abdominal disorders such as diverticulitis, cancer, liver disease, chronic infections such as tuberculosis, hepatitis B and C and shingles, and any anaemias. Keep your doctor informed if you have recently had any surgery or are scheduled for surgery in the near future. Offer a detailed medical and vaccination history. Discuss any recent vaccinations with the doctor. Inform the doctor if you are on any other JAK-2 inhibitor medicines, DMARD’s, painkillers, steroids and/or any drugs that affect the immunity and immune system of the body. Consult your doctor if you are planning to get pregnant or are breastfeeding. Avoid Barikind 4 Tablet use with alcohol.

Drug-Drug Interactions

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BaricitinibCiclosporin
Critical
BaricitinibLevamisole
Severe

Drug-Drug Interactions

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BaricitinibCiclosporin
Critical
How does the drug interact with Barikind 4 Tablet:
Co-administration of Barikind 4 Tablet with Cyclosporine can increase the risk of infections as well as some cancers.

How to manage the interaction:
Taking Ciclosporin with Barikind 4 Tablet is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
BaricitinibLevamisole
Severe
How does the drug interact with Barikind 4 Tablet:
Coadministration of Barikind 4 Tablet and levamisole can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Barikind 4 Tablet can be taken with levamisole if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
BaricitinibBetamethasone
Severe
How does the drug interact with Barikind 4 Tablet:
Co-administration of Betamethasone with Barikind 4 Tablet may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction, Betamethasone can be taken with Barikind 4 Tablet if prescribed by the doctor. Contact the prescriber if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning sensation during urination. Do not discontinue the medication without a doctor's advice.
BaricitinibFludarabine
Severe
How does the drug interact with Barikind 4 Tablet:
Coadministration of Barikind 4 Tablet and fludarabine can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Barikind 4 Tablet can be taken with fludarabine if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
BaricitinibOmacetaxine mepesuccinate
Severe
How does the drug interact with Barikind 4 Tablet:
Coadministration of Barikind 4 Tablet and omacetaxine mepesuccinate can raise your risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Barikind 4 Tablet can be taken with omacetaxine mepesuccinate if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
BaricitinibDexamethasone
Severe
How does the drug interact with Barikind 4 Tablet:
Co-administration of Dexamethasone with Barikind 4 Tablet can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction, Barikind 4 Tablet can be taken with Dexamethasone if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, severe abdominal pain, nausea, or vomiting, consult a doctor. Do not discontinue the medication without consulting a doctor.
BaricitinibPrimaquine
Severe
How does the drug interact with Barikind 4 Tablet:
Coadministration of Primaquine and Barikind 4 Tablet may raise the risk of serious and harmful infections.

How to manage the interaction:
Although taking Primaquine and Barikind 4 Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in the coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when urinating. Do not discontinue any medication without consulting a doctor.
BaricitinibPeginterferon alfa-2a
Severe
How does the drug interact with Barikind 4 Tablet:
Coadministration of Peginterferon alfa-2a with Barikind 4 Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Peginterferon alfa-2a with Barikind 4 Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.
BaricitinibRituximab
Severe
How does the drug interact with Barikind 4 Tablet:
Taking Rituximab with Barikind 4 Tablet may significantly increases the risk of infections.

How to manage the interaction:
Although taking Rituximab and Barikind 4 Tablet together can cause an interaction, it can be taken if A doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, breathing difficulty, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
BaricitinibThiotepa
Severe
How does the drug interact with Barikind 4 Tablet:
Coadministration of Thiotepa with Barikind 4 Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Thiotepa and Barikind 4 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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BARICITINIB-4MGHigh fat foods
Mild

Drug-Food Interactions

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BARICITINIB-4MGHigh fat foods
Mild
Common Foods to Avoid:
Frozen Meals, Cheese, Red Meat, Potato Chips, Hamburgers, Hot Dogs, Ice Cream

How to manage the interaction:
Coadministration of Barikind 4 Tablet and high-fat meals can decrease the absorption of Barikind 4 Tablet. Avoid fatty food and oily food while being treated with Barikind 4 Tablet.

Diet & Lifestyle Advise

  • Keep a healthy state of mind. Fear is the one of the biggest causes of decreased immunity. See a therapist if you feel the need. 
  • Meditation, music and yoga have also proven very effective in helping with mental health.
  • Keep yourself at a safe distance from people.
  • Always sneeze or cough into your elbow and keep a handkerchief on you.
  • Wash your hands with soap and water and keep yourself clean.
  • Eat more lean meats, healthy fats, fruits, vegetables and whole-grain foods to give you more energy. Load up on Vitamin-C rich citrus fruit for enhanced immunity.
  • Do not forget to take your Vitamin B complex and Vitamin C supplements every day as these are essential for the body and immunity.
  • Steam inhalation for 3-5 minutes every day and salt-water gargle with warm water has been proven very effective in keeping respiratory infections at bay and in promoting health. 
  • Avoid taking Barikind 4 Tablet with alcohol as there may be an interaction.
  • Stay hydrated by drinking plenty of water as dehydration is often seen in pneumonia.
  • Taking a stroll in the garden, or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. Doing weight-bearing exercises can prove very helpful in promoting bone health.
  • Avoid tobacco use as smoking hampers lung health and makes breathing even more difficult.
  • Spend time under the sun (however with proper sunscreen) for quality intake of Vitamin D. Vitamin D is necessary for the absorption of Calcium, which is the most important component of bones and can help with bone and joint pain.

Habit Forming

No

Therapeutic Class

IMMUNOMODULATORS

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Barikind 4 Tablet works by preventing the virus from attaching to the body’s cell receptors and thereby blocking its entry and spread.

If you suffer from Chronic Kidney Disease, please consult with your doctor before using Barikind 4 Tablet and discuss any concerns with them. Barikind 4 Tablet is to be used with caution in those suffering from kidney and liver problems.

Not enough literature exists to ascertain the effects of Barikind 4 Tablet on fertility. However, Barikind 4 Tablet should be absolutely avoided in pregnancy. Please consult your doctor in case of any concerns.

Advanced age, obesity, chronic kidney disease, lung disease, sickle cell disease, neurodevelopmental disorders (for example cerebral palsy) and diseases of metabolism are some risk factors for disease progression.

Drug-Drug Interactions Checker List

  • TRAMADOL
  • ABATACEPT
  • METHOTREXATE

Special Advise

  • Discuss contraception with your doctor while taking Barikind 4 Tablet .
  • Use Barikind 4 Tablet with caution in the elderly as they’re more prone to infections.

Disease/Condition Glossary

Rheumatoid Arthritis: Rheumatoid arthritis is an autoimmune inflammatory disorder of the joints. It is a chronic disease. Autoimmunity is when the body recognises its own cells as foreign and tends to attack them. Rheumatoid arthritis is often seen in conjunction with other autoimmune diseases such as hypothyroidism, inflammatory bowel disease (IBD), vitiligo, lupus etc. Symptoms include stiffness, swelling and weakness at the joints, lumps and redness on the skin, compromised movements, bone erosion and joint deformity. 

Atopic Dermatitis: Atopic dermatitis is a skin condition that makes the skin red, inflamed and itchy. It usually manifests as a rash behind the knees, and on the arms. It is commonly known as eczema.

Coronavirus Disease: Coronavirus disease is an infection caused by the SARS-CoV-2 virus. It can range from a mild cold, cough and fever to full-blown pneumonia. Drop-in oxygen saturations and breathlessness were also common symptoms noted. The new variant omicron however is supposed to cause only a mild disease characterised by a scratchy throat and fatigue only. 

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