Bestogesic Plus Tablet 10's belongs to a class of painkillers called non-steroidal anti-inflammatory drugs (NSAIDs). Pain can be temporary (acute) or long-lasting (chronic). Acute pain is caused by damage to the tissues of the muscle, bone or other organs for a short time. In contrast, chronic pain lasts for a long duration and is caused due to pathologies like nerve damage, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, etc. Besides this, it is also useful for dental pain, which can occur due to damage to the tooth nerve, infection, decay, extraction or injury.

Bestogesic Plus Tablet 10's is composed of two medicines: Nimesulide and Paracetamol. Together it relieves symptoms of arthritis, dysmenorrhea (painful periods or menstrual cramps) and reduce fever. Nimesulide is known to have an analgesic and anti-inflammatory effect for easing mild to moderate pain. It works by blocking the effect of a prostaglandin chemical responsible for inducing pain and inflammation in our bodies. Paracetamol acts as a mild analgesic and antipyretic (fever reducer). It lowers the elevated body temperature and mild pain by inhibiting the synthesis of a chemical messenger (prostaglandin) and promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Together it helps in reducing mild to moderate pain in a shorter duration.

Take Bestogesic Plus Tablet 10's exactly as directed by your doctor. The most common side effects of Bestogesic Plus Tablet 10's are loss of appetite (in case of liver condition), nausea, vomiting, abdominal pain, persistent tiredness or dark/discoloured urine. It is not necessary for everyone to experience the above side effects. In case of any discomfort, speak with your doctor.

Do not take Bestogesic Plus Tablet 10's if you are allergic to painkillers like aspirin, ibuprofen, naproxen or diclofenac. It is not recommended for use in children, people with liver disease, heart disease or gastric ulcers/bleeding problems. Bestogesic Plus Tablet 10's may be associated with a small increase in heart attack risk (myocardial infarction). Avoid alcohol consumption as it may damage your liver and cause increased side effects on taking this drug. Consult your doctor if your pain, inflammation and fever symptoms do not disappear even after ten days.

Bestogesic Plus Tablet 10's comprises nimesulide and paracetamol, primarily used to treat mild to moderate pain. Bestogesic Plus Tablet 10's is prescribed mainly to treat pain and relieve discomfort caused by conditions like tooth pain, arthritis, period pain and other types of short-term pains. It helps treat pain by blocking the chemical messenger in the brain responsible for causing fever, pain and inflammation. Nimesulide works by blocking the effect of a chemical known as prostaglandin, responsible for inducing pain and inflammation in our body. On the other hand, Paracetamol lowers the elevated body temperature and mild pain by inhibiting prostaglandin synthesis by promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Paracetamol has the advantage of producing less gastric irritation than other painkillers like aspirin.

• Nausea
• Vomiting
• Loss of appetite
• Abdominal pain
• Persistent tiredness
• Dark/discoloured urine

Bestogesic Plus Tablet 10's is contraindicated in patients with a history of hypersensitivity (allergic) reaction to Bestogesic Plus Tablet 10's, paracetamol, nimesulide, or other pain killers. Please inform your doctor before starting Bestogesic Plus Tablet 10's if you have an active stomach ulcer, recent gastrointestinal bleeding, asthma, recent by-pass heart surgery or severe kidney/liver impairment. Nimesulide present in Bestogesic Plus Tablet 10's is known to affect fertility, so if you are planning for pregnancy, contact the doctor. Bestogesic Plus Tablet 10's should be avoided in both pregnant (especially last trimester of pregnancy) and breastfeeding women, as it may pass the milk affecting the baby. Patients with heart diseases and recent stroke (bleeding in the brain) should not take Bestogesic Plus Tablet 10's as a substitute for aspirin. It should not be given to children (below 12 years) with symptoms of fever and chills or suffering from influenza (flu) or chickenpox.

Drug-Drug Interactions: Bestogesic Plus Tablet 10's is shown to interact with various drugs. Some of them include lithium, anticancer/antimetabolites (methotrexate), blood thinner or anticoagulant (warfarin, coumadin, aspirin), blood pressure or heart medicine, nausea medicine (metoclopramide, domperidone), diuretic/water pills (thiazides, furosemide), steroid medicine (prednisone), quinolones antibiotics (ciprofloxacin), respiratory medicines (theophyllines, ephedrine), immune system affecting medicine (cyclosporine), cholesterol-reducing medicine (colestyramine) and antidepressants (duloxetine). These drugs may affect the working of Bestogesic Plus Tablet 10's and may alter its efficacy.

Drug-Food Interactions: Excessive intake of alcoholic beverages, caffeine-containing food or drinks like coffee, tea, chocolate, and some fizzy drinks should be avoided while taking Bestogesic Plus Tablet 10's. Taking together may lead to drowsiness and dizziness and sleepiness.

Drug-Disease Interactions: Bestogesic Plus Tablet 10's should not recommend for people having bleeding disorders, like haemophilia, von Willebrand disease, or low blood platelets. Besides this, it should not be given to children suffering from influenza (flu) or chickenpox. It should also be avoided in case of the presence of gastric or duodenal ulcers.

• LITHIUM
• METHOTREXATE
• WARFARIN
• COUMADIN
• ASPIRIN
• METOCLOPRAMIDE
• DOMPERIDONE
• FUROSEMIDE
• PREDNISONE
• CIPROFLOXACIN
• EPHEDRINE
• THEOPHYLLINE
• CYCLOSPORINE
• CHOLESTYRAMINE
• DULOXETINE

• Include more glucosamine, chondroitin sulphate, vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help reduce inflammation in the tissue.
• Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching low,, impact aerobic exercises like walking on a treadmill, bike riding and swimming. You can also strengthen your muscles by lifting light weights.
• In chronic arthritis or joint pain conditions, fish like salmon, trout, tuna and sardines. These fishes are enriched with omega-3 fatty acids that minimize chemical cytokines, which ramp up inflammation.
• Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short time. Long-term immobility is harmful in conditions like arthritis. Use back support like a rolled-up towel to minimise pain at the back of your spine curve. Keep your knees and hips at a right angle. Besides this, you can also use a footrest if required.

Inform your doctor about any bleeding disorders as nimesulide in Bestogesic Plus Tablet 10's should be taken with care as it may interference in the functioning of platelets.

Pain: Pain can be short-term (acute) or long-term (chronic) in nature. Acute pain is for a short time caused by damage to the tissues of the muscle, bone or organs. At the same time, chronic pain lasts for longer duration; it is caused due to pathologies like nerve damage, osteoarthritis and dental pain due to damage to the tooth nerve, infection, decay, extraction or injury. Many women have painful periods known as dysmenorrhea, most often menstrual cramps. On the other hand, osteoarthritis is a degenerative disease that results in chronic pain in joints (especially the knee) and stiffness making daily tasks difficult.