Nimesulide+paracetamol
About
Nimesulide+paracetamol belongs to a class of painkillers called non-steroidal anti-inflammatory drugs (NSAIDs). Pain can be temporary (acute) or long-lasting (chronic). Acute pain is caused by damage to the tissues of the muscle, bone or other organs for a short time. In contrast, chronic pain lasts for a long duration and is caused due to pathologies like nerve damage, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, etc. Besides this, it is also useful for dental pain, which can occur due to damage to the tooth nerve, infection, decay, extraction or injury.
Nimesulide+paracetamol is composed of two medicines: Nimesulide and Paracetamol. Together it relieves symptoms of arthritis, dysmenorrhea (painful periods or menstrual cramps) and reduce fever. Nimesulide is known to have an analgesic and anti-inflammatory effect for easing mild to moderate pain. It works by blocking the effect of a prostaglandin chemical responsible for inducing pain and inflammation in our bodies. Paracetamol acts as a mild analgesic and antipyretic (fever reducer). It lowers the elevated body temperature and mild pain by inhibiting the synthesis of a chemical messenger (prostaglandin) and promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Together it helps in reducing mild to moderate pain in a shorter duration.
Take Nimesulide+paracetamol exactly as directed by your doctor. The most common side effects of Nimesulide+paracetamol are loss of appetite (in case of liver condition), nausea, vomiting, abdominal pain, persistent tiredness or dark/discoloured urine. It is not necessary for everyone to experience the above side effects. In case of any discomfort, speak with your doctor.
Do not take Nimesulide+paracetamol if you are allergic to painkillers like aspirin, ibuprofen, naproxen or diclofenac. It is not recommended for use in children, people with liver disease, heart disease or gastric ulcers/bleeding problems. Nimesulide+paracetamol may be associated with a small increase in heart attack risk (myocardial infarction). Avoid alcohol consumption as it may damage your liver and cause increased side effects on taking this drug. Consult your doctor if your pain, inflammation and fever symptoms do not disappear even after ten days.
Uses of Nimesulide+paracetamol
Medicinal Benefits
Nimesulide+paracetamol comprises nimesulide and paracetamol, primarily used to treat mild to moderate pain. Nimesulide+paracetamol is prescribed mainly to treat pain and relieve discomfort caused by conditions like tooth pain, arthritis, period pain and other types of short-term pains. It helps treat pain by blocking the chemical messenger in the brain responsible for causing fever, pain and inflammation. Nimesulide works by blocking the effect of a chemical known as prostaglandin, responsible for inducing pain and inflammation in our body. On the other hand, Paracetamol lowers the elevated body temperature and mild pain by inhibiting prostaglandin synthesis by promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Paracetamol has the advantage of producing less gastric irritation than other painkillers like aspirin.
Directions for Use
Storage
Side Effects of Nimesulide+paracetamol
- Nausea
- Vomiting
- Loss of appetite
- Abdominal pain
- Persistent tiredness
- Dark/discoloured urine
In-Depth Precautions and Warning
Drug Warnings
Nimesulide+paracetamol is contraindicated in patients with a history of hypersensitivity (allergic) reaction to Nimesulide+paracetamol, paracetamol, nimesulide, or other pain killers. Please inform your doctor before starting Nimesulide+paracetamol if you have an active stomach ulcer, recent gastrointestinal bleeding, asthma, recent by-pass heart surgery or severe kidney/liver impairment. Nimesulide present in Nimesulide+paracetamol is known to affect fertility, so if you are planning for pregnancy, contact the doctor. Nimesulide+paracetamol should be avoided in both pregnant (especially last trimester of pregnancy) and breastfeeding women, as it may pass the milk affecting the baby. Patients with heart diseases and recent stroke (bleeding in the brain) should not take Nimesulide+paracetamol as a substitute for aspirin. It should not be given to children (below 12 years) with symptoms of fever and chills or suffering from influenza (flu) or chickenpox.
Drug Interactions
Drug-Drug Interactions: Nimesulide+paracetamol is shown to interact with various drugs. Some of them include lithium, anticancer/antimetabolites (methotrexate), blood thinner or anticoagulant (warfarin, coumadin, aspirin), blood pressure or heart medicine, nausea medicine (metoclopramide, domperidone), diuretic/water pills (thiazides, furosemide), steroid medicine (prednisone), quinolones antibiotics (ciprofloxacin), respiratory medicines (theophyllines, ephedrine), immune system affecting medicine (cyclosporine), cholesterol-reducing medicine (colestyramine) and antidepressants (duloxetine). These drugs may affect the working of Nimesulide+paracetamol and may alter its efficacy.
Drug-Food Interactions: Excessive intake of alcoholic beverages, caffeine-containing food or drinks like coffee, tea, chocolate, and some fizzy drinks should be avoided while taking Nimesulide+paracetamol. Taking together may lead to drowsiness and dizziness and sleepiness.
Drug-Disease Interactions: Nimesulide+paracetamol should not recommend for people having bleeding disorders, like haemophilia, von Willebrand disease, or low blood platelets. Besides this, it should not be given to children suffering from influenza (flu) or chickenpox. It should also be avoided in case of the presence of gastric or duodenal ulcers.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionTaking Nimesulide+paracetamol with alcohol may cause dizziness or drowsiness. Besides this, it can also damage your liver if taken for a longer duration. So, avoid or limit the intake of alcoholic beverages with Nimesulide+paracetamol.
Pregnancy
unsafeUse of Nimesulide+paracetamol during pregnancy is not recommended as taking this medicine during the last 3 months of pregnancy may harm the unborn baby. Consult your doctor for further advice.
Breast Feeding
unsafeUse of Nimesulide+paracetamol during breastfeeding is not recommended as it may pass through the milk and harm the baby. Consult your doctor for further advice.
Driving
cautionAfter taking Nimesulide+paracetamol, you may notice dizziness, sleepiness, drowsiness. So, you should stop taking Nimesulide+paracetamol and contact your doctor.
Liver
cautionNimesulide+paracetamol to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.
Kidney
cautionNimesulide+paracetamol to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.
Children
cautionNimesulide+paracetamol is contraindicated in children below 20 kg body weight or younger than 6 years of age. It may cause kidney problems in children and adolescents who are dehydrated.
Habit Forming
Diet & Lifestyle Advise
- Include more glucosamine, chondroitin sulphate, vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help reduce inflammation in the tissue.
- Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching low,, impact aerobic exercises like walking on a treadmill, bike riding and swimming. You can also strengthen your muscles by lifting light weights.
- In chronic arthritis or joint pain conditions, fish like salmon, trout, tuna and sardines. These fishes are enriched with omega-3 fatty acids that minimize chemical cytokines, which ramp up inflammation.
- Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short time. Long-term immobility is harmful in conditions like arthritis. Use back support like a rolled-up towel to minimise pain at the back of your spine curve. Keep your knees and hips at a right angle. Besides this, you can also use a footrest if required.
Special Advise
Inform your doctor about any bleeding disorders as nimesulide in Nimesulide+paracetamol should be taken with care as it may interference in the functioning of platelets.
Patients Concern
Disease/Condition Glossary
Pain: Pain can be short-term (acute) or long-term (chronic) in nature. Acute pain is for a short time caused by damage to the tissues of the muscle, bone or organs. At the same time, chronic pain lasts for longer duration; it is caused due to pathologies like nerve damage, osteoarthritis and dental pain due to damage to the tooth nerve, infection, decay, extraction or injury. Many women have painful periods known as dysmenorrhea, most often menstrual cramps. On the other hand, osteoarthritis is a degenerative disease that results in chronic pain in joints (especially the knee) and stiffness making daily tasks difficult.
FAQs
Nimesulide+paracetamol is composed of two medicines: Nimesulide and Paracetamol. Nimesulide is known to have an analgesic and anti-inflammatory effect for easing mild to moderate pain. It works by blocking the effect of a prostaglandin chemical responsible for inducing pain and inflammation in our bodies. Paracetamol acts as a mild analgesic and antipyretic (fever reducer). It lowers the elevated body temperature and mild pain by inhibiting the synthesis of a chemical messenger (prostaglandin) and promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Together it helps in reducing mild to moderate pain in a shorter duration.
Yes, Nimesulide+paracetamol is known to cause dizziness. If you feel dizzy, please rest and avoid driving while you take Nimesulide+paracetamol as it can be harmful.
No, Nimesulide+paracetamol is not indicated for stomach pain. If you have stomach pain post-ingestion, it may be a sign of stomach ulcer or gastric bleeding. Do not take Nimesulide+paracetamol in this condition. It is better to inform your doctor in case of stomach pain post-ingestion of this medication.
No, Nimesulide+paracetamol should not be taken as a long term medication as it may lead to stomach ulcers/bleeding and kidney problems. For best results of Nimesulide+paracetamol, take it in doses and duration mentioned by your doctor.
Yes, Nimesulide+paracetamol should be preferably be taken with food to avoid an upset stomach. If taken on an empty stomach, it may cause stomach irritation and upset stomach.
You should not take Nimesulide+paracetamol if you have history of peptic ulceration, history of gastrointestinal haemorrhage, Crohn's disease or ulcerative colitis.
You should avoid intake of Nimesulide+paracetamol if you are allergic to Nimesulide+paracetamol, nimesulide or paracetamol, a regular heavy alcohol drinker, liver disease (increased liver enzyme), any type of recent ulcer or bleeding, suffering from flu or fever (with chills), in the last trimester of pregnancy or breastfeeding mother.
No, Nimesulide+paracetamol should not be taken if you plan to get pregnant as it contains nimesulide, which may affect your fertility. So, before starting Nimesulide+paracetamol, please consult your doctor.
