Bosutris 400mg Tablet 30's

Written By Lakshmithulasi Yarragunta , Pharm-D (PB)

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

MRP ₹8900

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Whats That

About Bosutris 400mg Tablet

Bosutris 400mg Tablet is an anti-cancer medicine used in the treatment of Leukemia. Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. Bosutris 400mg Tablet is used in the treatment of chronic myelogenous leukemia (CML). This medicine is used in patients with chronic, accelerated, or blast phase Ph+ (Philadelphia chromosome-positive) chronic myelogenous leukemia who are resistant or intolerant to prior therapy.

Bosutris 400mg Tablet contains Bosutinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

Bosutris 400mg Tablet may cause certain side effects, such as rash, fatigue, headache, back pain, decreased platelet count, back pain, nausea, vomiting, diarrhea, abdominal pain, loss of appetite, and dizziness. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Bosutris 400mg Tablet should be taken as advised by your doctor. Do not take more than the recommended dose of medicine. Your doctor will decide the dose of Bosutris 400mg Tablet based on the severity of your condition.

Bosutris 400mg Tablet should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before taking this medicine, inform your doctor if you have liver/kidney disease, gastrointestinal toxicity, myelosuppression, fluid retention, and hepatic toxicity, as may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment with Bosutris 400mg Tablet . Breastfeeding should be discontinued in nursing mothers during the treatment. Bosutris 400mg Tablet is not recommended for use in children below 18 years of age as the safety and efficacy are not established.

Uses of Bosutris 400mg Tablet

Philadelphia chromosome-positive chronic myeloid leukemia.

Directions for Use

Take Bosutris 400mg Tablet as advised by your doctor. Do not take more than the prescribed dose of medicine. Swallow the medicine as a whole with a glass of water. Do not chew crush or break the medicine.

Medicinal Benefits

Bosutris 400mg Tablet contains Bosutinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

Storage

Keep Bosutris 400mg Tablet out of the sight and reach of children.

Side effects of Bosutris 400mg Tablet

Loose/ Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Low Platelet Count

Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
If you experience severe bleeding or bruising, seek emergency medical attention immediately.

Stomach Pain

Drink water or other clear fluids.
To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
Include bland foods like rice, toast, crackers, and rice in your diet.
Avoid lying down immediately after eating as it may cause indigestion or heartburn.
Avoid acidic and spicy food as it may cause indigestion.

Vomiting

To prevent, manage, and treat Constipation caused by medication usage, follow these steps:

Preventing Vomiting (Before it Happens)
Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
Having a small meal before taking your medication can help reduce nausea and vomiting.
Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
Managing Vomiting (If it Happens)
Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
What to Do if Vomiting Persists
Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Rash

Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
Protect your skin from extreme heat and try to apply wet compresses.
Soak in the cool bath, which gives a soothing impact to the affected area.

High Body Temperature

Here's a comprehensive approach to managing medication-triggered fever:

Inform your doctor immediately if you experience a fever after starting a new medication.
Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
Monitor your body temperature to monitor fever progression.
Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Fatigue

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Drug Warnings

Bosutris 400mg Tablet should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before taking, inform your doctor if you have liver/kidney disease, diabetes, cardiac problems, increased blood pressure, gastrointestinal toxicity, myelosuppression, fluid retention, and hepatic toxicity, as the use of Bosutris 400mg Tablet in these patients may cause serious side effects. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment. Breastfeeding should be discontinued in nursing mothers during the treatment. Bosutris 400mg Tablet is not recommended for use in children below 18 years of age as the safety and efficacy are not established. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.

Drug-Drug Interactions

BosutinibYellow fever vaccine

Critical

BosutinibToremifene

Severe

Drug-Drug Interactions

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BosutinibYellow fever vaccine

Critical

How does the drug interact with Bosutris 400mg Tablet:
Combining Yellow fever vaccine with Bosutris 400mg Tablet can increase the risk of infection.

How to manage the interaction:
Taking Yellow fever vaccine with Bosutris 400mg Tablet can result in an interaction, but it can be taken if prescribed by a doctor. Do not stop using any medications without consulting a doctor.

BosutinibToremifene

Severe

How does the drug interact with Bosutris 400mg Tablet:
Taking Bosutris 400mg Tablet and Toremifene together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between Bosutris 400mg Tablet and Toremifene, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, or fainting. Do not discontinue any medications without consulting a doctor.

BosutinibSotalol

Severe

How does the drug interact with Bosutris 400mg Tablet:
Taking Sotalol with Bosutris 400mg Tablet can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Although there is an interaction between Sotalol and Bosutris 400mg Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, or fainting. Do not discontinue any medications without consulting a doctor.

BosutinibItraconazole

Severe

How does the drug interact with Bosutris 400mg Tablet:
Taking Bosutris 400mg Tablet with itraconazole can significantly elevate blood levels of Bosutris 400mg Tablet.

How to manage the interaction:
Although there is an interaction between Itraconazole and Bosutris 400mg Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, pain or burning during urination. Do not discontinue any medications without consulting a doctor.

BosutinibAmiodarone

Severe

How does the drug interact with Bosutris 400mg Tablet:
Coadministration of Bosutris 400mg Tablet with amiodarone may increase the risk of an irregular heart rhythm

How to manage the interaction:
Although there is an interaction between Bosutris 400mg Tablet and amiodarone, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.

BosutinibBCG vaccine

Severe

How does the drug interact with Bosutris 400mg Tablet:
Taking the BCG vaccine with Bosutris 400mg Tablet can increase the risk of infection.

How to manage the interaction:
Although there is an interaction between Bosutris 400mg Tablet and the BCG vaccine, it can be taken if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

BosutinibEnzalutamide

Severe

How does the drug interact with Bosutris 400mg Tablet:
Taking Bosutris 400mg Tablet with enzalutamide can decrease the blood levels of Bosutris 400mg Tablet, which decreases Bosutris 400mg Tablet's ability to treat your condition.

How to manage the interaction:
Although there is an interaction between Enzalutamide and Bosutris 400mg Tablet, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

BosutinibIloperidone

Severe

How does the drug interact with Bosutris 400mg Tablet:
Taking Bosutris 400mg Tablet and Iloperidone together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between Bosutris 400mg Tablet and Iloperidone, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, or fainting. Do not discontinue any medications without consulting a doctor.

BosutinibNatalizumab

Severe

How does the drug interact with Bosutris 400mg Tablet:
Coadministration of Bosutris 400mg Tablet with natalizumab can increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction between Bosutris 400mg Tablet and natalizumab, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.

BosutinibRifapentine

Severe

How does the drug interact with Bosutris 400mg Tablet:
Taking Bosutris 400mg Tablet with rifapentine can decrease the blood levels of Bosutris 400mg Tablet, which may make the medication less effective in treating your condition.

How to manage the interaction:
Although there is an interaction between Bosutris 400mg Tablet and rifapentine, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

BOSUTINIB-400MGGrapefruit and Grapefruit Juice

Moderate

Drug-Food Interactions

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BOSUTINIB-400MGGrapefruit and Grapefruit Juice

Moderate

Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking grapefruit or grapefruit juice with Bosutris 400mg Tablet can increase the blood levels and effects of Bosutris 400mg Tablet, which may increase the risk of side effects. Avoid the consumption of grapefruit and grapefruit juice.

Diet & Lifestyle Advise

After your treatment begins, several dietary adjustments can help you control side effects.
Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
Eat a healthy diet and exercise regularly to maintain proper weight.
Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
Get optimal sleep; rest well.
Avoid smoking and alcohol consumption.
Avoid fast and fried food, processed meats, refined carbs and added sugars.

Side Effects of Bosutris 400mg Tablet

Nausea
Diarrhoea
Painful urination
Decreased platelet count
Fatigue
Edema
Vomiting
Diarrhea
Abdominal pain
Headache
Back pain
Cough
Dizziness
Skin rash

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Bosutris 400mg Tablet Substitute

Bonitar 400 Tablet 10's

by Others

₹225.50per tablet

Bosuvi 400 mg Tablet 30's

by Others

₹205.00per tablet

Author Details

Written By

Lakshmithulasi Yarragunta

Pharm-D (PB)

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:49 AM IST

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Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does Bosutris 400mg Tablet work?

Bosutris 400mg Tablet contains Bosutinib, which works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells.

Can a pregnant women take Bosutris 400mg Tablet ?

Bosutris 400mg Tablet is known to cause embryo-fetal toxicity; hence, it is contraindicated for use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or at least six months after completion of the treatment.

Drug-Drug Interactions Checker List

PANTOPRAZOLE
ESOMEPRAZOLE
RITONAVIR
ITRACONAZOLE
KETOCONAZOLE
CLARITHROMYCIN
ERYTHROMYCIN
RIFAMPICIN
PHENYTOIN
PHENOBARBITAL
CARBAMAZEPINE

Special Advise

Bosutris 400mg Tablet should be administered only by a trained and experienced oncologist.
A blood test should be performed such as LFT and RFT, to check for liver/kidney function.
Weekly blood tests should be done during the treatment to check for CBC (Complete blood count).

Disease/Condition Glossary

Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia: Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. Chronic Myelogenous Leukemia is a type of blood cancer that originates in the myeloid cells or stem cells in your bone marrow. Ph+ chronic myeloid leukemia is a common form of CML that occurs when specific chromosomes swap position. This causes a chromosome abnormality, creating the Philadelphia chromosome. The abnormal chromosomes produce an abnormal protein called Bcr-Abl tyrosine kinase, which then triggers a signal to produce abnormal white blood cells in the bone marrow. Symptoms may include fatigue, fever, weight loss, and loss of appetite.