Bosutinib
About
Bosutinib is an anti-cancer medicine used in the treatment of Leukemia. Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. Bosutinib is used in the treatment of chronic myelogenous leukemia (CML). This medicine is used in patients with chronic, accelerated, or blast phase Ph+ (Philadelphia chromosome-positive) chronic myelogenous leukemia who are resistant or intolerant to prior therapy.
Bosutinib contains Bosutinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.
Bosutinib may cause certain side effects, such as rash, fatigue, headache, back pain, decreased platelet count, back pain, nausea, vomiting, diarrhea, abdominal pain, loss of appetite, and dizziness. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Bosutinib should be taken as advised by your doctor. Do not take more than the recommended dose of medicine. Your doctor will decide the dose of Bosutinib based on the severity of your condition.
Bosutinib should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before taking this medicine, inform your doctor if you have liver/kidney disease, gastrointestinal toxicity, myelosuppression, fluid retention, and hepatic toxicity, as may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment with Bosutinib. Breastfeeding should be discontinued in nursing mothers during the treatment. Bosutinib is not recommended for use in children below 18 years of age as the safety and efficacy are not established.
Uses of Bosutinib
Medicinal Benefits
Bosutinib contains Bosutinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.
Directions for Use
Storage
Side Effects of Bosutinib
- Nausea
- Diarrhoea
- Painful urination
- Decreased platelet count
- Fatigue
- Edema
- Vomiting
- Diarrhea
- Abdominal pain
- Headache
- Back pain
- Cough
- Dizziness
- Skin rash
In-Depth Precautions and Warning
Drug Warnings
Bosutinib should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before taking, inform your doctor if you have liver/kidney disease, diabetes, cardiac problems, increased blood pressure, gastrointestinal toxicity, myelosuppression, fluid retention, and hepatic toxicity, as the use of Bosutinib in these patients may cause serious side effects. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment. Breastfeeding should be discontinued in nursing mothers during the treatment. Bosutinib is not recommended for use in children below 18 years of age as the safety and efficacy are not established. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.
Drug Interactions
Drug-Drug Interactions: Bosutinib may interact with vaccines, proton pump inhibitors (pantoprazole, esomeprazole), CYP3A inhibitors (ritonavir, itraconazole, ketoconazole, clarithromycin, erythromycin), CYP3A inducers (rifampin, phenytoin, phenobarbitone, carbamazepine).
Drug-Food Interactions: Avoid alcohol consumption and smoking.
Drug-Disease Interactions: Inform your doctor if you have kidney or liver disease, gastrointestinal disorders, diabetes, hepatotoxicity, and cardiac disorders before taking Bosutinib.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid alcohol consumption while on treatment with Bosutinib to prevent serious adverse effects.
Pregnancy
unsafeBosutinib is not recommended for use in pregnancy as it may harm your fetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Bosutinib. Your doctor may prescribe this medicine if the benefits outweigh the risks.
Breast Feeding
cautionLimited data is available on the effect of Bosutinib on breastfeeding. Bosutinib should be avoided during breastfeeding. Hence, inform your doctor if you are breastfeeding. Your doctor may prescribe an alternative based on the symptoms and health condition.
Driving
unsafeBosutinib may cause dizziness and may make you feel drowsy. Hence, avoid driving or operating machines after taking Bosutinib or until you become alert.
Liver
cautionBosutinib is known to cause hepatotoxicity. Hence, inform your doctor if you have a pre-existing or a history of liver disease. A dose adjustment may be needed based on your condition.
Kidney
cautionIf you have a pre-existing or a history of kidney disease, inform your doctor before taking Bosutinib. Your doctor may reduce the dose of this medicine or prescribe a suitable alternative based on your condition.
Children
unsafeBosutinib is not recommended for use in children below 18 years of age as the safety and efficacy are not established.
Habit Forming
Diet & Lifestyle Advise
- After your treatment begins, several dietary adjustments can help you control side effects.
- Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
- Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
- Eat a healthy diet and exercise regularly to maintain proper weight.
- Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
- De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
- Get optimal sleep; rest well.
- Avoid smoking and alcohol consumption.
- Avoid fast and fried food, processed meats, refined carbs and added sugars.
Special Advise
- Bosutinib should be administered only by a trained and experienced oncologist.
- A blood test should be performed such as LFT and RFT, to check for liver/kidney function.
- Weekly blood tests should be done during the treatment to check for CBC (Complete blood count).
Patients Concern
Disease/Condition Glossary
Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia: Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. Chronic Myelogenous Leukemia is a type of blood cancer that originates in the myeloid cells or stem cells in your bone marrow. Ph+ chronic myeloid leukemia is a common form of CML that occurs when specific chromosomes swap position. This causes a chromosome abnormality, creating the Philadelphia chromosome. The abnormal chromosomes produce an abnormal protein called Bcr-Abl tyrosine kinase, which then triggers a signal to produce abnormal white blood cells in the bone marrow. Symptoms may include fatigue, fever, weight loss, and loss of appetite.
FAQs
Bosutinib contains Bosutinib, which works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells.
Bosutinib is known to cause embryo-fetal toxicity; hence, it is contraindicated for use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or at least six months after completion of the treatment.
