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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

About Bosutris 500 mg Tablet 30's

Bosutris 500 mg Tablet 30's is an anti-cancer medicine used in the treatment of Leukemia. Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. Bosutris 500 mg Tablet 30's is used in the treatment of chronic myelogenous leukemia (CML). This medicine is used in patients with chronic, accelerated, or blast phase Ph+ (Philadelphia chromosome-positive) chronic myelogenous leukemia who are resistant or intolerant to prior therapy.

Bosutris 500 mg Tablet 30's contains Bosutinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

Bosutris 500 mg Tablet 30's may cause certain side effects, such as rash, fatigue, headache, back pain, decreased platelet count, back pain, nausea, vomiting, diarrhea, abdominal pain, loss of appetite, and dizziness. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Bosutris 500 mg Tablet 30's should be taken as advised by your doctor. Do not take more than the recommended dose of medicine. Your doctor will decide the dose of Bosutris 500 mg Tablet 30's based on the severity of your condition.

Bosutris 500 mg Tablet 30's should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before taking this medicine, inform your doctor if you have liver/kidney disease, gastrointestinal toxicity, myelosuppression, fluid retention, and hepatic toxicity, as may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment with Bosutris 500 mg Tablet 30's. Breastfeeding should be discontinued in nursing mothers during the treatment. Bosutris 500 mg Tablet 30's is not recommended for use in children below 18 years of age as the safety and efficacy are not established.

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Whats That

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Non returnable*
COD available

Online payment accepted

Composition

BOSUTINIB-500MG

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

Uses of Bosutris 500 mg Tablet 30's

Philadelphia chromosome-positive chronic myeloid leukemia.

Medicinal Benefits

Bosutris 500 mg Tablet 30's contains Bosutinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

Side Effects of Bosutris 500 mg Tablet 30's

  • Nausea
  • Diarrhoea
  • Painful urination
  • Decreased platelet count
  • Fatigue
  • Edema
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Headache
  • Back pain
  • Cough
  • Dizziness
  • Skin rash

Directions for Use

Take Bosutris 500 mg Tablet 30's as advised by your doctor. Do not take more than the prescribed dose of medicine. Swallow the medicine as a whole with a glass of water. Do not chew crush or break the medicine.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Bosutris 500 mg Tablet 30's should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before taking, inform your doctor if you have liver/kidney disease, diabetes, cardiac problems, increased blood pressure, gastrointestinal toxicity, myelosuppression, fluid retention, and hepatic toxicity, as the use of Bosutris 500 mg Tablet 30's in these patients may cause serious side effects. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment. Breastfeeding should be discontinued in nursing mothers during the treatment. Bosutris 500 mg Tablet 30's is not recommended for use in children below 18 years of age as the safety and efficacy are not established. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.

Therapeutic Class

ANTINEOPLASTIC

Drug-Drug Interactions

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BosutinibYellow fever vaccine
Critical
BosutinibClarithromycin
Severe

Drug-Drug Interactions

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BosutinibYellow fever vaccine
Critical
How does the drug interact with Bosutris 500 mg Tablet 30's:
Combining Yellow fever vaccine with Bosutris 500 mg Tablet 30's can increase the risk of infection.

How to manage the interaction:
Taking Yellow fever vaccine with Bosutris 500 mg Tablet 30's can result in an interaction, but it can be taken if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
BosutinibClarithromycin
Severe
How does the drug interact with Bosutris 500 mg Tablet 30's:
Taking Bosutris 500 mg Tablet 30's with clarithromycin may raise blood levels of Bosutris 500 mg Tablet 30's, increasing the risk of side effects.

How to manage the interaction:
Although there is an interaction between clarithromycin and Bosutris 500 mg Tablet 30's, they can be taken together if prescribed by the doctor. However, if you experience fatigue, dizziness, diarrhea, sore throat, muscle aches, red or inflamed skin, pain during urination. Do not discontinue the medication without consulting a doctor.
BosutinibMoxifloxacin
Severe
How does the drug interact with Bosutris 500 mg Tablet 30's:
Taking Bosutris 500 mg Tablet 30's and Moxifloxacin together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Bosutris 500 mg Tablet 30's with Moxifloxacin can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, shortness of breath, or irregular heartbeat Do not discontinue any medications without consulting a doctor.
BosutinibNatalizumab
Severe
How does the drug interact with Bosutris 500 mg Tablet 30's:
Coadministration of Bosutris 500 mg Tablet 30's with natalizumab can increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction between Bosutris 500 mg Tablet 30's and natalizumab, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
BosutinibFluconazole
Severe
How does the drug interact with Bosutris 500 mg Tablet 30's:
Taking Bosutris 500 mg Tablet 30's with fluconazole can increase the blood levels of Bosutris 500 mg Tablet 30's. This can increase side effects such as nausea, vomiting, abdominal pain, and diarrhea.

How to manage the interaction:
Although there is a possible interaction, Fluconazole can be taken with Bosutris 500 mg Tablet 30's if prescribed by the doctor. However, consult your doctor if you experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
BosutinibAmiodarone
Severe
How does the drug interact with Bosutris 500 mg Tablet 30's:
Coadministration of Bosutris 500 mg Tablet 30's with amiodarone may increase the risk of an irregular heart rhythm

How to manage the interaction:
Although there is an interaction between Bosutris 500 mg Tablet 30's and amiodarone, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
BosutinibNefazodone
Severe
How does the drug interact with Bosutris 500 mg Tablet 30's:
Taking Bosutris 500 mg Tablet 30's with nefazodone can considerably increase blood levels of Bosutris 500 mg Tablet 30's.

How to manage the interaction:
Although there is an interaction between Bosutris 500 mg Tablet 30's with nefazodone, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or inflamed skin, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
BosutinibIdelalisib
Severe
How does the drug interact with Bosutris 500 mg Tablet 30's:
Taking Bosutris 500 mg Tablet 30's with idelalisib can increase the blood levels of Bosutris 500 mg Tablet 30's. This can increase side effects such as nausea, vomiting, abdominal pain, and diarrhea.

How to manage the interaction:
Although there is an interaction between Bosutris 500 mg Tablet 30's and idelalisib, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, red or inflamed skin, pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
BosutinibRibociclib
Severe
How does the drug interact with Bosutris 500 mg Tablet 30's:
Taking Bosutris 500 mg Tablet 30's and Ribociclib together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between Bosutris 500 mg Tablet 30's and ribociclib, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, or fainting. Do not discontinue any medications without consulting a doctor.
BosutinibRitonavir
Severe
How does the drug interact with Bosutris 500 mg Tablet 30's:
Taking Bosutris 500 mg Tablet 30's and Ritonavir together can raise the blood levels of Bosutris 500 mg Tablet 30's.

How to manage the interaction:
Taking Bosutris 500 mg Tablet 30's with Ritonavir together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, fever, chills, diarrhea, muscle aches, and burning during urination. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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BOSUTINIB-500MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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BOSUTINIB-500MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking grapefruit or grapefruit juice with Bosutris 500 mg Tablet 30's can increase the blood levels and effects of Bosutris 500 mg Tablet 30's, which may increase the risk of side effects. Avoid the consumption of grapefruit and grapefruit juice.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • PANTOPRAZOLE
  • ESOMEPRAZOLE
  • RITONAVIR
  • ITRACONAZOLE
  • KETOCONAZOLE
  • CLARITHROMYCIN
  • ERYTHROMYCIN
  • RIFAMPICIN
  • PHENYTOIN
  • PHENOBARBITAL
  • CARBAMAZEPINE

Diet & Lifestyle Advise

  • After your treatment begins, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Special Advise

  • Bosutris 500 mg Tablet 30's should be administered only by a trained and experienced oncologist.
  • A blood test should be performed such as LFT and RFT, to check for liver/kidney function.
  • Weekly blood tests should be done during the treatment to check for CBC (Complete blood count).

Disease/Condition Glossary

Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia: Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. Chronic Myelogenous Leukemia is a type of blood cancer that originates in the myeloid cells or stem cells in your bone marrow. Ph+ chronic myeloid leukemia is a common form of CML that occurs when specific chromosomes swap position. This causes a chromosome abnormality, creating the Philadelphia chromosome. The abnormal chromosomes produce an abnormal protein called Bcr-Abl tyrosine kinase, which then triggers a signal to produce abnormal white blood cells in the bone marrow. Symptoms may include fatigue, fever, weight loss, and loss of appetite.

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