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  1. Home
  2. Medicine

  3. Bozetan 125mg Tablet

Bozetan 125mg Tablet, Pack of 1 Tablet
Non returnable*
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Composition :

BOSENTAN-125MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Bozetan 125mg Tablet

Bozetan 125mg Tablet is an anti-hypertension medication primarily used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). Bozetan 125mg Tablet can even increase our exercising ability, delay disease progression, and improve quality of life. Blood pressure is the measurement of the force that our heart uses to pump blood to all parts of the body. Hypertension is a chronic condition when blood pressure is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart.

Bozetan 125mg Tablet contains Bosentan, and an endothelin receptor antagonist used to treat pulmonary arterial hypertension. It works by blocking the action of endothelin.  Endothelin narrows the blood vessels and increases the pressure in the blood vessels of the lungs. Bozetan 125mg Tablet helps to relax blood vessels by blocking endothelin and increasing the blood supply to the lungs.

Take Bozetan 125mg Tablet as prescribed by your doctor. You are advised to take Bozetan 125mg Tablet for as long as your doctor has prescribed it for you, depending upon your medical condition. You may experience swelling of legs and ankles, headaches, and diarrhoea in some cases. Most of these side effects of Bozetan 125mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. Some rare cases may cause anaemia and abnormal liver function such as nausea, vomiting, dark urine, and fever, which your doctor should know.

Please inform your doctor if you have liver dysfunction before starting Bozetan 125mg Tablet. If you are pregnant or breastfeeding, do not take Bozetan 125mg Tablet a pregnancy category X drug. If you are taking Bozetan 125mg Tablet, women should use a reliable form of the contraceptive pill to avoid pregnancy and continue to use it one month after stopping Bozetan 125mg Tablet. Also, the blood test for liver functions should be monitored regularly and for haemoglobin level.

Uses of Bozetan 125mg Tablet

Pulmonary arterial hypertension (PAH)

Directions for Use

Tablet: Bozetan 125mg Tablet can be taken with or without food. It should be swallowed as a whole with a glass of water, do not chew or crush it.Tablets for oral suspension: Check the label for directions before use. Disperse the tablet in the prescribed amount of water and swallow the contents. Do not crush, chew or swallow as a whole.

Medicinal Benefits

Bozetan 125mg Tablet is an anti-hypertension medication primarily used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). Bozetan 125mg Tablet can even increase our exercising ability, delay disease progression, and improve quality of life. It works by blocking the action of endothelin.  Endothelin narrows the blood vessels and increases the pressure in the blood vessels of the lungs. Bozetan 125mg Tablet helps to relax blood vessels by blocking endothelin and increasing the blood supply to the lungs. It also improves the quality of life, exercising ability, and delays the progression of pulmonary arterial hypertension.

Storage

Store in a cool and dry place away from sunlight
Side effects of Bozetan 125mg Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Get plenty of rest and avoid activities that tire you out to allow your body fight the infection.
  • Drink lots of fluids to help loosen mucus in the lungs.
  • Use over-the-counter medications like paracetamol or ibuprofen to manage fever.
  • Use a humidifier as it helps soothe irritated airways.
  • Do not make changes to your medication schedule or take over-the-counter medicines without consulting your doctor.
  • Stay hydrated by taking fluids like water, juices and soups etc.
  • Eat fruits and vegetables which contain vitamins.
  • Take iron rich food like dry fruits, green leafy vegetables and sea food etc.
  • Reduce intake of milk, cheese, yogurt, soy, chocolate, ice cream, Grapes, Popcorn, canned salmon, pomegranate.
  • Regular exercise like walking, jogging is helpful.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

Drug Warnings

Do not take Bozetan 125mg Tablet if you are allergic to Bozetan 125mg Tablet or any of its ingredients. Please inform your doctor if you have liver dysfunction before starting Bozetan 125mg Tablet. If you are pregnant or breastfeeding, do not take Bozetan 125mg Tablet as it is a pregnancy category X drug. It can lead to defects in the baby if taken during pregnancy. Also, after stoping Bozetan 125mg Tablet at least after a gap of one month, you should try to conceive so that Bozetan 125mg Tablet flushed out of body completely. If you are taking Bozetan 125mg Tablet, women should use a reliable form of the contraceptive pill to avoid pregnancy and continue to use it one month after stopping Bozetan 125mg Tablet. Blood tests for liver functions should be monitored regularly and for hemoglobin level as well. As low hemoglobin could be a sign of anemia.

Drug-Drug Interactions

verifiedApollotooltip
BosentanRegorafenib
Critical
BosentanCiclosporin
Critical

Drug-Drug Interactions

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BosentanRegorafenib
Critical
How does the drug interact with Bozetan 125mg Tablet:
Taking regorafenib with Bozetan 125mg Tablet it can increases the risk of side effects.

How to manage the interaction:
Taking Regorafenib with Bozetan 125mg Tablet is not recommended, please consult your doctor before taking it. They can be taken together if advised by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
BosentanCiclosporin
Critical
How does the drug interact with Bozetan 125mg Tablet:
When Bozetan 125mg Tablet is taken with Cyclosporine, it may increase the risk of side effects.

How to manage the interaction:
Taking Ciclosporin with Bozetan 125mg Tablet is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any symptoms like severe headache, nausea, or an increased heart rate, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
BosentanDesogestrel
Severe
How does the drug interact with Bozetan 125mg Tablet:
Bozetan 125mg Tablet can reduce the levels of Desogestrel in the blood.

How to manage the interaction:
Co-administration of Desogestrel with Bozetan 125mg Tablet can result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
BosentanMethadone
Severe
How does the drug interact with Bozetan 125mg Tablet:
Bozetan 125mg Tablet can lower the levels of Methadone in your blood, which could decrease its effectiveness in treating your condition.

How to manage the interaction:
Although using Bozetan 125mg Tablet and Methadone together can result in an interaction, they can be taken together if prescribed by your doctor. However, consult your doctor if you experience watery eyes, runny nose, sneezing, excessive sweating, fever, chills, tremors, body aches, or abdominal cramping. Do not stop taking any medications without consulting a doctor
BosentanVoclosporin
Severe
How does the drug interact with Bozetan 125mg Tablet:
Coadministration of voclosporin with Bozetan 125mg Tablet may reduce the blood levels of voclosporin, which may decrease its effectiveness in treating your condition.

How to manage the interaction:
Although using Bozetan 125mg Tablet and Voclosporin together can possibly result in an interaction, they can be taken together if advised by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
BosentanDrospirenone
Severe
How does the drug interact with Bozetan 125mg Tablet:
Bozetan 125mg Tablet can lower the levels of Drospirenone in your blood, which could decrease its effectiveness in treating your condition.

How to manage the interaction:
Although using Bozetan 125mg Tablet and Drospirenone together can result in an interaction, they can be taken together if your doctor advises. Do not stop taking any medications without consulting a doctor.
BosentanAxitinib
Severe
How does the drug interact with Bozetan 125mg Tablet:
Taking axitinib with Bozetan 125mg Tablet may significantly reduce the blood levels of axitinib, making the medication less effective in treating the condition.

How to manage the interaction:
Although using Bozetan 125mg Tablet and Axitinib together can result in an interaction, they can be taken together if advised by a doctor. Do not stop taking any medications without consulting a doctor.
BosentanButorphanol
Severe
How does the drug interact with Bozetan 125mg Tablet:
Taking butorphanol with Bozetan 125mg Tablet can lower the levels of Butorphanol in your blood, which could decrease its effectiveness in treating your condition.

How to manage the interaction:
Although using Bozetan 125mg Tablet and Butorphanol together can possibly result in an interaction, they can be taken together if advised by your doctor. However, consult your doctor if you experience excessive sweating, goose bumps, fever, chills, flushing, restlessness, irritability, anxiety, depression, pupil dilation, rapid heartbeat, body aches, abdominal cramping, loss of appetite, nausea, vomiting, diarrhea, and weight loss. Do not stop taking any medications without consulting a doctor.
BosentanHydrocodone
Severe
How does the drug interact with Bozetan 125mg Tablet:
Coadministration of hydrocodone and Bozetan 125mg Tablet may reduce the blood levels of hydrocodone, which may make the medication less effective in treating your pain.

How to manage the interaction:
Taking Bozetan 125mg Tablet with Hydrocodone together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience watery eyes, runny nose, sneezing, yawning, sweating, fever, chills, restlessness, irritability, anxiety, depression, dilated pupils, trembling, fast heartbeat, nausea, vomiting, diarrhea, weight loss, contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
BosentanOlaparib
Severe
How does the drug interact with Bozetan 125mg Tablet:
Coadministration of olaparib and Bozetan 125mg Tablet may significantly reduce the blood levels of olaparib, making the medication less effective in treating your condition.

How to manage the interaction:
Taking Bozetan 125mg Tablet and Olaparib can lead to an interaction, but it can be taken if advised by your doctor. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Keep your weight under control with BMI 19.5-24.9.
  • Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
  • Limit intake of sodium chloride (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
  • If you are taking alcohol, then only one serving for women and two servings is advisable.
  • Quitting smoking is the best strategy to lower the risk of heart disease.
  • Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress and practice mindfulness techniques.
  • Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
  • Try to include heart-healthy omega 3 fatty acid containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Bozetan 125mg Tablet Substitute

Substitutes safety advice

Product Substitutes

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Bozetan 125mg Tablet is an anti-hypertension medication primarily used to treat pulmonary arterial hypertension. It works by blocking the action of endothelin. Endothelin narrows the blood vessels and increases the pressure in the blood vessels of the lungs. Bozetan 125mg Tablet helps to relax blood vessels by blocking endothelin and increasing the blood supply to the lungs.

Pulmonary arterial hypertension is high pressure in the blood vessels that carry blood from the heart to the lungs. It can be due to constriction of blood vessels or some blockage in blood vessels' pathway.

Yes, in rare cases, $Name can cause anaemia. It can decrease your haemoglobin level, which may lead to anaemia. So, please regularly check your haemoglobin level if you are taking Bozetan 125mg Tablet.

Drug-Drug Interactions Checker List

  • AMIODARONE
  • ATORVASTATIN
  • SIMVASTATIN
  • ERYTHROMYCIN
  • RIFAMPICIN
  • FLUCONAZOLE
  • ITRACONAZOLE
  • KETOCONAZOLE
  • RITONAVIR
  • WARFARIN
  • CYCLOSPORINE
  • GLIBENCLAMIDE
  • SILDENAFIL
  • TADALAFIL

Special Advise

  • A blood test to check liver function should be regularly.
  • Blood test for low haemoglobin level should be checked regularly as it could be a sign of anaemia.
  • The pregnancy test is a must for women of childbearing potential.

Disease/Condition Glossary

 ,  ,Pulmonary arterial hypertension (PAH): High pressure in the blood vessels that carry blood from the heart to the lungs. It can be due to constriction of blood vessels or some blockage in blood vessels' pathway.

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