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  3. Calquence 100 mg Capsule 6's

Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Composition :

ACALABRUTINIB-100MG

Manufacturer/Marketer :

Astra Zeneca Pharma India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Calquence 100 mg Capsule

Calquence 100 mg Capsule is a tyrosine kinase inhibitor or cancer growth inhibitor that is primarily used to treat people with mantle cell lymphoma (MCL) who have had at least one prior treatment for their malignancy (cancer), as well as adults with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL). Cancer is caused by a genetic mutation that causes our cells to divide uncontrollably and spread into neighbouring tissues.

Calquence 100 mg Capsule contains Acalabrutinib, a tyrosine kinase inhibitor. Tyrosine kinases are enzymes in the body that transmit signals to cells, telling them to grow and divide. Acalabrutinib inhibits these signals to cancer cells. Cells die when their signals are disrupted. This could help to slow the progression of the cancer.

To treat your condition effectually, continue using Calquence 100 mg Capsule for as long as your doctor has prescribed it. The most common adverse reactions are anaemia (lack of blood), neutropenia (low count of neutrophils), upper respiratory tract infection, thrombocytopenia (Low platelet level), headache, diarrhoea, and musculoskeletal pain. You should talk to your doctor if you persistently experience these side effects.

It is recommended not to use if you are hypersensitive to any component present in Calquence 100 mg Capsule and suffer from Severe Hepatic Impairment. Calquence 100 mg Capsule can cause fetal harm when administered to a pregnant woman. It is critical not to become pregnant or get pregnant while undergoing therapy and for several months after the treatment. Using effective contraceptive methods is recommended while on therapy with Calquence 100 mg Capsule. Contact your doctor immediately if you or your partner becomes pregnant while undergoing therapy. Breastfeeding is usually not advised during this treatment. Alcohol should be avoided during treatment with this medicine. Safety and effectiveness in children have not been established.

Uses of Calquence 100 mg Capsule

Mantle cell lymphoma (MCL), chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL)

Directions for Use

Calquence 100 mg Capsule should be swallowed as a whole with a glass of water. Do not crush, chew, or break the tablets. The doctor determines the dose and duration based on your health condition.

Medicinal Benefits

Calquence 100 mg Capsule is primarily used to treat people with mantle cell lymphoma (MCL) who have had at least one prior treatment for their malignancy, as well as adults with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL). Calquence 100 mg Capsule contains Acalabrutinib, a tyrosine kinase inhibitor. Tyrosine kinases are enzymes in the body that send signals to cells, directing them to grow and divide. Acalabrutinib blocks these signals to cancer cells. Cancer cells die when their signals are interrupted. This could help to delay the progression of the cancer.

Storage

Keep out of sight and reach of children.
Side effects of Calquence 100 mg Capsule
  • Stay hydrated by taking fluids like water, juices and soups etc.
  • Eat fruits and vegetables which contain vitamins.
  • Take iron rich food like dry fruits, green leafy vegetables and sea food etc.
  • Reduce intake of milk, cheese, yogurt, soy, chocolate, ice cream, Grapes, Popcorn, canned salmon, pomegranate.
  • Regular exercise like walking, jogging is helpful.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Avoid taking raw fruits, nuts and vegetables.
  • Do not share your personal things with others like toothbrushes.
  • Clean the wounds and cuts using soap and water.
  • Wash your hands thoroughly and frequently and maintain hygiene.
  • Get a good quality of sleep.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Drug Warnings

Before taking the Calquence 100 mg Capsule, inform your doctor about all your medical conditions, sensitivities, and medications you are using. If you are a woman capable of having children, you should use an effective method of contraception during Acalabrutinib treatment and for at least one week after the last dose. If you are a man, you should use a barrier method of contraception to prevent your partner from becoming pregnant while taking Acalabrutinib and for at least one week after the last dose. Unless the doctor suggests, do not use any other medicine, including herbal or vitamin supplements.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Calquence 100 mg Capsule:
When Calquence 100 mg Capsule is taken with Erythromycin, the amount of Calquence 100 mg Capsule in the blood can increase.

How to manage the interaction:
Taking Erythromycin with Calquence 100 mg Capsule together can result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these signs and symptoms - feeling sick, diarrhea, stomach pain, bleeding, feeling weak, dizzy, faint, fever, sore throat, muscle pain, trouble breathing, or pain while urinating - make sure to call your doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Calquence 100 mg Capsule:
Coadministration of Fosaprepitant with Calquence 100 mg Capsule can reduce the metabolism and increase the levels of Calquence 100 mg Capsule in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Fosaprepitant with Calquence 100 mg Capsule together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Calquence 100 mg Capsule:
The combined use of Calquence 100 mg Capsule and Diclofenac Diethylamine can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Calquence 100 mg Capsule and Diclofenac Diethylamine can lead to an interaction, but it can be taken if a doctor advises. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, tarry stools, coughing up or vomiting blood, severe headache, or weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Calquence 100 mg Capsule:
Taking clopidogrel with Calquence 100 mg Capsule may increase the risk of bleeding.

How to manage the interaction:
There could be a possible interaction between clopidogrel and Calquence 100 mg Capsule, but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience any unusual bleeding or have other signs of bleeding, like feeling dizzy or lightheaded, red or black, sticky stools, or severe headaches. Do not discontinue any medication without consulting your doctor.
How does the drug interact with Calquence 100 mg Capsule:
Taking Verapamil with Calquence 100 mg Capsule can significantly increase the blood levels of Calquence 100 mg Capsule.

How to manage the interaction:
Although taking verapamil and Calquence 100 mg Capsule together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, headache, shortness of breath, chest pain or tightness, rapid heartbeat, fever, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Calquence 100 mg Capsule:
Using dasatinib together with Calquence 100 mg Capsule may increase the risk of bleeding.

How to manage the interaction:
Although taking Dasatinib and Calquence 100 mg Capsule together can cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these symptoms - like difficulty with blood clotting, bleeding, complications, bruising, feeling dizzy or lightheaded, having red or black stools, coughing up blood, experiencing severe headaches, weakness, or vomiting - make sure to contact a doctor right away. Do not stop using any medications without talking to a doctor.
How does the drug interact with Calquence 100 mg Capsule:
Taking Calquence 100 mg Capsule with posaconazole can considerably raise Calquence 100 mg Capsule levels in the blood. This may increase the side effects such as infections, abnormal heart rhythm, and bleeding.

How to manage the interaction:
Although using posaconazole and Calquence 100 mg Capsule together can result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor if you experience dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination.
How does the drug interact with Calquence 100 mg Capsule:
Taking Rabeprazole together with Calquence 100 mg Capsule results in a decreased effectiveness of Calquence 100 mg Capsule.

How to manage the interaction:
Although taking Rabeprazole and Calquence 100 mg Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Calquence 100 mg Capsule:
Taking Ciprofloxacin with Calquence 100 mg Capsule may increase your risk of acquiring irregular heart rhythm, anemia, bleeding issues, or infections.

How to manage the interaction:
Co-administration of Ciprofloxacin with Calquence 100 mg Capsule can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience paleness, exhaustion, dizziness, fainting, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, pain in the muscles, breathing difficulty, blood in the phlegm, weight loss, red or irritated skin, body sores, and discomfort or burning when urinating, consult the doctor.
How does the drug interact with Calquence 100 mg Capsule:
Using Calquence 100 mg Capsule together with ketorolac may increase the risk of bleeding.

How to manage the interaction:
Although there is a interaction between Ketorolac and Calquence 100 mg Capsule, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual bleeding, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • After your treatment begins, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs, and added sugars.

Side Effects of Calquence 100 mg Capsule

  • Feeling sick (nausea)
  • Being sick (vomiting)
  • Fatigue (
  • Anaemia (lack of blood)
  • Neutropenia (low count of neutrophils)
  • Upper respiratory tract infection
  • Thrombocytopenia (low platelet level)
  • Headache
  • Diarrhea
  • Musculoskeletal pain (myalgia)
  • Abdominal pain
  • Fatigue (tiredness)
  • Bruising
  • Rash
  • Haemorrhage (bleeding)
  • Epistaxis (nosebleed)

Habit Forming

No

Therapeutic Class

KINASE INHIBITORS

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Calquence 100 mg Capsule contains Acalabrutinib, a tyrosine kinase inhibitor. Tyrosine kinases are enzymes in the body that send signals to cells, directing them to grow and divide. Acalabrutinib blocks these signals to cancer cells. Cancer cells die when their signals are interrupted. This could help to delay the progression of the cancer.

While taking Calquence 100 mg Capsule, make sure you visit your doctor at all the appointments to ensure that treatment works. Regular monitoring of blood and lipid tests and weight checks are required. An effective way of contraception should be used by both men and women while taking the Calquence 100 mg Capsule.

Mantle cell lymphoma (MCL) is diagnosed by taking a biopsy of tumour tissue and examining the cells under a microscope.

You can take the missed dose if you forget to take your acalabrutinib, which is less than 3 hours after your usual time. Then, take the next dose at the regular time. Do not take your missed dose if more than 3 hours have passed. Wait and take the next dose at the regular time. Do not take a double dose to make up for a missing one.

Drug-Drug Interactions Checker List

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Special Advise

  • Keep all of your doctor's and laboratory appointments.
  • Pregnancy testing is recommended prior to starting treatment with Calquence 100 mg Capsule.

Disease/Condition Glossary

Cancer: Cancer is a genetic change in which our cells divide uncontrollably and spread into surrounding tissues. There are two types of cancer: benign (localized) and metastatic (spread to the whole body). Types of cancer include blood, lung, breast, etc. Cancer growth can be prevented by chemotherapy, radiation, and stem cell therapy.

Mantle Cell lymphoma (MCL): Mantle Cell lymphoma (MCL) is an aggressive, rare form of non-Hodgkin lymphoma (NHL) that arises from cells originating in the “mantle zone.” The mantle zone is the outer ring of small lymphocytes surrounding the centre of a lymphatic nodule.

Have a query?

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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Calquence 100 mg Capsule.

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Pregnancy

Unsafe

Calquence 100 mg Capsule should not be used during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

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Breast Feeding

Unsafe

Calquence 100 mg Capsule should not be used in breastfeeding. Discuss with your doctor if you have any concerns.

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Driving

Caution

Calquence 100 mg Capsule does not influence the ability to drive or use machines. However, go only if you are alert, as the Calquence 100 mg Capsule may cause tiredness in some people.

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Liver

Caution

Avoid using Calquence 100 mg Capsule in patients with severe hepatic impairment. The safety of Calquence 100 mg Capsule has not been evaluated in patients with moderate or severe hepatic impairment. So, caution should be exercised while using Calquence 100 mg Capsule in patients with liver impairment. If you have a pre-existing or a history of liver disease, inform your doctor before taking the Calquence 100 mg Capsule. Your doctor will weigh the benefits and potential risks before prescribing Calquence 100 mg Capsule.

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Kidney

Caution

Caution should be exercised while using Calquence 100 mg Capsule in patients with kidney impairment. If you have a pre-existing or a history of kidney disease, inform your doctor before taking the Calquence 100 mg Capsule. Your doctor will weigh the benefits and potential risks before prescribing Calquence 100 mg Capsule.

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Children

Caution

Safety and effectiveness in patients below the age of 18 years have not been established. Hence, use is not recommended.

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