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  3. Cardiomart AP 5mg/4mg Tablet

Written By Santoshini Reddy G , M Pharmacy
Reviewed By Hari Kumar , MBBS
Cardiomart AP 5mg/4mg Tablet, Pack of 1 Tablet
Cardiomart AP 5mg/4mg Tablet, Pack of 1 Tablet
Non returnable*
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Composition :

AMLODIPINE-5MG + PERINDOPRIL ERBUMINE-4MG

Consume Type :

ORAL

Return Policy :

Not Returnable

About Cardiomart AP 5mg/4mg Tablet

Cardiomart AP 5mg/4mg Tablet belongs to the group of anti-hypertensive medicines used to treat high blood pressure (hypertension). Additionally, it is also used to treat stable coronary artery disease. High blood pressure is a condition in which the blood exerts increased pressure on the walls of blood vessels. Stable coronary artery disease is a condition in which the blood supply to the heart is blocked or reduced.
 
Cardiomart AP 5mg/4mg Tablet is a combination of two drugs, namely: Amlodipine and Perindopril erbumine. Amlodipine relaxes the blood vessels, thereby improves blood flow. Perindopril erbumine widens the blood vessels, making it easier for the heart to pump blood through them. Together, Cardiomart AP 5mg/4mg Tablet helps lower the blood pressure, thereby reduces the chances of heart problems such as heart attack and stroke.  
 
You are advised to take Cardiomart AP 5mg/4mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as oedema, headache, dizziness, nausea, and abdominal pain. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.
 
Cardiomart AP 5mg/4mg Tablet is not recommended during early pregnancy and should not be taken when more than 3months pregnant as it may cause serious harm to the baby. Cardiomart AP 5mg/4mg Tablet is not recommended for breastfeeding mothers and children. Cardiomart AP 5mg/4mg Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Inform your doctor about all the medicines you are taking and your health condition to rule out any unpleasant side effects.

Uses of Cardiomart AP 5mg/4mg Tablet

Hypertension (high blood pressure), stable coronary artery disease

Directions for Use

Take Cardiomart AP 5mg/4mg Tablet before a meal. Swallow Cardiomart AP 5mg/4mg Tablet as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Cardiomart AP 5mg/4mg Tablet is a combination of two drugs, namely: Amlodipine and Perindopril erbumine. Cardiomart AP 5mg/4mg Tablet belongs to the group of anti-hypertensive medicines used to treat high blood pressure (hypertension) and/or stable coronary artery disease. Amlodipine is a calcium channel blocker that relaxes the blood vessels, thereby improving blood flow. Perindopril erbumine is an angiotensin-converting enzyme inhibitor that widens the blood vessels; this makes it easier for the heart to pump blood through them. Together, Cardiomart AP 5mg/4mg Tablet helps treat hypertension, thereby reducing the chances of heart problems such as heart attack and stroke.

Storage

Keep Cardiomart AP 5mg/4mg Tablet out of reach and sight of children.
Side effects of Cardiomart AP 5mg/4mg Tablet
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Drug Warnings

Do not take Cardiomart AP 5mg/4mg Tablet if you are allergic to any of its contents; if you have angioedema, severe water retention, low blood pressure, or low blood potassium. Inform your doctor if you have diabetes, heart problems, gout, parathyroid gland problems, heart failure, collagen disease, atherosclerosis (hardening of arteries), excess acid in the blood, liver/kidney problems, if you are on a low-salt diet, if you are taking lithium/potassium-sparing diuretics, or if you are taking any other blood pressure-lowering medicines. Cardiomart AP 5mg/4mg Tablet is not recommended during early pregnancy and should not be taken when more than 3 months pregnant as it may cause serious harm to the baby. Cardiomart AP 5mg/4mg Tablet is not recommended for breastfeeding mothers and children. Cardiomart AP 5mg/4mg Tablet may cause dizziness, so drive with caution. Keep your doctor informed about your health condition and medications to rule out any interactions.

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
PerindoprilAliskiren
Critical

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
How does the drug interact with Cardiomart AP 5mg/4mg Tablet:
Using Cardiomart AP 5mg/4mg Tablet together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Cardiomart AP 5mg/4mg Tablet with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
PerindoprilAliskiren
Critical
How does the drug interact with Cardiomart AP 5mg/4mg Tablet:
Combining Aliskiren with Cardiomart AP 5mg/4mg Tablet can increase the risk of low blood pressure, high potassium levels, and kidney damage.

How to manage the interaction:
Taking Cardiomart AP 5mg/4mg Tablet with Aliskiren is not recommended, but can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
AmlodipineRifapentine
Severe
How does the drug interact with Cardiomart AP 5mg/4mg Tablet:
Coadministration of Cardiomart AP 5mg/4mg Tablet and Rifapentine may significantly reduce the blood levels of Cardiomart AP 5mg/4mg Tablet, which may make the medication less effective.

How to manage the interaction:
There may be a possibility of interaction between Cardiomart AP 5mg/4mg Tablet and Rifapentine, but it can be taken if prescribed by a doctor. If you have any symptoms, make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
AmlodipineCarbamazepine
Severe
How does the drug interact with Cardiomart AP 5mg/4mg Tablet:
Coadministration of Cardiomart AP 5mg/4mg Tablet and carbamazepine together may significantly reduce Cardiomart AP 5mg/4mg Tablet blood levels, making the medicine less effective.

How to manage the interaction:
Although there is an interaction between Cardiomart AP 5mg/4mg Tablet with carbamazepine, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact the doctor immediately. Do not stop using any medications without talking to a doctor.
AmlodipineFosphenytoin
Severe
How does the drug interact with Cardiomart AP 5mg/4mg Tablet:
When Cardiomart AP 5mg/4mg Tablet is taken with Fosphenytoin, it may decrease the blood levels of Cardiomart AP 5mg/4mg Tablet, which may make Cardiomart AP 5mg/4mg Tablet less effective.

How to manage the interaction:
Although taking Cardiomart AP 5mg/4mg Tablet and Fosphenytoin together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without a doctor's advice.
AmlodipinePhenobarbital
Severe
How does the drug interact with Cardiomart AP 5mg/4mg Tablet:
Using phenobarbital and Cardiomart AP 5mg/4mg Tablet may drastically lower Cardiomart AP 5mg/4mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although co-administration of phenobarbital with Cardiomart AP 5mg/4mg Tablet can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AmlodipineRifampicin
Severe
How does the drug interact with Cardiomart AP 5mg/4mg Tablet:
Coadministration of Cardiomart AP 5mg/4mg Tablet and rifampicin together may lower Cardiomart AP 5mg/4mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although there is an interaction between Cardiomart AP 5mg/4mg Tablet and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
AmlodipinePhenytoin
Severe
How does the drug interact with Cardiomart AP 5mg/4mg Tablet:
Using Cardiomart AP 5mg/4mg Tablet and phenytoin together may drastically lower Cardiomart AP 5mg/4mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although Cardiomart AP 5mg/4mg Tablet with phenytoin can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AmlodipineSimvastatin
Severe
How does the drug interact with Cardiomart AP 5mg/4mg Tablet:
Taking simvastatin with Cardiomart AP 5mg/4mg Tablet may result in considerably higher blood levels of simvastatin and may increase the risk of side effects (liver damage and rhabdomyolysis - an uncommon but serious illness characterized by the breakdown of skeletal muscle tissue).

How to manage the interaction:
Although taking Cardiomart AP 5mg/4mg Tablet with simvastatin can result in an interaction, it can be taken if a doctor has advised it. If you have unexplained muscular pain, soreness, or weakness while using simvastatin, especially if these symptoms are accompanied by fever or dark-colored urine, consult the doctor immediately. However, if you develop a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, consult the doctor. Do not stop using any medications without a doctor's advice.
AmlodipineNitisinone
Severe
How does the drug interact with Cardiomart AP 5mg/4mg Tablet:
Coadministration of Cardiomart AP 5mg/4mg Tablet and Nitisinone may increase the blood levels and effects of Nitisinone.

How to manage the interaction:
Taking Nitisinone with Cardiomart AP 5mg/4mg Tablet together can result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these symptoms or if you feel unwell after taking your medication, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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AMLODIPINE-5MG+PERINDOPRIL ERBUMINE-4MGPotassium rich foods
Moderate

Drug-Food Interactions

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AMLODIPINE-5MG+PERINDOPRIL ERBUMINE-4MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Taking Cardiomart AP 5mg/4mg Tablet with potassium-containing salt substitutes or potassium supplements can cause high levels of potassium in the blood. Avoid taking potassium-containing salt substitutes or potassium supplements while being treated with Cardiomart AP 5mg/4mg Tablet.

Diet & Lifestyle Advise

  • You are advised to consume low salt and low-fat diet. 
  • Regular exercise is also recommended.
  • Eat a diet rich in whole grains, vegetables, and fruits.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight with proper diet and exercise.
  • Practice meditation or yoga as it helps in managing stress.

Side Effects of Cardiomart AP 5mg/4mg Tablet

  • Oedema
  • Headache
  • Dizziness
  • Flushing
  • Light-headedness due to low blood pressure
  • Tiredness
  • Weakness
  • Nausea
  • Vomiting

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Cardiomart AP 5mg/4mg Tablet Substitute

Substitutes safety advice

Product Substitutes

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Hari Kumar

Reviewed By

Hari Kumar

MBBS

Last Updated

Jul 8, 2025 | 9:44 AM IST

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Cardiomart AP 5mg/4mg Tablet contains Amlodipine and Perindopril erbumine. Amlodipine relaxes the blood vessels, thereby improving blood flow. Perindopril erbumine widens the blood vessels; this makes it easier for the heart to pump blood through them. Together, Cardiomart AP 5mg/4mg Tablet helps treat high blood pressure.

Cardiomart AP 5mg/4mg Tablet may cause palpitations, a sensation that the heart is racing, pounding, or fluttering. A minor fluctuation should not be a worry; however, if palpitations continue or you begin to feel unwell, speak with your doctor.

High blood pressure increases the workload on the arteries and heart. If untreated, it could damage the blood vessels of the heart, brain, and kidney and might result in stroke, heart failure or kidney failure. Hypertension increases the risk of heart attacks. Therefore, anti-hypertensives such as Cardiomart AP 5mg/4mg Tablet are used to lower the blood pressure to normal; this reduces the risk of developing these disorders.

Do not stop taking Cardiomart AP 5mg/4mg Tablet without consulting your doctor, as it may lead to a rise in blood pressure. To treat your condition effectually, continue taking Cardiomart AP 5mg/4mg Tablet for as long as your doctor has prescribed it. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Cardiomart AP 5mg/4mg Tablet.

Light-headedness could be a side-effect of Cardiomart AP 5mg/4mg Tablet. It occurs due to low blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking; instead, lie down and get up slowly only when you feel better. People taking Cardiomart AP 5mg/4mg Tablet are advised to regularly monitor their blood pressure levels to avoid unpleasant events.

Avoid consuming grapefruit and grapefruit juice whilst taking Cardiomart AP 5mg/4mg Tablet as it might increase the blood levels of amlodipine; this can lead to an unpredictable increase in the blood pressure-lowering effect of Cardiomart AP 5mg/4mg Tablet. Inform your doctor if you are on a salt-restricted diet, use salt substitutes or if you are taking potassium supplements.

Drug-Drug Interactions Checker List

  • LITHIUM
  • DANTROLENE
  • ESTRAMUSTINE
  • SACUBITRIL+VALSARTAN
  • TRIAMTERENE
  • AMILORIDE
  • ALISKIREN
  • HEPARIN
  • TRIMETHOPRIM+SULFAMETHOXAZOLE
  • EPLERENONE
  • SPIRONOLACTONE

Special Advise

  • Regular monitoring of blood pressure levels, kidney function and electrolyte levels while taking Cardiomart AP 5mg/4mg Tablet is advised.
  • If you are due to undergo any surgery, inform the doctor that you are taking Cardiomart AP 5mg/4mg Tablet.

Disease/Condition Glossary

High blood pressure (hypertension): It is a condition in which the blood exerts increased pressure on the walls of blood vessels leading to hypertension. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Raised blood pressure can cause chest pain (angina) and heart attack (when the blood supply to the heart is blocked). High blood pressure also causes brain damage (stroke) and kidney failure. Symptoms of high blood pressure include headache, dizziness, nose bleed, changes in vision, chest pain, weakness and dyspnoea (shortness of breath). However, most of the time, the signs and symptoms of hypertension are none.

Stable coronary artery disease: It is a condition in which the blood supply to the heart is blocked or reduced. Atherosclerosis (build-up of plaque in the arteries) is the main cause of stable coronary artery disease.

Have a query?

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Alcohol

Caution

Avoid consuming alcohol as it might cause increased dizziness.

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Pregnancy

Unsafe

Cardiomart AP 5mg/4mg Tablet is not recommended during early pregnancy and should not be taken when more than 3 months pregnant as it may cause serious harm to the baby. Please consult your doctor if you are pregnant, think you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Cardiomart AP 5mg/4mg Tablet is not recommended for breastfeeding mothers. Talk to your doctor if you have any concerns.

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Driving

Caution

Cardiomart AP 5mg/4mg Tablet may cause dizziness, do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have liver problems or any concerns regarding this. Avoid taking Cardiomart AP 5mg/4mg Tablet if you have severe liver disease or hepatic encephalopathy.

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Kidney

Caution

Dose adjustment may be needed. Avoid taking Cardiomart AP 5mg/4mg Tablet if you have severe kidney problems. Please consult your doctor if you have kidney problems or any concerns regarding this.

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Children

Unsafe

Cardiomart AP 5mg/4mg Tablet is not recommended for children as safety and effectiveness have not been established.

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