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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

Online payment accepted

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Composition :

CARMUSTINE-100MG

Manufacturer/Marketer :

Therdose Pharma Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Carmuther 100 Injection

Carmuther 100 Injection is a chemotherapeutic medicine used in the treatment of brain tumors. A tumor is defined as the formation of solid mass tissue due to the abnormal growth of cells. A brain tumor is a serious condition where the cells (cancerous or non-cancerous) grow abnormally in the brain. Carmuther 100 Injection is also used in the treatment of multiple myeloma in combination with prednisone, Hodgkin’s Disease, and non-Hodgkin’s Disease in combination with other approved drugs.

Carmuther 100 Injection contains Carmustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells.

Carmuther 100 Injection may cause certain side effects, such as nausea, vomiting, headache, pale skin, dizziness, stomach upset, tiredness, loss of balance, and pain at the site of injection. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Carmuther 100 Injection is a parenteral preparation. A trained healthcare professional will administer it. Hence, do not self-administer.

Carmuther 100 Injection should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before administration, inform your doctor if you have liver/kidney disease, cardiac disorders, or respiratory conditions. Carmuther 100 Injection may cause pulmonary toxicity, bone marrow suppression, gastrointestinal toxicity, nephrotoxicity and hepatotoxicity in some patients. Hence, careful monitoring should be done during the entire treatment. This medicine is known to cause fetal harm in pregnant women. Hence, inform your doctor if you are pregnant or are planning to become pregnant. Breastfeeding should be discontinued in nursing mothers during the treatment.

Uses of Carmuther 100 Injection

Brain Tumors, Multiple Myeloma, Hodgkin’s Disease, Non-Hodgkin’s Disease.

Directions for Use

Carmuther 100 Injection will be administered by a trained healthcare professional. Hence, do not self-administer. 

Medicinal Benefits

Carmuther 100 Injection contains Carmustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells.

Storage

Store in a cool and dry place away from sunlight
Side effects of Carmuther 100 Injection
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
Managing Medication-Triggered UTIs: A Comprehensive Approach
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.
  • Rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

Drug Warnings

Carmuther 100 Injection should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before administration, inform your doctor if you have liver/kidney disease, cardiac disorders, or respiratory conditions. Carmuther 100 Injection may cause pulmonary toxicity, bone marrow suppression, gastrointestinal toxicity, nephrotoxicity and hepatotoxicity in some patients. Hence careful monitoring should be done during the entire treatment. This medicine is known to cause fetal harm in pregnant women. Hence, inform your doctor if you are pregnant or are planning to become pregnant. Breastfeeding should be discontinued in nursing mothers during the treatment. It is unknown whether Carmuther 100 Injection can be administered in children or not. If administered, close monitoring of the child is needed. Avoid alcohol consumption and smoking as it can lead to serious adverse effects.

Drug-Drug Interactions

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CarmustineClozapine
Severe
CarmustineBaricitinib
Severe

Drug-Drug Interactions

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CarmustineClozapine
Severe
How does the drug interact with Carmuther 100 Injection:
Combining Carmuther 100 Injection with Clozapine can increase the risk of neutropenia.

How to manage the interaction:
Taking Clozapine with Carmuther 100 Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience any of these symptoms - severe infection, fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, or pain during urination, contact your doctor immediately. Do not stop using any medications without talking to a doctor.
CarmustineBaricitinib
Severe
How does the drug interact with Carmuther 100 Injection:
Coadministration of baricitinib and Carmuther 100 Injection can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Carmuther 100 Injection if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
CarmustineEtanercept
Severe
How does the drug interact with Carmuther 100 Injection:
When Etanercept is used with Carmuther 100 Injection, the severity of infection may increase.

How to manage the interaction:
Co-administration of Etanercept with Carmuther 100 Injection can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
CarmustineCladribine
Severe
How does the drug interact with Carmuther 100 Injection:
Taking Cladribine with Carmuther 100 Injection can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Cladribine and Carmuther 100 Injection, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CarmustineInfliximab
Severe
How does the drug interact with Carmuther 100 Injection:
When Carmuther 100 Injection is taken with Infliximab it can increase the risk or severity of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Infliximab and Carmuther 100 Injection, but it can be taken if prescribed by a doctor. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, losing weight, or experiencing pain or burning while urinating, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
CarmustineLeflunomide
Severe
How does the drug interact with Carmuther 100 Injection:
Combining Carmuther 100 Injection with Leflunomide can increase the risk of negative side effects.

How to manage the interaction:
Co-administration of Carmuther 100 Injection with Leflunomide can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms - liver problems, complications, infection, fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, pain, joint pain, swelling, bruising, skin rash, itching, loss of appetite, tiredness, nausea, vomiting, dark urine or bleeding - contact your doctor right away. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • After your treatment begins, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Carmuther 100 Injection Substitute

Substitutes safety advice
  • CONSIUM 100MG INJECTION

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    5017.60per tablet
  • Bicnu 100 mg Injection 1's

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    5330.00per tablet
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  • Carstim 100 mg Combipack Injection 1's

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  • Nitsum 100 mg Injection 1's

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Carmuther 100 Injection contains Carmustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis.

Carmuther 100 Injection may cause pulmonary toxicity, bone marrow suppression, gastrointestinal toxicity, nephrotoxicity and hepatotoxicity in some patients. Hence, inform your oncologist about your complete medical history, including current medication, to rule out any side effects/interactions.

Drug-Drug Interactions Checker List

  • ABACAVIR
  • ZIDOVUDINE
  • ADEFOVIR
  • ABATACEPT
  • ETANERCEPT
  • ACENOCOUMAROL
  • WARFARIN
  • PHENYTOIN

Special Advise

  • Carmuther 100 Injection should be administered only by a trained and experienced oncologist.
  • A blood test should be performed such as LFT, RFT, and PFT, to check for liver/kidney function, and pulmonary function.
  • Weekly blood tests should be done for at least six weeks after the dose is administered to check for CBC (Complete blood count).
  • Carmuther 100 Injection should be administered carefully without touching the skin as it can cause serious hyperpigmentation. Hence where gloves during administration.

Disease/Condition Glossary

Brain Tumors: It is a serious condition where the cells (cancerous or non-cancerous) grow abnormally in the brain. A tumor is defined as the formation of solid mass tissue due to the abnormal growth of cells. There are different types of brain tumors which can be either benign (non-cancerous) or malignant (cancerous). Carmuther 100 Injection is used in the treatment of glioblastoma (a malignant tumor that occurs in the brain and spinal cord), brainstem glioma (a tumor that affects the brain stem of the CNS), medulloblastoma (a cancerous tumor that mostly occurs in children affecting the cerebellum (lower back part of the brain)), astrocytoma (growth of cells in astrocytes which support and connect nerve cells), ependymoma (a tumor that occurs outside the CNS or within the brain parenchyma, and metastatic brain tumors.

Hodgkin’s Disease: Hodgkin’s disease or lymphoma is a blood cancer of a certain type of cells called WBCs, specifically lymphocytes. Lymphocytes normally help control infection and maintain the body's normal immunity. However, in a cancerous state, there is an abnormal multiplication of these blood cells, causing many problems such as fatigue, fever, loss of appetite, itching, night sweats and lymph node swelling.

Multiple myeloma: It is a type of cancerous tumor that affects the plasma cells of the bone marrow. These cells collect in the bone marrow and divide uncontrollably, leading to kidney and bone damage. Symptoms include bone pain, loss of appetite, fever, and frequent infections. Generally, multiple myeloma cannot be cured, but the signs and symptoms can be reduced greatly or disappear after a period of time.

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