Celginase 10000 Injection 1's

Written By Veda Maddala , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

MRP ₹1792.5

(Inclusive of all Taxes)

₹268.9 Cashback (15%)

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Non returnable*

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Prescription drug

Whats That

About Celginase 10000 Injection

Celginase 10000 Injection belongs to the class of medicines called antineoplastic (anticancer) agents used in the treatment of acute lymphoblastic leukaemia (a type of blood and bone marrow cancer). Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer. It is a type of blood cancer which causes excessive production of lymphocytes (a type of white blood cells) by the bone marrow.

Celginase 10000 Injection contains L Asparaginase which works by lowering asparagine levels in the body, which is necessary for the survival of cancer cells. Thus, Celginase 10000 Injection stops the cancer cells from dividing and growing.

Celginase 10000 Injection will be administered by a healthcare professional; do not self-administer. Sometimes, Celginase 10000 Injection may cause common side effects such as nausea, weight loss, generalised pain or muscle pain, infections or a decrease in normal blood content. Most of these side effects of Celginase 10000 Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to L asparaginase or other medicines, please tell your doctor. You are recommended to avoid breastfeeding during treatment with Celginase 10000 Injection as there may be a risk to the feeding child. If you are pregnant or planning pregnancy, please inform your doctor before receiving Celginase 10000 Injection. Also, you are recommended to use effective contraceptive methods before and for at least 3 months after treatment with Celginase 10000 Injection to prevent pregnancy. Celginase 10000 Injection is given to children in doses as advised by the doctor, depending on the age. Avoid driving after receiving Celginase 10000 Injection as it may cause drowsiness or dizziness.

Uses of Celginase 10000 Injection

Acute lymphoblastic leukaemia

Directions for Use

Celginase 10000 Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Celginase 10000 Injection contains L Asparaginase, an anticancer agent used in the treatment of acute lymphoblastic leukaemia (a type of blood and bone marrow cancer). It lowers the levels of asparagine in the body, which is necessary for the survival of cancer cells. Thus, Celginase 10000 Injection stops the cancer cells from dividing and growing.

Storage

Keep Celginase 10000 Injection out of reach and sight of children.

Side effects of Celginase 10000 Injection

Severe Allergic Reaction

If you experience or encounter any severe allergic reaction, stop using medication and consult the doctor right away.
Tell your doctor about the allergic reaction, including the medication taken and any symptoms experienced.
Your doctor will evaluate the severity of the reaction and determine the best course of action.
To ensure a full recovery, follow your doctor's advice, attend scheduled follow-up appointments, and undergo recommended tests to monitor progress and adjust treatment as needed.

Allergic Reactions

Managing Medication-Related Skin Allergies: A Step-by-Step Guide

If you experience signs of skin allergies such as redness, itching, or irritation after taking medication, contact your doctor right away.
To alleviate skin allergy symptoms, your doctor may change your medication regimen or offer tailored medication management advice.
Your doctor may recommend or prescribe drugs to relieve discomfort.
Cool compresses or calamine lotion can help relieve redness and itching on the afflicted skin area.
Staying hydrated by consuming plenty of water can help relieve discomfort.
Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

Abnormal liver function test

High Body Temperature

Here's a comprehensive approach to managing medication-triggered fever:

Inform your doctor immediately if you experience a fever after starting a new medication.
Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
Monitor your body temperature to monitor fever progression.
Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Inflammation Of Pancreas

Managing Medication-Triggered Pancreatitis: A Step-by-Step Guide:

If you take medication and get severe stomach pain, feel nauseous, vomit, or have a fever, get emergency medical help right away. This could be a sign of pancreatitis, an inflammation of the pancreas.
Your doctor may alter your treatment plan, provide supportive therapy, or prescribe alternative medications to manage the reaction. They will also perform regular tests to monitor your progress and adjust your treatment as needed.
Follow your doctor's advice, including dietary recommendations and lifestyle changes, and avoid triggers like alcohol and fatty foods.
Monitor your condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

Reaction At The Site Of Something

Inform your physician if you notice redness, heat, swelling, or pus since these are infection signs.
Your physician can prescribe medication to reduce symptoms and promote healing.
Do not scratch to prevent irritation and infection.
Clean and dry the area to prevent infection.
Apply heat or cold packs to reduce pain and swelling.
Massage the area lightly to promote blood flow and reduce swelling.
Inform your physician if you notice signs of infection such as redness, swelling, or pus to prevent complications.

Vomiting

To prevent, manage, and treat Constipation caused by medication usage, follow these steps:

Preventing Vomiting (Before it Happens)
Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
Having a small meal before taking your medication can help reduce nausea and vomiting.
Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
Managing Vomiting (If it Happens)
Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
What to Do if Vomiting Persists
Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Drug Warnings

If you are allergic to L asparaginase or any other medicines, please tell your doctor. You are recommended to avoid breastfeeding during treatment with Celginase 10000 Injection as there may be a risk to the feeding child. If you are pregnant or planning for pregnancy, please inform your doctor before receiving Celginase 10000 Injection. Also, you are recommended to use effective contraceptive methods before and for at least three months after treatment with Celginase 10000 Injection to prevent pregnancy. Celginase 10000 Injection is given to children in doses as advised by the doctor, depending on the age. Avoid driving after receiving Celginase 10000 Injection if you experience drowsiness or dizziness. Celginase 10000 Injection may increase the risk of infections. Therefore, consult your doctor if you notice any signs of infection and avoid contact with people having viral infections. If you experience any significant bleeding during treatment with Celginase 10000 Injection, inform your doctor immediately, as Celginase 10000 Injection may affect your body’s ability to prevent excessive bleeding.

Drug-Drug Interactions

AsparaginaseThalidomide

Severe

AsparaginaseLeflunomide

Severe

Drug-Drug Interactions

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AsparaginaseThalidomide

Severe

How does the drug interact with Celginase 10000 Injection:
Taking thalidomide together with Celginase 10000 Injection may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Celginase 10000 Injection together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

AsparaginaseLeflunomide

Severe

How does the drug interact with Celginase 10000 Injection:
Taking Celginase 10000 Injection with leflunomide may raise the risk of severe infections, and liver problems.

How to manage the interaction:
Although there is an interaction between Celginase 10000 Injection and leflunomide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.

AsparaginaseBexarotene

Severe

How does the drug interact with Celginase 10000 Injection:
The use of Celginase 10000 Injection with bexarotene may raise the risk of inflammation of the pancreas.

How to manage the interaction:
Co-administration of Celginase 10000 Injection with Bexarotene can result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor if you have symptoms such as persistent nausea, vomiting, abdominal soreness, and upper abdominal pain, especially if it worsens after eating or extends to the back. Do not stop using any medications without talking to a doctor.

AsparaginaseNatalizumab

Severe

How does the drug interact with Celginase 10000 Injection:
Taking Celginase 10000 Injection with Natalizumab together can increase the risk of developing serious infections.

How to manage the interaction:
Taking Celginase 10000 Injection with Natalizumab together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, discomfort or burning when you urinate, progressive weakness on one side of the body, clumsiness of limbs, disturbance of vision, confusion, or changes in thinking, memory, and personality, consult a doctor. Do not stop using any medications without talking to a doctor.

AsparaginaseMipomersen

Severe

How does the drug interact with Celginase 10000 Injection:
Coadministration of Celginase 10000 Injection and Mipomersen may increase the risk of liver problems.

How to manage the interaction:
Although taking Celginase 10000 Injection and Mipomersen together can evidently cause an interaction, it can be taken if your doctor has suggested it. Call a doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes. Do not stop using any medications without talking to a doctor.

AsparaginaseTeriflunomide

Severe

How does the drug interact with Celginase 10000 Injection:
The use of Celginase 10000 Injection in conjunction with teriflunomide may raise the risk of severe infections, liver problems.

How to manage the interaction:
Co-administration of Celginase 10000 Injection with Teriflunomide can result in an interaction, but it can be taken if a doctor has advised it. However, If you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, consult the doctor. Do not stop using any medications without talking to a doctor.

AsparaginaseLomitapide

Severe

How does the drug interact with Celginase 10000 Injection:
Coadministration of Celginase 10000 Injection and Lopitamide may increase the risk of liver issues.

How to manage the interaction:
Taking Celginase 10000 Injection with Lomitapide together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

AsparaginaseDalteparin

Moderate

How does the drug interact with Celginase 10000 Injection:
Using dalteparin with Celginase 10000 Injection may increase your risk of blood clots or bleeding.

How to manage the interaction:
Although taking Desogestrel and Fosamprenavir together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fast heartbeat, anxiety, constipation, cough, dark urine, diarrhea, dizziness, lightheadedness, fainting, fever, hives or welts, itching skin or rash call your doctor right away. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Maintain a balanced diet including fruits and vegetables rich in nutrients and low-fat proteins like lean meats, fish and poultry.
Drink plenty of water daily during treatment with Celginase 10000 Injection, as some cancer therapies may cause dehydration.
Exercise regularly and maintain a healthy body weight.
Regularly wash your hands and avoid contact with people having infections.
Quit smoking.

Side Effects of Celginase 10000 Injection

Nausea
Vomiting
Weight loss
Generalised pain or muscle pain
Infections
Swelling at the injection site
loss of appetite
headache
lack of energy
drowsiness
Stomach cramps

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

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Author Details

Written By

Veda Maddala

M Pharmacy

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:48 AM IST

We provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does Celginase 10000 Injection work?

Celginase 10000 Injection contains L Asparaginase, an anticancer agent that works by lowering asparagine levels in the body, which is necessary for the survival of cancer cells. Thus, Celginase 10000 Injection stops the cancer cells from dividing and growing.

Does Celginase 10000 Injection increase blood sugar levels?

Celginase 10000 Injection may increase blood sugar levels. This can be controlled by receiving insulin. However, if you notice any symptoms such as increased thirst, dry mouth, frequent urination, tiredness, or blurred vision, please inform your doctor, as these might be symptoms of high blood sugar levels.

Does Celginase 10000 Injection cause stomach pain?

Celginase 10000 Injection may cause stomach pain in some patients. You are advised to inform your doctor immediately if you have stomach pain, as it may be a sign of pancreatitis (inflammation of the pancreas).

Drug-Drug Interactions Checker List

CYTARABINE
METHOTREXATE
VINCRISTINE
PREDNISONE

Special Advise

Your doctor will monitor you closely during and after treatment with Celginase 10000 Injection for normal blood content, allergic reactions, and kidney, pancreas and liver functions.

Disease/Condition Glossary

Acute lymphoblastic leukaemia (ALL): It is a type of blood cancer which causes excessive production of lymphocytes (a type of white blood cells) by the bone marrow. It is the most common childhood cancer. The symptoms include bleeding from gums, weakness, bone pain, joint pain, bruises, extreme tiredness, paleness, enlarged lymph nodes in the neck, groin region or under the arms, fever or shortness of breath. The risk factors include exposure to high levels of radiation, viral infections, inherited syndromes, smoking, prolonged exposure to certain chemicals or chemotherapy drugs or even diesel.