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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

Online payment accepted

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Composition

CLADRIBINE-10MG

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About CLADRIM 10MG INJECTION

CLADRIM 10MG INJECTION belongs to a group of anticancer medicines called purine analogue used in the treatment of hairy cell leukaemia. Leukaemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. 

CLADRIM 10MG INJECTION contains Cladribine, which belongs to the class of purine antimetabolites. It works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes.

CLADRIM 10MG INJECTION may cause certain side effects such as insomnia, dizziness, cough, abdominal pain, rash, constipation, fatigue, vomiting, nausea, headache, cough, constipation, weakness, and pain at the site of injection. Most of these side effects of CLADRIM 10MG INJECTION do not require medical attention and gradually resolve over time. A trained healthcare professional will administer CLADRIM 10MG INJECTION. Hence, do not self-administer.

If you are allergic to CLADRIM 10MG INJECTION, inform your doctor and avoid receiving it. Inform your doctor about your complete medical and medication history before starting treatment with CLADRIM 10MG INJECTION. CLADRIM 10MG INJECTION is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, consult your doctor if you are pregnant, planning to become pregnant or breastfeeding. Let the doctor know if you have/had kidney or liver disease, hemolytic anaemia, or severe bone marrow suppression before starting the treatment, as it may worsen your condition. Inform your doctor if you have received any vaccination before starting the treatment.

Uses of CLADRIM 10MG INJECTION

Hairy cell Leukemia.

Directions for Use

An oncology doctor will administer CLADRIM 10MG INJECTION. Self-administration is not recommended.

Medicinal Benefits

CLADRIM 10MG INJECTION contains Cladribine, which is used in the treatment of multiple sclerosis. It works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes. Thus, CLADRIM 10MG INJECTION stops the multiplication of abnormal cells and causes the death of cancer cells.

Storage

Store in a cool and dry place away from sunlight

Side Effects of CLADRIM 10MG INJECTION

  • Nausea
  • Abdominal pain
  • Constipation
  • Weakness
  • Injection site reactions
  • Pain at the site of injection
  • Headache
  • Dizziness
  • Insomnia
  • Anxiety
  • Muscle pain
  • Rash

Drug Warnings

If you are allergic to CLADRIM 10MG INJECTION, inform your doctor and avoid receiving it. Inform your doctor about your complete medical and medication history before starting treatment with CLADRIM 10MG INJECTION. CLADRIM 10MG INJECTION is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, consult your doctor if you are pregnant, planning to become pregnant or breastfeeding. Let the doctor know if you have/had kidney or liver disease, haemolytic anaemia, severe bone marrow suppression, thrombocytopenia (low number of platelets), or neutropenia (low white blood cells) before starting the treatment, as it may worsen your condition. If you are about to receive any vaccinations, inform your doctor beforehand, as it may cause infection.

Drug-Drug Interactions

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CladribineFluorouracil
Severe
CladribinePenicillamine
Severe

Drug-Drug Interactions

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CladribineFluorouracil
Severe
How does the drug interact with Cladrim 10mg Injection:
Combining Cladrim 10mg Injection with Fluorouracil can increase the risk of side effects.

How to manage the interaction:
Taking Cladrim 10mg Injection with Fluorouracil together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CladribinePenicillamine
Severe
How does the drug interact with Cladrim 10mg Injection:
Taking Cladrim 10mg Injection with penicillamine can increase the risk of developing serious infections.

How to manage the interaction:
Taking Cladrim 10mg Injection with Penicillamine together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CladribinePeginterferon alfa-2b
Severe
How does the drug interact with Cladrim 10mg Injection:
Taking Peginterferon alfa-2b with Cladrim 10mg Injection can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Cladrim 10mg Injection and Peginterferon alfa-2b, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CladribineRucaparib
Severe
How does the drug interact with Cladrim 10mg Injection:
Taking Rucaparib with Cladrim 10mg Injection can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Cladrim 10mg Injection and Rucaparib, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor right away. These symptoms include fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate. Do not stop using any medications without a doctor's advice.
CladribineBetamethasone
Severe
How does the drug interact with Cladrim 10mg Injection:
Co-administration of Cladrim 10mg Injection with Betamethasone can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Betamethasone and Cladrim 10mg Injection together can evidently cause an interaction, it can be taken if a doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CladribineLenalidomide
Severe
How does the drug interact with Cladrim 10mg Injection:
Taking Cladrim 10mg Injection with lenalidomide can increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction between lenalidomide and Cladrim 10mg Injection, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination, consult a doctor. Do not discontinue any medications without consulting a doctor.
CladribineBasiliximab
Severe
How does the drug interact with Cladrim 10mg Injection:
Combining Basiliximab with Cladrim 10mg Injection can increase the risk of serious infections.

How to manage the interaction:
Co-administration of Basiliximab with Cladrim 10mg Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CladribineThalidomide
Severe
How does the drug interact with Cladrim 10mg Injection:
Taking thalidomide together with Cladrim 10mg Injection may increase the risk of blood clots.

How to manage the interaction:
Although taking thalidomide and Cladrim 10mg Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
CladribineParamethadione
Severe
How does the drug interact with Cladrim 10mg Injection:
Using Cladrim 10mg Injection together with paramethadione can increase the risk of developing serious infections.

How to manage the interaction:
Taking Cladrim 10mg Injection with Paramethadione together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CladribineChloramphenicol
Severe
How does the drug interact with Cladrim 10mg Injection:
Taking Cladrim 10mg Injection together with chloramphenicol may increase the risk of infections.

How to manage the interaction:
There may be a possibility of interaction between Cladrim 10mg Injection and Chloramphenicol, but it can be taken if prescribed by a doctor. If you have any of these symptoms - fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination, make sure to contact your doctor right away. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a balanced diet including fruits and vegetables rich in nutrients and low-fat proteins like lean meats, fish and poultry.
  • Drink plenty of water daily while receiving the medication, as some cancer therapies may cause dehydration.
  • Exercise regularly and maintain a healthy body weight.
  • Regularly wash your hands and avoid contact with people having infections.
  • Quit smoking.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Special Advise

Regular blood tests are recommended while receiving CLADRIM 10MG INJECTION to monitor any signs of anemia, neutropenia and thrombocytopenia.

Disease/Condition Glossary

Hairy cell Leukemia: It is a rare type of cancer that occurs in the bone marrow and blood. It increases the number of lymphocytes (a type of white blood cell). The symptoms include fever, enlarged liver, bone or joint pain, shortness of breath, weakness, and bleeding from gums or bruises.

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