Panobinostat
About
Panobinostat belongs to the group of anti-cancer medicines used to treat multiple myeloma. Multiple myeloma, also known as myeloma, is a type of bone marrow cancer that affects several areas of the body, such as the spine, skull, pelvis, and ribs.
Panobinostat contains Panobinostat. It works by blocking the action of histone deacetylase in myeloma cells. Thereby, it can prevent myeloma cells from growing and multiplying.
Depending on your medical condition, you are advised to take Panobinostat for as long as your doctor prescribes it. Sometimes, you may experience common side effects, such as diarrhoea, fatigue, nausea, peripheral oedema, decreased appetite, pyrexia, vomiting and hematologic laboratory abnormalities. Do not be reluctant to talk with your doctor if you persistently experience any of these side effects.
Do not take Panobinostat if you are allergic to any of its components or if you are pregnant. Do not try to become pregnant as Panobinostat may cause Embryo-Fetal Toxicity. Advise women not to breastfeed while taking Panobinostat. Inform your doctor if you are suffering from Hepatic dysfunction, as this increases panobinostat exposure. Your doctor reduces the dose in patients with mild to moderate hepatic (liver) impairment. It is recommended not to be used in people with severe hepatic (liver) impairment. If you feel dizzy or lightheaded when taking panobinostat, you should not operate machinery or drive a car.
Uses of Panobinostat
Medicinal Benefits
Panobinostat contains Panobinostat, which belongs to the anti-cancer medicines used to treat multiple myeloma. It works by blocking the action of histone deacetylase in myeloma cells. Thereby, it can prevent myeloma cells from growing and multiplying.
Directions for Use
Side Effects of Panobinostat
- Nausea
- Vomiting
- Appetite loss
- Feel dizzy
- Lightheaded
- Low blood pressure
- Diarrhea
- Fatigue (tiredness)
- Peripheral edema
- Decreased appetite
- Pyrexia
- Vomiting
- Hematologic laboratory abnormalities
In-Depth Precautions and Warning
Drug Warnings
Do not take Panobinostat if you are allergic to any of its contents. Inform your doctor about your health condition and medications to rule out any side effects/interactions. Always take this medicine exactly as your doctor or healthcare professional has told you. To treat your condition effectually, continue taking Panobinostat for as long as your doctor has prescribed. Do not stop Panobinostat midway. Talk to your doctor before taking Panobinostat if you have severe allergic reactions to Panobinostat or other medicines or suffer from any medical illness. Avoid taking Panobinostat if you are pregnant or breastfeeding because this Panobinostat can cause harmful effects on the unborn baby. Both women and men using this Panobinostat should use birth control to avoid pregnancy. Inform your doctor if you have a history of low blood pressure; your doctor will closely monitor and manage it. If you are taking medication to help lower your blood pressure, you may need to reduce or discontinue it while taking panobinostat.
Drug Interactions
Drug-Drug Interactions: Panobinostat may interact with medicines used to treat benign prostatic hyperplasia (e.g. alfuzosin), anticoagulant (e.g. apixaban), vaccines (e.g. BCG vaccine, Dengue vaccine), antibiotics (e.g. clarithromycin, ciprofloxacin), antithrombotic drugs (e.g. dabigatran), HIV medications (e.g. efavirenz) and immunomodulating medication (e.g. fingolimod).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have Low blood pressure, cardiac toxicity (Arrhythmias, Ischemic Heart Disease, Electrolyte Abnormalities), myelosuppression (decreased activity of bone marrow), renal or hepatic impairment and infections (Bacterial/Fungal/Protozoal/Viral).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionAvoid alcohol consumption while on treatment with Panobinostat.
Pregnancy
unsafePanobinostat should not be taken during pregnancy as it might cause fetal harm. Inform your doctor immediately if you are conceiving while on therapy.
Breast Feeding
unsafeYou should not breastfeed when taking Panobinostat as it is unknown if the panobinostat can pass to your baby in the milk.
Driving
cautionPanobinostat can cause a drop in blood pressure, which can make you feel dizzy, lightheaded or like you are about to faint. If you feel dizzy or lightheaded when taking Panobinostat, you should not operate machinery or drive a car.
Liver
cautionCaution should be exercised. Monitor hepatic enzymes and adjust the dosage if abnormal liver function tests are observed during panobinostat therapy.
Kidney
cautionLimited information is available. Please inform your doctor before prescribing Panobinostat if you have kidney impairment. Your doctor will weigh the benefits and potential risks before prescribing Panobinostat.
Children
consult your doctorThe safety and efficacy of Panobinostat in children has not been established.
Habit Forming
Diet & Lifestyle Advise
- De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
- Performing yoga may also help in improving both physical and mental health.
- Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
- Eat a healthy diet and exercise regularly to maintain proper weight.
- Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
- Get optimal sleep; rest well.
- Avoid smoking and alcohol consumption.
- Avoid fast food, fried food, processed meats, refined carbs and added sugars.
Special Advise
- Monitoring of complete blood count while taking Panobinostat is advised.
- Drink plenty of fluids to prevent urinary problems.
- If you are due to have any surgery, inform the doctor that you are taking Panobinostat.
- Insomnia or difficulty sleeping at night is a common side effect of panobinostat. This may be minimised by taking panobinostat in the morning.
Patients Concern
Disease/Condition Glossary
Multiple myeloma, also known as myeloma, is a type of bone marrow cancer that affects several areas of the body, such as the spine, skull, pelvis, and ribs.
FAQs
Panobinostat contains Panobinostat. It works by blocking the action of histone deacetylase in myeloma cells. Thereby, it can prevent myeloma cells from growing and multiplying.
Do not stop taking Panobinostat on your own. Depending on your medical condition, you are advised to take Panobinostat for as long as your doctor prescribes it. Do not hesitate to speak with your doctor if you experience difficulty taking Panobinostat.
No, it is unsafe to father a child while taking Panobinostat. It is recommended for sexually active men to use condoms while on treatment and for at least six months after their last dose of Panobinostat.
The amount of red blood cells, white blood cells, and platelets in your blood may decrease as a result of Panobinostat. This can lead to anaemia (shortness of breath, exhaustion, and weakness) and fatigue, and make you more prone to infection and increase your risk of bleeding. You will be given supportive medication to alleviate these adverse effects and increase your blood cell count if necessary.
Panobinostat can induce swelling in the hands, ankles, and feet (peripheral oedema). Fluid may also accumulate around the abdomen, making you feel bloated. Your doctor will discuss a treatment strategy for your fluid retention with you. Diuretics (water tablets) are typically used to assist your body in removing excess fluid.
