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  1. Home
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  3. Clodrem 5% Cream

Clodrem 5% Cream, Pack of 1 Cream
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Whats That

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Synonym :

ACICLOVIR

Composition :

ACYCLOVIR-5%W/W

Manufacturer/Marketer :

Cubit Healthcare

Consume Type :

TOPICAL

Return Policy :

Not Returnable

About Clodrem 5% Cream

Clodrem 5% Cream belongs to the class of 'antivirals' that is generally used to treat recurrent herpes labialis (cold sores) in immunocompetent adults and adolescents aged 12 and up. Recurrent herpes simplex labialis, often known as oral herpes, is a disorder caused by the herpes simplex virus that affects the lips. It's a common and contagious illness that spreads quickly.

Clodrem 5% Cream contains acyclovir, it exerts antiviral activity against herpes simplex viruses (HSV) by interfering with DNA synthesis and limiting viral replication.

Clodrem 5% Cream is solely for the topical treatment of recurrent HSV lesions on the lips and face. It should be used as prescribed by your doctor. Dry lips, desquamation (scale off or peel off), dryness of skin, cracked lips, scorching skin, pruritus, flakiness of skin, and stinging on the skin were the most prevalent adverse effects to Clodrem 5% Cream at the site of topical administration. These side effects may not occur in every patient who takes this drug and will fade over time. Please notify your doctor if the side effects last longer or worsen.

Clodrem 5% Cream is restricted for use in people who are sensitive to acyclovir, valacyclovir or any component of the formulation. Clodrem 5% Cream should not be applied on mucous membranes including in the eye or inside the mouth or nose. The effect of Clodrem 5% Cream has not been established in immunocompromised patients. Before using Clodrem 5% Cream, consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Clodrem 5% Cream is recommended not for use in children below 12 years.

Uses of Clodrem 5% Cream

Recurrent herpes labialis (cold sores)

Directions for Use

Take the prescribed amount and apply it to the affected area(s) for 4 days, 5 times a day.

Medicinal Benefits

Clodrem 5% Cream treats viral infections caused by the herpes simplex and varicella-zoster viruses. It consists of Acyclovir, an antiviral drug. It works by killing and stopping the growth of the virus. Clodrem 5% Cream effectively treats herpes simplex encephalitis (brain inflammation by herpes simplex virus) and neonatal herpes simplex virus infection. Clodrem 5% Cream is also useful in preventing the reactivation of the cytomegalovirus infection in seropositive (showing a positive result of a blood test for a particular antibody) patients following bone marrow transplantation.

Storage

Store in a cool and dry place away from sunlight
Side effects of Clodrem 5% Cream
Here are the steps to manage angioedema (Swelling Under The Skin) as a side effect of medication:
  • If you experience angioedema, inform your doctor immediately. Treatment can help keep the swelling under control.
  • Seek medical attention if symptoms are severe, such as difficulty breathing or swallowing.
  • Follow your doctor's instructions to manage symptoms, which may include stopping or adjusting the medication that triggered angioedema.
  • Your doctor may also recommend antihistamines, steroids, or other treatments to reduce swelling and inflammation.
  • Make dietary and lifestyle changes as recommended, such as avoiding trigger foods or reducing stress.
  • Monitor your condition closely and track your symptoms to report them to your doctor.
  • Consult your doctor again if symptoms worsen or do not improve or if you experience any new or concerning symptoms.
  • If you experience or encounter any severe allergic reaction, stop using medication and consult the doctor right away.
  • Tell your doctor about the allergic reaction, including the medication taken and any symptoms experienced.
  • Your doctor will evaluate the severity of the reaction and determine the best course of action.
  • To ensure a full recovery, follow your doctor's advice, attend scheduled follow-up appointments, and undergo recommended tests to monitor progress and adjust treatment as needed.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Apply a gentle lip balm with ingredients such as castor seed oil or shea butter.
  • Ensure you are hydrated by drinking plenty of water; this helps heal your lips.
  • Avoid licking your lips or picking at them.
  • Use a humidifier at home, particularly at night, to maintain moisture in the air.
  • Protect your lips from sun exposure by using SPF lip balm and avoid using any irritating components.
  • Stay away from metal objects that could irritate your lips.
  • Consume a vitamin-rich diet to enhance the health of your skin overall.
  • Apply moisturizer immediately after showering or bathing.
  • Use a moisturizer containing lanolin, petroleum jelly, glycerine, hyaluronic acid or jojoba oil.
  • Do not use hot water for bathing. Instead use warm water and limit showers and bath to 5 to 10 minutes.
  • Apply a sunscreen with SPF-30 or higher.
  • Avoid harsh soaps, detergents and perfumes.
  • Do not scratch or rub the skin.
  • Drink adequate water to prevent dehydration.
  • Wear pants, full sleeves and a wide-brimmed hat while going out in the sun.
  • Apply a gentle lip balm with ingredients such as castor seed oil or shea butter.
  • Ensure you hydrate by drinking plenty of water; that ensures healing for your lips.
  • Avoid licking your lips or picking at them.
  • Use a humidifier at home, particularly at night, to maintain moisture in the air.
  • Protect your lips from sun exposure by using SPF lip balm and avoid using any irritating components.
  • Stay away from metal objects that could irritate your lips.
  • Consume a vitamin-rich diet to enhance the health of your skin overall.

Drug Warnings

Inform your doctor if you use prescription, non-prescription drugs, and herbal products before using Clodrem 5% Cream. And also let your doctor know if you are allergic to any components in Clodrem 5% Cream. Inform your doctor of your medical history before starting Clodrem 5% Cream. Though it is safe to use during pregnancy or breastfeeding, you must inform the healthcare provider before using the Clodrem 5% Cream.

Drug-Drug Interactions

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No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Choose foods high in protein. Ground meats, eggs, cottage cheese, yoghurt, custard, beans, lentils, and smoothies are examples of protein-rich soft foods.
  • Consume modest, regular meals. It may be easier for you to consume fewer portions at a time.
  • Drink through a straw. This can assist in moving foods past the unpleasant sores in your mouth.
  • Every day, drink at least 8-10 eight-ounce glasses of water. Drink fluids in between meals.
  • Citrus fruits and juices, salty or spicy foods, and acidic foods like tomatoes are all things to avoid if you have mouth sores.
  • Do not consume carbonated or caffeinated beverages, beer, wine, liquor, or any other sort of alcohol.
  • Avoid alcohol. Alcohol can irritate the mouth.
  • Hot foods can induce tongue and throat irritation.
  • Maintain good oral hygiene. Rinse your mouth numerous times every day.
  • Use alcohol-free mouthwash. A painful mouth is exacerbated by alcohol.
  • Use a toothbrush with gentle bristles.
  • Avoid smoking, cigars, and tobacco products.

Habit Forming

No

Therapeutic Class

ANTIVIRALS

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 20, 2024 | 1:15 PM IST

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Drug-Diseases Interactions

verifiedApollotooltip
ACYCLOVIR-5%W/WOther disorders of kidney and ureter, not elsewhere classified
Severe
ACYCLOVIR-5%W/WVolume depletion
Moderate

Drug-Diseases Interactions

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ACYCLOVIR-5%W/WOther disorders of kidney and ureter, not elsewhere classified
Severe
How does the disease interact with Clodrem 5% Cream:
Acyclovir should be used with caution to patients who have impaired kidney function. In patients with moderate to severe renal impairment, dosage modifications are advised.

How to manage the interaction:
The use of Clodrem 5% Cream in kidney disease patients is not advised as it may increase the severity of kidney disease. Your doctor may adjust the dosing according to the severity of your kidney disease.
ACYCLOVIR-5%W/WVolume depletion
Moderate
How does the disease interact with Clodrem 5% Cream:
Patients who are dehydrated may be more susceptible to nephrotoxicity from using acyclovir. Acyclovir should be infused intravenously over the course of an hour, along with appropriate hydration.

How to manage the interaction:
Clodrem 5% Cream is excreted through the kidneys, dehydration may cause damage to kidney functions. Clodrem 5% Cream infusion over an hour is recommended in dehydrated patients. Urine output should be monitored.
ACYCLOVIR-5%W/WCare involving dialysis
Moderate
How does the disease interact with Clodrem 5% Cream:
Hemodialysis effectively removes acyclovir from the body. Following 6 hours of dialysis, it has been demonstrated that plasma levels of acyclovir decrease by 60%. After hemodialysis, acyclovir should be administered. If not, a second dosage might be administered following each hemodialysis session.

How to manage the interaction:
Patients undergoing hemodialysis should be given Clodrem 5% Cream after completing hemodialysis as hemodialysis removes 60% of Clodrem 5% Cream from the body.

FAQs

Clodrem 5% Cream contains acyclovir, it exerts antiviral activity against herpes simplex viruses (HSV) by interfering with DNA synthesis and limiting viral replication. Thus it treats recurrent herpes labialis (cold sores).

Clodrem 5% Cream is contraindicated in patients allergic to acyclovir, valacyclovir or any component of the formulation.

In rare cases, angioedema (the swelling of the deeper layers of the skin, caused by a build-up of fluid) has been identified in Postmarketing Experience.

Systemic medication interactions are unlikely due to Clodrem 5% Cream's low systemic absorption. Clinical experience has revealed no interactions caused by the concurrent topical or systemic administration of other medicines with Clodrem 5% Cream.

Special Advise

  • Take proper precautions if you are infected with herpes to prevent the spread of infection to others.

Disease/Condition Glossary

Recurrent herpes labialis (cold sores): Recurrent herpes simplex labialis, often known as oral herpes, is a disorder caused by the herpes simplex virus (HSV), particularly the HSV type I that affects the mouth. It's a common and contagious illness that spreads quickly.

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