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  3. Clostop 500 mg Tablet 10's

Clostop 500 mg Tablet 10's, Pack of 10
Clostop 500 mg Tablet 10's, Pack of 10
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Non returnable*
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Composition :

MEFENAMIC ACID-250MG + TRANEXAMIC ACID-500MG

Manufacturer/Marketer :

Alembic Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Clostop 500 mg Tablet

Clostop 500 mg Tablet is a combination medicine used to treat dysmenorrhea (period pain) and menorrhagia (heavy menstrual bleeding). Besides this, Clostop 500 mg Tablet is also used to treat severe blood loss, swelling in various body parts, fever, inflammation, and migraine headache. Menstrual cramps, also known as dysmenorrhea, are characterized by cramps and pain during menstruation. Menorrhagia is a condition with abnormally heavy or prolonged bleeding during menstruation/periods.

Clostop 500 mg Tablet is a combination of two drugs: Tranexamic acid (anti-fibrinolytic) and Mefenamic acid (NSAID). Tranexamic acid helps the body's natural blood clot process by preventing fibrin's breakdown, this stops fibrinolysis, a process that stops blood clot formation. Mefenamic acid works by blocking the effect of chemical messengers that cause pain.

You are advised to take Clostop 500 mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as nausea, vomiting, diarrhoea, indigestion, heartburn, and headache. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Clostop 500 mg Tablet may cause dizziness, so drive with caution. Clostop 500 mg Tablet should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol along with Clostop 500 mg Tablet as it could lead to increased drowsiness and dizziness, it might also increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side-effects/interactions.

Uses of Clostop 500 mg Tablet

Dysmenorrhea (period pain) and menorrhagia (heavy menstrual bleeding).

Directions for Use

Take Clostop 500 mg Tablet with food to prevent stomach upset. Swallow Clostop 500 mg Tablet as a whole with a glass of water, do not chew, or break it.

Medicinal Benefits

Clostop 500 mg Tablet is a combination of two drugs, namely: Tranexamic acid and Mefenamic acid. Clostop 500 mg Tablet is used to treat abdominal pain, dysmenorrhea (period pain), and menorrhagia (heavy menstrual bleeding). Additionally, Clostop 500 mg Tablet is also used to treat severe blood loss, swelling in various body parts, fever, inflammation, and migraine headache. Tranexamic acid is an anti-fibrinolytic agent that helps the body's natural blood clot process by preventing fibrin's breakdown, this stops fibrinolysis, a process that stops blood clot formation. Mefenamic acid is an NSAID that works by blocking the effect of a chemical messenger in the body, known as cyclo-oxygenase (COX) enzymes that make other chemical prostaglandins. By blocking the COX enzyme's effect, lesser prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Together, Clostop 500 mg Tablet helps treat heavy bleeding and pains/cramps during periods.

Storage

Keep Clostop 500 mg Tablet out of reach and sight of children.
Side effects of Clostop 500 mg Tablet
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.
  • Include omega-3 rich foods like fatty fish, ground flax, flaxseed oil, and walnuts.
  • Consume calcium-rich dairy products for bone health.
  • Eat green and leafy vegetables for essential nutrients.
  • Include lean protein sources like eggs and whole grains.
  • Use herbs and spices for added flavor and nutrition.
  • Choose fortified foods for extra nutritional benefits.
  • Get plenty of sleep for overall health and well-being.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Lie down or take a nap in dark and quiet room.
  • To avoid dehydration, drink plenty of fluids.
  • In case of mild to moderate migraine, you can take over-the-counter pain relievers like paracetamol or ibuprofen.
  • Apply an ice pack or cool cloth on your forehead.
  • Try relaxation techniques such as yoga, meditation, or deep breathing to reduce stress and relax.
  • Avoid foods and drinks that trigger migraine such as chocolate, alcohol, cheese, caffeine, processed meats, artificial sweeteners and dried fruits.
  • Manage your stress by eating healthy, exercising and a regular sleep schedule.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Drug Warnings

Do not take Clostop 500 mg Tablet if you are allergic to any of its contents or if you have severe heart failure. Inform your doctor if you have/had deep vein thrombosis, pulmonary embolism (block a blood vessel in the lungs), coagulopathy (formation of blood clots), epilepsy, irregular periods, heart, kidney, or liver problems. Consult your doctor if you are pregnant or breastfeeding. Clostop 500 mg Tablet may cause dizziness and drowsiness, so drive only if you are alert. Clostop 500 mg Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Clostop 500 mg Tablet as it could lead to increased drowsiness and can increase the risk of stomach bleeding. Do not take any other NSAIDs for pain relief along with Clostop 500 mg Tablet unless prescribed.

Drug-Drug Interactions

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Tranexamic acidMedroxyprogesterone
Critical
Tranexamic acidEtonogestrel
Critical

Drug-Drug Interactions

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Tranexamic acidMedroxyprogesterone
Critical
How does the drug interact with Clostop 500 mg Tablet:
Taking Medroxyprogesterone acetate with Clostop 500 mg Tablet may increase the risk of blood clots.

How to manage the interaction:
Taking Medroxyprogesterone with Clostop 500 mg Tablet is not recommended but can be taken if prescribed by a doctor. Consult your doctor immediately if you experience symptoms such as chest pain, shortness of breath, coughing up blood, blood in the urine, sudden loss of vision, and pain, redness, or swelling in your arm or leg. Do not stop using any medications without talking to your doctor.
Tranexamic acidEtonogestrel
Critical
How does the drug interact with Clostop 500 mg Tablet:
Co-administration of Clostop 500 mg Tablet may cause blood clotting when taken with Etonogestrel.

How to manage the interaction:
Taking Clostop 500 mg Tablet with Etonogestrel is not recommended, as it can lead to an interaction but can be taken if prescribed by the doctor. However, If you suffer from chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult your doctor immediately.
Tranexamic acidDrospirenone
Critical
How does the drug interact with Clostop 500 mg Tablet:
Taking drospirenone with Clostop 500 mg Tablet may increase the risk of blood clot formation.

How to manage the interaction:
Taking Clostop 500 mg Tablet with Drospirenone is not recommended, as it can lead to an interaction but can be taken if prescribed by the doctor. However, If you suffer from chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult your doctor immediately.
Tranexamic acidLevonorgestrel
Critical
How does the drug interact with Clostop 500 mg Tablet:
Taking Levonorgestrel with Clostop 500 mg Tablet may increase the risk of blood clot formation which can lead to serious conditions such as heart problems and kidney failure.

How to manage the interaction:
Taking Clostop 500 mg Tablet with Levonorgestrel may leads to an interaction but can be taken if prescribed by the doctor. However, if you experience chest pain; shortness of breath; coughing up blood; blood in the urine; sudden loss of vision; and pain, redness, or swelling in your arm or leg, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Tranexamic acidEthinylestradiol
Critical
How does the drug interact with Clostop 500 mg Tablet:
Taking Ethinylestradiol with Clostop 500 mg Tablet may increase the risk of blood clot formation.

How to manage the interaction:
Taking Ethinylestradiol with Clostop 500 mg Tablet is not recommended, as it can lead to an interaction, but can be taken if a doctor has prescribed it. However, if you suffer from chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult doctor immediately. Do not stop using any medications without talking to a doctor.
Tranexamic acidEstrone
Severe
How does the drug interact with Clostop 500 mg Tablet:
Co-administration of Estrone with Clostop 500 mg Tablet can increase the risk of blood clots.

How to manage the interaction:
Taking Estrone with Clostop 500 mg Tablet can possibly lead to an interaction, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Tranexamic acidCarfilzomib
Severe
How does the drug interact with Clostop 500 mg Tablet:
Co-administration of Carfilzomib with Clostop 500 mg Tablet can increase the risk of blood clots.

How to manage the interaction:
Taking carfilzomib with Clostop 500 mg Tablet is not recommended due to its increased effects, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Tranexamic acidChlorotrianisene
Severe
How does the drug interact with Clostop 500 mg Tablet:
Co-administration of Chlorotrianisene with Clostop 500 mg Tablet can increase the risk of blood clots.

How to manage the interaction:
Taking chlorotrianisene with Clostop 500 mg Tablet is not recommended due to its increased effects, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Tranexamic acidEstramustine
Severe
How does the drug interact with Clostop 500 mg Tablet:
Co-administration of Estramustine with Clostop 500 mg Tablet can increase the risk of blood clots.

How to manage the interaction:
Taking Estramustine with Clostop 500 mg Tablet possibly lead to an interaction, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Tranexamic acidTretinoin
Severe
How does the drug interact with Clostop 500 mg Tablet:
Co-administration of tretinoin with Clostop 500 mg Tablet may increase the risk of blood clots.

How to manage the interaction:
Taking tretinoin with Clostop 500 mg Tablet is not recommended due to its increased effects, however, it can be taken only if your doctor has advised it. If you experience symptoms such as chest pain, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Follow a healthy diet. Include vegetables, fruits, and whole grains in your meals.
  • Stay hydrated; drink plenty of water.
  • Cut down on sugars, salts, spicy food, coffee, and alcohol.
  • A heating pad can help ease the pain by placing it on the belly or lower back.
  • Exercise can help ease the pain of menstrual cramps.
  • Avoid stress by performing meditation or yoga.
  • Massage your lower back or abdomen to relieve the pain.
  • Take proper rest.

Habit Forming

No

Therapeutic Class

ANTIFIBRINOLYTIC AGENTS

Clostop 500 mg Tablet Substitute

Substitutes safety advice

Product Substitutes

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 8, 2025 | 9:34 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Clostop 500 mg Tablet contains Tranexamic acid and Mefenamic acid. Tranexamic acid helps the body's natural blood clot process by preventing the breakdown of fibrin, this stops fibrinolysis, a process that stops blood clot formation. Mefenamic acid works by blocking the effect of chemical messengers that cause pain.

Diarrhoea might be a side-effect of Clostop 500 mg Tablet . Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if you experience severe diarrhoea or if you find blood in stools.

Clostop 500 mg Tablet should not be taken for longer durations unless prescribed by the doctor. Clostop 500 mg Tablet is usually prescribed for a few days at the time of heavy bleeding and cramps.

Clostop 500 mg Tablet is used to treat dysmenorrhea (period pain), pain due to heavy bleeding during periods, and menstrual cramps. Take Clostop 500 mg Tablet only as prescribed and do not overdose.

Consult your doctor before taking contraceptive pills along with Clostop 500 mg Tablet . When taken together, there is an increased risk of deep vein thrombosis (blood clot in the deep vein, usually legs).

Clostop 500 mg Tablet contains mefenamic acid, an NSAID which might increase the risk of cardiovascular thrombotic events, myocardial infarction, and stroke. Therefore, avoid taking Clostop 500 mg Tablet if you have heart-related problems unless prescribed by the doctor.

Drug-Drug Interactions Checker List

  • IBUPROFEN
  • CELECOXIB
  • DULOXETINE
  • FLUOXETINE
  • SERTRALINE

Disease/Condition Glossary

Menorrhagia: Menorrhagia is a condition with abnormally heavy or prolonged bleeding during menstruation/periods. The exact cause of menorrhagia is unknown, but it could be due to hormonal imbalance, dysfunction of the ovaries, uterine fibroids, polyps, inherited bleeding disorders, intrauterine devices, or medications. Symptoms include socking through one/more sanitary pads/tampons for every hour, needing to use double sanitary protection to control the flow, needing to wake up during the night to change the pad, bleeding for more than a week, passing blood clots, unable to do daily activities due to heavy flow, tiredness, and fatigue.

Dysmenorrhea: Menstrual cramps, also known as dysmenorrhea, is characterised by cramps and pain during menstruation due to heavy flow. Pain, cramps, and discomfort during periods are normal. However, excessive pain during periods is not normal and requires medication. Symptoms of dysmenorrhea include intense throbbing pain in the lower abdomen, dull, continuous aches, pain in the lower back and thighs, nausea, headache, and dizziness. The pain usually starts 1-3 days prior to the period, peaks one day before the period starts, and subsides 2-3days after the onset of the period.

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