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Reviewed By Sureshvarma D , MPharma
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Manufacturer/Marketer :

Probios Healthcare

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About CO-Trimoxazole DS Tablet

CO-Trimoxazole DS Tablet belongs to the group of medicines called antibiotics used to treat and prevent lung infections caused by a bacteria called Pneumocystis jirovecii, infections caused by a bacteria called Toxoplasma, urinary tract infections (water infections), respiratory tract infections such as bronchitis, ear infections such as otitis media. Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body. Infectious or harmful bacteria can make you sick and reproduce quickly in your body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. CO-Trimoxazole DS Tablet does not work against infections caused by the virus, including cold and flu.

CO-Trimoxazole DS Tablet contains Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids, which are necessary for the survival of bacteria. By inhibiting these, CO-Trimoxazole DS Tablet kills the bacteria and stops their growth. Thereby, it helps to treat bacterial infections.

Take CO-Trimoxazole DS Tablet as prescribed by your doctor. The dose and duration of CO-Trimoxazole DS Tablet can vary depending on your condition and the severity of the infection. In some cases, you may experience certain common side effects such as headache, diarrhoea, skin rashes, nausea, vomiting, heart problems, fever, convulsions or seizures, blood or cloudiness in your urine, hallucinations, and mouth ulcers. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Before starting CO-Trimoxazole DS Tablet , please inform your doctor if you have any allergy (against any antibiotic), or kidney or liver problems. Do not take CO-Trimoxazole DS Tablet on your own as self-medication may lead to antibiotic resistance in which antibiotics fail to act against specific bacterial infections. Consult your doctor before taking CO-Trimoxazole DS Tablet if you are pregnant or breastfeeding. Avoid alcohol consumption to prevent unpleasant side effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting. CO-Trimoxazole DS Tablet should not be given to children below 12 years. Keep your doctor informed about all the medicines you are taking and your health condition to rule out any unpleasant side effects. Also, it is recommended to complete the course of medicine even if you feel better, as it is an antibiotic. Leaving it in between may lead to even severe infection that will, in fact, stop responding to the antibiotic (antibiotic resistance).

Uses of CO-Trimoxazole DS Tablet

Bacterial infections

Directions for Use

Tablet: Take it as advised by your doctor. Swallow it as a whole with water; do not crush, break or chew it.Syrup: Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack. The dose and duration can vary depending on your condition and the severity of the infection.

Medicinal Benefits

CO-Trimoxazole DS Tablet belongs to the group of medicines called ‘antibiotics’ used to treat various bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain, and toxoplasmosis (infection caused by a bacteria called toxoplasma). CO-Trimoxazole DS Tablet contains Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids, which are necessary for the survival of bacteria. By inhibiting these, CO-Trimoxazole DS Tablet kills the bacteria and stops their growth. Thereby, it helps to treat bacterial infections. CO-Trimoxazole DS Tablet is a broad-spectrum antibiotic that is active against a wide range of gram-positive and gram-negative bacteria such as Streptococcus pneumonia, Escherichia coli, Klebsiella species, Enterobacter species, Haemophilus influenzae, etc.

Storage

Store in a cool and dry place away from sunlight

Side Effects of CO-Trimoxazole DS Tablet

  • Mouth ulcers
  • Headache
  • Mouth ulcers
  • Diarrhea
  • Blood or cloudiness in your urine
  • Depression
  • Tingling or numbness in your hands and feet
  • Hallucinations

Drug Warnings

Do not take CO-Trimoxazole DS Tablet if you are allergic to any of its contents if you have severe liver or kidney problems, thrombocytopenia (low levels of platelets in the blood), or porphyria (rare blood problem that affects the skin or nervous system). Do not take CO-Trimoxazole DS Tablet on your own, as self-medication may lead to antibiotic resistance in which antibiotics fail to act against specific bacterial infections. Consult your doctor immediately if you experience skin rash or prolonged, significant diarrhoea with abdominal pains. Talk to your doctor before taking CO-Trimoxazole DS Tablet if you have severe allergies, asthma, ulcers, blood disorders, thyroid dysfunction, diabetes, are elderly, underweight, or malnourished if you have a folic acid deficiency, glucose-6-phosphate dehydrogenase deficiency, or high levels of potassium in the blood. Avoid taking CO-Trimoxazole DS Tablet if you are pregnant or breastfeeding unless prescribed by a doctor. Avoid alcohol consumption while taking CO-Trimoxazole DS Tablet to prevent unpleasant side-effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting. CO-Trimoxazole DS Tablet will not treat a viral infection. Drink plenty of fluids to prevent kidney stones while taking CO-Trimoxazole DS Tablet .

Drug-Drug Interactions

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TrimethoprimBCG vaccine
Critical
TrimethoprimPhenytoin
Severe

Drug-Drug Interactions

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TrimethoprimBCG vaccine
Critical
How does the drug interact with CO-Trimoxazole DS Tablet:
Taking CO-Trimoxazole DS Tablet with BCG vaccine can reduce the effectiveness of the BCG vaccine

How to manage the interaction:
Although there is an interaction between CO-Trimoxazole DS Tablet and BCG vaccine is not recommended, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
TrimethoprimPhenytoin
Severe
How does the drug interact with CO-Trimoxazole DS Tablet:
Co-administration of CO-Trimoxazole DS Tablet with phenytoin may increase the blood levels and effects of phenytoin.

How to manage the interaction:
Although there is an interaction between CO-Trimoxazole DS Tablet and phenytoin, but can be taken together if prescribed by doctor. However, if you experience nausea, vomiting, twitching eye movements, blurred vision, difficult to speak, loss of balance or coordination, tremors (shaking of hands legs), and confusion contact your doctor immediately. Do not discontinue any medications without consulting to your doctor.
TrimethoprimTelmisartan
Severe
How does the drug interact with CO-Trimoxazole DS Tablet:
Taking CO-Trimoxazole DS Tablet with telmisartan may increase potassium levels in the blood.

How to manage the interaction:
Although there is an interaction between telmisartan and CO-Trimoxazole DS Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, and a weak pulse. Do not discontinue the medications without consulting a doctor.
TrimethoprimPerindopril
Severe
How does the drug interact with CO-Trimoxazole DS Tablet:
Taking perindopril with CO-Trimoxazole DS Tablet can cause hyperkalemia(high levels of potassium in blood) which can increase the risk of kidney problems and abnormal heart rhythm.

How to manage the interaction:
Co-administration of Perindopril with CO-Trimoxazole DS Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat contact your doctor immediately. Do not stop using any medications without a doctor's advice. Do not discontinue any medications without consulting your doctor.
TrimethoprimAzilsartan medoxomil
Severe
How does the drug interact with CO-Trimoxazole DS Tablet:
Coadministration of Azilsartan medoxomil with CO-Trimoxazole DS Tablet may increase potassium levels in the blood.

How to manage the interaction:
Although there is an interaction between azilsartan medoxomil and CO-Trimoxazole DS Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience vomiting, weakness, or tingling in your hands and feet. Do not discontinue any medications without a doctor's advice.
TrimethoprimCaptopril
Severe
How does the drug interact with CO-Trimoxazole DS Tablet:
Taking captopril with CO-Trimoxazole DS Tablet may increase the risk of hyperkalemia (high level of potassium in the blood) and kidney problems.

How to manage the interaction:
Although there is a interaction between CO-Trimoxazole DS Tablet and captopril, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
TrimethoprimLidocaine
Severe
How does the drug interact with CO-Trimoxazole DS Tablet:
Taking Lidocaine with CO-Trimoxazole DS Tablet may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Co-administration of CO-Trimoxazole DS Tablet with Lidocaine can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience, gray skin color, feeling sick, having a headache, feeling dizzy or lightheaded, feeling tired, having trouble breathing, a fast or irregular heartbeat, feeling anxious or confused, contact your doctor right away. Do not stop using any medications without talking to your doctor.
TrimethoprimRamipril
Severe
How does the drug interact with CO-Trimoxazole DS Tablet:
Taking Ramipril with CO-Trimoxazole DS Tablet can increase the potassium levels in the blood, increasing the risk of kidney problems.

How to manage the interaction:
Although there is an interaction between ramipril and CO-Trimoxazole DS Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience weakness, confusion, numbness or tingling, and uneven heartbeats. Do not stop taking any medication without consulting your doctor.
TrimethoprimQuinapril
Severe
How does the drug interact with CO-Trimoxazole DS Tablet:
Taking CO-Trimoxazole DS Tablet with Quinapril can cause high levels of potassium in the blood.

How to manage the interaction:
Although there is a interaction between CO-Trimoxazole DS Tablet and Quinapril, but it can be taken if prescribed by a doctor. If you notice any of these signs like feeling unwell, feeling dehydrated it's best to contact your doctor right away. Do not stop using any medications without a doctor's advice.
TrimethoprimQuinidine
Severe
How does the drug interact with CO-Trimoxazole DS Tablet:
Using CO-Trimoxazole DS Tablet can cause higher levels of Quinidine in the blood which increases risk of side effects.

How to manage the interaction:
There may be a possibility of interaction between CO-Trimoxazole DS Tablet and Quinidine, but it can be taken if prescribed by a doctor. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Antibiotics can alter the useful bacteria in the stomach, which helps in digestion. Therefore, you are advised to take foods rich in probiotics, such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk natto, and cheese.
  • Eat fiber-rich food like whole grains, beans, lentils, berries, broccoli, peas, and bananas.
  • Avoid foods rich in calcium, grapefruit, and grapefruit juice, as they might hinder antibiotic absorption.
  • Avoid the consumption of alcohol to treat your condition effectively.
  • Avoid the usage of tobacco.
  • To cure your condition, effectually complete the full course of CO-Trimoxazole DS Tablet even though you find symptomatic relief.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS

CO-Trimoxazole DS Tablet Substitute

Substitutes safety advice
  • Cotrimoxazole DS Tablet 10's

    by AYUR

    2.52per tablet
  • Trimzole-DS Tablet 10's

    by Others

    3.24per tablet
  • Co-Trimoxazole Double Strength Tablet 10's

    by Others

    1.28per tablet
  • Viktrim DS Tablet 10's

    by Others

    2.70per tablet

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

CO-Trimoxazole DS Tablet contains Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids, which are necessary for the survival of bacteria. By inhibiting these, CO-Trimoxazole DS Tablet kills the bacteria and stops their growth. Thus, helps to treat bacterial infections.

CO-Trimoxazole DS Tablet causes thrush or candidiasis, a fungal infection occurring due to the overgrowth of yeast-like fungus in the mouth or throat. Regularly rinse your mouth with water to prevent the growth of fungus.

Diarrhoea might be a side-effect of CO-Trimoxazole DS Tablet . Drink lots of fluids and eat food rich in fibre if you experience diarrhoea. If you find blood in your stools (tarry stools) or if you experience prolonged diarrhoea with abdominal pain, stop taking CO-Trimoxazole DS Tablet and consult your doctor. Do not take anti-diarrheal medicine on your own.

It is recommended to complete the course of CO-Trimoxazole DS Tablet even if you feel better as it is an antibiotic, and leaving it in between may lead to recurring infections. Continue taking CO-Trimoxazole DS Tablet for as long as your doctor has prescribed to treat your condition effectually.

CO-Trimoxazole DS Tablet may affect certain laboratory test results. Inform the person doing the tests that you are taking CO-Trimoxazole DS Tablet .

CO-Trimoxazole DS Tablet may cause high levels of potassium in the blood, leading to abnormal heartbeats (palpitations). Regular potassium levels and heart rate monitoring is recommended while taking CO-Trimoxazole DS Tablet .

Drug-Drug Interactions Checker List

  • AMANTADINE
  • CYCLOSPORINE
  • INDOMETHACIN
  • LEUCOVORIN
  • METHOTREXATE
  • PYRIMETHAMINE
  • BENAZEPRIL
  • QUINAPRIL
  • ENALAPRIL
  • LISINOPRIL
  • RAMIPRIL
  • CHLORTHALIDONE
  • HYDROCHLOROTHIAZIDE
  • WARFARIN

Special Advise

  • CO-Trimoxazole DS Tablet may affect certain laboratory test results, such as blood tests. Inform the person doing the tests that you are taking CO-Trimoxazole DS Tablet . Your doctor may advise you to get regular tests if you have kidney problems or if you have been prescribed CO-Trimoxazole DS Tablet for a longer duration to know if the medicine is working properly.

Disease/Condition Glossary

Bacterial infections: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect our body. Infectious or harmful bacteria can make you sick and reproduce quickly in your body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. It can target any body part and multiply very quickly. When you get infected with bacteria, you can experience generalized symptoms like fevers, chills, and fatigue. Bacteria are of various forms comprising, commonly spherical, rod, and spiral-shaped. Bacterial infections vary from minor illnesses like sore throat and ear infections to severe brain infections like meningitis and encephalitis. Anyone can become infected with a bacterial infection. But, people with weak immune systems or taking immunosuppressive medicine are more prone to bacterial infection.

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