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About Creptrim 800mg/160mg Tablet

Creptrim 800mg/160mg Tablet belongs to the group of medicines called ‘antibiotics’ used to treat bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body. Creptrim 800mg/160mg Tablet does not work against infections caused by the virus, including cold and flu. 

Creptrim 800mg/160mg Tablet is a combination of two antibiotics, namely: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids, which are necessary for the survival of the bacteria. By inhibiting these, Creptrim 800mg/160mg Tablet stops the growth of bacteria and kills them. Thereby, it helps to treat bacterial infections.

Your doctor will decide the dose and duration of Creptrim 800mg/160mg Tablet based on your condition and the severity of the infection. In some cases, you may experience certain common side-effects such as high levels of potassium in the blood, palpitations (abnormal heartbeats), thrush or candidiasis (fungal infection), headache, nausea, diarrhoea, and skin rashes. Most of these side-effects do not require medical attention and resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Before starting Creptrim 800mg/160mg Tablet, please inform your doctor if you have any allergy (against any antibiotic), kidney or liver problems. Do not take Creptrim 800mg/160mg Tablet on your own as self-medication may lead to antibiotic-resistance in which antibiotics fail to act against specific bacterial infections. Consult your doctor before taking Creptrim 800mg/160mg Tablet if you are pregnant or breastfeeding. Avoid alcohol consumption to prevent unpleasant side-effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting. Creptrim 800mg/160mg Tablet is not recommended for children below 12years.

Uses of Creptrim 800mg/160mg Tablet

Bacterial infections

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush or chew the tablet/capsule. Syrup/Suspension/Drops: Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper; shake the pack well before each use.

Medicinal Benefits

Creptrim 800mg/160mg Tablet belongs to the group of medicines called ‘antibiotics’ used to treat various bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). Creptrim 800mg/160mg Tablet is a combination of two antibiotics, namely: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids, which are necessary for the survival of the bacteria. By inhibiting these, Creptrim 800mg/160mg Tablet kills the bacteria and stops their growth. Thereby, it helps to treat bacterial infections. Creptrim 800mg/160mg Tablet is a broad-spectrum antibiotic which is active against a wide range of gram-positive and gram-negative bacteria such as Streptococcus pneumonia, Escherichia coli, Klebsiella species, Enterobacter species, Haemophilus influenzae, etc.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Creptrim 800mg/160mg Tablet if you are allergic to any of its contents; if you have severe liver or kidney problems, thrombocytopenia (low levels of platelets in the blood), or porphyria (rare blood problem). Consult your doctor immediately if you experience skin rash or prolonged, significant diarrhoea with abdominal pain. Talk to your doctor before taking Creptrim 800mg/160mg Tablet if you have severe allergies, asthma, ulcers, blood disorders, thyroid dysfunction, diabetes, are elderly, underweight or malnourished; if you have a folic acid deficiency, glucose-6-phosphate dehydrogenase deficiency, or high levels of potassium in the blood. Consult your doctor if you are pregnant or breastfeeding. Avoid alcohol consumption while taking Creptrim 800mg/160mg Tablet to prevent unpleasant side-effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting.

Drug-Drug Interactions

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TrimethoprimBCG vaccine
Critical
TrimethoprimPotassium acetate
Severe

Drug-Drug Interactions

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TrimethoprimBCG vaccine
Critical
How does the drug interact with Creptrim 800mg/160mg Tablet:
Taking Creptrim 800mg/160mg Tablet with BCG vaccine can reduce the effectiveness of the BCG vaccine

How to manage the interaction:
Although there is an interaction between Creptrim 800mg/160mg Tablet and BCG vaccine is not recommended, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
TrimethoprimPotassium acetate
Severe
How does the drug interact with Creptrim 800mg/160mg Tablet:
Taking potassium acetate with Creptrim 800mg/160mg Tablet may increase potassium levels in the blood which can increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Creptrim 800mg/160mg Tablet and Potassium acetate, you can take these medicines together if prescribed by your doctor. However, if you have unusual symptoms contact your doctor right away. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Creptrim 800mg/160mg Tablet:
Taking Lidocaine with Creptrim 800mg/160mg Tablet may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Co-administration of Creptrim 800mg/160mg Tablet with Lidocaine can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience, gray skin color, feeling sick, having a headache, feeling dizzy or lightheaded, feeling tired, having trouble breathing, a fast or irregular heartbeat, feeling anxious or confused, contact your doctor right away. Do not stop using any medications without talking to your doctor.
TrimethoprimFosphenytoin
Severe
How does the drug interact with Creptrim 800mg/160mg Tablet:
Taking fosphenytoin with Creptrim 800mg/160mg Tablet may increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between fosphenytoin and Creptrim 800mg/160mg Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience, weakness, vomiting, blurry vision, or trouble speaking. Do not discontinue any medications without consulting a doctor.
TrimethoprimCaptopril
Severe
How does the drug interact with Creptrim 800mg/160mg Tablet:
Taking captopril with Creptrim 800mg/160mg Tablet may increase the risk of hyperkalemia (high level of potassium in the blood) and kidney problems.

How to manage the interaction:
Although there is a interaction between Creptrim 800mg/160mg Tablet and captopril, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Creptrim 800mg/160mg Tablet:
When amiloride is taken with Creptrim 800mg/160mg Tablet it may raise potassium levels in the blood. (High potassium levels can cause hyperkalemia, which can lead to kidney failure, muscular paralysis, abnormal heart rhythm).

How to manage the interaction:
Although there is an interaction between amiloride and Creptrim 800mg/160mg Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience nausea, vomiting, weakness, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Creptrim 800mg/160mg Tablet:
Enalapril combined with Creptrim 800mg/160mg Tablet can cause hyperkalemia by elevating blood potassium levels. In severe cases, hyperkalemia can induce muscle paralysis, renal damage, and cardiac problems. The risk is increased if you are elderly, dehydrated, or have a history of renal or cardiovascular disease.

How to manage the interaction:
Although taking Enalapril together with Creptrim 800mg/160mg Tablet may possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience signs and symptoms of hyperkalemia, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat. It is advised to limit the intake of potassium-rich foods like tomatoes, bananas, mangoes, beans, and potassium-containing supplements. Do not discontinue any medication without consulting your doctor.
How does the drug interact with Creptrim 800mg/160mg Tablet:
Coadministration of Creptrim 800mg/160mg Tablet with methotrexate can increase the risk or severity of blood disorders.

How to manage the interaction:
Although there is a possible interaction between Creptrim 800mg/160mg Tablet and methotrexate, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as pale skin, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not stop using any medications without consulting to a doctor.
TrimethoprimRopivacaine
Severe
How does the drug interact with Creptrim 800mg/160mg Tablet:
Using ropivacaine with Creptrim 800mg/160mg Tablet can cause higher levels of Creptrim 800mg/160mg Tablet in the blood.

How to manage the interaction:
Although taking Ropivacaine and Creptrim 800mg/160mg Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion contact your doctor immediately. Do not stop using any medications without a doctor's advice.
TrimethoprimProcaine
Severe
How does the drug interact with Creptrim 800mg/160mg Tablet:
Co-administration of Creptrim 800mg/160mg Tablet with procaine may increase the risk of blood disorders.

How to manage the interaction:
Taking Creptrim 800mg/160mg Tablet with Procaine together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms like gray skin, feeling sick, headache, dizziness, tiredness, trouble breathing, fast heartbeat, or feeling anxious or confused, contact your doctor right away. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Antibiotics can alter the useful bacteria in the stomach, which help in digestion. Therefore, you are advised to take foods rich in probiotics such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk, natto and cheese.
  • Eat fibre rich food like whole grains, beans, lentils, berries, broccoli, peas and bananas.
  • Avoid foods rich in calcium, grapefruit and grapefruit juice as they might hinder the absorption of antibiotics.
  • Avoid consumption of alcohol and usage of tobacco.

Habit Forming

No

Therapeutic Class

ANTIBIOTIC COMBINATION

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Creptrim 800mg/160mg Tablet is a combination of two antibiotics, namely: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. By inhibiting these, Creptrim 800mg/160mg Tablet kills the bacteria and stops their growth. Thereby, helps to treat bacterial infections.

Creptrim 800mg/160mg Tablet causes thrush or candidiasis, which is a fungal infection occurring due to the overgrowth of yeast-like fungus in the mouth or throat. Regularly rinse your mouth with water to prevent the growth of fungus.

Diarrhoea might be a side-effect of Creptrim 800mg/160mg Tablet. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience prolonged diarrhoea with abdominal pain, stop taking Creptrim 800mg/160mg Tablet and consult your doctor. Do not take anti-diarrheal medicine on your own.

It is recommended to complete the course of Creptrim 800mg/160mg Tablet even if you feel better as it is an antibiotic, and leaving it in between may lead to recurring infections. Continue taking Creptrim 800mg/160mg Tablet for as long as your doctor has prescribed to treat your condition effectually.

Do not take Creptrim 800mg/160mg Tablet on your own as self-medication may lead to antibiotic-resistance in which antibiotics fail to act against specific bacterial infections.

Creptrim 800mg/160mg Tablet may affect certain laboratory test results. Inform the person doing the tests that you are taking Creptrim 800mg/160mg Tablet.

Creptrim 800mg/160mg Tablet may cause high levels of potassium in the blood, which could lead to abnormal heartbeats (palpitations). Regular monitoring of potassium levels and heart rate is advised while taking Creptrim 800mg/160mg Tablet.

Drug-Drug Interactions Checker List

  • GLIBENCLAMIDE
  • AZITHROMYCIN
  • METRONIDAZOLE
  • ALBUTEROL
  • BENDROFLUMETHIAZIDE
  • GLICLAZIDE

Special Advise

  • Creptrim 800mg/160mg Tablet may affect certain laboratory test results such as blood tests. Inform the person doing the tests that you are taking Creptrim 800mg/160mg Tablet. 
  • Your doctor may advise you to get regular tests if you have kidney problems or if you have been prescribed Creptrim 800mg/160mg Tablet for a longer duration, to know if the medicine is working properly.

Disease/Condition Glossary

Bacterial infections: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect the body. Infectious or harmful bacteria can make you sick and reproduce quickly in the body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. Symptoms include fever, chills, and fatigue. Anyone can become infected with a bacterial infection. But, people with a weak immune system or taking immunosuppressive medicine are more prone to bacterial infection.

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