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About Danatrim 800mg/160mg Tablet

Danatrim 800mg/160mg Tablet belongs to the group of medicines called ‘antibiotics’ used to treat bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body. Danatrim 800mg/160mg Tablet does not work against infections caused by the virus, including cold and flu. 

Danatrim 800mg/160mg Tablet is a combination of two antibiotics, namely: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids, which are necessary for the survival of the bacteria. By inhibiting these, Danatrim 800mg/160mg Tablet stops the growth of bacteria and kills them. Thereby, it helps to treat bacterial infections.

Your doctor will decide the dose and duration of Danatrim 800mg/160mg Tablet based on your condition and the severity of the infection. In some cases, you may experience certain common side-effects such as high levels of potassium in the blood, palpitations (abnormal heartbeats), thrush or candidiasis (fungal infection), headache, nausea, diarrhoea, and skin rashes. Most of these side-effects do not require medical attention and resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Before starting Danatrim 800mg/160mg Tablet, please inform your doctor if you have any allergy (against any antibiotic), kidney or liver problems. Do not take Danatrim 800mg/160mg Tablet on your own as self-medication may lead to antibiotic-resistance in which antibiotics fail to act against specific bacterial infections. Consult your doctor before taking Danatrim 800mg/160mg Tablet if you are pregnant or breastfeeding. Avoid alcohol consumption to prevent unpleasant side-effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting. Danatrim 800mg/160mg Tablet is not recommended for children below 12years.

Uses of Danatrim 800mg/160mg Tablet

Bacterial infections

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush or chew the tablet/capsule. Syrup/Suspension/Drops: Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper; shake the pack well before each use.

Medicinal Benefits

Danatrim 800mg/160mg Tablet belongs to the group of medicines called ‘antibiotics’ used to treat various bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). Danatrim 800mg/160mg Tablet is a combination of two antibiotics, namely: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids, which are necessary for the survival of the bacteria. By inhibiting these, Danatrim 800mg/160mg Tablet kills the bacteria and stops their growth. Thereby, it helps to treat bacterial infections. Danatrim 800mg/160mg Tablet is a broad-spectrum antibiotic which is active against a wide range of gram-positive and gram-negative bacteria such as Streptococcus pneumonia, Escherichia coli, Klebsiella species, Enterobacter species, Haemophilus influenzae, etc.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Danatrim 800mg/160mg Tablet if you are allergic to any of its contents; if you have severe liver or kidney problems, thrombocytopenia (low levels of platelets in the blood), or porphyria (rare blood problem). Consult your doctor immediately if you experience skin rash or prolonged, significant diarrhoea with abdominal pain. Talk to your doctor before taking Danatrim 800mg/160mg Tablet if you have severe allergies, asthma, ulcers, blood disorders, thyroid dysfunction, diabetes, are elderly, underweight or malnourished; if you have a folic acid deficiency, glucose-6-phosphate dehydrogenase deficiency, or high levels of potassium in the blood. Consult your doctor if you are pregnant or breastfeeding. Avoid alcohol consumption while taking Danatrim 800mg/160mg Tablet to prevent unpleasant side-effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting.

Drug-Drug Interactions

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TrimethoprimBCG vaccine
Critical
TrimethoprimPotassium gluconate
Severe

Drug-Drug Interactions

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TrimethoprimBCG vaccine
Critical
How does the drug interact with Danatrim 800mg/160mg Tablet:
Taking Danatrim 800mg/160mg Tablet with BCG vaccine can reduce the effectiveness of the BCG vaccine

How to manage the interaction:
Although there is an interaction between Danatrim 800mg/160mg Tablet and BCG vaccine is not recommended, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
TrimethoprimPotassium gluconate
Severe
How does the drug interact with Danatrim 800mg/160mg Tablet:
Taking potassium gluconate with Danatrim 800mg/160mg Tablet can increase the risk of high potassium levels in the blood.

How to manage the interaction:
Although there is a possible interaction between Danatrim 800mg/160mg Tablet and Potassium gluconate, you can take these medicines together if prescribed by your doctor. However, if you are feeling sick, feeling weak, confused, or having a weak or irregular heartbeat contact your doctor immediately. Do not stop using any medications without talking to your doctor.
How does the drug interact with Danatrim 800mg/160mg Tablet:
Co-administration of Calcium folinate with Danatrim 800mg/160mg Tablet may increase rates of treatment failure.

How to manage the interaction:
Although there is an interaction between calcium folinate and Danatrim 800mg/160mg Tablet, but it can be taken together if prescribed by the doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to your doctor.
How does the drug interact with Danatrim 800mg/160mg Tablet:
Taking Lisinopril with Danatrim 800mg/160mg Tablet may increase potassium levels in the blood.

How to manage the interaction:
Although taking Danatrim 800mg/160mg Tablet and Lisinopril together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without consulting doctor.
How does the drug interact with Danatrim 800mg/160mg Tablet:
Taking Lidocaine with Danatrim 800mg/160mg Tablet may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Co-administration of Danatrim 800mg/160mg Tablet with Lidocaine can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience, gray skin color, feeling sick, having a headache, feeling dizzy or lightheaded, feeling tired, having trouble breathing, a fast or irregular heartbeat, feeling anxious or confused, contact your doctor right away. Do not stop using any medications without talking to your doctor.
How does the drug interact with Danatrim 800mg/160mg Tablet:
When amiloride is taken with Danatrim 800mg/160mg Tablet it may raise potassium levels in the blood. (High potassium levels can cause hyperkalemia, which can lead to kidney failure, muscular paralysis, abnormal heart rhythm).

How to manage the interaction:
Although there is an interaction between amiloride and Danatrim 800mg/160mg Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience nausea, vomiting, weakness, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Danatrim 800mg/160mg Tablet:
Using Danatrim 800mg/160mg Tablet together with valsartan may increase potassium levels in the blood.

How to manage the interaction:
Although taking Danatrim 800mg/160mg Tablet together with Valsartan may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Danatrim 800mg/160mg Tablet:
Danatrim 800mg/160mg Tablet may decrease the blood levels and effects of folic acid.

How to manage the interaction:
Although there is a possible interaction between Folic acid and Danatrim 800mg/160mg Tablet, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without consulting your doctor.
How does the drug interact with Danatrim 800mg/160mg Tablet:
Taking Irbesartan with Danatrim 800mg/160mg Tablet may increase potassium levels in the blood and kidney problems.

How to manage the interaction:
Although taking Irbesartan with Danatrim 800mg/160mg Tablet together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult your doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Danatrim 800mg/160mg Tablet:
Taking Danatrim 800mg/160mg Tablet with Quinapril can cause high levels of potassium in the blood.

How to manage the interaction:
Although there is a interaction between Danatrim 800mg/160mg Tablet and Quinapril, but it can be taken if prescribed by a doctor. If you notice any of these signs like feeling unwell, feeling dehydrated it's best to contact your doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Antibiotics can alter the useful bacteria in the stomach, which help in digestion. Therefore, you are advised to take foods rich in probiotics such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk, natto and cheese.
  • Eat fibre rich food like whole grains, beans, lentils, berries, broccoli, peas and bananas.
  • Avoid foods rich in calcium, grapefruit and grapefruit juice as they might hinder the absorption of antibiotics.
  • Avoid consumption of alcohol and usage of tobacco.

Habit Forming

No

Therapeutic Class

ANTIBIOTIC COMBINATION

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Danatrim 800mg/160mg Tablet is a combination of two antibiotics, namely: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. By inhibiting these, Danatrim 800mg/160mg Tablet kills the bacteria and stops their growth. Thereby, helps to treat bacterial infections.

Danatrim 800mg/160mg Tablet causes thrush or candidiasis, which is a fungal infection occurring due to the overgrowth of yeast-like fungus in the mouth or throat. Regularly rinse your mouth with water to prevent the growth of fungus.

Diarrhoea might be a side-effect of Danatrim 800mg/160mg Tablet. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience prolonged diarrhoea with abdominal pain, stop taking Danatrim 800mg/160mg Tablet and consult your doctor. Do not take anti-diarrheal medicine on your own.

It is recommended to complete the course of Danatrim 800mg/160mg Tablet even if you feel better as it is an antibiotic, and leaving it in between may lead to recurring infections. Continue taking Danatrim 800mg/160mg Tablet for as long as your doctor has prescribed to treat your condition effectually.

Do not take Danatrim 800mg/160mg Tablet on your own as self-medication may lead to antibiotic-resistance in which antibiotics fail to act against specific bacterial infections.

Danatrim 800mg/160mg Tablet may affect certain laboratory test results. Inform the person doing the tests that you are taking Danatrim 800mg/160mg Tablet.

Danatrim 800mg/160mg Tablet may cause high levels of potassium in the blood, which could lead to abnormal heartbeats (palpitations). Regular monitoring of potassium levels and heart rate is advised while taking Danatrim 800mg/160mg Tablet.

Drug-Drug Interactions Checker List

  • GLIBENCLAMIDE
  • AZITHROMYCIN
  • METRONIDAZOLE
  • ALBUTEROL
  • BENDROFLUMETHIAZIDE
  • GLICLAZIDE

Special Advise

  • Danatrim 800mg/160mg Tablet may affect certain laboratory test results such as blood tests. Inform the person doing the tests that you are taking Danatrim 800mg/160mg Tablet. 
  • Your doctor may advise you to get regular tests if you have kidney problems or if you have been prescribed Danatrim 800mg/160mg Tablet for a longer duration, to know if the medicine is working properly.

Disease/Condition Glossary

Bacterial infections: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect the body. Infectious or harmful bacteria can make you sick and reproduce quickly in the body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. Symptoms include fever, chills, and fatigue. Anyone can become infected with a bacterial infection. But, people with a weak immune system or taking immunosuppressive medicine are more prone to bacterial infection.

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