Crimat 25 mg Injection 2.5 ml belongs to the group of medicines called skeletal muscle relaxants used to reduce and relieve muscle spasms (excessive tension in the muscles) occurring during surgery in intensive care. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable. When the nerve impulses that control the muscle movements are damaged or interrupted, it could lead to muscle spasms.

Crimat 25 mg Injection 2.5 ml contains ‘Atracurium’ that works by blocking the action of acetylcholine on skeletal muscles. Thus, stop sending a pain signal to the brain, relieving muscle stiffness or muscle spasm along with pain and surgery. Crimat 25 mg Injection 2.5 ml is used during surgery.  It is also used during general anaesthesia to ease tracheal intubation (a tube into the windpipe) and controlled ventilation.

Crimat 25 mg Injection 2.5 ml is given by the healthcare professional during surgery.  In some cases, you may experience tachycardia (rapid heartbeat), temporary hypotension (low blood pressure), wheezing, bronchospasm (asthma-like symptoms), skin flushing, and urticaria (nettle rash). Most of these side effects of Crimat 25 mg Injection 2.5 ml do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Before receiving Crimat 25 mg Injection 2.5 ml inform your doctor if you have had myasthenia gravis or Eaton-Lambert syndrome,  severe electrolyte disorder, asthma-like symptoms (a history of allergy, asthma or bronchospasm), burns and lack of adequate circulatory filling (hypovolaemia), pregnant or breastfeeding mother. Your doctor will prescribe Crimat 25 mg Injection 2.5 ml only if the benefits outweigh the risks. Crimat 25 mg Injection 2.5 ml is not recommended in neonates (children under the age of one month). Crimat 25 mg Injection 2.5 ml is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees Celsius else its efficiency might get lost. Do not store in the freezer or the fridge.

Crimat 25 mg Injection 2.5 ml belongs to the group of medicines called muscle relaxants used to reduce and relieve muscle contraction (excessive tension in the muscles) during surgery, other procedures, and in intensive care. It is also used to calm muscles while on a breathing machine, during general anaesthesia to ease tracheal intubation (a tube into the windpipe), and controlled ventilation. It works by blocking the action of acetylcholine on skeletal muscles. Also, stop sending a pain signal to the brain, relieving muscle stiffness or muscle spasm along with pain and surgery. An experienced doctor must give Crimat 25 mg Injection 2.5 ml under carefully controlled conditions. It is used during procedures that require that the patient is fully anaesthetized (unconscious) or heavily sedated.

• Tachycardia (rapid heartbeat)
• Temporary hypotension (low blood pressure)
• Wheezing
• Bronchospasm (asthma-like symptoms)
• Skin flushing
• Urticaria (nettle rash)

Before you receive Crimat 25 mg Injection 2.5 ml, tell your doctor if you have a disease that affects the muscles and nervous control (neuromuscular disease such as myasthenia gravis or Eaton-Lambert syndrome (muscle disorder)), a severe electrolyte disorder, cancer spread widely from a primary source (carcinomatosis), a sensitivity to histamine, asthma-like symptoms (a history of allergy, asthma or bronchospasm), burns, lack of adequate circulatory filling (hypovolaemia). Crimat 25 mg Injection 2.5 ml should not be given to pregnant women unless prescribed. If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking Crimat 25 mg Injection 2.5 ml. Mothers should stop breastfeeding for 24 hours after receiving Crimat 25 mg Injection 2.5 ml. Crimat 25 mg Injection 2.5 ml is not recommended in neonates (children under the age of one month) as safety and effectiveness in pediatric patients below the age of 1 month have not been established. Crimat 25 mg Injection 2.5 ml some formulations containing benzyl alcohol. In neonates, benzyl alcohol has been associated with an increased incidence of neurological and other complications, sometimes fatal.

Drug-Drug Interaction: Crimat 25 mg Injection 2.5 ml may interact with antibiotics (polymyxins, spectinomycin, tetracyclines, lincomycin, clindamycin, vancomycin), antiarrhythmic medicines (lidocaine, procainamide, quinidine), diuretics (furosemide, thiazides, acetazolamide, mannitol), medicines used to control blood pressure (propranolol, oxprenolol diltiazem, nicardipine, nifedipine, verapamil), antiepileptic medicines (carbamazepine, phenytoin), drugs used to treat rheumatism (chloroquine, d-penicillamine), corticosteroids (beclomethasone, budesonide, prednisolone, fluticasone, mometasone, triamcinolone), medicines used to lower blood pressure during surgery (trimetaphan, hexamethonium), muscle relaxant (dantrolene), an anaesthetic drug (ketamine), treatment of mental illness (lithium, chlorpromazine).

Drug-Food Interaction: Avoid alcohol intake and tobacco consumption with Crimat 25 mg Injection 2.5 ml as it may cause increased drowsiness, dizziness, and lack of concentration.

Drug-Disease Interaction: Crimat 25 mg Injection 2.5 ml may have interactions with burns, histamine, myasthenia gravis (muscle disease), paresis (partial paralysis), pulmonary impairment, liver disease, kidney dysfunction, and seizures (fits).

• POLYMYXIN B
• TETRACYCLINE
• LINCOMYCIN
• CLINDAMYCIN
• VANCOMYCIN
• LIDOCAINE
• PROCAINAMIDE
• QUININE
• FUROSEMIDE
• ACETAZOLAMIDE
• PROPRANOLOL
• DILTIAZEM
• NIFEDIPINE
• VERAPAMIL
• CARBAMAZEPINE
• PHENYTOIN
• CHLOROQUINE
• PENICILLAMINE
• BECLOMETASONE
• BUDESONIDE
• PREDNISOLONE
• FLUTICASONE
• MOMETASONE
• TRIAMCINOLONE
• DANTROLENE
• KETAMINE
• LITHIUM
• CHLORPROMAZINE
• SPECTINOMYCIN
• MANNITOL
• TRIMETAPHAN
• HEXAMETHONIUM

• Avoid freezing and hot temperatures.

• Avoid wearing tight-fitting clothes. Instead, wear loose garments.

• Rest well, and get plenty of sleep.

• To avoid developing pressure sores, change your position every two hours.

• Hot or cold therapy can help treat muscle spasms. Apply an ice pack or hot pack on the muscle for 15-20minutes.

• Stay hydrated, and drink plenty of water.

An experienced healthcare professional must only give Crimat 25 mg Injection 2.5 ml under carefully controlled conditions.

Muscle spasm (contraction): It is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable. When the nerve impulses that control the muscle movements are damaged or interrupted, it could lead to muscle spasms. Symptoms include muscle tightness, joint stiffness, unusual posture, difficulty moving, and pain in affected muscles and joints. Muscle relaxants can treat muscle spasms. Muscle relaxants sedate the muscle and help in inhibiting painful contractions. Muscle weakness is common in the surgical intensive care unit (ICU). Surgical procedures can affect the respiratory muscles through many mechanisms, including thoracoabdominal mechanics (affecting the thorax and the abdomen), reflexes, neuromechanical coupling, and loss of muscular integrity. Impairment of respiratory muscle function after surgery may lead to postoperative complications such as hypoventilation (a state in which a reduced amount of air enters the lungs), hypoxia (an absence of enough oxygen in the tissues), atelectasis (Complete or partial collapse of a lung), and infections, some of which may be life-threatening.