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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

About DABAZ 500MG INJECTION

DABAZ 500MG INJECTION is a chemotherapeutic medicine used in the treatment of skin cancer. Cancer is a condition where the cells grow and reproduce uncontrollably in a specific body part. These cancerous cells can attack and destroy surrounding healthy tissue and organs. DABAZ 500MG INJECTION is used in the treatment of metastatic malignant melanoma. It is a serious condition in which the cancer grows in melanocytes and also spreads to other parts of the body. DABAZ 500MG INJECTION is also used as a second-line therapy in the treatment of Hodgkin’s Disease when used in combination with other approved drugs.

DABAZ 500MG INJECTION contains Dacarbazine, which belongs to the class of alkylating agents. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This helps prevent the growth and further spread of cancerous or non-cancerous cells.

DABAZ 500MG INJECTION may cause certain side effects, such as nausea, vomiting, headache, dizziness, and pain at the site of injection. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. DABAZ 500MG INJECTION is a parenteral preparation. A trained healthcare professional will administer it. 

DABAZ 500MG INJECTION should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including medications you take, to rule out any side effects/interactions. Before administration, inform your doctor if you have liver/kidney disease or heart problems. DABAZ 500MG INJECTION may cause hemopoietic (bone marrow) depression, hepatic toxicity, and hepatic necrosis in some patients. Hence, careful monitoring of blood and liver functioning should be done during the entire treatment. This medicine is known to cause fetal harm if used in pregnancy. Hence, inform your doctor if you are pregnant, planning to become pregnant and breastfeeding before taking DABAZ 500MG INJECTION.

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Whats That

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Non returnable*
COD available

Online payment accepted

Manufacturer/Marketer

Int-Intas Laboratories Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

Uses of DABAZ 500MG INJECTION

Metastatic Malignant Melanoma, Hodgkin’s Disease.

Medicinal Benefits

DABAZ 500MG INJECTION contains Dacarbazine, which belongs to the class of alkylating agents. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This helps prevent the growth and further spread of cancerous or non-cancerous cells.

Side Effects of DABAZ 500MG INJECTION

  • Nausea
  • Dizziness
  • Fever
  • Chills
  • Sore throat
  • Headache
  • Vomiting
  • Cough
  • Decreased platelet count
  • Bruising or bleeding gums
  • Pain at the site of injection

Directions for Use

DABAZ 500MG INJECTION will be administered by a trained healthcare professional. Hence, do not self-administer. 

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

DABAZ 500MG INJECTION should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before administration, inform your doctor if you have liver/kidney disease or cardiac disorders. DABAZ 500MG INJECTION may cause hemopoietic (bone marrow) depression, hepatic toxicity, and hepatic necrosis in some patients. Hence, careful monitoring should be done during the entire treatment. This medicine is known to cause fetal harm in pregnant women and breastfeeding mothers. Hence, inform your doctor if you are pregnant, planning to become pregnant and breastfeeding. It is unknown whether DABAZ 500MG INJECTION can be administered to children or not. If administered, close monitoring of the child is needed. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.

Therapeutic Class

CHEMOTHERAPY

Drug-Drug Interactions

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DacarbazineClozapine
Severe
DacarbazineInfliximab
Severe

Drug-Drug Interactions

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DacarbazineClozapine
Severe
How does the drug interact with DABAZ 500MG INJECTION:
Combining DABAZ 500MG INJECTION with Clozapine can increase the risk of neutropenia.

How to manage the interaction:
Although taking DABAZ 500MG INJECTION and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
DacarbazineInfliximab
Severe
How does the drug interact with DABAZ 500MG INJECTION:
When DABAZ 500MG INJECTION is taken with Infliximab, it can increase the risk or severity of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Infliximab and DABAZ 500MG INJECTION, but it can be taken if prescribed by a doctor. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
DacarbazineKetoconazole
Severe
How does the drug interact with DABAZ 500MG INJECTION:
When DABAZ 500MG INJECTION is taken with Ketoconazole, it can increase the risk of liver damage.

How to manage the interaction:
There may be a possibility of interaction between DABAZ 500MG INJECTION and Ketoconazole, but it can be taken if prescribed by a doctor. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.
DacarbazineTofacitinib
Severe
How does the drug interact with DABAZ 500MG INJECTION:
Taking DABAZ 500MG INJECTION with Tofacitinib may increase the risk of serious infection.

How to manage the interaction:
There may be a possibility of interaction between DABAZ 500MG INJECTION and Tofacitinib, but it can be taken if prescribed by a doctor. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not discontinue any medications without consulting your doctor.
DacarbazineCladribine
Severe
How does the drug interact with DABAZ 500MG INJECTION:
The combined use of cladribine with DABAZ 500MG INJECTION can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between DABAZ 500MG INJECTION and Cladribine, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
DacarbazineEtanercept
Severe
How does the drug interact with DABAZ 500MG INJECTION:
When Etanercept is used with DABAZ 500MG INJECTION, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Etanercept and DABAZ 500MG INJECTION together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
DacarbazineThalidomide
Severe
How does the drug interact with DABAZ 500MG INJECTION:
Taking thalidomide together with DABAZ 500MG INJECTION may increase the risk of blood clots.

How to manage the interaction:
Although taking thalidomide and DABAZ 500MG INJECTION together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
DacarbazineBaricitinib
Severe
How does the drug interact with DABAZ 500MG INJECTION:
Coadministration of DABAZ 500MG INJECTION with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Baricitinib and DABAZ 500MG INJECTION together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • ABACAVIR
  • ZIDOVUDINE
  • ADEFOVIR
  • WARFARIN
  • ACENOCOUMAROL
  • PHENYTOIN
  • ABATACEPT

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Avoid going out in the hot sun, as it can harm your skin.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Special Advise

  • DABAZ 500MG INJECTION should be administered only by a trained and experienced oncologist.
  • A blood test should be performed, such as LFT and RFT, to check for liver/ and kidney function.
  • Weekly blood tests should be done for after the dose is administered to check for CBC (Complete blood count).

Disease/Condition Glossary

Metastatic Malignant Melanoma: Melanoma is a type of skin cancer in which the cancer cells grow in melanocytes. It is mainly caused by harmful UV radiation from the sun. When the cancer cells spread to other parts of the body, it is known as Metastasis. Malignant melanoma is common in fair-skinned and freckled individuals. It results in mole formation, typically on the skin of the face. 

Hodgkin’s Disease: Hodgkin’s disease or lymphoma is a blood cancer of a certain type of cells called WBCs, specifically lymphocytes. Lymphocytes normally help control infection and maintain the body's normal immunity. However, in a cancerous state, there is an abnormal multiplication of these blood cells, causing many problems such as fatigue, fever, loss of appetite, itching, night sweats and lymph node swelling.

DABAZ 500MG INJECTION Substitute

Substitutes safety advice
  • DACAREX 500MG INJECTION

    by Others

    994.86per tablet
  • DECARB 500MG INJECTION

    by Others

    223.18per tablet
  • Dacarb 500 mg Injection 1's

    by Others

    519.30per tablet
  • Celdaz 500 Injection 1's

    by Others

    522.50per tablet
  • Dacmed 500 Injection 1's

    by Others

    906.39per tablet
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