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  3. Dacsted 200 Injection 1's

Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Composition :

DACARBAZINE-200MG

Manufacturer/Marketer :

Halsted Pharma Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Dacsted 200 Injection 1's

Dacsted 200 Injection 1's is a chemotherapeutic medicine used in the treatment of skin cancer. Cancer is a condition where the cells grow and reproduce uncontrollably in a specific body part. These cancerous cells can attack and destroy surrounding healthy tissue and organs. Dacsted 200 Injection 1's is used in the treatment of metastatic malignant melanoma. It is a serious condition in which the cancer grows in melanocytes and also spreads to other parts of the body. Dacsted 200 Injection 1's is also used as a second-line therapy in the treatment of Hodgkin’s Disease when used in combination with other approved drugs.

Dacsted 200 Injection 1's contains Dacarbazine, which belongs to the class of alkylating agents. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This helps prevent the growth and further spread of cancerous or non-cancerous cells.

Dacsted 200 Injection 1's may cause certain side effects, such as nausea, vomiting, headache, dizziness, and pain at the site of injection. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Dacsted 200 Injection 1's is a parenteral preparation. A trained healthcare professional will administer it. 

Dacsted 200 Injection 1's should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including medications you take, to rule out any side effects/interactions. Before administration, inform your doctor if you have liver/kidney disease or heart problems. Dacsted 200 Injection 1's may cause hemopoietic (bone marrow) depression, hepatic toxicity, and hepatic necrosis in some patients. Hence, careful monitoring of blood and liver functioning should be done during the entire treatment. This medicine is known to cause fetal harm if used in pregnancy. Hence, inform your doctor if you are pregnant, planning to become pregnant and breastfeeding before taking Dacsted 200 Injection 1's.

Uses of Dacsted 200 Injection 1's

Metastatic Malignant Melanoma, Hodgkin’s Disease.

Directions for Use

Dacsted 200 Injection 1's will be administered by a trained healthcare professional. Hence, do not self-administer. 

Medicinal Benefits

Dacsted 200 Injection 1's contains Dacarbazine, which belongs to the class of alkylating agents. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This helps prevent the growth and further spread of cancerous or non-cancerous cells.

Storage

Keep Dacsted 200 Injection 1's out of the sight and reach of children.
Side effects of Dacsted 200 Injection
  • Aim for at least five servings of a well-balanced diet per day that is full of vibrant fruits and vegetables.
  • Eat more whole foods, lean meats, and plant-based foods, and eat healthy fruits like bananas, oranges, and berries.
  • Limit alcohol intake and abstain from smoking to promote general wellbeing.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.

Drug Warnings

Dacsted 200 Injection 1's should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before administration, inform your doctor if you have liver/kidney disease or cardiac disorders. Dacsted 200 Injection 1's may cause hemopoietic (bone marrow) depression, hepatic toxicity, and hepatic necrosis in some patients. Hence, careful monitoring should be done during the entire treatment. This medicine is known to cause fetal harm in pregnant women and breastfeeding mothers. Hence, inform your doctor if you are pregnant, planning to become pregnant and breastfeeding. It is unknown whether Dacsted 200 Injection 1's can be administered to children or not. If administered, close monitoring of the child is needed. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Dacsted 200 Injection:
Taking thalidomide together with Dacsted 200 Injection may increase the risk of blood clots.

How to manage the interaction:
Although taking thalidomide and Dacsted 200 Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dacsted 200 Injection:
Combining Dacsted 200 Injection with Clozapine can increase the risk of neutropenia.

How to manage the interaction:
Although taking Dacsted 200 Injection and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
How does the drug interact with Dacsted 200 Injection:
When Dacsted 200 Injection is taken with Ketoconazole, it can increase the risk of liver damage.

How to manage the interaction:
There may be a possibility of interaction between Dacsted 200 Injection and Ketoconazole, but it can be taken if prescribed by a doctor. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.
How does the drug interact with Dacsted 200 Injection:
Taking Dacsted 200 Injection with Tofacitinib may increase the risk of serious infection.

How to manage the interaction:
There may be a possibility of interaction between Dacsted 200 Injection and Tofacitinib, but it can be taken if prescribed by a doctor. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Dacsted 200 Injection:
When Dacsted 200 Injection is taken with Infliximab, it can increase the risk or severity of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Infliximab and Dacsted 200 Injection, but it can be taken if prescribed by a doctor. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Dacsted 200 Injection:
When Etanercept is used with Dacsted 200 Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Etanercept and Dacsted 200 Injection together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Dacsted 200 Injection:
Coadministration of Dacsted 200 Injection with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Baricitinib and Dacsted 200 Injection together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Dacsted 200 Injection:
The combined use of cladribine with Dacsted 200 Injection can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Dacsted 200 Injection and Cladribine, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Avoid going out in the hot sun, as it can harm your skin.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.

Side Effects of Dacsted 200 Injection 1's

  • Nausea
  • Dizziness
  • Fever
  • Chills
  • Sore throat
  • Headache
  • Vomiting
  • Cough
  • Decreased platelet count
  • Bruising or bleeding gums
  • Pain at the site of injection

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Dacsted 200 Injection 1's contains Dacarbazine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis.

Dacsted 200 Injection 1's may cause hemopoietic (bone marrow) depression, hepatic toxicity, and hepatic necrosis in some patients. Hence, inform your oncologist about your complete medical history, including current medication, to rule out any side effects/interactions.

Drug-Drug Interactions Checker List

  • ABACAVIR
  • ZIDOVUDINE
  • ADEFOVIR
  • WARFARIN
  • ACENOCOUMAROL
  • PHENYTOIN
  • ABATACEPT

Special Advise

  • Dacsted 200 Injection 1's should be administered only by a trained and experienced oncologist.
  • A blood test should be performed, such as LFT and RFT, to check for liver/ and kidney function.
  • Weekly blood tests should be done for after the dose is administered to check for CBC (Complete blood count).

Disease/Condition Glossary

Metastatic Malignant Melanoma: Melanoma is a type of skin cancer in which the cancer cells grow in melanocytes. It is mainly caused by harmful UV radiation from the sun. When the cancer cells spread to other parts of the body, it is known as Metastasis. Malignant melanoma is common in fair-skinned and freckled individuals. It results in mole formation, typically on the skin of the face. 

Hodgkin’s Disease: Hodgkin’s disease or lymphoma is a blood cancer of a certain type of cells called WBCs, specifically lymphocytes. Lymphocytes normally help control infection and maintain the body's normal immunity. However, in a cancerous state, there is an abnormal multiplication of these blood cells, causing many problems such as fatigue, fever, loss of appetite, itching, night sweats and lymph node swelling.

Have a query?

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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Dacsted 200 Injection 1's to prevent serious side effects.

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Pregnancy

Unsafe

Dacsted 200 Injection 1's is not recommended for use in pregnancy as it may harm your fetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Dacsted 200 Injection 1's. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving Dacsted 200 Injection 1's. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Caution

Dacsted 200 Injection 1's will be administered in the hospital setting. Hence, driving is not recommended.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Dacsted 200 Injection 1's. It may cause hepatic necrosis when administered with other antineoplastics. Hence, Dacsted 200 Injection 1's should be used with caution in patients with liver problems. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Dacsted 200 Injection 1's. It should be used with caution in patients with renal impairment. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

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Children

Consult your doctor

Limited information is available for the use of Dacsted 200 Injection 1's in children. It will be administered to the children only if clearly needed. If administered, careful monitoring of the child is needed.

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