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  3. Deferglob 250mg Tablet

Deferglob 250mg Tablet, Pack of 1 Tablet
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Hari Kumar , MBBS
Non returnable*
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Composition :

DEFERASIROX-250MG

Consume Type :

ORAL

Return Policy :

Not Returnable

About Deferglob 250mg Tablet

Deferglob 250mg Tablet belongs to the group of medicines called iron chelators. Deferglob 250mg Tablet is indicated for treating chronic iron overload due to blood transfusions (transfusional hemosiderosis) in patients two years older. It can also be indicated for treating chronic iron overload in patients ten years of age and older with non-transfusion-dependent thalassemia (NTDT).

The active ingredient in Deferglob 250mg Tablet is deferasirox. It is a trivalent iron selective chelating agent. It binds the excess iron and eliminates it through faeces. The danger of organ damage is reduced as a result.

Deferglob 250mg Tablet is available in the form of oral formulations. Please take Deferglob 250mg Tablet in the dose and duration prescribed by your doctor based on specific medical conditions. In some cases, you may experience common side effects such as diarrhoea, vomiting, nausea, abdominal pain, skin rashes, and increased serum creatinine. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue using Deferglob 250mg Tablet for as long as your doctor has prescribed it. Do not use Deferglob 250mg Tablet without a doctor's advice if you have a skin reaction or irritation to any medicine. Consult your doctor before using the Deferglob 250mg Tablet if you are pregnant or breastfeeding. Do not use Deferglob 250mg Tablet in more than prescribed doses or longer duration as it may cause adverse effects. Keep your doctor informed about your health condition and all the medicines you take before taking Deferglob 250mg Tablet to rule out any side effects.

Uses of Deferglob 250mg Tablet

Deferglob 250mg Tablet is indicated for treating chronic iron overload that occurs due to blood transfusions (transfusional hemosiderosis) in patients two years of age and older. It can also be indicated for treating chronic iron overload in patients ten years of age and older with non-transfusion-dependent thalassemia (NTDT).

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Deferasirox is the active component in Deferglob 250mg Tablet. It's a chelating agent that selectively binds to trivalent iron. It binds extra iron and excretes it in the faeces. As a result, the risk of organ damage is lowered.

Storage

Store in a cool and dry place away from sunlight
Side effects of Deferglob 250mg Tablet
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Increased creatinine levels must be corrected immediately with the help of a doctor.
  • Reduce strenuous activities that can lead to muscle breakdown and production of creatinine.
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding tissue.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Avoid smoking and drinking alcohol.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.

Drug Warnings

Do not take Deferglob 250mg Tablet if you are allergic to Deferglob 250mg Tablet or its ingredients. Deferglob 250mg Tablet is not usually recommended if you are a pregnant or lactating woman; there is not enough information to say whether it's safe. However, your doctor may prescribe it if they think the medicine's benefits outweigh the risks. It is unknown whether Deferglob 250mg Tablet alters the ability to drive, so do not drive or operate machinery if you experience any symptoms affecting your ability to concentrate and react. Seek medical attention if the symptoms persist longer. Avoid consuming alcohol along with Deferglob 250mg Tablet as it could lead to unpleasant side effects. Should monitor elderly and paediatric patients closely for toxicity.

Drug-Drug Interactions

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DeferasiroxMipomersen
Severe
DeferasiroxTenofovir alafenamide
Severe

Drug-Drug Interactions

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DeferasiroxMipomersen
Severe
How does the drug interact with Deferglob 250mg Tablet:
Mipomersen may cause liver problems and using it with Deferglob 250mg Tablet may increase that risk.

How to manage the interaction:
Although taking Deferglob 250mg Tablet and Mipomersen together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms, it's important to contact your doctor right away: fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, bleeding, abdominal pain, or dark urine. Do not discontinue any medications without first consulting your doctor.
DeferasiroxTenofovir alafenamide
Severe
How does the drug interact with Deferglob 250mg Tablet:
Tenofovir may cause kidney problems and combining it with Deferglob 250mg Tablet may increase that risk.

How to manage the interaction:
Although taking tenofovir and Deferglob 250mg Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhoea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not discontinue any medications without a doctor's advice.
DeferasiroxWarfarin
Severe
How does the drug interact with Deferglob 250mg Tablet:
Coadministration of Warfarin with Deferglob 250mg Tablet may increase the risk of gastrointestinal ulcers and bleeding.

How to manage the interaction:
There may be a possible interaction between Deferglob 250mg Tablet and Warfarin, but they can be taken together if a doctor has prescribed them. However, consult a doctor immediately if you experience abdominal pain, bloating, dizziness, lightheadedness, loss of appetite, nausea, vomiting (especially with fresh or dried blood that looks like coffee grounds), and red or black, tarry stools, contact a doctor. Do not discontinue any medications without consulting a doctor.
DeferasiroxNabumetone
Severe
How does the drug interact with Deferglob 250mg Tablet:
Taking Nabumetone and Deferglob 250mg Tablet together can increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Co-administration of Nabumetone with Deferglob 250mg Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
DeferasiroxUrokinase
Severe
How does the drug interact with Deferglob 250mg Tablet:
Using Deferglob 250mg Tablet together with Urokinase may increase the risk of gastrointestinal ulcers.

How to manage the interaction:
Co-administration of Urokinase with Deferglob 250mg Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
DeferasiroxCilostazol
Severe
How does the drug interact with Deferglob 250mg Tablet:
Co-administration of Deferglob 250mg Tablet with cilostazol can increase the risk or severity of gastrointestinal ulcers and bleeding.

How to manage the interaction:
Taking Deferglob 250mg Tablet with cilostazol together can possibly result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as stomach pain, bloating, dizziness, lightheadedness, decreased hunger, nausea, vomiting (especially with fresh or dried blood that looks like coffee grounds), and red or black, tarry stools. Do not discontinue any medications without consulting a doctor.
DeferasiroxKetoprofen
Severe
How does the drug interact with Deferglob 250mg Tablet:
Combining Ketoprofen with Deferglob 250mg Tablet can increase the risk of gastrointestinal bleeding and ulcers.

How to manage the interaction:
Co-administration of Ketoprofen with Deferglob 250mg Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
DeferasiroxClopidogrel
Severe
How does the drug interact with Deferglob 250mg Tablet:
Taking Deferglob 250mg Tablet together with clopidogrel may increase the risk of gastrointestinal ulcers and bleeding.

How to manage the interaction:
Although taking clopidogrel together with Deferglob 250mg Tablet has a possibility of interaction, it can be taken if prescribed by your doctor. However, if you experience abdominal pain, bloating, dizziness, lightheadedness, red or black, tarry stools oe headache. Do not discontinue any medication without consulting your doctor.
DeferasiroxSulfasalazine
Severe
How does the drug interact with Deferglob 250mg Tablet:
Coadministration of Deferglob 250mg Tablet and Sulfasalazine may increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking sulfasalazine and Deferglob 250mg Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhoea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not discontinue any medications without a doctor's advice.
DeferasiroxClozapine
Severe
How does the drug interact with Deferglob 250mg Tablet:
Taking Deferglob 250mg Tablet with Clozapine may increase the risk of infections.

How to manage the interaction:
Although taking Deferglob 250mg Tablet and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact your doctor. They may be able to recommend other options for you that won't cause any problems. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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DEFERASIROX-250MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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DEFERASIROX-250MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
The blood levels and effects of caffeine may be enhanced by Deferglob 250mg Tablet. Avoid consumption of caffeinated drinks during the treatment with Deferglob 250mg Tablet. If you experience any unusual symptoms call a doctor.

Diet & Lifestyle Advise

  • Choose foods high in nutrients, such as fruits, vegetables, and whole grains.
  • Replace fatty protein sources with lean alternatives and consume modest quantities of healthy fat sources for improved well-being.
  • Create a diet that includes vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources.
  • Instead of saturated and trans fats, choose monounsaturated and polyunsaturated fats (fish, nuts, and vegetable oils).
  • Select/prepare foods and beverages with fewer added sugars/caloric sweeteners.
  • Be mindful of salt; consume no more than 2,300 mg each day.
  • Limit or avoid alcohol and caffeine consumption.

Habit Forming

No

Therapeutic Class

CHELATING AGENTS

Deferglob 250mg Tablet Substitute

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Hari Kumar

Reviewed By

Hari Kumar

MBBS

Last Updated

Jul 8, 2025 | 9:41 AM IST

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Deferasirox is the active component in Deferglob 250mg Tablet. It's a chelating agent that selectively binds to trivalent iron. It binds extra iron and excretes it in the faeces. As a result, the risk of organ damage is lowered.

No, it is a prescribed drug given by a physician for preventing specific medical conditions. Taking it on your own can cause unwanted side effects.

Take the missed dose as soon as possible. However, skip the missed dose and return to your regular dosing schedule if it is time for the next dose. Do not take a double dose to make up for the dose that you missed.

Deferglob 250mg Tablet is safe if used in the dose and duration recommended by your doctor. Take it precisely as directed, and do not skip any dose. Follow your doctor's guidelines carefully and inform your doctor if any of the side effects disturb you.

Hemochromatosis, or iron overload, is a condition in which your body stores too much iron. It can cause severe damage to your body, including to your heart, liver and pancreas.

Drug-Drug Interactions Checker List

  • ALUMINIUM HYDROXIDE
  • REPAGLINIDE
  • THEOPHYLLINE
  • BUSULFAN
  • ASPIRIN
  • CELECOXIB
  • DILTIAZEM
  • PARACETAMOL

Special Advise

  • Monitor blood counts, liver function, and renal function monthly.
  • Monitor serum ferritin monthly to assess the patient’s response to therapy and minimize the risk of over-chelation.

Disease/Condition Glossary

Hemochromatosis, or iron overload, is a condition in which your body stores too much iron. It can cause severe damage to your body, including to your heart, liver and pancreas.

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