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Written By aquibnaseer ,
Reviewed By Sunny S , MBBS
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Composition :

GLIMEPIRIDE-4MG

Manufacturer/Marketer :

Micro Labs Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Diapride-4 Tablet

Diapride-4 Tablet belongs to a class of antidiabetic called 'sulfonylureas' used to lower raised blood sugar levels in Type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus - NIDDM). Type 2 diabetes develops if the body does not produce enough insulin or when your body's insulin does not work as well as it should. Insulin is a substance that helps to lower the level of sugar in your blood, especially after meals.

The Diapride-4 Tablet contains Glimepiride which acts on insulin-secreting cells called beta cells inside the pancreas and activates calcium channels on cells which lets insulin pass out of the cell. This insulin then makes each cell in the body take up glucose and utilize it, thus lowering raised blood glucose. Therefore, it prevents symptoms of type 2 diabetes.

Take Diapride-4 Tablet as prescribed by your doctor. Some people may experience an allergic reaction (skin rash, hives & sensitivity to sun rays), liver dysfunction (jaundice, bile duct blockage, and hepatitis), seizures, coma & low glucose levels. Most of these side effects of Diapride-4 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. 

Diapride-4 Tablet should not be stopped even if you feel better without consulting your doctor as the sugar level keeps changing. If you stop taking Diapride-4 Tablet abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy) and nerve damage (neuropathy). Diapride-4 Tablet should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Please inform your doctor if you have any heart disease or plan to get pregnant or breastfeed.

Uses of Diapride-4 Tablet

Type 2 diabetes

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Diapride-4 Tablet is used in people with type 2 diabetes to minimize elevated blood sugar levels with a balanced diet and exercise in combination. Diapride-4 Tablet  can be combined with insulin or other forms of oral antidiabetic medication. Diapride-4 Tablet decreases blood sugar levels in a diabetic patient by increasing the production and secretion of insulin from the pancreas beta cells. Thus, it helps in controlling increased blood sugar levels after the meal.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Diapride-4 Tablet

  • Allergic reactions
  • Headache
  • Nausea
  • Blood pressure drop
  • Shock
  • Abnormal liver function
  • Including skin and eye yellowing (jaundice)
  • Bile flow issues (cholestasis)
  • Liver inflammation (hepatitis) or failure of the liver

Drug Warnings

Before taking Diapride-4 Tablet , inform your doctor if you are healing from injury, had or going to have surgery, have fever infections or other sources of stress, then contact your doctor as it might be appropriate to adjust care temporarily. If you have a serious kidney/liver disease, breastfeeding or pregnant, consult the doctor before using Diapride-4 Tablet . Do not take Diapride-4 Tablet if you are allergic to sulpha drugs, glimepiride, or any other antidiabetic medicines or have a deficiency of glucose 6-phosphate dehydrogenase (G6PD). A heart disease patient should consult a doctor before taking the Diapride-4 Tablet as it may worsen the heart disease's current conditions. Do not take Diapride-4 Tablet with oral contraceptives as it may increase blood sugar levels. On the other hand, taking Diapride-4 Tablet with pain killers like aspirin or ibuprofen can lower your blood sugar.

Drug-Drug Interactions

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GlimepirideMiconazole
Severe
GlimepirideTrovafloxacin
Severe

Drug-Drug Interactions

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GlimepirideMiconazole
Severe
How does the drug interact with Diapride-4 Tablet:
Co-administration of Miconazole with Diapride-4 Tablet may increase the blood levels and effects of Diapride-4 Tablet leading to low blood glucose levels.

How to manage the interaction:
Although there is a possible interaction between Miconazole and Diapride-4 Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat Consult a doctor immediately. Do not stop using medications without a doctor's advice.
GlimepirideTrovafloxacin
Severe
How does the drug interact with Diapride-4 Tablet:
When Diapride-4 Tablet is taken with Trovafloxacin, it can affect blood glucose levels either hypoglycemia or hyperglycemia.

How to manage the interaction:
Taking Diapride-4 Tablet with Trovafloxacin together can possibly result in an interaction, but it can be taken if a doctor has advised it. It's important to be aware of symptoms like increased urination and thirst, and to contact your doctor if you experience any concerning symptoms. Your doctor may be able to suggest alternative medications that don't interact with your diabetes treatment. Do not stop using any medications without a doctor's advice.
GlimepirideBisoprolol
Severe
How does the drug interact with Diapride-4 Tablet:
Concomitant use of bisoprolol with Diapride-4 Tablet may increase the risk, severity, and/or duration of hypoglycemia (low blood sugar). It may also mask some of the symptoms of hypoglycemia such as palpitation, tremor, and rapid heartbeat, making it more difficult to recognize an oncoming episode.

How to manage the interaction:
Although there may be an interaction, bisoprolol can be taken with Diapride-4 Tablet if prescribed by the doctor. Consult the prescriber if you develop symptoms of low blood sugar like shakiness, dizziness, sweating, nausea, hunger, weakness, or lightheadedness.
GlimepirideSulfadiazine
Severe
How does the drug interact with Diapride-4 Tablet:
Taking Diapride-4 Tablet with Sulfadiazine may increase the risk of low blood sugar.

How to manage the interaction:
Although there is a possible interaction, Diapride-4 Tablet can be taken with sulfadiazine if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Do not discontinue the medications without consulting a doctor. Do not discontinue the medications without consulting a doctor.
GlimepirideBumetanide
Severe
How does the drug interact with Diapride-4 Tablet:
Bumetanide may interfere with blood glucose control and reduce the effectiveness of Diapride-4 Tablet.

How to manage the interaction:
Although there is a possible interaction, Diapride-4 Tablet can be taken with bumetanide if prescribed by the doctor. Monitoring of blood glucose levels is advised.
GlimepirideEnoxacin
Severe
How does the drug interact with Diapride-4 Tablet:
Taking Diapride-4 Tablet with Enoxacin, may affect blood glucose levels which may lead to hypoglycemia (low blood glucose) and hyperglycemia (high blood glucose).

How to manage the interaction:
Taking Diapride-4 Tablet with Enoxacin together can possibly result in an interaction, but it can be taken if a doctor has advised it. This can be a good thing if you need help lowering your blood sugar, but it can also be a problem if it goes too low. If you notice any of these symptoms, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
GlimepirideFurosemide
Severe
How does the drug interact with Diapride-4 Tablet:
Co-administration of Furosemide may interfere with blood glucose control and lower the effectiveness of Diapride-4 Tablet.

How to manage the interaction:
Although there is a possible interaction, Diapride-4 Tablet can be taken with furosemide if prescribed by the doctor. Regular monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
GlimepirideVoriconazole
Severe
How does the drug interact with Diapride-4 Tablet:
Co-administration of Diapride-4 Tablet with Voriconazole may increase the blood levels and effects of Diapride-4 Tablet.

How to manage the interaction:
Although there is a possible interaction, Diapride-4 Tablet can be taken with voriconazole if prescribed by the doctor. Consult the prescriber if you experience headache, dizziness, and rapid heartbeat. Do not discontinue the medications without consulting a doctor.
GlimepiridePromazine
Severe
How does the drug interact with Diapride-4 Tablet:
When Diapride-4 Tablet is taken with Promazine may interfere with blood glucose control and reduce the effectiveness of Diapride-4 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Diapride-4 Tablet and Promazine, but it can be taken if prescribed by a doctor. It's important to keep an eye on how much urine you're producing. If you notice any of these signs - very high or very low blood sugar levels - make sure to contact a doctor right away. Do not stop using any medications without talking to a doctor.
GlimepirideParoxetine
Severe
How does the drug interact with Diapride-4 Tablet:
Taking Diapride-4 Tablet with Paroxetine may increase the risk of low blood sugar.

How to manage the interaction:
Although there is a possible interaction, Diapride-4 Tablet can be taken with paroxetine if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar like headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Do not discontinue the medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do regular exercise such as cycling, walking, jogging, dancing or swimming for a minimum of 30 minutes per day. Invest at least 150 minutes of your week in exercise.
  • Maintain healthy body weight as obesity is also related to the onset of diabetes.
  • Maintain a low fat and a low sugar diet. Replace carbohydrates containing foods with whole grains, fruits and vegetables as carbohydrates turn to sugars leading to high blood sugar.
  • Avoid consumption of alcohol and quit smoking.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS AND ANTIHYPERGLYCEMICS

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Author Details

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Drug-Diseases Interactions

verifiedApollotooltip
GLIMEPIRIDE-4MGHypertensive heart and renal disease
Severe
GLIMEPIRIDE-4MGUnspecified kidney failure
Severe

Drug-Diseases Interactions

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GLIMEPIRIDE-4MGHypertensive heart and renal disease
Severe
How does the disease interact with Diapride-4 Tablet:
When compared to diet alone or diet plus insulin, the use of oral hypoglycemic medications may be associated with an increased risk of cardiovascular mortality. This alert is based on the University Group Diabetes Programme (UGDP) project, a long-term prospective clinical investigation aimed to assess the efficacy of glucose-lowering medications in preventing or delaying vascular problems in non-insulin-dependent diabetes patients. Patients treated for 5 to 8 years with diet with a fixed dose of either tolbutamide (a sulfonylurea) or phenformin (a biguanide) had a cardiovascular death risk nearly 2.5 times that of patients treated with diet alone, resulting in the cessation of both therapies in the research. Regardless of how these findings are interpreted, doctors and patients should be aware of the possibility.

How to manage the interaction:
The use of oral hypoglycemic agents may be associated with an increased risk of heart problems. Let the doctor know if you have heart problems.
GLIMEPIRIDE-4MGUnspecified kidney failure
Severe
How does the disease interact with Diapride-4 Tablet:
Sulfonylureas are metabolised in the liver and eliminated in the urine and faeces as metabolites (some of which have pharmacologic activity). Patients with poor liver and/or renal function who are treated with sulfonylureas may be exposed to increased serum drug concentrations, increasing the risk of severe hypoglycemia episodes. In the context of hepatic impairment, gluconeogenic ability may be reduced, adding to the risk. Sulfonylurea therapy should be used with caution in people who have liver or kidney illness. It is possible that lower dosages and longer intervals between dosage adjustments will be required. If hypoglycemia occurs during treatment, it may be prolonged in these patients due to slower medication metabolism and/or excretion.

How to manage the interaction:
In patients with kidney problems, severe hypoglycemic episodes may occur. Therapy should be administered cautiously in patients with renal disease.
GLIMEPIRIDE-4MGOther disorders of adrenal gland
Moderate
How does the disease interact with Diapride-4 Tablet:
Hypoglycemia is a common side effect of insulin and/or oral hypoglycemic medications. Patients who are debilitated or malnourished, those with defective counterregulatory mechanisms (e.g., autonomic neuropathy and adrenal or pituitary insufficiency), and those receiving beta-adrenergic blocking agents should exercise caution when using these drugs.

How to manage the interaction:
Care should be taken in patients who may be particularly susceptible to the development of hypoglycemic episodes during treatment.
GLIMEPIRIDE-4MGAnaemia due to enzyme disorders
Moderate
How does the disease interact with Diapride-4 Tablet:
In patients with glucose 6-phosphate dehydrogenase (G6PD) impairment, sulfonylureas can cause hemolytic anaemia. In individuals with G6PD deficiency, these medicines should be administered with caution, and a non-sulfonylurea option should be considered. Postmarketing reports of hemolytic anaemia in patients receiving these medications who did not have known G6PD deficiency have been received.

How to manage the interaction:
Therapy should be used with caution in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency. The use of a non-sulfonylurea alternative should be considered.
GLIMEPIRIDE-4MGOther disorders of fluid, electrolyte and acid-base balance
Moderate
How does the disease interact with Diapride-4 Tablet:
Treatment with sulfonylureas may cause hyponatremia in individuals who are taking other drugs or have medical disorders that cause hyponatremia, or it may stimulate the secretion of antidiuretic hormone. Certain sulfonylureas have been linked to the syndrome of inappropriate antidiuretic hormone (SIADH) secretion, and these medications may enhance the peripheral (antidiuretic) action of ADH and/or increase ADH release. Caution should be exercised when treating individuals who have hyponatremia or are at increased risk of developing hyponatremia, such as the elderly, those using diuretics, or those who are volume-depleted.

How to manage the interaction:
Caution should be used when treating patients with low sodium or at greater risk of developing low sodium such as elderly patients, patients taking diuretics or those who are volume-depleted.

FAQs

The Diapride-4 Tablet contains Glimepiride which acts on insulin-secreting cells called beta cells inside the pancreas and activates calcium channels on cells which lets insulin pass out of the cell. This insulin then makes each cell in the body take up glucose and utilize it, thus lowering raised blood glucose. Therefore, it prevents symptoms of type 2 diabetes.

A patient is advised to take the missed dose as soon as possible or skip to the next dose if it's been too late. A patient should never attempt to take a double dose to compensate for the missed dose as it may prove harmful.

Diapride-4 Tablet is not recommended with warfarin as these two drugs are contraindicated with each other and hence may result in any harmful symptom when taken together in heart patients.

Avoid intake of Diapride-4 Tablet and consult a doctor if you have an allergy to sulfa drugs, diabetic ketoacidosis, heart disease, liver or kidney disease, an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD).

Your blood sugar might get decreased, so regular blood glucose monitoring is required. Signs and symptoms of low blood sugar level are feeling very hungry, dizziness, irritability, confusion, anxiety or shakiness. Try to eat or drink a fast-acting sugar source (like fruit juice, hard candy, crackers, raisins or non-diet soda).

No, Diapride-4 Tablet is only prescribed to treat type 2 diabetes and not type 1 diabetes. If you are type 1 diabetic patient consult with a doctor so that insulin forms can be prescribed for the same.

The patient is advised to talk to a doctor before taking contraceptive pills if he/she is already taking Diapride-4 Tablet , then the doctor may change the dose of Diapride-4 Tablet . This is because oral contraceptive pills change body responds to the sugar.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • ROSUVASTATIN
  • DULOXETINE
  • DAPAGLIFLOZIN
  • GLYBURIDE
  • INSULIN
  • CANAGLIFLOZIN
  • SITAGLIPTIN
  • EMPAGLIFLOZIN
  • FUROSEMIDE
  • ATORVASTATIN
  • PREGABALIN
  • METFORMIN
  • NAPROXEN
  • CLOPIDOGREL
  • IBUPROFEN
  • WARFARIN

Disease/Condition Glossary

Type 2 diabetes: It is a chronic (long-lasting) condition that keeps the body from properly utilizing insulin. Hence, people affected with type 2 diabetes either do not produce enough insulin, or there is resistance to the action of insulin. Middle-aged or older are most likely to suffer from type 2 diabetes, so it is also known as adult-onset diabetes. Symptoms of type 2 diabetes include increased thirst, frequent urination at night, slow wound healing, increased hunger, fatigue, and blurred vision. In some cases, there may be weight gain while in rare cases weight loss may be observed. The complication of type 2 diabetes also includes nerve problems, kidney problems, the damaged retina of eyes or blindness, loss of limbs, sexual dysfunction, and an increased chance of heart attack or stroke.

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